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Volume 16 (1987)
- Issue 6 Pages 1717-
- Issue 5 Pages 1673-
- Issue 4 Pages 1593-
- Issue 3 Pages 1127-
- Issue 2 Pages 701-
- Issue 1 Pages 1-
Volume 16, Issue 2
Displaying 101-114 of 114 articles from this issue
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Y. ASANUMA, J. TANAKA, K. SUZUKI, T. KAWAMURA, S. KASHIMA, H. KOYAMA, ...1987 Volume 16 Issue 2 Pages 1074-1077
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSIn these 5 years, we have treated 17 cases of sepsis in infants for a total of 43 times using exchange transfusion and 10 could survive. Being encouraged by this result and to eliminate the possibility of antibody formation against transfused platelet, the miniature system of plasmapheresis specific for infants has been developed and evaluated ex vivo. For plasma exchange (PE), 5 normal and 5 jaundiced rabbits were used for 2 hrs. Blood and plasma flow rates were 10ml/min and 1.7ml/min, respectively. Total plasma volume exchanged averaged 200ml. For plasma cross circulation (PCC), 5 pairs of normal big dog and jaundiced little dog were used. As to plasma separation, plasma flow rate was stable at 1.7ml/min for 2 hrs with transmembrane pressure less than 100mmHg. Sieving coefficients for total protein and albumin were more than 0.9 at 2 hrs. WBC decreased by 55-62% in PE and 11-35% in PCC at 30min, but returned to the initial values at 2 hrs. Percent reduction of total bilirubin exceeded 50%. This system is safe, biocompatible and efficient and clinical application for infants is being proposed.View full abstractDownload PDF (533K) -
M. MIZUNO, M. IKEGAME, T. FUJISHIRO, H. HASEGAWA, T. YANAI, K. KOJIMA, ...1987 Volume 16 Issue 2 Pages 1078-1081
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDMSO was administered in the hope that DMSO will work favourably in removing Bence-Jones protein at plasma exchange (PE) in patient with Bence-Jones type of myeloma. Administering DMSO resulted in a increase in the sieving coefficient (SC) and removal amount of Bence-Jones protein and the filtrated volume increased and rise in TMP was inhibited. SC of other proteins such as β2-MG, Alb and IgG were changed in the extracoporeal method, This suggests that DMSO will also change the separability for the various molecular proteins. The side effects were not seen in our clinical application of DMSO.View full abstractDownload PDF (521K) -
T. SHINODA, T. SHIBAMOTO, Y. IINO, H. OSHIMA, N. YOSHIYAMA1987 Volume 16 Issue 2 Pages 1082-1084
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe effects of plasmapheresis (double-filtration plasmapheresis: DFPP) on two cases with pemphigus vulgaris and one case with bullous pemphigoid were evaluated. DFPP was performed because of steroid-resistance in case 1 and 3, and for the purpose of steroid dose reduction in case 2. Skin lesions were improved in several days after DFPP initiated in case 1 and 3. In case 2, it was able to reduce the steroid dose without aggravation of the skin lesion, but relapse was recognized with too fast dose reduction. The intercellular antibody titer was reduced after each DFPP procedure, but it was not carrelated with disease activity in the long-term followup period. It was also of no practical use for quantitative evaluation of the efficiency of DFPP filters. It was concluded that the therapeutic plasmapheresis was efficient for pemphigus vulgaris and bullous pemphigoid.View full abstractDownload PDF (470K) -
T. TAIRA, S. IWASAKI, K. TAKAYAMA, E. KINUGASA, H. NAKAYAMA, T. AKIZAW ...1987 Volume 16 Issue 2 Pages 1085-1088
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSLeucocytapheresis with microaggregate removal filter [Sepacell R 500new:S] was clinically applied to RA patient. About 1010 leucocytes were removed by 1.5L of whole blood treatment. The decrease in lymphocyte subset of OKT8 and increase in H/S by the treatment were observed, which persisted until one week later. During the leucocytapheresis, neither complement activation nor release of leucotriens nor bemolysis was noted. From these results, [S] can be applied safely and effectively for leucocytapheresis. The more selective lymphocyte separation with less platelet removal will contribute its widespred clinical application.View full abstractDownload PDF (375K) -
I. ITAGAKI, Y. MORI, M. SIMAGAKI, K. TANAKA, T. SAKAI, H. IKEDA, T. TO ...1987 Volume 16 Issue 2 Pages 1090-1093
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe have developed the polysulfone capillary plasma separator, and evaluated separation efficiency, plasma quality and complement activation. The observed maximum filtration rate was 18ml/min for 0.2m2 module and 21ml/min for 0.3m2 module. The recovery rates of coagulation factors VII and IX were both greater than 95%. C3 activation was detected, but C4 was not adversely affected. It is considered that the new polysulfone membrane exerts no influence on complement activation via the classical. pathway. We conclude that the new plasma separator is available for donor plasmapheresis to secure source material of coagulation factors.View full abstractDownload PDF (572K) -
H. MATSUDA, M. TAMURA, H. YOSHIDA, R. OHI, T. TOMONO, H. IKEDA, K. FUK ...1987 Volume 16 Issue 2 Pages 1094-1098
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSA newly developed membrane plasma separation system for donor plasmapheresis (DP), namely NDP-100, is a single-needled system having a special blood flow circuit of “recycling” and a pump controling the inlet-entering blood flow to be stable. Our clinical experiences with more than 300 procedures of DP revealed that this system had equal or higher efficiencies (both ‘plasmapheresis efficiency’ and ‘plasma extraction efficiency’) than the most refined DP system by the centrifugal method.View full abstractDownload PDF (836K) -
H. IKEDA, H. HAYAMIZU, T. TOMONO, M. TAMURA, M. KASAI, K. FUKUI, H. HA ...1987 Volume 16 Issue 2 Pages 1099-1102
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSNDP-100 was improved from the view points of donor safety, quality of plasma and easiness of operation and subjected to the clinical tests. The results of the clinical tests indicated that the NDP-100 was safe for donor and easy for operation. It could be operated as efficient as PCS with regard to the operation related parameters.
