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Volume 29 (1990)
- Issue 6 Pages 793-
- Issue 5 Pages 635-
- Issue 4 Pages 487-
- Issue 3 Pages 363-
- Issue 2 Pages 143-
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Volume 29, Issue 6
Displaying 1-24 of 24 articles from this issue
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(Part1) Extraordinary collecting of ceils from lung cancersTakashi YAMADA, Nobuhide MASAWA, Junro YOSHITAKE, Yukitoshi OHKUBO, Hi ...1990 Volume 29 Issue 6 Pages 793-805
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSVarious problems on the cytodiagnosis of lung cancers, such as following respects, were presented and discussed from a practical point of view.
1. Situations disturbing cancer cell collection induced by extraordinary causes.
i) Extensive necrosis of giant cell carcinoma.
ii) Wide-spreading of bronchiolo-alveolar adenocarcinoma through the alveolar epithelium to the another lobes of lung.
iii) Unsuspected intrabronchial extension of malignant thymoma.
2. Collection of two or three kinds of cancer cells due to the rare causes.
i) Metaplastic changes of small cell anaplastic carcinoma.
ii) Paradoxical exfoliation of different kinds of cancer cells from large cell anaplastic carcinoma.
iii) Pulmonary blastoma and carcinosarcoma.
The situation of these extraordinary cancer cell collection from pulmonary malignancies were discussed with showing many cytologic and histologic features of own cases.View full abstractDownload PDF (31424K) -
Taku KATOH, Hisao TAKAHASHI, Hiroshi KIN, Riki OKEDA, Bin TAKEDA1990 Volume 29 Issue 6 Pages 806-812
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSImmunocytochemical studies of 45 cases of brain tumors (astrocytoma·grade 27, pleomorphic xanthoastrocytoma 1, astroblastoma 1, anaplastic astrocytoma 8, glioblastoma 9, oligodendroglioma 4, ependymoma 1, meningioma 6, neurinoma 2, pituitary adenoma 3, metastatic carcinoma 3) were done using six antibodies of intermediate filaments and neuron specific proteins.
GFAP was very useful to discriminate glial tumors and ependymoma from other tumors because glial tumors and ependymoma only were positive, and gliomas showed decrease in high-malignancy.
Positive NFP seen in cases of glioblastomas and pituitary adenomas was considered to be due to dysdifferentiation.
Positive Vimentin seen in gliomas, which reversely correlated with positivity of GFAP, was explained by dedifferentiation.
Cytokeratin was very useful to discriminate metastatic carcinoma and pituitary adenomas from other primary brain tumors, because metastatic carcinomas and pituitary adenomas only were positive.
NSE showed no specifically for a certain type of brain tumors.
S-100 was very useful to discriminate neurinoma from meningioma, because the both cytologically resemble each another and neurinomas were intense positive and meningiomas were negative or feeble positive.View full abstractDownload PDF (4469K) -
Minoru MATSUDA, Naomi YAMATO, Akira WADA1990 Volume 29 Issue 6 Pages 813-818
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSFine needle aspirates of the histologically confirmed 48cases of papillary carcinoma, 5 cases of non-papillary carcinoma and 47 cases of benign nodules of thyroid gland were microscopically examined. In each specimen, 10 random high power fields, including cellular groups, were carefully checked. The numbers of cells with intranuclear inclusions and/or nuclear grooves, as well as psammoma bodies were counted, and a semi-quantitative estimate of their frequency was observed. Intranuclear inclusions were found in 35 (72.9%) out of 48 cases of papillary carcinoma. But, they were not found in non-papillary carcinoma or benign nodules. Nuclear grooves were observed in all 48 