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Volume 65 (2012)
- Issue 6 Pages 253-
- Issue 5 Pages 207-
- Issue 4 Pages 145-
- Issue 3 Pages 97-
- Issue 2 Pages 59-
- Issue 1 Pages 3-
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Volume 65, Issue 5
Displaying 1-4 of 4 articles from this issue
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Reviews
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(Young Investigator Award of JSFNS (2012))Tsuyoshi Tsuduki2012 Volume 65 Issue 5 Pages 207-213
Published: 2012
Released on J-STAGE: October 26, 2012
JOURNAL FREE ACCESSIn this study, the physiological effects of fatty acids with conjugated double bonds were widely examined in vitro and in vivo. Initially, a method for determination of conjugated fatty acids in food and biological samples was established. We then clarified that the oxidative stability of conjugated fatty acids was improved by the form of triacylglycerol and addition of an antioxidant (vitamin E), and the influence of this effect on the metabolism and pharmacokinetics of conjugated fatty acids was clarified in vivo. In addition, anti-tumor, anti-angiogenesis, and anti-obesity effects of conjugated fatty acids were found for the first time, thus demonstrating the usefulness of conjugated fatty acids. This communication mainly outlines the data obtained for conjugated linolenic acid.View full abstractDownload PDF (1734K) -
(Young Investigator Award of JSFNS (2012))Tohru Hira2012 Volume 65 Issue 5 Pages 215-220
Published: 2012
Released on J-STAGE: October 26, 2012
JOURNAL FREE ACCESSEnteroendocrine cells sense luminal nutrients, but the molecular mechanisms by which dietary peptides induce gut hormone secretions are still unclear. Using a cholecystokinin (CCK)-producing enteroendocrine cell line, it was revealed that the calcium-sensing receptor functions as the receptor for phenylalanine and also for various dietary peptides. Oral administration of a dietary peptide that stimulates CCK secretion reduced both food intake in rats and appetite sensation in humans. Stimulation of glucagon-like peptide-1 (GLP-1) secretion is a promising way to attenuate postprandial hyperglycemia. We found that a dietary peptide prepared from corn zein strongly stimulated GLP-1 secretion in vitro and in vivo. The zein peptide administered into the ileum of rats effectively attenuated the elevation of glycemia through enhancement of GLP-1 secretion and subsequent insulin secretion. The peptide also reduced plasma dipeptidyl peptidase-IV (DPP-IV) activity after intraluminal administration. These findings are important for understanding nutrient-sensing mechanisms in the gut, and also suggest that enhancement of gut hormone secretion by luminal food factors such as dietary peptides could be a novel strategy for control of appetite and glucose metabolism.View full abstractDownload PDF (1806K)
Research Note
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Kyoji Yoshino, Yukino Kishi, Takashi Kanetaka, Kunimasa Koga2012 Volume 65 Issue 5 Pages 221-227
Published: 2012
Released on J-STAGE: October 26, 2012
JOURNAL FREE ACCESSThis study investigated the preventive effects of water extracts prepared from the leaves and stems of Salacia reticulata on type I allergy in mice. Oral administration of the S. reticulata extracts to mice at doses of 200 and/or 400 mg/kg body weight significantly inhibited mouse type I allergy. The increases in the levels of some cytokines, such as interleukin-4 and interleukin-10, and that of immunoglobulin E in the abdominal wall of mice with type I allergy were also suppressed by oral administration of these S. reticulata extracts. The possibly active components in the leaves were thought to be certain polyphenolic compounds, such as (-)-epicatechin, and that in the stems was thought to be mangiferin. The leaves and stems of S. reticulata would be a suitable foodstuff for prevention of type I allergy.View full abstractDownload PDF (901K)
Research Data
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Hiroyuki Sakakibara, Yoko Ichikawa, Sanae Tajima, Yoshie Makino, Yusuk ...2012 Volume 65 Issue 5 Pages 229-235
Published: 2012
Released on J-STAGE: October 26, 2012
JOURNAL FREE ACCESSFlavonoids are a major group of natural products that are widely distributed in dietary plants, exerting beneficial functions such as antioxidant activity. The purpose of this study was to propose protocols for a flavonoid-poor menu satisfying the daily nutrient requirements for use in clinical studies to evaluate the bioavailability and functional activities of target flavonoids. First, a ranking of flavonoid-rich foodstuffs consumed in Japan was compiled based on their standard daily consumption, and it was decided not to use foodstuffs containing more than 0.1 μmol flavonoids per dish for preparation of meals. Two daily menus were then developed using other foodstuffs satisfying the dietary reference intakes for Japanese males. Furthermore, we confirmed that the target flavonoid could not be detected （＜0.2 μmol per meal） in the developed menus, indicating that volunteers would be able to achieve the Dietary Reference Intakes for Japanese, 2005, with negligible flavonoid intake by consuming the meals we had developed. In conclusion, we have been able to propose protocols for preparation of flavonoid-poor meals that would be useful for clinical studies.View full abstractDownload PDF (736K)
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