Furthermore, the test production of Factor VIII preparation (RCG-5) indicated that the qualities of the plasma collected by the membrane method was as good as the fresh frozen plasma currently used for the Factor VIII fractionation.View full abstractDownload PDF (2181K) -
K. HIROTO, K. SAKAI, H. IKEDA, T. TOMONO1987 Volume 16 Issue 2 Pages 1103-1106
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSEffects of additives and pH on the separation of plasma components were studied in in vitro experiments. The additives which suppress the surface aggregation of IgG increased the SC of protein at low temperatures. The SC for albumin and IgG reached to the maximum at their isoelectric points. The variation of SC with pH level is caused by the radius of plasma protein depending on pH. Separation efficiency of albumin and IgG is improved by changes in pH, and the (4) membrane is capable of completely separating albumin and IgG at a pH of 4.8.View full abstractDownload PDF (499K) -
[in Japanese]1987 Volume 16 Issue 2 Pages 1107
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (222K) -
K. ICHIKAWA, N. INOUE, M. HIRAISHI, F. KANAI, K. OHNISHI, Z. YAMAZAKI, ...1987 Volume 16 Issue 2 Pages 1108-1111
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe combined use of FUT and persantin has been investigated as an anticoagulation method during plasma collection. DP-1 apparatus and membrane separator PEX-15 was used, using double blood access extracorporeal circulation (QB 50ml/min, QP 12ml/min) system.
Infusion rate of FUT and persantin were 50mg/h and 25mg/ml respectively. Platelet counts remained almost constant and so the pharmacological addictive effects could been clearly shown during the procedure.View full abstractDownload PDF (418K) -
H. SAKURAI, K. OZAWA, K. SAKAI1987 Volume 16 Issue 2 Pages 1112-1115
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSCeramic membranes are suitable for blood treatment because of the capability of complete and repeated regeneration and the limited distribution of pore size. This paper deals with plasma separation with ceramic membranes and the dependence of filtration performance on membrane properties and operating conditions. Wall shear rate, membrane length and inner diameter affect filtrate flux. However, filtrate flux is independent of transmembrane pressure of above 25mmHg and mean pore diameter of above 1μm. Ceramic membranes with pore diameters ranging from 1.0 to 1.5μm, a length of 30cm and an inner diameter of 1mm are required to produce higher filtrate flux at a wall shear rate of 2000s-1 and a transmembrane pressure of 25mmHg than currently-utilized synthetic polymer membranes.View full abstractDownload PDF (524K) -
K. OZAWA, H. SAKURAI, K. SAKAI1987 Volume 16 Issue 2 Pages 1116-1119
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSElution tests with pure water (PW), 1N nitric acid (NA), 544ppm sodium hypochlorite and bovine plasma (BP) were performed to elucidate the elution of membrane constituents for ceramic membranes based on the Standards for Approval of Hemodialyzers, the Ministry of Health and Welfare, Japan, Sintered alumina ceramic membranes elute a fairly small amounts of membrane constituents for any elution tests. Porous glass membranes are detected no elution of aluminum, and a large amounts of boron and silicon with any solvent. After rinsing with NA, B and Si are eluted in small amounts with PW and in large amounts with BP. Surface modification is required to prevent the elution of boron and silicon for porous glass membranes.View full abstractDownload PDF (532K) -
[in Japanese]1987 Volume 16 Issue 2 Pages 1120
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (165K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1987 Volume 16 Issue 2 Pages 1123-1125
Published: April 15, 1987
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSDownload PDF (598K)