cases of papillary carcinoma, 4 (80%) out of 5 cases of non-papillary carcinoma and 36 (76.6%) out of 47 cases of benign nodules. When cases in which 10 or more nuclear grooves were found in the 10 high power fields of each specimen selected, 24 (50%) out of 48 cases of papillary carcinoma contained nuclear grooves. Whereas, 4 (8.5%) out of 47 cases of benign nodules contained nuclear grooves. In papillary carcinoma of 13 cases with the absence of intranuclear inclusion, 4 cases contained nuclear grooves. In these cases, the presence of nuclear grooves was considered to be useful for cytologic diagnosis of papillaly carcinoma. Intranuclear inclusions appear to be more valuable than nuclear grooves on cytologic preparation of papillary carcinoma. When nuclear grooves are seen in abundance on a cytologic specimen, they can be considered to be a useful criterion for the diagnosis of papillary carcinoma. However, when only a few nuclear grooves are seen, this significance is markedly diminished. Occurence of psammoma body was low in this series.View full abstractDownload PDF (5901K) -
Sin-ichi MURATA, Hirosumi ITOI, Yoji URATA, Yasunari TSUCHIHASHI, Fumi ...1990 Volume 29 Issue 6 Pages 819-828
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn order to elucidate pathological differences between the benign follicular tumors and follicular carcinomas of the thyroid, we carried out a combined, quantitative analysis of DNA content and nuclear morphology. We employed a recently developed system in which an autostaging cytofluorometer was combined with an image processor. Using the present system, we carried out correlated cytofluorometric and nuclear morphometric analysis on 5 adenomatous hyperplasias, 12 follicular adenomas and 12 follicular carinomas of the thyroid. The cytocentrifuged smears from these specimens were stained with propidium iodide for nuclear DNA. The cells in S-G2 phases were more frequent in carcinomas than in hyperplasias and adenomas, while the nuclear DNA content histogram pattern of some carcinomas was similar to that of hyperplasias and adenomas. On the other hand, nuclear morphometric parameters (area, perimeter, DNA content per area, shape constant, etc.) of diploid malignant cells have wider variations compared to those of the diploid cells of benign tumors. It therefore appears that the combined analysis of the nuclear morphometry and DNA cytofluorometry would provide a useful means for elucidating differences between the benign and malignant tumors of the thyroid.View full abstractDownload PDF (8295K) -
Hiroshi MIYAMOTO, Hiroshi ISOBE, Takashi ENDO, Toru SHIMIZU, Masao HAR ...1990 Volume 29 Issue 6 Pages 829-834
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe examined the relationship among nuclear DNA content, cytomorphologic features, and prognosis in squamous cell carcinoma of the lung. We found no significant relationship between either the light green stain intensity of cytoplasm or the number of keratinized cancer cells and the prognosis of patients. The 5-year survival of patients with large nucleic tumors (tumors with nuclei greater than 11μm in mean diameter) was 71%, and that of patients with small nucleic tumors (tumors with nuclei less than 10μm in mean diameter) was 20%(p <0.001). Patients with diploid tumors had significantly longer survival times (a 5-year survival rate of 63%) than did those with aneuploid tumors (29%)(p <0.01). Patients with tumors having both largenuclei and a DNA index of 1.0 had the longest survival times (a 5-year survival rate of 100%). This was followed by patients with large nucleic tumors and a DNA index of more than 1.51 (71%). However, all patients with small nucleic tumors and a DNA index of more than 1.51 died within 30 months.
