ORAL THERAPEUTICS AND PHARMACOLOGY

Sensitivity of clinically isolated Enterobacter gergoviae to various antibacterial agents

YOSHIHIKO MASUDA, MITSUKO SHINOHARA, KIYOSHI OHURA

2007 Volume 26 Issue 3 Pages 73-75
Published: December 01, 2007
Released on J-STAGE: June 08, 2010

DOIhttps://doi.org/10.11263/jsotp1982.26.73

JOURNAL FREE ACCESS

Show abstractHide abstract

We investigated the antimicrobial susceptibilities of Enterobacter gergoviae using 12 strains that were isolated from a tooth with periapical lesion. Antibacterial activity was estimated using minimum inhibitory concentrations. Antimicrobial agents examined were gentamicin (GM), cefalotin (CET), sulbactam ampicillin (SBT/ABPC), ampicillin (ABPC), ofloxacin (OFLX), and erythromycin (EM) . GM, OFLX and EM showed high sensitivity in comparison with ATCC 33028.

View full abstract

Download PDF (359K)
Duodenal ulcer induced by TS-1 in adjuvant chemotherapy for head and neck cancer: A case report

—A case of digestive tract disorder induced by TS-1—

MASATO TAKEUCHI, HIROYUKI NAITO, KAZUO SHIIKI

2007 Volume 26 Issue 3 Pages 76-79
Published: December 01, 2007
Released on J-STAGE: June 08, 2010

DOIhttps://doi.org/10.11263/jsotp1982.26.76

JOURNAL FREE ACCESS

Show abstractHide abstract

TS-1 is an oral anticancer agent which has significant therapeutic action against head and neck cancer. However, myelosuppression, liver and digestive tract disorders are known as adverse reactions. We present a case of duodenal ulcer which was considered to be induced by TS-1.
A 76-year-old female, who was diagnosed as having lower gingival cancer, underwent left neck dissection, hemimandibular resection and reconstruction with rectal abdominal myocutaneous free flap. She was given a daily dose of 100 mg of TS-1 as adjuvant chemotherapy after the surgical treatment. She complained of dull abdominal pain 12 days after treatment with TS-1. Because the symptom became worse, she was hospitalized urgently. Endoscopic examination showed multiple duodenal ulcers which were well defined, with even deepness. We immediately stopped TS-1 administration. These ulcers subsided after the withdrawal of TS-1 with fasting and fluid therapy for several days.
In case of long-term administration of TS-1 for advanced/recurrent head and neck cancer, it must be considered that acute ulcer of the digestive tract may be induced as an adverse reaction.

View full abstract

Download PDF (3983K)
A case of Cronkhite-Canada syndrome with hypogeusia

NAOYA ARAI, TAKEFUMI KOJIMA, TETSUO SUZUKI, TERUO AMAGASA

2007 Volume 26 Issue 3 Pages 80-85
Published: December 01, 2007
Released on J-STAGE: June 08, 2010

DOIhttps://doi.org/10.11263/jsotp1982.26.80

JOURNAL FREE ACCESS

Show abstractHide abstract

Cronkhite-Canada syndrome (CCS) is a rare, sporadically occurring and non-familial syndrome. We report a case of CCS with hypogeusia. A 68-year-old male was suffering from diarrhea and anorexia. Endoscopic examination revealed gastrointestinal polyposis. He visited our clinic complaining of taste disturbance. Together with hyperpigmentation of skin, nail dystrophy and smooth tongue, he was diagnosed as CCS. The patient was treated with predonine and then zinc sulfate. Two months later, taste score was greatly improved. The gastrointestinal polyps were found to have disappeared at 4 months and the blood zinc concentration to have recovered at 6 months after treatment. The patient's progress remains good about 5 years later.

View full abstract

Download PDF (3935K)
[title in Japanese]

2007 Volume 26 Issue 3 Pages 86-89
Published: December 01, 2007
Released on J-STAGE: June 08, 2010

DOIhttps://doi.org/10.11263/jsotp1982.26.86

JOURNAL FREE ACCESS

Download PDF (370K)
[title in Japanese]

2007 Volume 26 Issue 3 Pages 98-132
Published: December 01, 2007
Released on J-STAGE: June 08, 2010

DOIhttps://doi.org/10.11263/jsotp1982.26.98

JOURNAL FREE ACCESS

Download PDF (4949K)

Register with J-STAGE for free!