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Volume 22, Issue 2
Displaying 51-64 of 64 articles from this issue
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M YAMAUCHI, S ADACHI, M ANDOU, M NAKAYA, Y KAWASHIMA1993 Volume 22 Issue 2 Pages 507-510
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSA gelatin-sealed Knitted Dacron grafts which have zero-porosity were implanted in 96 patients with either aortic aneurysms or aorto-iliac occulusive diseases. There was no measurable blood loss at implantation from the body of the sealed graft (Gelseal Triaxial), although there was no significant difference in blood loss and blood transfusion between the sealed graft group and the non-sealed graft groupo Twenty patients (24%) of the sealed graft group showed fever in the 2nd postoperative week, but there was no significant difference in the body temperature between the two groups in the 3rd postoperative week. The values of CRP of the fever group in Gelseal Triaxial were significantly higher than those of the non-sealed graft group both in the 2nd and 3rd postoperative week. There was only one case with graft infection. The patency rate was 100%, ranging from 1 month to 61 months (mean 13 months). Gelseal Triaxial is a clinically useful graft with no major complications.View full abstractDownload PDF (490K) -
K. KATSUMOTO, T. NIIBORI1993 Volume 22 Issue 2 Pages 511-515
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSFor the past few years, we have developed glassy carbon stents for sutureless intraluminal graft and have experienced their clinical applications to abdominal and thoracic aorta. We have noticed that psedointima was not found in the inner surface of glassy carbon stents, so we developed another kinds of stent. Three kinds of stents were developed for experimental implantation to the thoracic or abdominal aorta of nine beagle dogs. The developed stents were 1) four pieces of stainless steel bored stents with 300 micron in thickness 2) two pieces of laser bored stainless steel stents with 160 micron in thickness 3) three pieces of spiral stents made of shape memory alloy. After 3 to 6 months, the implanted animals were sacrificed and the surface of the stents were examined using a scanning electron microscope. We found pseudointima in all of the three kinds of stents. In one of three shapememory alloy stents, organized thrombi were found in the middle. All of the bored stainless steel stents were found free of thrombus and their pseudointimal formation were excellent and were thought to be best suitable for intraluminal prosthesis.View full abstractDownload PDF (5573K) -
M KATO, H TAKANO, H IMAGAWA, Y YOSHIOKA, T MATUDA, K OHNISHI1993 Volume 22 Issue 2 Pages 516-521
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThis study addresses the development of a new intraluminal aortic prosthesis (IA graft) and the evaluation of its efficacy in internal obliteration of experimental aortic dissection in acute phase-implantation. The newly devised IA graft is a self-expandable metallic stent (Gianturco stent) outer-jacketed with a thin open-cell structured microporous film made of segmental polyurethane (thickness; 0.2mm, pore size; 0.1mm). Experimental thoracic dissections were surgically created in four mongrel dogs. IA graft, inserted into the 12Fr Teflon catheter by compression, was implanted into the true lumen of descending aorta through a femoral artery. The IA graft was expanded by using pushing rod and stayed on the entry. Angiographic observation showed that all the entries were obliterated. Macroscopic observation showed that false lumens were partially clotted. A prototype device developed here may promise to offer an effective therapeutic procedure for obliteration of Stanford type B dissection with minimum invasion.View full abstractDownload PDF (8545K) -
Y. NAKAGAWA, K. OTA, T. KAWAI, S. TERAOKA, S. FUTINOUE, T. AGISHI1993 Volume 22 Issue 2 Pages 522-527
