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Volume 63 (1996)
- Issue 6 Pages 441-
- Issue 5 Pages 319-
- Issue 4 Pages 255-
- Issue 3 Pages 175-
- Issue 2 Pages 79-
- Issue 1 Pages 2-
Volume 63, Issue 4
Displaying 1-7 of 7 articles from this issue
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Akira Teramoto1996 Volume 63 Issue 4 Pages 255-258
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDownload PDF (691K) -
Rika Iwakiri, Koiti Inokuchi, Kazuo Dan, Ichiji Wakabayashi1996 Volume 63 Issue 4 Pages 259-267
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSWe studied the quantitative changes in PML/retinoic acid receptor α (PML/RARα) fusion mRNA using the reverse transcriptase-polymerase chain reaction (RT-PCR) and the in vitro differentiation of leukemic cells from eight acute promyelocytic leukemia (APL) patients during treatment with all-trans retinoic acid (ATRA). In three patients, the intensity of the chimeric PML/RARα bands decreased rapidly after the start of ATRA therapy. However, these three patients required variable periods of time to obtain complete remission (CR) (24, 29 and 100 days). In the five other patients, the chimeric bands decreased slowly, and the time until CR also varied (22, 28, 30, 39 and 67 days). As for the in vitro assay, leukemic cells from the three patients who achieved CR in a short period of time (22, 28 and 30 days) showed marked differentiation in response to 1 μmol/L ATRA, and leukemic cells from the four patients with slow or delayed clinical responses to ATRA did not show morphological differentiation in vitro. These findings suggest that the clinical response of APL patients to ATRA is predicted from the results of the in vitro differentiation assay, but not by RT-PCR analysis of the PML/RARα fusion mRNA.View full abstractDownload PDF (2194K) -
with reference to the pathophysiologic significance of taurine conjugated deoxycholic acid and chenodeoxycholic acidAkira Toyoshima, Masahide Ito, Seishi Tsunoda, Masamichi Umakoshi1996 Volume 63 Issue 4 Pages 268-274
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSSince chronic gastritis is adversely affected by reflux bile acids, we are interested in which of these bile acids cause the most damage to the gastric mucosa as ulcerogenic factors in the stomach. We examined 34 patients suffering from the peptic ulcers, and have assumed that taurine conjugated deoxycholic acid (TDC) and chenodeoxycholic acid (TCDC) may act as the mst ulcerogenic factors. Moreover TCDC was suggested to be associated with the cystic dilatation of the gastric gland. It was also suggested that TDC is involved in the increased frequency of intestinal metaplasia as a factor backgrounding cancer.View full abstractDownload PDF (1553K) -
Yoko Itsuki, Satoru Suzuki1996 Volume 63 Issue 4 Pages 275-285
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSWe examined the possibility of the use of the IL-4 gene in cancer immuno-gene therapy protocols. Colon carcinoma cell (colon 26) clones engineered to express IL-4 were established. Expression of IL-4 significantly reduced tumorigenicity of colon 26 cells. Administration of anti-IL-4 antibody reversed the non-tumorigenic phenotype of the cells. Mice immunized with MMC-treated IL-4 positive cells rejected challenging IL-4 negative colon 26 cells. Strong CTL responses against colon 26 cells were observed in immunized mice. The lytic activity was tumor specific, and was blocked by the antibody against CD8. Histological examination showed that extensive infiltration of eosinophils occurred on day 5 after inoculation, while lymphocytes became the majority of the infiltrating cells on day 8. These results indicate that the expression of IL-4 in colon 26 cells can induce both eosinophil mediated local tumor killing and T-cell mediated systemic immunity in vivo. The dual mode of action of IL-4 may provide a basis for the adnantage of IL-4 secrating tumor cells to apply in the cancer immuno-gene therapy.View full abstractDownload PDF (2676K) -
Kotoe Kaneda1996 Volume 63 Issue 4 Pages 286-293
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSNine patients with lumbar spinal problems (patient group) and four healthy volunteers as a control group were examined by the microneurographic technique.
A tungsten microelectrode (impedance 2-5MΩ) was introduced into the peroneal nerve in the affected limb in the patient group. Muscle sympathetic nerve activities were rectified and integrated every 0.1sec. Muscle sympathetic nerve activity was expressed as the burst number of integrated muscle sympathetic nerve activities per minute (burst rate) and the burst number per 100 heart beats (burst incidence). Statistical analyses were performed by ANOVA.
The mean burst rate was 22.5±5.3 burst/min in the patient group, and 11.9±1.9 burst/min in the control group. The mean burst incidence was 31.7±8.2 burst/100 HB in the patient group and 17.1±4.3 burst/100 HB in the control group. Both the mean burst rate and mean burst incidence were higher in the patient group than in the control group (mean burst rate: p< 0.005, mean burst incidence: p<0.01).
In 62.5% of the patients with increased muscle sympathetic nerve activity, dysesthesia (tingling, and pin prick sensations) was complained of. There was a positive correlation between dysesthesia and increased basic activity of the muscle sympathetic nerve. This suggests the sympathetic nervous system may be involved in inducing abnormal sensations.View full abstractDownload PDF (1378K) -
Hong Yo, Osamu Mori, Yoshiharu Ohaki, Takashi Kawamura, Goro Asano1996 Volume 63 Issue 4 Pages 294-298
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSAdenomatoid tumors arising in the uterus are not well-recognized and sometimes mistaken for other benign or malignant neoplasms. This study describes three cases of uterine adenomatoid tumors with clinical, light microscopic, histochemical and electron microscopical studies. Four distinctive histologic patterns (solid, adenoid, angiomatoid, cystic) were identified. Acid mucopolysaccharide was present in three cases and was digested by hyaluronidase. Immuno-histochemically, tumor cells were positive for cytokeratin and vimentin. Electron microscopy revealed microvilli, intermediate filaments and dilated intercellular spaces. This gives further support to a mesothelial origin of the adenomatoid tumor. Interestingly, one case showed that the adenomatoid tumor was multiple and one nodule was connected with leiomyomatous nodule. In the other case, the tumor was large (5×4×4.5cm). These features were unusual.View full abstractDownload PDF (2061K) -
1996 Volume 63 Issue 4 Pages 299-310
Published: August 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDownload PDF (3060K)
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