Cases of gout have rapidly increased also in Japan in recent years, and the case reports of it are no longer mere a subject of curiosity but this disease has come to be recognized as one of the diseases of principal joints. In Europe from early days hot springs are known empirically to be beneficial in the treatment of this ailment. However, its action mechanism is not yet necessarily clear.
In order to clarify this point the author studied the effects of drinking and bathing on the uric acid metabolism at the Misasa Hot Springs where it is known that the spring water is composed of radioactive saline water containing sodium bicarbonate. As the result of the study it was found that the drinking of Misasa hot springs water accelerates the blood circulation in the kidneys, which in turn increases the quantity of urination and also decreases the acidity in urine. Thus it increases uric acid lysis in the urine and decreases blood uric acid concentration. The result is acceleration of the excretion of uric acic into urine. It has been proven that bathing at this hot springs improves the values of P. S. P. tests, especially bathing at a relative low temperature for a long period of time enhances the uric acid clearance. This has demonstrated that Misasa hot springs water is effective for the treatment of gouty patients. The author has thought that simple alkaline hot spring water is also the one to be indicated for the treatment of gout.

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Effects of bathing in the thermal spring waters were investigated on healing of primarily closed wound. The simple thermal spring was employed in whole experimental and clinical observations.
In rats, tensile strength of sutured wounds were acceralated to some extent by bathing in the thermal spring waters. Moderately irritating effect of the spring waters, which results in a slightly elevated histamine formation and a capillary dilatation in the skin, was demonstrated as a possible mechanism.
Chemical irritants, when allpied to the experimental wound, delayed the gain of tensile strength. The hindrance thus produced was counteracted by bathing the rats in the thermal spring water.
Wound healing was delayed in the rats whose movements were restricted afer wound infliction, possibly due to the excessive adrenal irritation. Restoration of healing wound was observed when these restricted rats were subjected to the thermal bathing, 15 minuits, daily.
All these evidences showed that the thermal spring bathing be beneficial for healing of primarily closed wound.
Hence, clinical observations were undertaken on the selected group of 27 surgical patients including 15 gastrectomy cases. They were allowed to start full bathing on the 4th postoperative day. No attempt was made to keep water off from the operative wounds.
Respiration of the patients were acceralated as well as the circulatory functions, resulting in an elevated actual pH and a lowered pCO₂. Expectoration of sputum was stimulated.
There were evidences indicating the adrenal cortical stimulation induced by the first postoperative bathing. From the viewpoint of Na/K ratio in urine, however, recovery from the postoperative catabolism was seemed rather promoted.
No adverse effect was found both in wound healing and in general convalescence. Remarkable improvement was observed in the patient's psychic states.
These findings may suggest the acceralating effect of early postoperative bathing on wound healing.

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It has been originally said that it is contraindication for the patients with pulmonary tuberculosis to bath and drink hot spring. For a long time we have been doubtful and incomrehensible of its reason as we could not systematically justify it by experimental and scientific foundation.
Therefore, since about thirteen years we have investigated the influence of the bathing and drinking on the patients with pulmonary tuberculosis excluding severe cases at Tokura-Kamiyamada Spa (sulphated alkaline spring). The main results of the experiment were as follows.
1) Bathing and drinking were used as the experimental method. In the former the slight cases took bath (40°C) every day or every other day, the moderate cases 1 or 2 days every week. And each patient drank 200cc of spring (indifferent temperature) in the morning and in the evening.
The next various items of investigation were inspected for comparatively long period at the fixed time before and after bathing and drinking.
2) Acidity of gastric juice, liver function, gastrointestinal disturbance, haemogram, E. S. R., sputum, X-Ray finding of chest and stomach, body weight, subjective symptom, basic metabolic rate, adrenocortical function, urinary excretion of dihydroascorbic acid, degree of fatigue, blood pressure, CRP, serum protein, ventilating function, resistance in air way, E. C. G. and statistical observation were studied.
3) From above effects of some items we can recognize a little good influence on patients rather than bad influence. In short, the liver function and hemoglobin concentration were increased by bathing and drinking, the improvement of adrenocortical function was indicated, basic metabolic rate was modulated, ventilating function and recovery from fatigue was influenced well. 94% of patients discharged during the past 10 years were statistically occupied by the improved cases in discharge who took both ways, bathing and drinking.
4) According to these results of the experiment it can be said that the Spa treatment is far from injurious, it is useful, for the patients with pulmonary tuberculosis.
I believe Spa treatment should be carried out more positively if we have correct knowledge about character of Spa and stadium of pulmonary tuberculosis.