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe developed a new polyurethane vascular access graft coated with gelatin and reinforced with knitted polyester fibers (PE-PEUG). Advantages over expanded-polytetrafluoroethylene (E-PTFE) graft were previously reported in experimental studies. From August 1990, 45 PE-PEUG including 39 loop and 6 streight, were implanted to create AV shunt in 44 patients on maintenance hemodialysis. Hemostasis from the suture line was achieved within 5 minutes in all cases. Bleeding from the needle holes stopped within 5min with gentle finger pressure. Minimal local edema was developed in only a few patients. Aneurysmal dilatation was observed in one patient. No seroma formation was found in all cases. Our clinical studies showed that the PE-PEUG has several advantages over E-PTFEG. They are; 1) prompt hemostasis, 2) no persistent edema and no formation of seroma, 3) no change in elasticity, 4) enough mechanical strength. However, cumulative patency rate at one year without severe high risk patients was 57.1%. This result is inferior to that with E-PTFE graft implanted in our series. More work will be necessary to improve its patency rate.View full abstractDownload PDF (5677K) -
-AS COMPARED WITH A KNITTED VELOUR DACRON VASCULAR PROSTHESES (USCI SAUVAGETM BIONIT II)-K GAN, T SHIDA, N WAKITA1993 Volume 22 Issue 2 Pages 528-531
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe used a new woven velour Dacron vascular prostheses (VelexTM) in ten cases of replacement of abdominal aortic aneurysm. As compared with a knitted velour Dacron vascular prostheses (USCI SauvageTM Bionit II) used in thirty cases of the same operation, the handling of VelexTM was as easy as that of SauvageTM. The intra-operative blood loss of VelexTM group was significantly lesser than that of SauvageTM group (382±185gm vs. 760±326gm, p=0.048). And the operation time was significantly shorter in VelexTM group than that in Sauvagegroup (151±33 min. vs. 215±38min., p=0.012). There was no complication caused by prostheses in each groups in early post operative period. So it is concluded that the usage of VelexTM vascular prostheses may decrease the intraoperative blood loss, and may shorten the operation time during replacement of abdominal aortic aneurysm compared to SauvageTM vascular prostheses.View full abstractDownload PDF (482K) -
H. YOSHIDA, T. SASAJIMA, K. GO, M. INABA, Y. IZUMI, A. NAOE, N. OTANI, ...1993 Volume 22 Issue 2 Pages 532-536
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe have implanted reinforced biosynthetic ovine collagen vascular prostheses (Omniflow®) in 28 cases with arteriosclerosis obliterans. The operative procedures employed were 2 of femorofemoral bypass, 27 of femoropopliteal bypass above the knee and a femoropopliteal bypass below the knee. The indication for surgery was intermittent claudication in 26 cases and tissue necrosis in 2 cases. The largest period of implantation was 30 months, and two grafts were occluded at 1 and 9 months after implantation. The primary cumulative patency rate in femoropopliteal bypass above the knee at 2 years was 91.5% and the secondary patency rate was 95.2%. Aneurysmal change of the graft has not been found. We conclude that Omnif low may be a useful vascular graft for femoropopliteal bypass above the knee.View full abstractDownload PDF (3637K) -
M. INABA, T. SASAJIMA, Y. IZUMI, K. GO, H. YOSHIDA, N. OTANI, N. AZUMA ...1993 Volume 22 Issue 2 Pages 537-541
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSWe studied the healing characteristics and the patency of CORVITA® vascular graft. Thirteen grafts were implanted in abdominal aorta of mongrel dogs. The graft used was 6mm in diameter and 6cm in length. Three dogs died within 14 days and the remaining 10 dogs were followed from 3 to 21 months. The gross appearance of the graft revealed good healing at both anastomotic sites, and mild anastomotic stenosis at 3 and 6 months after implantation. In histological examinationthe intimal thickness of these regions was about 100μm. But fibrin clot and thrombus were found focally on the surface of the same grafts and the intimal thickness was more than 500μm there. In these grafts, the endothelial cell coverage was localized within several millimeters from the anastomotic site in electon microscopy. In one graft, a segmental stenosis was seen at the middle and distal portion of the graft at 7 months after implantation. There were no thrombus on the surface of the graft and the neointima was almost completed at 20 months after implantation. Seven grafts remained patent from 3 to 21 months (average 11.6 months) and the patency rate was 70%. In conclusion, severe anastomotic intimal hyperplasia was not seen in this study. But the intimal healing of CORVITA® graft is not better than we expected.View full abstractDownload PDF (7709K) -