These findings suggest that the malignancy level of squamous cell lung cancers and the prognosis could be determined by studying the nuclear size and the DNA content of the tumor.View full abstractDownload PDF (3500K) -
Hirofumi SAKAMOTO, Takuji TANAKA, Akira TATEMATSU, Sigeyuki SUGIE, Nao ...1990 Volume 29 Issue 6 Pages 835-838
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSComputer-assisted image analysis was used for quantification of the number and area of silver-positive nucleolar organizer region (Ag-NOR) of cells in the cytological specimens from mastopathy, fibroadenoma and breast cancer. The mean numbers of Ag-NOR in mastopathy (6 cases), fibroadenoma (7 cases) and mammary cancer (7cases) were 1.74±0.69, 1.66±0.77 and 4.20±2.29, respectively and the mean areas (μm2) of Ag-NOR were 3.26±1.79in mastopathy, 3.79±2.20 in fibroadenoma and 12.5±7.10 in cancer. Both the number and area of malignant lesion were significantly greater than those of benign lesions (P<0.05). These results suggest that computer-assisted image analysis of the number and area of Ag-NOR can be used to differentiate malignancy from benign pathological lesions in the breast cytological specimens.View full abstractDownload PDF (3104K) -
Sonoko NATSUME, Masato SHINFUKU, Tatsunari SATAKE, Eiji NISHIKAWA, Hir ...1990 Volume 29 Issue 6 Pages 839-844
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSEight cases (A group) having transitional cell carcinoma (TCC) localized in the upper urinary tract (renal pelvis and ureter), and 8 cases (B group) having TCC in both the upper urinary tract and bladder, were examined. The incidence of tumor cells in the voided urine and the renal urine obtained by various instruments, and the possible correlation between tumor size and this incidence, were investigated.
Incidences of cells in both voided urine and renal urine were relatively high at 75% and 69% respectively. Tumor size was thought to be one of the important factors influencing the incidence of TCC cells recognized in a smear.
It is necessary to perform the cytological examinations of both renal and voided urine in order to improve the diagnostic rate of TCC in the upper urinary tract. In the present study, more than 4 cytological examinations were necessary to obtain TCC cells in a smear of the voided urine.View full abstractDownload PDF (3317K) -
Toshihiko MORI, Hiroe OIKAWA, Keiko ITO, Ichiro NASU, Yukinori YONEMOT ...1990 Volume 29 Issue 6 Pages 845-850
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSTsuyama town of Miyagi Prefecture in Japan has a population of about 5000. This town was selected as a model district for the screening of uterine cervical cancer in 1966 and yearly screening tests have been carried out subsequently. In the present study, the results for 20 years up to 1985 are summarized and analyzed. In the first year, 1966, 397 of 1956 women above the age of 30 years participated the study, with the rate of participation of 24.9%. Invasive carcinoma was found in 1, carcinoma in situ (CIS) in 3 and dysplasia in 1.
Invasive carcinoma was found in 3 subjects during the 20years. All these cases were experienced prior to 1972, and none appeared after 1972. After the beggining of the screening in 1966, the rate of participation increased, staying above 30% after 1972. Three cases of CIS were found in 1966, followed by occasional detection subsequently, until the total of 7 cases were found. Dysplasia was found almost every year, giving the total of 33 cases. In 1985, among the total number of 1106 women above the age of 50 years, 371 or 33.5% were never examined in the screening test over the 20 year period between 1966 and 1985. In 1985, among the total number of 1383 women above the age of 40 years, 608 or 44.0% were not examined during the 10 year period between 1976 and 1985. Though the rate of participation in the screening test for uterine cervical cancer in a model district exceeded 30%, the number of subjects who have never been examined were found to be unexpectedly high.View full abstractDownload PDF (712K) -
Ryo KONNO, Shinji SATO, Masayuki HORIGUCHI, Kazuo SHIKANO, Nobuo YAEGA ...1990 Volume 29 Issue 6 Pages 851-857
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSForma1in-fixed, paraffin-embedded biopsy samples of 16 vulvar condylomata, 6 cervical condylomata and 13 penile condylomata from male partners were analyzed for the presence of HPV-6/11 DNA by in situ hybridization using a biotin-labeled DNA probe (ViraType in situ). HPV-6/11 DNA was detected in 11 vulvar samples (68.6%), in 4 cervical samples (66.7%) and in 11 penile samples (84.6%).
Investigation of sexual partners revealed that seven of 12 couples (58.3%) shared HPV-6/11.
The signal intensity of the HPV DNA was generally strong in the superficial cell layers and weak in the parabasal or basal cell layers.
