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Volume 58 (2005)
- Issue 6 Pages 307-
- Issue 5 Pages 259-
- Issue 4 Pages 177-
- Issue 3 Pages 131-
- Issue 2 Pages 51-
- Issue 1 Pages 3-
Predecessor
Volume 58, Issue 5
Displaying 1-4 of 4 articles from this issue
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Yasunori Hamauzu, Toshiya Nosaka, Yoshio Ishizuka, Mitsukimi Sugimoto2005 Volume 58 Issue 5 Pages 259-266
Published: October 10, 2005
Released on J-STAGE: December 10, 2009
JOURNAL FREE ACCESSIn terms of reduction of risk factors for arteriosclerosis, we compared the effects of daily intake of blueberries with those of spontaneous exercise using male Wistar rats. In experiment I, in which the rats were maintained for 11 weeks on a normal diet, the serum HDL-cholesterol level in rats that were supplied with additional blueberry paste every day was higher than that in the control rats. In experiment II, in which the rats were maintained on a high-fat diet, the calcium/elastin level (an index of arterial calcification) was lowest in rats that were supplied with blueberries daily, although there was no improvement in the serum cholesterol level. The serum cholesterol level and the triglyceride level were both decreased in the rats allowed spontaneous exercise, and their calcium/elastin level was also lower than that in the control rats. These results suggest that daily intake of blueberries and spontaneous exercise are both effective for decreasing of risk of arteriosclerosis, although the degree of the effect of each factor seems to be different.View full abstractDownload PDF (1402K) -
Akiko Matsuo, Kenji Sato, Yasushi Nakamura, Kozo Ohtsuki2005 Volume 58 Issue 5 Pages 267-272
Published: October 10, 2005
Released on J-STAGE: December 10, 2009
JOURNAL FREE ACCESSBrown rice is recently used as a healthy food ingredient, because of its high nutritive value, although it contains relatively large amount of phytic acid. Owing to its mineral chelating property, phytic acid has negative effects on the bioavailability of essential minerals especially in the children and women in pregnancy. In this study, an attempt to reduce the phytic acid content of brown-rice bread by addition of Aspergillus niger phytase was done. For the analysis of phytic acid in these bread, white rice, brown rice and soy bean products, an anion-exchange HPLC and a post-column detection method with Wade reagent were used. From the preliminary experiment, it was found that the loaf volumes of brown-rice breads were reduced, especially in 50% brown-rice one. Thirty % brown-rice bread, therefore, was used in the next experiment, where the additions of 0.2g and 1.0g of the phytase (per 521g of bread material) to the doughs and breads during mixing, fermentation, and baking were done. The results suggest that the addition of 0.2g of the phytase to 521g of total material before baking can reduce the phytic acid content in brown-rice bread, with less negative effect on appearance of bread than the addition of 1.0g of the phytase.View full abstractDownload PDF (3086K) -
Effects on Lymphocyte Proliferation and Immunological FunctionJinHua Piao, Yukari Ikehara, Tsutomu Sasaki, Takeshi Miyagi, Miyuki Az ...2005 Volume 58 Issue 5 Pages 273-280
Published: October 10, 2005
Released on J-STAGE: December 10, 2009
JOURNAL FREE ACCESSWe examined the effects of fucoidans differing in molecular weight and composition extracted from Cladosiphon okamuranus Tokida and Fucus vesiculosus on lymphocyte-mediated immunological function and the proliferative responses of normal lymphocytes and leukemic cells. Fucoidan from Fucus vesiculosus, which contains a low proportion of uronic acid and a high proportion of sulfate, strongly inhibited the proliferative responses of normal activated lymphocytes and leukemic cells and induction of apoptosis. In contrast, fucoidan from Cladosiphon okamuranus which contains a higher proportion of uronic acid and a lower proportion of sulfate, exhibited both mitogenic activity against normal T lymphocytes and efficient production of inflammatory cytokines from macrophages at low concentrations. These fucoidans showed less inhibitory activity against leukemic cells and activated lymphocytes. Our results suggest that the biological properties of fucoidans as either immuno-stimulators or apoptosis inducers may be dependent on molecular weight, or differences in the components of polysaccharides.View full abstractDownload PDF (3902K) -
Tomohiro Itoh, Yuko Itoh, Hiroshige Hibasami, Hirotaka Katsuzaki, Kuni ...2005 Volume 58 Issue 5 Pages 281-287
Published: October 10, 2005
Released on J-STAGE: December 10, 2009
JOURNAL FREE ACCESSWe have reported previously that treatment of KATO III cells, a human gastric cancer cell line, with hot-water extracts from adzuki beans inhibited their growth and induced apoptosis. This extract also suppressed benzo (a) pyrene-induced tumorigenesis in the forestomach of A/J mice. In the present study, this extract was chromatographed on an ODS column using H2O-methanol as the eluent, and an apoptosis-inducing substance was purified by ODS-HPLC using the same eluent. Mass spectrometry and 1H-, 13C-NMR identified the apoptosis-inducing substance as catechin-7-O-β-glucopyrano-side (C7G). C7G suppressed the proliferation of both KATO III cells and HL-60 cells, but not that of normal cells. The DNA fragmentation induced by C7G was suppressed by N-acetyl-L-cysteine, implying that the antitumorigenic effect of the adzuki bean extract might be due to active oxygen-induced apoptosis.View full abstractDownload PDF (4237K)
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