Takamasa TAKEUCHI, Yasuharu IMAI, Kazuo SAWATARI, Kazuaki ISHIHARA, Sh ...1993 Volume 22 Issue 2 Pages 542-544
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSA soft, pliable, and low polous vascular prosthesis fabricated from ultra-fine polyester fibers was used in 7 patients with congenital heart defects from October 1991 through September 1992. Surgical procedures included aortic arch reconstruction (3), intraventricular conduit (2), intraatrial conduit (2), and subclavian artery-descending aortic bypass (1). There were no graft-related problems occured in postoperative follow-up periods. Two patients died in 4 days and 7 months after operation. Histological examination in late death patient confirmed that there was neither thrombus nor stenosis in the prosthesis, and the inner surface of prosthesis was smoothly covered with neointima. These results suggest that this new vascular prosthesis made of ultra-fine polyester fibers can be satisfactolily utilized not only for an aortic graft but also for an intraventricular or intraatrial conduit in reconstructive cardiovascular surgery for congenital heart defects.View full abstractDownload PDF (1858K) -
K WATANABE, H KURUMATANI, H KATAOKA, T KUNITOMO, T TAKEYAMA1993 Volume 22 Issue 2 Pages 545-549
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSA new low porosity artificial vascular graft (Toray graft or T-graft) was developed which is free from various drawbacks of conventional grafts such as poor suturability, unraveling at a cut edge, poor formation and instability of neointima. T-graft was made by newly developed following fiber technologies: 1) providing a two-ply woven tube of a combination of ultrafine polyester fiber (UPF) and ordinary thick fiber (OPF) for softness. 2) forming nap of UPF on the surface of the tube for better healing. 3) entangling the nap with the woven substratum and making double velour by water jet punching for unravel resistance. 4) wholly cleaning the graft to minimize adverse tissue reaction. Biostability of UPF was confirmed by animal implantation tests. T-graft passed 1 billion load recycling fatigue test and showed excellent biocompatibility in animal tests. This graft was clinically applied and its excellent handling performances were confirmed. So far, its clinical adverse effects have not been reported.View full abstractDownload PDF (5832K) -
T. KOMATSU, K. ARAI, N. KAWAI, H. NISHIDE, E. TSUCHIDA, T. KAKIZAKI, K ...1993 Volume 22 Issue 2 Pages 550-553
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSSolution properties and O2 transporting ability of lipidheme-microsphere composed of oil droplet covered with lipidheme (totally synthetic artificial red cell) are described. Electron micrographs indicated microsphere formation and its particle diameter was controlled from 30 to 200nm. The suspension was characterized by its low viscosity (1, 2cP), specific gravity (1.001), and controlled oncotic pressure. The lipidheme-microsphere bound oxygen reversibly and the P1/2(O2) was 41 torr at 37°C. O2 solubility of the lipidheme-microsphere was more than that of human blood caused by its high heme concentration. Exchange transfusion with the suspension to dogs weighing ca. 8kg was carried out and circulation half life in blood stream was determined (12hr). This result suggests that the lipidheme-microsphere has potential to act as an efficient oxygen carrier in blood stream.View full abstractDownload PDF (1865K) -
A. USUBA, M. MIYAZAWA, J. MIURA, Y. ENDON, H. INOUE, R. MOTOKI, K. SAK ...1993 Volume 22 Issue 2 Pages 554-559
