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Volume 50 (2011)
- Issue 6 Pages 313-
- Issue 5 Pages 255-
- Issue 4 Pages 209-
- Issue 3 Pages 147-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 50, Issue 5
Displaying 1-8 of 8 articles from this issue
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Original Articles
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Tomohiko YAMAGUCHI, Akihiko KAWAHARA, Yoshiki NAITO, Tomoki TAIRA, Hid ...2011 Volume 50 Issue 5 Pages 255-260
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSObjective : We studied characteristic cytological findings in pancreatic cancer cells with small nuclei and compared them to inflammatory lesions.
Study Design : Our materials were 27 cases of pancreatic cancer for which we conducted morphometric image analysis to measure the nuclear area. Cytological smears were microscopically examined for background material, cell arrangement, nucleus, chromatin pattern, and nucleoli. Pancreatic cancer cells with a small nuclear area were defined as smaller than three times the average lymphocytic nuclear area. In a detailed comparative study, we used 12 cases of inflammatory lesions.
Results : Morphometric image analysis showed that nuclear area differed significantly different among the 13 cases of pancreatic cancer with a small nuclear area, which were characterized by nuclear contour irregularity, anisonucleosis, coffee-bean-like nuclei, and background necrosis, and the 12 cases of inflammatory lesion, which were characterized by background necrosis, nuclear contour irregularity, anisonucleosis, and coffee-bean-like nuclei (P<0.05).
Conclusion : Nuclear findings are important in differentially diagnosing pancreatic cancer with small nuclei and inflammatory lesions.View full abstractDownload PDF (774K) -
—Evaluation of structural atypia and cellular atypia—Naruaki MATSUI, Hiroshi KAZIWARA, Kanako WAKUI, Hitoshi ITOH, Takashi ...2011 Volume 50 Issue 5 Pages 261-269
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSObjective : We evaluated the cytological diagnosis of endometrioid adenocarcinoma (G1) and endometrial hyperplasia compared to conventional cytological criteria.
Study Design : Cases involved 35 of G1, 10 of atypical endometrial hyperplasia (AEH), 11 of complex hyperplasia (EH-C), and 13 of simple hyperplasia. We investigate the following features :
(1) atypical cell clump frequency—clumps with highly dense glands (CHDE), dendriform clumps (DC), papillary clumps (PC), irregularly branching glands (IBG), and clumps of dilated glands (CDG)
(2) the occurrence of associated features—disordered cell arrangement, squamous metaplasia, background and neutrophilic inclusion, and endometrial stromal cells.
Results : Cytologically, we observed no significant difference between clumps of dilated glands and irregular branching gland in EH-S and EH-C ; numerous CHDE in AEH ; CHDE and DC appeared in EA. Associated features, such as disordered cell arrangement, squamous metaplasia, background, and neutrophilic inclusion, differed significantly.
Conclusion : To cytologically differentially diagnose EA in different EH phases, diversified assessment is needed especially for (1) squamous metaplasia, and (2) background and neutrophil inclusion are emphasized in addition to conventional aspects.View full abstractDownload PDF (1335K) -
Katsumi KOBATA, Morishige TAKESHITA, Shinji MATSUMOTO, Yutaka KAMIHARA ...2011 Volume 50 Issue 5 Pages 270-278
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSObjective : We determined the cytohistological features of primary breast malignant lymphoma (PBML).
Study Design : We cytologically classified 13 PBML cases based on WHO classification and immunohistologically determined cell features using B-cell markers.
Result : Of these, 10 cases (77%) consisted of diffuse large B-cell lymphoma (DLBCL), among which tumor cells in 6 were classified into centroblastic (CB) type, 1 CB/Burkitt (CB/B) type, and 3 mixed cell type (Mixed), and 3 (23%) cases classified as mucosa-associated lymphoid tissue lymphoma (MALT). Immunohistologically, tumor cells of in the 10 with DLBCL were positive for multiple myeloma 1 (MUM1) and 2 coexpressing CD10. 8 cases had nongerminal center B cell phenotype. Four of the 6 CB cases showed strongly MUM1-positive lymphoma cells and all 3 Mixed cases were weakly positive for MUM1. The 5-year survival of the 10 DLBCL cases was 65%, with 2 type CB cases dying of disease.
Conclusion : The 13 cases we studied showed 3 cytological types of 10 DLBCL cases and 3 MALT, underscoring the importance of understanding the 4 of PBML features in cytological breast-tumor diagnosis, CB type, CB/Burrkit type, Mixed type and MALT type.View full abstractDownload PDF (1231K)
Clinical Articles
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Shigeru TSUCHIDA, Masaru KOJIMA, Satomi TABATA, Harumi KAMIYAMA, Yoshi ...2011 Volume 50 Issue 5 Pages 279-282
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSBackground : Classical Hodgkin lymphoma (cHL) rarely simultaneously occurs as a composite lymphoma with marginal zone B-cell lymphoma (MZBCL). We report a case of primary thyroid gland MZBCL and cHL.
