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Volume 108, Issue 2
Displaying 1-4 of 4 articles from this issue
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Naoki FUJIKURA, Tatsuro YOKOYAMA, Yukinori MASUDA, Ken-ichi SHIKADA, S ...1996 Volume 108 Issue 2 Pages 39-48
Published: 1996
Released on J-STAGE: February 06, 2007
JOURNAL FREE ACCESSThe aim of the present study was to investigate the effect of efonidipine hydrochloride (efonidipine) on myocardial oxygen balance in anesthetized open-chest dogs, and the results were compared to those of nifedipine or nisoldipine. Efonidipine (10 and 30 μg/kg) lowered the mean blood pressure, and the extent of the hypotension was similar to those induced by nifedipine (1 and 3 μg/kg) and nisoldipine (1 and 3 μg/kg). The hypotensive effect of efonidipine was very slow in onset and long-lasting as compared with that of nifedipine. Efonidipine and nisoldipine decreased the heart rate, but nifedipine increased it. Efonidipine (30 μg/kg) and nifedipine (1 and 3 μg/kg) slightly increased myocardial oxygen consumption. Nisoldipine (3 μg /kg) tended to increase myocardial oxygen consumption. Since efonidipine, nifedipine and nisoldipine decreased the arterio-venous oxygen difference and increased coronary sinus outflow, these drugs increased the oxygen supply to the myocardium. Furthermore, these drugs decreased myocardial oxygen demand. From these results, it is suggested that efonidipine may be useful for improving myocardial oxygen balance.View full abstractDownload PDF (7837K) -
Takeshi MUSHIROI, Rika SHIBAHARA, Yojiro UKAI, Yoshiaki YOSHIKUNI, Kiy ...1996 Volume 108 Issue 2 Pages 49-63
Published: 1996
Released on J-STAGE: February 06, 2007
JOURNAL FREE ACCESSEffects of a novel TRH analog, montirelin hydrate (NS-3), on the EEG were compared with those of TRH in intact and posterior hypothalamic area (PHA)-lesioned rats. In the intact rats, NS-3 at 0.01 mg/kg and TRH at 1 mg/kg produced no changes in the sleep-waking cycle. NS-3 at 0.1 mg /kg caused an increase in the time spent in the arousal stage and delayed the onset of the slow wave sleep (SS). On the other hand, TRH at 10 mg/kg increased the time spent in the SS stage and decreased the time in the A1 stage during 2 to 4 hr after injection without increasing the arousal stage, although it delayed the onset of SS. No abnormal EEG was observed after NS-3 or TRH administration in the intact rats. Electrolytic ablation of the PHA elicited continuous behavioral resting and caused increases in the slow-wave components in the cortical EEG and loss of generation of the hippocampal rhythmic slow activity. NS-3 at 0.01 mg/kg and TRH at 1 mg/kg caused the reappearance of the hippocampal rhythmic slow activity. In addition, NS-3 at 0.1 mg /kg and TRH at 10 mg/kg decreased the slow-wave components and increased the fast-wave components in the cortical EEG. In conclusion, NS-3 showed a distinct analeptic effect with a 100-fold higher potency than that of TRH in both the intact and PHA-lesioned rats.View full abstractDownload PDF (10822K) -
Michie SHIMAMURA, Koji NISHIZAWA, Akira YAMASHITA1996 Volume 108 Issue 2 Pages 65-75
Published: 1996
Released on J-STAGE: February 06, 2007
JOURNAL FREE ACCESSThe various symptoms that women experience in the climacteric period, such as flashing, depression, paresthesia and insomnia, have been termed the menopausal syndrome. Since Kamikihi-to (KMK) has been administered clinically for several of these symptoms, the effects of KMK were evaluated in a series of experiments using adult ovariectomized (OVX) rats. After surgery, KMK and other drugs were administered daily for 7 or 8 days until the experiments. OVX rats showed significantly higher electric shock thresholds, and KMK restored their sensitivity to electric shock in a dose-dependent manner. Furthermore, the latency of OVX rats in the step-through passive avoidance test was significantly shortened, and KMK prolonged the latency significantly. OVX rats showed a significantly decreased number of correct choices and an increased number of errors in the 8-arm radial maze task, and KMK normalized both of these parameters in a dosedependent manner. The blood pressure of OVX rats was significantly increased, and KMK improved the blood pressure levels. These findings suggest that KMK might be useful for treatment of the menopausal syndrome, and it is considered that the improvements induced by KMK are due to other actions, such as normalization of the central nervous system, rather than sex hormones.View full abstractDownload PDF (8605K) -
Teruko YANASE, Koji NISHIZAWA, Osamu INOUE, Takayuki SUKAMOTO, Yuji SA ...1996 Volume 108 Issue 2 Pages 77-83
Published: 1996
Released on J-STAGE: February 06, 2007
JOURNAL FREE ACCESSOral administration of Kami-kihi-to (KMK) dose-dependently inhibited the response to acetic acid-induced writhing in mice. The KMK-induced antinociceptive action was reduced by pretreatment with yohimbine, an α2-adrenergic antagonist, or cyproheptadine, a serotonergic antagonist, but not naloxone, an opiate antagonist. The antinociceptive action of KMK was clearly reduced by pretreatment with α-methyl-DL-p-tyrosine, reserpine or p-chlorophenylalanine or by simultaneous treatment with diethyldithiocarbamate, all of which are monoamine synthetic inhibitors or monoamine depletors. After spinal transection, the antinociceptive effect of KMK was markedly reduced. These findings suggest that the antinociceptive action of KMK may be related to pain inhibitory systems such as the serotonergic and noradrenergic systems at the supraspinal level.View full abstractDownload PDF (5670K)
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