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I. Triangular pulses of about 500-1500 milliseconds rise-time were found to be effective for selective stimulation of denervated muscle.
When deprived of its nerve supply, muscle becomes less sensitive to brief faradic stimuli and more sensitive to long galvanic stimuli. However, the increased sensitivity to galvanism brought about by denervation is not great enough to prevent the possibility of unwanted stimulation of sensory nerves and normally innervated antagonist muscles.
Selectivity of the stimulus can be improved, and the incidence of unwanted stimulation reduced, by making use of the property of accommodation. If the stimulating current is turned on gradually instead of abruptly, nerve or muscle accommodate to the current; that is to say, the threshold rised and a stronger current is required for stimulation to be effective. Nerve, muscle and denervated muscle all have different minimum rate of current rise which is barely fast enough to catch up with the threshold. Therefor it is apparent that selective excitation of denervated muscle can be achieved by a wide of triangular pulses, having rise-time of 500-1500 msec.
II. The quartz mercury vapour lamp (QML) emits a considerable proportion of its energy in the wave band in the region between 2800 and 2500Å which the sun spectrum does not contain, while fluorescent sun lamp (FSL) emits energy in the region between 2800 and 3800Å having a peak at about 3100Å.
FSL has beneficial effects on the growth of mice kept in darkness, while QML affects rather harmfully.
FSL and Black Light Lamp (which emits energy in the region between 3100 and 3800Å) raise the power of resistance of mice to cold.
QML has harmful effects on the histological changes of mice spleen damaged by X-ray irradiation, while FSL and infrared ray show curative effects on them.

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Some problems about the microwave therapy were discussed in this paper. In physical therapy, adequate heating of the deeper tissue without excessive heating of the superficial layer is desirable.
Comparison between tissue temperatures before and after exposure of microwave showed that the temperature in the depth of 5cm from skin rose to a peak (about 3°C higher than that before exposure) in first 15-20 minutes.
Exposure of microwave for 20 minutes on the stomach at a distance of 5cm from the skin showed no elevation of the temperature in the stomach cavity, and the rectal temperature also did not rise.
Two machines of the microwave therapy were compared in respect to the subjective feeling of heat and the grade of erythema of patients exposed by each machine. Some differences were found between them. From this reason it is necessary that the strict standard of the structure of the machine should be settled as soon as possible.
To observe the influence of the microwave upon the affected muscle, values of serum creatin phosphokinase and serun transaminase were measured in rabbits whose muscle was injured by injection of Trimeresurus venom. The results suggest that the microwave acts to accelerate the regeneration of the affected muscle in its chronic stadium and to accelerate its destruction in its acute stadium.

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1) The inquing of spread of augospel in the Iwate Perfecture in which the mortality due to cerebral vascular lesions is very high revealed that low frequency therapy is not applied widely for therapy of postapoplectic hemiplegia.
2) Performing of low frequency spinal electrification improved ability of physical movements, particuraly in the lower extramitites.
3) Spinal electrification was effective for even the patients who were in the long postapoplectic duration.
4) Although blood pressure was charged to a certain degree by spinal electrification, no crisis might occur in the apoplectic patients associated with hypertention.
5) No definite tendency was observed in the urinary catecholamine excretion during the pre- and post- spinal electrifications. Effective cases, however, were found in the patients showing small amount of catecholamine in the urine.
6) Spinal electrification for postapoplectic hemiplegia decreased blood pressure and resistence of peripheral blood-vessels, and increased digital blood flow.

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The therapeutic use of ultrasound has been investigated in a series of 427 patients with pain, such as rheumatoid arthritis, osteoarthritis, neuralgia (primary or secondary), myalgia, traumatic and skin diseases.
1) Methods:
US-intensity; 2w/cm, 1Mc/s
Moving method, 10 treatments in each patient.
Exposure; 10min.
2) Therapeutic effect in different disease:
In 88 patients with skin disease, sprain, contusion and back myalgia, over 30% of them were cured or improved 100%, In patients with rheumatoid arthritis, cervical spondylosis, neuralgia and tenovaginitis the two third of them were improved excellently. In four patients with acute gouty arthritis, the net result of US-therapy was spectacularly good.
3) Synergistic therapy:
In a series of 128 patients with rheumatoid arthritis, synergistic therapy of intra-articular injection of steroid hormone and US-treatment were given. The effect of intra-articular injection of steroid hormone have shown to be lasted longer than single intra-articular injection, In a series of 50 patients with skin disease, the phonophoretic trial of cream or ointment containing steroid hormone with US-treatment were performed. The therapeutic effect was good to excellent in patients with eczema or dermatitis.
In a series of 28 patients with sprain and contusion, the synergistic therapy of ointment containing heparinoid preparation with US-treatment have been studied in 17 patients. The swelling, pain and subcutaneous hemorrhage in those patients were improved earlier.
4) No appreciable side effect of US-therapy was observed in our study. The US-therapy appears to be important addition to the existing therapeutic armamentarium for diseases we have studied.

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For the whole field of Pelo-therapy, I beg you to refer his literature on “Pelo-therapy” by Dr. Ichiro Hattori, of Institute of Balneo-therapeutics, Kyushu University.
I will show you the actual scene of practical technic of heat-treatment, which I have developed by means of using slime mud of Ariake-Sea, by “8mm” film.
The summaries of my peculiar heat-treatment are as follows:
1) This treatment is a very cheap and local method of medical one, for the materials are inexhaustible slime mud of Ariake-Sea.
2) As slime mud is heated by “auto-vlave”, heat is passed into the inside of mud in a short time, and kept effectively for a long time.
3) The heated mud is wrapped in disinfected cloth, and applied to the affected parts of patients without touching the skin directly, and many points of advantage by this method are as follows; (a) It is convenient for making fit the form of mud to the affected parts. (b) The skin is not only soiled, but also protected from contagion of skin-diseases. (c) The mud is collected simply and used again and again to this treatment.

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