Case : An 83-year-old Japanese woman seen for a right neck mass suspected to be a thyroid tumor was suggested in fine-needle aspiration (FNA) cytology to have undifferentiated carcinoma. Lymph node biopsy imprint cytology showed numerous monocytoid B cells and scattered Reed-Sternberg (RS) cells. Histologically, the lymph node lesion consisted of MZBCL and cHL. Immunohistochemically, MZBCL and RS cells were CD20+, CD43+, and bcl-2+. In situ hybridization showed numerous Epstein-Barr virus-encoded smallRNA+tumor cells, including RS cells.
Conclusions : Thyroid gland cHL have rarely been reported. In our case, at least a portion of thyroid gland cHL was secondarily transformed extranodal MZBCL.View full abstractDownload PDF (598K) -
Kayoko NAKAMURA, Masafumi KITANO, Masakazu FUJIMOTO, Hiromi SAKASHITA, ...2011 Volume 50 Issue 5 Pages 283-288
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSBackground : Chordoid gliomas are rare, slow-growing third-ventricle neoplasms. We discuss their cytological differentiation.
Case : A 50-year-old woman seen for sudden-onset headache and vomiting was found in computed tomography and magnetic resonance imaging to have a well-circumscribed third-ventricle mass extending to the lateral ventricle. The tumor was removed. Squash cytology showed sheet-like epithelioid cells and isolated cells with lymphocytes. Tumor cells had foamy cytoplasm and oval nuclei, with some cells showing binucleated and intranuclear inclusion. Histological and ultrastructural findings indicated chordoid glioma.
Conclusion : The difficulty in differentiating chordoid glioma from chordoma or chordoid meningioma based on cytology alone requires detailed cytomorphological, immunohistochemical, and ultrastructural study to ensure a correct chordoid glioma diagnosis.View full abstractDownload PDF (956K) -
Kazuhito MATSUMOTO, Kikuko HAMANAKA, Fukuji IKEZAKI, Yasuyoshi SHIKAMA2011 Volume 50 Issue 5 Pages 289-294
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSBackground : We report a case of tumor-forming Bence Jones myeloma with marked nuclear pleomorphism.
Case : A 61-year-old man seen for chest pain, lumbago, and sacral pain was found in radiological examination to have multiple osteolytic pubic bone, vertebral, and rib lesions. Pubic bone biopsy indicated multiple myeloma cytologically and histologically. This was confirmed immunohistochemically, confirming Bence Jones protein (BJP) (λ) multiple myeloma. Serum and urine immunoelectrophoresis showed λ-light-chain M protein without a long chain component. Imprint pubic bone tumor cytology showed that most neoplastic plasma cells had polymorphous cleaved, multilobated, or monocytoid nuclei. Cytologically, sternal bone marrow aspirate was the same as that of the pubic bone tumor.
Conclusion : Unusual cases identifying variant neoplastic plasma cells with atypical nuclei have been reported that may be difficult to diagnose. Our experience indicates that May-Giemsa staining and further immunohistochemical studies, as needed, may be useful in identifying these tumors.View full abstractDownload PDF (992K) -
Kyoko TSUCHIYA, Yoichiro YAMAMOTO, Miyuki MATSUBARA, Keiko YANAGIHARA, ...2011 Volume 50 Issue 5 Pages 295-300
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSBackground : Primary breast angiosarcoma is extremely rare. We report a case of painful, rapidly growing angiosarcoma.
Case : A 40-year-old woman finding a lump and strain in her right breast 1.5 years earlier noted rapid, painful growth in the last three months. Fine-needle aspiration (FNA) detected spindle-shaped tumor cells in a massive amount of blood components, with a tubular, net-like structure. Core needle biopsy (CNB) showed immunocytochemical staining positive for CD31, CD34, and Factor VIII. The final diagnosis was high-grade angiosarcoma. Postoperatively, we found a dark-red 72×55 mm tumor with intratumorous hemorrhage.
Conclusion : Angiosarcoma tumors usually grow rapidly and painlessly, but intratumorous hemorrhage may cause pain as in our case. Angiosarcoma is rare but highly malignant, making it important to provide sufferers with useful knowledge, starting with a correct diagnosis.View full abstractDownload PDF (987K)
Brief Note
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Kaori HANAOKA, Shinpei MATSUMOTO, Masayuki IKEDA, Suzuko KUMAZAWA, Hir ...2011 Volume 50 Issue 5 Pages 301-302
Published: 2011
Released on J-STAGE: October 29, 2011
JOURNAL FREE ACCESSWe report a case of parotid gland lymph node Merkel cell carcinoma metastasis arising in facial skin and diagnosed by aspiration cytology. Right parotid lymph node metastasis clinically suspected from Merkel cell carcinoma was supplemented by aspiration cytology. The specimen contained numerous carcinoma cells with small round nuclei, finely stippled chromatin, scarce cytoplasm, and dot-like Merkel cell carcinoma-specific CK20-positive intracytoplasmic inclusions. Such metastasis is only confirmable by aspiration cytology with immunocytochemistry without taking a histological specimen.View full abstractDownload PDF (375K)
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