ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
Volume 19, Issue 3
Displaying 1-8 of 8 articles from this issue
  • [in Japanese]
    2000 Volume 19 Issue 3 Pages 105-111
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
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  • SHIGETO AMINO, JIN ASARI, HIROSHI IDA, TOMOYO SASAKI, JUNKO OHASHI, YU ...
    2000 Volume 19 Issue 3 Pages 112-117
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Xylocaine® and Citanest® in cartridge form (all contain 1.8 mL) are currently often used as local anesthetics in not only general but also pediatric dentistry. The purpose of this investigation was to clinically examine the efficacy of the ORA® inj. cartridge (1.0 mL) in pediatric dentistry.
    The following findings were obtained, based on an examination of 29 cases (14 boys and 15 girls) .
    1. The average quantity of ORA® inj. cartridge (1.0 mL) usage was 0.72 mL in children. In most pediatric dental procedures, anesthetic injections of less than 1.0 mL were found to be adequate.
    2. Among the 29 cases, there were 24 complete responses with no pain (82.8%), 3 partial responses (10.3%), and 2 minor responses (6.9%) . No cases were judged to be ineffective.
    3. Side effects were not observed in all cases. Based on the findings above, the ORA® inj. cartridge (1.0 mL) is considered to be effective in pediatric dental procedures.
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  • —Comparison between 1-day and 3-day therapy with lenampicillin—
    TAKASHI YOSHII, YOSHIHIKO HAMAMOTO, SHIGETADA MURAOKA, OSAMU TERANOBU, ...
    2000 Volume 19 Issue 3 Pages 118-123
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    To examine the optimal duration of antibiotic administration after mandibular third molar surgery in healthy patients, a comparative study was conducted regarding the postoperative infection and healing process for 139 patients receiving 1-day or 3-day prophylaxis with lenampicillin. There were no postoperative infections. Dry socket developed in 8.3% of 60 cases in the 1-day group, and in 7.6% of 79 cases in the 3-day group, but the incidence of dry socket with respect to the degree of impaction was not significantly different between the groups. There was no correlation between the length of surgery and the occurrence of dry socket. Scores indicating clinical symptoms for the seven days after surgery (body temperature, redness, swelling, spontaneous pain, pain upon swallowing, tenderness, trismus, and lymph node findings) reflected no significant difference between the groups, irrespective of the degree of impaction. These results suggest that the duration of prophylaxis can be shortened for patients with no underlying disease.
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  • TAKEKI FUJISHIRO, TAZUKO SATOH
    2000 Volume 19 Issue 3 Pages 124-136
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Effects of macrolide antibiotics used in dental practice on chemotaxis and phagocytosis of polymorphonuclear leukocytes (PMN) were investigated by means of a rabbit mandibular infection model prepared according to the Satoh-Heimdahl method. Erythromycin (EM), clarithromycin (CAM), roxithromycin (RXM), josamycin (JM), midecamycin (MDM), and rokitamycin (RKM) were selected for the study, and the following results were obtained:
    1) With regard to the influence of macrolide treatment at low concentrations (1μg/ mL) on PMN chemotaxis, enhancement of the activity was slightly observed by treatments with EM and JM, in the 12th week, but there was no significant difference. An inhibitory tendency was observed by treatments with the other drugs, but there was no significant difference.
    2) With regard to the influence of macrolide treatment at low concentrations (1μg/mL) on PMN phagocytosis, in term of phagocytosis rate, enhancement of the activity was slightly observed by treatments with CAM and RKM, in the 12th week, but there was no significant difference. An inhibitory tendency was observed by treatments with the other drugs, but there was no significant difference. In terms of phagocytic index, a tendency for enhanced activity was observed with EM alone, but there was no significant difference. An inhibitory tendency was observed by treatments with the other drugs, but there was no significant difference.
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  • SHINTARO KIMURA, HIROE OKUHARA, HIDEKI HARASAWA, MAYUMI WATANABE, MIKI ...
    2000 Volume 19 Issue 3 Pages 137-145
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    A questionnaire survey was conducted on“Patient Drug Information”in cooperation with hospital pharmacies at Tokyo Medical and Dental University Hospital, and at Hokkaido University Hospital, School of Dentistry.
    A significant difference was noted between the 2 hospitals in the frequency of replies stating that the information is“hard to read.”As for the necessity of drug information, almost 100% of patients replied“Drug information is necessary.”Most patients reported, “The sentences used are understandable.”As for the usefulness of drug information, most of the patients reported“Drug information is useful”. The replies suggested that patients are very interested in drug side effects. Most patients“did not research drug information”by themselves, because they“don't know how to collect information”or they“don't have time to do so.”
    The above findings suggest that“Patient Drug Information”is fairly well understood and used by patients. However, drug information should be written in a more legible and understandable style.
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  • OSAMU FUJISHITA, IKUO WADA, AKIRA SUZUKI, SHINTARO KIMURA, KATSUHISA A ...
    2000 Volume 19 Issue 3 Pages 146-149
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Medical insurance approval of dental medications at 10 national university dental hospitals in Japan was investigated. Some analgesic and antipyretic drugs, antibiotics, and anticancer agents were not covered by insurance for dental use in Japan. Examples of drugs not covered by insurance include Pontal® syrup (Mefenamic acid), Anhiba® suppository (Acetaminophen), Fosmicin-s® for injection (Fosfomycin sodium), Pentcillin for injection (Piperacillin sodium), Dalacin S® injection (Cli damycin phosphate), Minomycin®intravenous (Minocycline Hydrochloride), Oncovin®for injection (Vincristine sulfate), Nidran®for injection (Nimustine Hydrochloride), Krestin®, and Bestatine® capsule (Ubenimex) . These drugs are not indicated for dental use (off-label use), but expansion of medical insurance coverage for dental drugs is desired by Japanese dentists. To increase insurance coverage of medications, cooperation between medical administrative organs, medical and dental scientific societies, and pharmaceutical companies is necessary.
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  • 2000 Volume 19 Issue 3 Pages 150
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Download PDF (99K)
  • 2000 Volume 19 Issue 3 Pages 157-191
    Published: December 01, 2000
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
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