No malignant lesions resulted from the condyloma acuminatum caused by HPV-6/11. There was only mild dysplasia in both sexes.View full abstractDownload PDF (7818K) -
Hiroshi Ishihara, Yasunobu Kanamori, Kaichiro Morishita, Yukihisa Mina ...1990 Volume 29 Issue 6 Pages 858-862
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytological features of endometrial carcinoma were quantitatively analysed, compared with endometrial hyperplasia and normal endometrium. A total of 39 cases, consisting of 19 cases of endometrial carcinoma (Grade 1), 10 of endometrial hyperplasia (adenomatous hyperplasia) and 10 of normal endometrium (5 proliferative phase and 5 secretory phase) were examined retrospectively.
This study revealed that values for both coefficients of variation (CV) of nuclear size and the distance between nuclei were large in endometrial carcinoma and small in normal endometrium. In endometrial hyperplasia, CV of the distance between nuclei was larger thanthat of nuclear diameter.
The other observed features of endometrial carcinoma were as follows ; high incidence of nucleoli or large nucleoli, many clusters, clusters with nuclei protruding from the margin, few co-existing normal clusters, multiple stratification and red blood cells on the background.
This study concluded that quantitative analysis was useful for cytodiagnosis of uterine endometrium.View full abstractDownload PDF (604K) -
Hideo YOKOTA, Yoshiya MABUCHI, Taro HOSOMICHI, Masanori KIMURA, Hideak ...1990 Volume 29 Issue 6 Pages 863-868
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSTo investigate into the significance of cytodiagnosis of endometrial smears in the postpartum management of hydatidiform mole, the specimens obtained by sequential aspiration were examined for trophoblastic cells, referring to the urinary concentration of human chorionic gonadotropin (HCG). The subjects were 13 women with hydatidiform mole and 4 women with invasive mole.
Among the 13 women with hydatidiform mole, the number of patients harboring trophoblastic cells decreased with time after delivery, as evidenced by the figures of 10 (77%) at 1 week, 5 (39%) at 2 weeks, 3 (23%) at 3 weeks, and nil at 4 weeks. The disappearance of trophoblastic cells and the substitute appearance of endometrial repair cells were followed by reduction of the urinary HCG concentrations falling below the luteinizing hormone (LH) concentration.
For the 4 women with invasive mole, all were positive for trophoblastic cells and showed high HCG concentrations even 4 or more weeks after hydatidiform molar delivery. Chemotherapy enabled all the patients to turn negative for trophoblastic cells but positive for endometrial repair cells, and reduced their urinary HCG concentrations to the LH concentrations or less. These time-dependent cytological changes helped us in establishing the treatment of choice.
These findings suggest the significance of examination of endometrial smears for trophoblastic cells in the management of postmolar women, particularly among those whose smears remain positive for these cells even 4 or more weeks after delivery, who are strong candidates for secondary pathological changes.View full abstractDownload PDF (2937K) -
Osamu IWANARI, Jinya MIYAKO, Satoru MAKAYAMA, Kanji RYUKOU, Naoki YOSH ...1990 Volume 29 Issue 6 Pages 869-876
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSFor earlier and more accurate cytological diagnosis of non-neoplastic endometrium, endometrial hyperplasia, and endometrial cancer in patients with metrorrhagia, we attempted a screening using a scoring system for endometrial cytology.
1) From the mean score calculated retrospectively in 122 patients aged 30 years or above (97 with normal endometrium, 8 with endometrial hyperplasia, 5 atypical endometrial hyperplasia, 12 with endometrial cancer), scores of 0-6 were regarded as indicating normal endometrium, 7-12 as hyperplasia, and 13-18 as endometrial cancer.
2) The accuracy by prospective scoring in 3 patients with cystic glandular hyperplasia, 9 with adenomatous hyperplasia, 11 with adenocarcinoma endometrial type G 1, and 3 with adenocarcinoma endometrial type G 3 was 73.3%, 80.0%, 88.6%, 100% and 100%, respectively.
