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Volume 91 (1988)
- Issue 6 Pages 335-
- Issue 5 Pages 275-
- Issue 4 Pages 173-
- Issue 3 Pages 121-
- Issue 2 Pages 61-
- Issue 1 Pages 1-
Volume 91, Issue 3
Displaying 1-5 of 5 articles from this issue
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Yutaka ASHIDA, Motonobu MURAKAMI, Masahiro MIZUNO, Hiroshi SAITA, Take ...1988 Volume 91 Issue 3 Pages 121-127
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSTo elucidate the anti-ulcer mechanism of mezolidon (KM-1146, 2 (3, 4-dimethoxyphenyl)-5-methylthiazolidine-4-one), we investigated gastric mucosal blood flow (laser-Doppler method), transmucosal potential difference, gastroduodenal mucosal surface pH and blood viscosity in rats under a water-immersion stress condition. In the control group, gastric mucosal ulcers occurred three hours after the onset of water-immersion. At that time, gastric mucosal blood flow decreased to 40% and the potential difference decreased to 48%. In the mezolidon-pretreated group, gastric mucosal ulcers were significantly reduced, and the potential difference was significantly higher than in the control group. Gastric mucosal blood flow increased significantly to 120% twenty minutes after the onset of water-immersion and then decreased, but was significantly higher than in the control group. Gastroduodenal mucosal surface pH was not affected by the pretreatment with mezolidon under this condition. Pretreatment with mezolidon did not affect blood viscosity. In conclusion, the anti-ulcer effect of mezolidon may involve the increase and, /or maintenance of gastric mucosal blood flow, but more investigations are necessary to understand the mechanism involved.View full abstractDownload PDF (5304K) -
Shin-ichi MORISHITA, Takashi SAITO, Masamichi SHOJI, Yasuharu HIRAI, A ...1988 Volume 91 Issue 3 Pages 129-140
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSPharmacological properties of “Reiousan”, a crude drug preparation consisting of bezoar and ginseng, were studied. The hypotensive effect on spontaneously hypertensive rat, inhibition of platelet aggregation, acetic acid-induced writhing, stress ulcer, CCl4 and d-galactosamine-induced hepatic injury, and facilitation of recovery from neuroparalysis and muscular fatigue, protective effect on anoxic brain damages, antipyretic effect, and facilitation of learning in aged mice were observed after administration of “Reiousan”. It was suggested that bezoar and ginseng act synergistically in causing the hypotensive effect, acetic acid-induced writhing and drug-induced hepatic injury, and protection from anoxic brain damages and muscular fatigue.View full abstractDownload PDF (7834K) -
Hiroyuki SONOKI, Yasumi UCHIDA, Takanobu TOMARU, Tsuneaki SUGIMOTO1988 Volume 91 Issue 3 Pages 141-150
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSThe effects of TMB-8, an inhibitor of Ca2+ release from the intracellular store site, on impaired left ventricular relaxation caused by global ischemia were examined in 45 anesthetized dogs. In the non-ischemic group, the intracoronary infusion of 100 μg/min TMB-8 suppressed the decrease in T, an index of left ventricular relaxation, by increasing the atrial pacing rate. In the ischemic group, the intracoronary infusion of 30 and 100 μg/min TMB-8 suppressed the increases of T and left ventricular end-diastolic pressure caused by ischemia and increase of pacing rate. The results indicate that TMB-8 suppresses the ability of relaxation in non-ischemic myocardium and prevents the impairment of left ventricular relaxation induced by left ventricular global ischemia.View full abstractDownload PDF (7510K) -
Cardiohemodynamic and respiratory effects of eptazocine, a new analgesic agent, in anesthetized dogsTakahito KIMURA, Hiroko MURAKAMI, Hisashi SAKAI, Isami WAKI1988 Volume 91 Issue 3 Pages 151-161
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSCardiohemodynamic and respiratory effects of eptazocine, a new analgesic agent, were studied and compared with those of pentazocine and butorphanol in anesthetized dogs. Eptazocine (1 mg/kg, i.v.) increased the heart rate (HR), left ventricular dP/dt (LVdP/dt) and cardiac output (CO), and scarcely affected the blood pressure (BP), left ventricular end-diastolic pressure (LVEDP), right atrial pressure, pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure. On the other hand, eptazocine (3 mg/kg, i.v.) decreased BP, LVdP/dt, CO and LVEDP and did not influence the pulmonary circulation. Pentazocine (1 mg/kg and 3 mg/kg, i.v.) increased BP, LVdP/dt and CO, while HR was not altered. Pentazocine also increased PAP. Butorphanol (0.1 mg/kg and 0.3 mg/kg, i.v.) decreased BP, HR and LVdP/dt, while other hemodynamic parameters were not changed. In spontaneously breathing anesthetized dogs, eptazocine (1 mg/kg and 3 mg/kg, i.v.) caused a decrease of respiratory minute volume. The fall in PO2 and pH, and a rise in PCO2 were simultaneously observed in blood gas analysis. These respiratory depressant effects of eptazocine were short-lasting, and they were less potent than those of pentazocine. Butorphanol scarcely affected the respiration. These results suggest that eptazocine has different cardiohemodynamic effects than other analgesics and produces mild respiratory depression.View full abstractDownload PDF (6713K) -
Taeko HATA, Tomitaro KITA, Yoshitaka NISHIMURA1988 Volume 91 Issue 3 Pages 163-171
Published: 1988
Released on J-STAGE: February 23, 2007
JOURNAL FREE ACCESSSART-stressed (repeated cold-stressed) rats, experimental model animals for vagotonic-type dysautonomia, have been reported to show EEG with lower-amplitude fast waves during resting-arousal and higher-amplitude slow waves during slow-wave sleep compared to normal rats. In this report, the effects of certain drugs on EEG alterations were investigated using the power spectral analysis. EEG was measured 60 min after a single dose of drugs and on the day following the final dose of 6 administrations. Neurotropin, a sedative analgesic, slightly increased faster waves on resting-arousal EEG and slower waves on slow-wave sleep EEG in normal rats, and it prevented SART stress-induced EEG alterations during both resting-arousal and slow-wave sleep. Alprazolam, a minor tranquilizer, and GABOB, a GABA related compound, were also effective on SART stressinduced EEG alterations. Alprazolam produced remarkable but transient high-amplitude fast waves in the resting-arousal EEG of normal rats, and GABOB produced lasting lowamplitude fast waves in the slow-wave sleep EEG of normal rats. From the above results, it appears that Neurotropin may have an effect on EEG alterations caused by SART stress and that its action is likely due to mechanisms different from those of alprazolam and GABOB.View full abstractDownload PDF (6404K)
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