ACTA HISTOCHEMICA ET CYTOCHEMICA
Online ISSN : 1347-5800
Print ISSN : 0044-5991
ISSN-L : 0044-5991
Volume 52, Issue 2
Displaying 1-1 of 1 articles from this issue
REGULAR ARTICLE
  • Puja Neopane, Durga Paudel, Koki Yoshida, Bhoj Raj Adhikari, Tetsuro M ...
    Article type: Regular Article
    2019 Volume 52 Issue 2 Pages 35-43
    Published: April 25, 2019
    Released on J-STAGE: April 25, 2019
    Advance online publication: February 23, 2019
    JOURNAL FREE ACCESS FULL-TEXT HTML

    RNase 7 is a skin-derived antimicrobial peptide expressed in various epithelial tissues. It is upregulated by stimulation with microbes and pro-inflammatory cytokines. Herein, we examined the expression levels of RNase 7 in tissues from normal and inflamed oral epithelia and salivary glands via immunohistochemistry. RNase 7 was expressed mainly in the surface layers of the parakeratinized and orthokeratinized oral epithelium. In addition, it was strongly and weakly expressed in oral lichen planus and radicular cysts, respectively. RNase 7 was constitutively expressed in salivary glands, particularly in the serous and duct cells. In the case of Sjogren’s syndrome, RNase 7 was strongly expressed in serous, ductal, and mucous cells in areas with lymphocytic infiltration. The localization patterns of RNase 7 were similar to those of other epithelial antimicrobial peptides, including beta-defensins. Thus, epithelial antimicrobial peptides may act against microbial infections in a coordinated manner in oral epithelia and salivary glands.

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