3) The frequency of false nagative findings in hyperplasia or more serious conditions was 6.2% and was 0% in cancer alone. False positive findings were obtained in 7.5% of subjects with normal endometrium, and in only 1.2% of subjects with normal endometrium had scores of 13 or above.
These results suggest the applicability of screening for endometrial neoplasia using this scoring method.View full abstractDownload PDF (988K) -
Akira IDO, Tetsuo SHIMIZU, Eiichi SAKAI, Yuka FUJITA, Tadakatsu TSUJI, ...1990 Volume 29 Issue 6 Pages 877-882
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA 52-year-old female showed a coin lesion in the right lower lobe on her chest X-ray film. She had no complaints.
A right lower lobectomy revealed an elastic hard, yellow tumor in the right posterior basal segment, measuring 3×3×2.5cm. Histologically, the main part of the tumor was composed of spindle-ahaped fibroblast-like cells with a typical storiform pattern, and of round histiocyte-like cells. There were no bizarre hyperchromatic nuclei and abnormal mitoses.
These findings confirmed this tumor was compatible with benign fibrous histiocytoma.
Although benign fibrous histiocytoma is rare, it should be included in diseases for the differential diagnosis of lung mass lesions. At present, 16 months after the operation, the patient is in good health without evidence of recurrence.View full abstractDownload PDF (10607K) -
Yasuhiro Nakamura, Takeo Yaguchi, Kozue Masaike, Hideaki Yanai, Yoshin ...1990 Volume 29 Issue 6 Pages 883-885
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of Storongyloides stercoralis infection found incidentally in the sputum cytology is reported. Numerous number of both rhabditiform and filariform larvae were detected. The patient had been under a debilitating condition and getting treatment for silicosis, gastric cancer and tuberculosis. The presence of numerous larvae was considered to be an autoinfection unique to this parasite.View full abstractDownload PDF (2943K) -
Yasue SHITARA, Keiko MAJIMA, Yumiko SHIOZAWA, Kenji KAWAGUCHI, Nobuaki ...1990 Volume 29 Issue 6 Pages 886-892
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of malignant mesothelioma who presented characteristic intracytoplasmic crystalloid inclusions composed of the whorled rough endoplasmic reticulum. A brief discussion on their diagnostic value is also given.
A 61-year-old man was admitted because of pleural effusion. The computed tomography demonstrated a mild right pleural thickening, but the diagnosis could not be made with any certainty by cytological examination of the effusion or biopsy of the pleura. The patient was followed in another hospital with thoracentesis, but was readmitted due to the gradual bulging of the chest wall around the thoracentesis. The pleural effusion was markedly viscous, and a diagnosis of malignant mesothelioma was made by cytological and biopsy examinations.
The cytological study performed on the first admission revealed numerous mesothelial cells with papillary structure but no significant atypism. Most of the cells contained intracytoplasmic crystalloid inclusions. Ultrastructurally, the inclusions were made up of concentric lamellar rough endoplasmic reticulum. Fibrils with 12.2 nm periodical cross-striation were present in the cisternae of the reticulum. Such crystalloid inclusions were also observed in the mesothelioma cells on the second admission. As the significance of such inclusions is not clear, further study is necessary to determine whether or not they have diagnostic significance.View full abstractDownload PDF (14251K) -
Report of a case with imprint cytologyHiroshi SONOBE, Schunichi MANABE, Yuji OHTSUKI, Eiji OHHARA, Eriko MIY ...1990 Volume 29 Issue 6 Pages 893-897
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThere have been only a few reports concerning the cytology of epithelioid sarcoma. We describe a typical case of a 29-year-old male. He had the primary tumor in the subcutaneous tissue of the left forearm eight years previously, and thereafter, multifocally in the extremities and body. Histologically, tumor cells contained atypical nuclei and abundant eosinophilic cytoplasm, and proliferated in a sheet or trabecular pattern with a central necrotic focus and surrounding intense fibrosis. Ultrastructurally, tumor cells contained euchromatin-rich irregular-shaped nuclei with prominent nucleoli, and many intermediate filaments running irregularly throughout the cytoplasm. A few microvilli and pinocytotic vesicles were present, but neither obvious basal laminae nor junctional complexes were detected.
