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Volume 12 (1993)
- Issue 3 Pages 151-
- Issue 2 Pages 73-
- Issue 1 Pages 1-
Volume 12, Issue 1
Displaying 1-9 of 9 articles from this issue
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I : Clinical effects of recombinant human granulocyte colony-stimulating factorMASASHI YOSHIDA, KIYOMI KAWASHIMA, KAZUMASA SUGIHARA, HIROSHI MUKAI, M ...1993 Volume 12 Issue 1 Pages 1-7
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSRecently we reported satisfactory clinical effects of the recombinant human granulocyte-colony stimulating factor (rhG-CSF) on neutropenia in cytotoxic chemotherapy for five cases of oral cancer histopathologically diagnosed as squamous cell carcinoma. Intra-arterial combination chemotherapies with TPP (THP-ADM, CDDP and PEP) for three cases and PP (CDDP and PEP) for two cases were carried out.
Subsequent recovery of the absolute neutrophil count was observed following repeated administrations of rhG-CSF (subcutaneous injection of therapy doses of 75μg/day for 3 days and maintaining doses of 25μg/day for 3 days) . The chemotherapy-induced neutropenic duration was shortened without side effects.
The administration of rhG-CSF is thus shown to reduce the hematopoietic toxicity of chemotherapy for oral cancer and indicate its possibility to enhance dose intensity.View full abstractDownload PDF (672K) -
HIROYUKI NAITOH1993 Volume 12 Issue 1 Pages 8-16
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSIn the present study, new oral cephems, cefpodoxime proxetil (CPDX-PR), cefteram pivoxil (CFTM-PI), cefuroxime axetil (CXM-AX), cefetamet pivoxil (CEMT-PI) and cefditoren pivoxil (CDTR-PI) were administered orally to five healthy male volunteers after meal with crossover tests. Afterwards blood concentrations of the drugs were measured by bioassay. A pharmacokinetic study was performed using one compartment model.View full abstractDownload PDF (620K) -
JIRO SASAKI, TAKASHI MORISHIMA, HIROSHI TAKAI, KATSUYOSHI IKEJIMA, KAZ ...1993 Volume 12 Issue 1 Pages 17-32
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe clinical efficacy, safety and utility, and also the optimal dose of Cefpodoxime proxetil (CPDX-PR) in the treatment of odontogenic infections such as periodontitis, pericoronitis and osteitis of jaw were evaluated in 12 institutions. CPDX-PR was applied to 228 patients for odontogenic infections and the dosage was divided into two doses. (200 mg/day and 400 mg/day) The following results were obtained.
1) The overall clinical efficacy rate determined according to the standards established by the committee was 88.8 %. The efficacy rates were 87.3%, 88.4% and 90.3 %for periodo-ntitis, pericoronitis and osteitis of jaw, respectively. The overall efficacy rate assessed by the principal investigators was 86.5%.
2) The efficacy rates of 200 mg group and 400 mg group as judged by the committee were 87.1% and 91.2%, respectively.
3) On the bacteriological effect, eradication rate judged by the committee was 90.3 %. The MIC80 against 77 strains of Oral Streptococci was 0.39 μg/ ml.
4) Side effects were noted in 3 patients (1.4%) out of 221 patients and the symptoms were diarrhea, gastralgia and dizziness. These symptoms were mild. Abnormal changes in laboratory tests were found in 12 patients (7.8 %) out of 154 patients examined. Major items were elevation of transaminase and increase of eosinophil.
