ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
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Volume 27, Issue 3
Displaying 1-5 of 5 articles from this issue
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  • Analysis of the stability and microbiological safety of aznol saline gargle in hospital preparations widely used for the treatment of oral cancer patients with oral mucositis
    MINA USHIYAMA, RYUJI IKEDA, TETSUYA NITTA, YUSUKE TAZITSU, AKIHIKO MIY ...
    2008 Volume 27 Issue 3 Pages 143-150
    Published: December 01, 2008
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.27.143
    JOURNAL FREE ACCESS
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    In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.
    We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.
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  • Results of medicine revaluation in the odontology department
    YOSHIO SAITO
    2008 Volume 27 Issue 3 Pages 151-156
    Published: December 01, 2008
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.27.151
    JOURNAL FREE ACCESS
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    The application of chlorhexidine gluconate for oral mucosa disinfection was prohibited in Japan after the revaluation of medicines in 1985. Dental practices have been influenced by medicine revaluations in the past. Therefore, this study investigated the details of past revaluations and obtained the following results. As for 139 medicine products, indications of the dental area were deleted. The classification according to medicinal effect was 47 antimicrobial medicine products (33.8%), 25 vitamin preparation products (18.0%), 23 dental medicine products (16.6%), and 21 medicine products (15.1 %) for the skin. As for 13 (56.5%) out of 23 products in dental medicine, neither manufacturing nor sales have been continued.
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  • [title in Japanese]
    2008 Volume 27 Issue 3 Pages 157-160
    Published: December 01, 2008
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.27.157
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2008 Volume 27 Issue 3 Pages 161-163
    Published: December 01, 2008
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.27.161
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2008 Volume 27 Issue 3 Pages 170-194
    Published: December 01, 2008
    Released on J-STAGE: June 08, 2010
    DOIhttps://doi.org/10.11263/jsotp1982.27.170
    JOURNAL FREE ACCESS
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