In the imprint cytology, tumor cells were round or polygonal in shape, containing round nuclei with a somewhat delicate nuclear margin, granular chromatin and one or two conspicuous nucleolei, and possessed broad clear or deeply stained cytoplasm. Mitotic figures were occasionally found.Tumor cells were positive for keratin, vimentin and EMA, and negative for S-100 protein. Therefore, it is considered possible to distinguish the epithelioid sarcoma from other tumors based on the above characteristics.View full abstractDownload PDF (7164K) -
Hidekazu OTA, Miki KUSHIMA, Kazuo KAZAMA, Yoshiko TSUDA, Takao SUZUKI, ...1990 Volume 29 Issue 6 Pages 898-902
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of primary testicular malignant lymphoma is reported. A 82-year-old male was admitted to our hospital, complaining of fever and swelling of the right scrotum. Aspiration cytology of swelled scrotum revealed large round cells and small lymphoid cells, which are not conjugated each other. In the begining, seminoma was suspected. In theresected testis, tumor cells consisted of diffuse proliferation of large and medium sized lymphoma cells, immunologically positive for LCA, L 26 and MB-1. Non-Hodgkin's lymphoma, diffuse mixed type was diagnosed. Seminoma was cytologically characterized by a two cell pattern composed of large tumor cells with prominent nucleoli, and lymphocytes and positive for PAS stain. Non-Hodgkin's lymphoma, mixed type revealed large and medium sized lymphoma cells. Testicular lymphoma was frequent in men over 50 years of age. In the cytological diagnosis, PAS stain and immunohistochemical study were effective methods for differential diagnosis of malignant lymphoma and seminoma of the testis.View full abstractDownload PDF (9301K) -
Tai SATO, Toshiya MIURA, Kiyomi HASEGAWA, Michiko KASAI, Taeko OKADA, ...1990 Volume 29 Issue 6 Pages 903-907
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThis is a case report of renal cell carcioma, pleomorphic type diagnosed by aspiration cytology in a 57-year-old male. Tumor cells obtained by aspiration cytology were composed of both epithelial clusters of glandular cells with foamy cytoplasm and hyperchromatic nuclei and sarcomatous cells of isolated bizarre or spindle cells. The presence of scattered isolated spindle cells, and bizarre cells with cellular pleomorphism strongly suggested a sarcoma. However. We diagnosed it, a renal cell carcinoma, pleomorphic type because of presence of epithelial cell clusters in addition to sarcomatous cells.
Diagnosis of this case was decided by aspiration cytology. No tumor cells were detected in the urine. Aspiration biopsy cytology is useful to make a diagnosis of renal tumor including renal cell carcinoma of pleomorphic type.View full abstractDownload PDF (6883K) -
Yuji OHTSUKI, Shunichi MANABE, Hiroshi SONOBE, Yuhei OKADA, Katsuhiko ...1990 Volume 29 Issue 6 Pages 908-911
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe here report on the cytological, immunohistochemical and scanning electron microscopic findings in a case of osteoclastoid type giant cell carcinoma of the pancreas in a 71 y-o female. She was admitted because of obstructive jaundice in Oct. 1988, and diagnosed as having a tumor of the pancreatic head metastasizing to the gall-bladder and lymph nodes. The tumor of the pancreatic head, 5×5.5 cm in size, protruded into the duodenal lumen. Each tumor nodule including the metastatic foci was greyish or brownish-red with focal necrosis in the cut surface, and a clear margin.
