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Volume 32 (1999)
- Issue 6 Pages 449-
- Issue 5 Pages 381-
- Issue 4 Pages 299-
- Issue 3 Pages 203-
- Issue 2 Pages 103-
- Issue 1 Pages 5-
Volume 32, Issue 6
Displaying 1-12 of 12 articles from this issue
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Yuri Hagiwara, Mitsuoki Eguchi, Shuichi Ueda1999 Volume 32 Issue 6 Pages 449-457
Published: 1999
Released on J-STAGE: February 26, 2010
JOURNAL FREE ACCESSPostnatal development of vimentin positive and glial fibrillary acidic protein (GFAP) positive elements in the striatum of the rat was analyzed by immunohistochemistry. Regional and chronological differences in the transformation of vimentin-positive radial glial cells were observed in the dorsal and ventral striatum. In the dorsal striatum, unwinding of the fasciculus of vimentin-positive fine fibers from the periphery toward the more central region of the striatum was observed from postnatal day (P) 3 to P7. In the ventral striatum, however, a fragmented transformation characterized by the segmental disappearance of vimentin-positive radial glial fibers was observed from P3 to P14. On the other hand, GFAP-positive astroglial cells were observed first in the dorsocaudal part of the striatum near the corpus callosum at PO. Numbers of GFAP-positive astroglial cells increased with age, and distribution of these cells extended toward the medial region of the striatum. At P14, these GFAP-positive cells were distributed throughout the striatum, including the dorsal and ventral striatum. These findings indicate that differences in transformation of radial glial cells in the ventral and dorsal striatum may be attributed to differences in neurogenesis and formation of neuronal circuits in the dorsal and ventral striatum. These results provide new insight into the role of radial glial cells in the developing striatum.View full abstractDownload PDF (14910K) -
Yoshihiro Abiko, Michiko Nishimura, Jiro Mitamura, Firoz Rahemtulla, P ...1999 Volume 32 Issue 6 Pages 459-463
Published: 1999
Released on J-STAGE: February 26, 2010
JOURNAL FREE ACCESSThe present study investigated the localization of biglycan, decorin and large chon-droitin-sulphate proteoglycans (versican) in 32 cases of pleomorphic adenoma (PA) by immunohistochemical staining. The neo-plastic epithelium of PA showed wide staining for versican and biglycan. Myxomatous and chondroid tissues showed restricted staining for versican and biglycan. The intense staining for decorin was observed in fibrous connective tissue of the capsule, whereas only one case in the present study showed the positive staining for decorin in the mesenchymal tissues of PA. These results indicated that both biglycan and versican might be involved in, at least in part, the morphogenesis of neoplastic epithelium and mesenchymal tissues in PA.View full abstractDownload PDF (3291K) -
Kiyokazu Morioka, Hiromi Takano-Ohmuro, Masasumi Sameshima, Takashi Ue ...1999 Volume 32 Issue 6 Pages 465-476
Published: 1999
Released on J-STAGE: February 26, 2010
JOURNAL FREE ACCESSIn the dorsal skin of fetal rats, the epidermis on day 16 of gestation consisted of a single or a few layers of undifferentiated cells, and it developed to display the full strata, i. e the stratum (s.) corneum (horny layer), s. granulosum (granular layer), s. spinosum (spinous layer), and s. germinativum (basal layer) by the day of birth. Perinuclear electron lucent special areas, which were also detectable by conventional staining under light microscope, appeared in the cells of the s. spinosum or the s. granulosum on the day of birth. We call such an area the “peri-nuclear compartment (PNC) ”. The PNC was not partitioned by membranous structures either. Typical PNCs became recognizable on the day of birth. The cell nuclei seemed to be digested inside of the PNC of the cells located in the outermost area of the s. granulosum or sometimes in the boundary between the s. granulosum and the s. corneum. In the initial phase of nuclear extinction, morphology of the nucleus undergoing degeneration resembles that of apoptotic cells. In comparison to the morphological degeneration of the nucleus, DNA fragmentation was suggested to occur earlier. Localization of cathepsin B and cathepsin D in the s. spinosum and s. granulosum as revealed by immunohistochemistry, together with an electron microscopic study on the appearance of autophagosomes in those areas, suggested a contribution of autophagy to the digestion of organelles including mitochondria and endoplasmic reticula in the terminal differ-entiation of epidermal cells.View full abstractDownload PDF (21851K) -
Jian-Ping Lu, Shineng Zhu, Baoping Song, Jianqun Mao, Shilun Lu, Yinha ...1999 Volume 32 Issue 6 Pages 477-480
Published: 1999
Released on J-STAGE: February 26, 2010
JOURNAL FREE ACCESSIn situ telomeric repeat amplification protocol (TRAP) assay was used to show the telomerase activity on the cryostat section of hepatocellular carcinoma (HCC) operation specimens from hepatitis B virus (HBV, N=5) or hepatitis C virus (HCV, N=5) positive patients. The non-cancerous areas of the specimens were used as controls. Hepatocytes in non-cancerous tissue showed no or weak telomerase activity. Hyperplastic and dysplastic liver cells showed telomerase activity. Telomerase activity was detected in 4/5 or 5/5 of the HCC specimens from HBV or HCV positive cases respectively. The intensity was moderate in 2 samples, weak in 2 samples and negative in 1 sample in the former cases; strong in 2 samples, and moderate in 3 samples in the latter cases. Telomerase activity was usually expressed in the cell nucleus. These findings suggest that telomerase is activated in the process of carcinogenesis of hepatocytes. Elevated telomerase activity is related to the carcino-genesis of hepatocellular carcinoma in HBV or HCV positive patients. We noticed that inflammatory cells and fibroblasts in the stroma of both cancerous and non-cancerous areas also displayed positive telomerase activity, indicating that this factor should be considered in data analyzing.View full abstractDownload PDF (2588K) -
THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYShigetada NAKANISHI, Dai WATANABE, Masataka NISHIMURA, Setsuo HIROHASH ...1999 Volume 32 Issue 6 Pages 487-494
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYKazushi Fujimoto, Masahito OYAMADA, Tsutomu MATSUSHITA, Tetsuro TAKAMA ...1999 Volume 32 Issue 6 Pages 495-501
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYR.Yoshiyuki OSAMURA, Kiyotsugu KOJIMA, Akishi Ooi, Yoichi Tani, Hirosh ...1999 Volume 32 Issue 6 Pages 502-516
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYKohtaro Takei, Naoaki SAITO, Norio SAKAI, Yasuhito SHIRAI, Atsushi MIY ...1999 Volume 32 Issue 6 Pages 517-525
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYMamoru Nagano, Atuko Fujioka, Koh Shinoda, Maki YOSHIDA, Mayumi NISHI, ...1999 Volume 32 Issue 6 Pages 526-534
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYAkira Matsuno, Tadashi Nagashima, R.Yoshiyuki Osamura, Hiromi IKE, Yos ...1999 Volume 32 Issue 6 Pages 535-543
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYLiliam Pineda, Takayuki Harada, Akinobu Nakano, Yoshitaka Ohsugi, Akir ...1999 Volume 32 Issue 6 Pages 544-552
Published: 1999
Released on J-STAGE: February 26, 2010
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THE 40TH MEMORIAL SCIENTIFIC MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRYTakanori Nagaoka, Seiichiro Okajima, Masahito Oyamada, Tetsuro Takamat ...1999 Volume 32 Issue 6 Pages 553-561
Published: 1999
Released on J-STAGE: July 27, 2010
JOURNAL FREE ACCESSDownload PDF (2397K)
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