ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
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Volume 25, Issue 1
Displaying 1-5 of 5 articles from this issue
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  • A case of intractable chronic osteomyelitis of the mandible accompanied with pathologic fracture and tardive dyskinesia
    KAYOKO NODA, JOUJI NOMURA, YOSHIHIKO MATSUMURA, SHIGEAKI YANASE, MOTOK ...
    2006 Volume 25 Issue 1 Pages 1-7
    Published: April 01, 2006
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.25.1
    JOURNAL FREE ACCESS
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    A case of severe chronic osteomyelitis of the mandible accompanied with fracture of the mandibular angle and tardive dyskinesia in a 78-year-old male is reported.
    As treatment with intravenous antibiotics or decortication was not effective, intra-arterial infusion of the antibiotics was performed. This therapy was very effective without complication.
    In our case, as the patient had had tardive dyskinesia in the past, it was considered that the severe chronic osteomyelitis was closely related to chronic tendoperiotitis caused by muscular overuse.
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  • Differentiation of the expression of A2a adenosine receptor in macrophage cell lines RAW264
    KYOKO WATANABE, SHINYA SHIRASU, KIYOSHI DAITO, MASAHARU MOTOYAMA, YOSH ...
    2006 Volume 25 Issue 1 Pages 8-16
    Published: April 01, 2006
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.25.8
    JOURNAL FREE ACCESS
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    Macrophages are essential for controlling the majority of infections, and are mediators of natural immunity. During infection, lipopolysaccharide (LPS) stimulates macrophages to produce pro-inflammatory cytokines. Interferon-γ (IFN-γ) is also a major activation factor for macrophages. More recently, it has been shown that A2a adenosine receptor (A2aR) is a critical part of the physiological negative feedback mechanism for limitation and termination of tissue-specific and systemic inflammatory responses. It is useful and meaningful to gain information about interaction with LPS, which generates the inflammation, and IFN-γ, which is a major activation factor for macrophages, and adenosine receptors, which terminate the inflammation. The aim of this study is to evaluate the abilities of adenosine, LPS and IFN-γ on the expression of A2aR in the mouse macrophage cell line RAW264.
    Only LPS (10 ng/mL) increased the proliferation in RAW264. ATP (10-4 M) markedly potentiated the expression of A2aR in RAW264. Similarly IFN-γ (102 unit/mL and 103 unit/mL) significantly potentiated the expression of A2aR in RAW264.
    These results suggest that ATP and IFN-γ may affect the expression of A2aR in macrophages.
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  • A simple method of obtaining lingual mucosal cells with a toothbrush for DNA extraction
    YASUHIRO IMAMURA, PAO-LI WANG, TOMOKO KUNO, JUN-ICHI OTOGOTO, TAKEO FU ...
    2006 Volume 25 Issue 1 Pages 17-21
    Published: April 01, 2006
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.25.17
    JOURNAL FREE ACCESS
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    In the post-genomic era, it is necessary to gain a better understanding of the relationship between genes and oral disease. For example, single nucleotide polymorphisms (SNPs) are the most common form of DNA sequence variation and searching for SNPs covers many genes. To perform genetic testing such as testing for SNPs, DNA samples need to be obtained from patients. In the near future, genetic testing will become widespread as a chair-side procedure in general practice. It would be optimal to use a method that results in minimum bodily injury and that does not cause anxiety to patients. Here, we report a simple method of obtaining lingual mucosal cells with a toothbrush for extraction of DNA samples.
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  • [title in Japanese]
    2006 Volume 25 Issue 1 Pages 22-24
    Published: April 01, 2006
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.25.22
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2006 Volume 25 Issue 1 Pages 25-30
    Published: April 01, 2006
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.25.25
    JOURNAL FREE ACCESS
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