In touch smear preparations of the main tumor, osteoclastoid type multinucleated giant cells and mononuclear cells were found. These tumor cells had nuclei with clear nucleoplasm and prominent nucleoli, and their cytoplasm was abundant. The tumor of the gall bladder showed the same findings as those observed in the tumor of the pancreatic head tumor.
Immunohistochemically, the multinucleated giant cells were positive for an antiserum to the α subunit of S-100 protein and also a monoclonal antibody, MB-1, in their cytoplasm. Scanning electron microscopic findings revealed nuclear excavation, some pits in the surface of the multinucleated giant cells, and extending irregular cytoplasmic processes. These multinucleated cells were intimately intermingled with mononuclear cells.
These are the touch smear findings of osteoclastoid type giant cell carcinoma in the pancreas, supported by the histopathological studies. Although this tumor, having a better prognosis than the ordinary giant cell type, is rare, these characteristic findings should be kept in mind in order to diagnose correctly tumors of the pancreaticoduodenal region.View full abstractDownload PDF (6519K) -
Masaki TAKAHARA, Eiki ITO, Osamu HAYAKAWA, Hidemitsu MIZUUCHI, Kenchir ...1990 Volume 29 Issue 6 Pages 912-919
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSPrimary malignant melanoma of the vagina occurred in 4 patients who were under our care. The cytological and histological findings in these lesions are described. Papanicolaou smears were studied at 200 and 400 magnifications. In the latest case, malignant melanoma cells were examined consecutively with a light microscope (LM), a scanning electron microscope (SEM), and a transmission electron microscope (TEM).
1) No intranuclear vacuolation was found in any case. Mutual inclusion and intrahistiocytoplasmic melanin granules were demonstrated in only one case.
2) The cell arrangements were generally sporadic with occasional loose clusters.
3) The nuclei were horse-shoe shaped cells with irregular margins.
4) Cytometry revealed that the oval or spindle-shaped cells were small, 16.5 and 12.8μ on average in the major and minor diameters, respectively.
5) TEM examination of the malignant melanoma cells demonstrated the presence of melanosomes having diameters of 0.2-0.3μ.
From these findings, it was concluded that in the case of a tumor containing either oval or spindle-shaped cells which are small and arranged in such a way as to be intermediate between sarcoma and epithelial tumors, melanoma should be suspected even if no melanin granules are demonstrated. In addition, the LM-SEM-TEM technique used for exfoliative cytology seems to be a useful diagnostic method which can effectively demonstrate melanosomes in a place of a biopsy.View full abstractDownload PDF (11717K) -
Emi HORIMOTO, Motoiki KOIZUMI, Yasushi YAMAKAWA, Satoru SAGAE, Michio ...1990 Volume 29 Issue 6 Pages 920-924
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe present the case of a 70-years-old woman with primary malignant lymphoma of the uterus, clinical stage II E in the Ann Arbor classification. She visited our clinic with genital bleeding. On admission, we diagnosed hydronephrosis and psychological symptoms were present. Laboratory examination was within normal limits, except for elevated LDH levels.
According to the histopathological findings, this case was classified as a non-Hodgkin lymphoma, diffuse and medium sized cell type in the LSG (Lymphoma Study Group of Japan) classification. The Papanicolaou-stained cervical smear showed small cells with naked nuclei and an increased nuclear-cytoplasmic (N/C) ratio.View full abstractDownload PDF (4329K) -
Akimasa SATO1990 Volume 29 Issue 6 Pages 925-926
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (216K) -
Sohei KITAZAWA, Kiyoshi SATO1990 Volume 29 Issue 6 Pages 927-928
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (4486K) -
Junichi KOYATSU, Katsunari KINA, Touru KAWASHIMA, Hiroshi SHIMOTA, Kaz ...1990 Volume 29 Issue 6 Pages 929-930
Published: November 22, 1990
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (2336K)
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