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe purpose of this study was to evaluate the effects of liposome encapsulated hemoglobin named “Neo Red Cells (NRC)” on the canine hemorrhagic shock model and its safety for the vital organs in a whole blood exchange model. Under mechanical ventilation inhaling room air, hemorrhagic shock was induced and then NRC was transfused in dogs. The same procedure was repeated 3-5 times. After NRC transfusion, the peripheral vascular resistance was reduced due to the low viscosity of NRC thus relieving the burden on the heart. The oxygen-transport capacity of NRC was 2-4 times that of natural erythrocytes because the affinity for oxygen was regulated by appropriately adding inositol hexaphosphate as allosteric effector. Two dogs whose blood was exchanged with NRC (exchange rate was from 84 to 90%) have been living over a year without any side effect (one has survived 16 months, the other 14 months). A dog sacrified on the 15th postoperative day for autopsy, microscopically showed no side effects in vital organs. We conclude that NRC is more suitable than natural blood for treatment of hemorrhagic shock and safe for vital organs.View full abstractDownload PDF (809K) -
K SAKAGUCHI, M SUZUKI, Y OGATA, K SUZUKI, T KAMITANI1993 Volume 22 Issue 2 Pages 560-565
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe biodistribution of the NEO RED CELL (NRC)-- artificial red blood cells prepared by encapsulating stroma free hemoglobin (SFH) within liposomes --were studied in rats. After 30ml/kg injection of 14C-Inulin-containing NRC, the blood radioactivity decreased with a half-life of 32.0hr. And the radioactivity was transfered to the reticuloendothelial system (RES) from the blood, and total radioactivity in the spleen and the liver reached 54% of i. v. injected dose at 3days post injection. The human hemoglobin derived from the NRC in the spleen and the liver were degraded and cleared within 7days post injection. The effect of NRC on the phagocytic activity of the RES was measured on colloidal carbon clearance in the rat. The phagocytic activity of over 40ml/kg i. v. group was decreased slightly at 4hr post treatment, but it made recovery within lday.View full abstractDownload PDF (2126K) -
S TAKEOKA, H SAKAI, H NISHIDE, E TSUCHIDA1993 Volume 22 Issue 2 Pages 566-569
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe quality of artificial red cells (ARC); Hb-vesicles (200nmφ), can be evaluated from the lamellarity (n) of Hb-vesicles and the concentration of Hb in lipid membrane vesicles ([Hb]in) as well as oxygen binding properties of Hb vesicles. It is important to prepare Hb-vesicles with higher concentration of Hb ([Hb]in) and lower lamellarity (n). [Hb]in increased with the concentration of Hb used for the preparation of Hb-vesicles. The Hb-vesicles with smaller lamellarity could be obtained with lowering the preparation temperature. Covering of lipid membrane to the concentrated Hb solution was also influenced by the ionic strength and the pH of the Hb solution because lipids and Hb are electrolytes. The highest [Hb]/[Lipid] ratio was obtained when the pH was at around isoelectric point of Hb (pI=7.0). The lamellarity decreased with decreasing the concentration of NaCl.View full abstractDownload PDF (395K) -
S. TOKUYAMA, L. WANG, K. AKAMA, O. NAKACHI, T. SATOH, S. SEKIGUCHI, E. ...1993 Volume 22 Issue 2 Pages 570-574
Published: April 15, 1993
Released on J-STAGE: October 07, 2011
JOURNAL FREE ACCESSThe regulation of the oxygen affinity with allosteric effectors and the dehydration, in the presence of saccharides, of the hemoglobin vesicle (abbreviated as ARC) that was obtained by encapsulating the purified Hb with polymerizable phospholipids, were investigated. The oxygen affinity of ARC can be modulated to the same level as that of red blood cell (P50=27.0mmHg, OTE=25.0%, n=2.5) by coencapsulating demand amount of pyridoxal-5-phosphate or 2, 3-diphosphoglycerate and chloride ion. Furthermore, the dried ARC, which was dehydrated in the presence of saccharides, can be recovered by dispersion of the powdered ARC in water. The change in the particle size, the leak of the interior Hb and the increase in the metHb percentage were not observed. The oxygen affinity was also maintained unchanged.View full abstractDownload PDF (589K)