From the above results, CPDX-PR was considered to be useful in the treatment of odontogenic infections. As for the recommended dose, a daily dose of 200 mg proved to exert the expected effect.View full abstractDownload PDF (1659K) -
—Comparison between lidocaine and propitocaine—TOORU OKAYASU, IZUMI NOGUCHI, MAMI SASAO, YOSHIHIRO AMEMIYA1993 Volume 12 Issue 1 Pages 33-38
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe effects of 2 % lidocaine with epinephrine 1/80000, 3 %propitocaine with felypressin 0.03IU/ml, 1.5 % etidocaine with epinephrine 1/200000, and 2 % lidocaine without epinephrine, when used for oral infiltration anesthesia, were studied. Ten healthy male volunteers, ranging in age from 20.5 to 34.9 years (mean±SD, 26.7±4.3 years), took part in the study. A volume of 0.5 ml of the respective anesthetic solution was deposited supraperiosteally in the apical area of the maxillary medial incisor. The intensity of 80 was regarded as complete analgesia, and 30 as relative analgesia, and frequency and duration of analgesias were investigated, along the pain threshold value, with the electric pulp stimulator. As a result, etidocaine was shown to have almost the same analgesic effect as propitocaine, but weaker than lidocaine with epinephrine, when applied for oral infiltration anesthesia.View full abstractDownload PDF (638K) -
HIDEO YAMAMOTO, KATSUNORI ISHIBASHI, JIRO SASAKI, TAKASHI MORISHIMA, K ...1993 Volume 12 Issue 1 Pages 39-45
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe concentration of CPDX in serum, tooth extraction wound and oral tissues after single administration with CPDX-PR 100 mg or 200 mg were determined, and the result was obtained as follows:
1. CPDX-PR 200 mg was administered to 59 patients to examine serum concentration of CPDX. The serum level as CPDX ranged from 0.19 to 5.87 μg/ml, mean±S. D. value was 2.37±1.23 μg/ml. when the serum level was set at MICs of Oral Streptococci (0.78μg/ml) as a target level, 89.8 % of patients showed levels exceeding the target level.
2. To examine an effusion of tooth extraction wound of CPDX, CPDX-PR 200 mg was administered to 207 patients. After 135-300 minutes, 82.8% of patients showed effusion concentrations higher than the target level (0.78μg/ml) .
3. After oral administration of CPDX-PR 200 mg, the peak level of CPDX in gingiva, alveolar bone, dental sac and cyst wall were 2.20μg/g, 1.07μg/g, 2.04μg/g, 1.77μg/g, respectively, and its mean±S.D. value were 1.17+0.43μg/g (21 samples), 0.57+0.24μg/g (15 samples), 0.97±0.54 μg/g (13 samples), 0.96±0.62μg/g (12 samples), respectively.
4. The transfer ratio of effusion of tooth extraction wound levels to serum level was 66.6%, and its ratio of gingiva, cyst wall, dental sac and alveolar bone levels were 47.3%, 37.6%, 37.5%, 17.7%, respectively.
From the above results, the concentration of CPDX in serum, tooth extraction wound was high, and good penetration into oral tissues was obtained.View full abstractDownload PDF (697K) -
AYUKO TAKAO, EIKO YOSHIZAWA, HIROMASA NAGASHIMA, MASATO SAKAI, NOBUKO ...1993 Volume 12 Issue 1 Pages 46-54
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSIncidence and characteristics of staphylococci in healthy human saliva were studied.
1. In 79 out of 92 volunteers (85.9 %), staphylococci was found out.
2. Major staphylococcal species which were isolated from saliva were S. aureus and S. epidermidis.
3. Sixty one strains of S.aureus were isolated from 49 carriers.
4. Coagulase type II, VII, non-typable (NT) were in high proportions in the saliva strains.
5. Twenty four isolates (39.3 %) produced enterotoxins and 1 (1.6 %) produced TSST-1.
6. Almost saliva strains were sensitive against antimicrobial agents, except for PCG and ABPC, and MIC values were similar to those of methicillin-sensitive S. aureus (MSSA) isolated from a hospital in Tokyo.
7. Methicillin-resistant S. aureus (MRSA) strains from the same hospital showed a high resistance to many drugs except for RFP, VCM and ABK.View full abstractDownload PDF (879K) -
AKIHIRO KANEKO, JIRO SASAKI1993 Volume 12 Issue 1 Pages 55-66
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe strains studied here were isolated at the institutes where clinical tests of new antimicrobial agents from September, 1989 to June, 1991 was conducted by multi centric isolation method.
The total number of the strains was 1024; among them 563 were aerobic, Gram positive strains (55.0 %) . Including anaerobic strains, the total number of Gram positive strains was 813 (78.4 %) . Measurement of minimum inhibitory concentration (MIC) was carried out by the standard method of the Japan Society of Chemotherapy.
Although the susceptibility of ampicillin remains as low as before, among those continuously used, there are some which show comparatively high MIC's. It seemed that ampicillin has come to be influenced by some resistance.
The susceptibilities of ester-type cephems, cefteram pivoxil (cefteram), cefuroxime axetil (cefuroxime) and cefpodoxime proxetil (cefpodoxme) are all excellent. Cefdinir (non-ester-type) also has excellent susceptibility.View full abstractDownload PDF (864K) -
1993 Volume 12 Issue 1 Pages 67-68
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSDownload PDF (163K) -
1993 Volume 12 Issue 1 Pages 69
Published: April 01, 1993
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSDownload PDF (121K)
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