We evaluated the efficacy, usefulness and safety of acupuncture and moxibustion treatment in rheumatoid arthritis, by the randomized, parallel-group, multi-center study with the drug-treated outpatient group as the control. The endpoints, important in the clinical assessment of acupuncture treatment, included the improvement criteria in ACR core set variables and the Japanese version of the Arthritis Impact Measurement Scales Version 2 (AIMS-2), a system of evaluation of the QOL of patients with RA. Regarding intervention (therapy), a therapy chart for each stage of disease was drawn up to give local and systemic treatment in consideration of the patient's activity and disability in each stage of rheumatoid arthritis, so that generally consistent therapy adapted to the patient's condition would be provided. Result 1. Patients eligible for analysis were 80 patients of A-group (drug therapy group) (80 females, 2 males, 2dropped) and 90 patients of B-group (drug plus acupuncture and moxibustion group), total 170 patients. 2. Patients who satisfied the improvement criteria in ACR core set variables (improved patients) were 8 of 80 patients in A-group and 20 of 90 patients in B-group. The improvement rate was significantly higher for B-group treated by drug plus acupuncture and moxibustion versus A-group, with P=0.04 in 2×2 table chi square test. 3. In QOL change investigated by AIMS-2 questionnaire, the improvement occurred significantly more frequently in the drug plus acupuncture and moxibustion group, with difference between groups at 12 months after the initiation of clinical study at P=0.001. 4. Changes in the subjects included in AIMS-2 questionnaire: Improvement was significantly more frequent in the drug plus acupuncture and moxibustion group versus drug therapy group in respect to the ability to walk, finger function, housework, sociableness, pain, mood, and the degree of subjective improvement. In the present randomized, parallel-group, multicenter study, a significant improvement was detected in the drug plus acupuncture and moxibustion group versus the drug therapy group in the aforesaid respect, which suggested that the use of acupuncture and moxibustion combined with the conventional therapy would prevent deterioration of physical functions, improve blood circulation, stabilize mental status, and thereby contribute to the improvement of QOL in patients with rheumatoid arthritis.
The purpose of this study is to observe the changes in peripheral blood flow in those subjects who perspired during and/or after stimulation by moxibustion. Observations were made on a total of ten subjects consisting of six males and four females with a mean age of 28. 1 years. The subjects were divided into two groups: subjects who perspired and those who did not. Stimulation was applied to the Ashi-sanri (St. 36 spot) of the right leg, and blood flow was measured with a Laser-Doppler blood flow meter attached near the stimulation point on the proximal side. Data were processed using statistical analysis method. Significant differences in the mean blood flow values were noted between the two groups (perspiring and non-perspiring). The non-perspiring group recorded lower values of peripheral blood flow than the perspiring group. Chi square testing of statistical analysis demonstrated a trend for subjects with more negative attitudes toward moxibustion treatment to perspire more during and/or after stimulation by moxibustion than those with a positive attitude (p<0.006). These results suggest that the sympathetic nervous system may be activated more strongly by application of moxibustion in those with negative attitudes toward moxibustion.
The objective of this paper is to define the basis for the translational research and its knowledge framework in balneology aiming to approach the disease prevention. As a method to attain this objective, we advocate the knowledge framework that can bridge gene ontology (GO), balneologic ontology (BO), and clinical ontology (CO) virtually at a client site with three sided basic concepts as (1) the logically extended anatomical index from micro to macro, (2) the knowledge representation based on feature described logical conceptual unit, and (3) the EBM (Evidence Based Medicine) based quality evaluation of knowledge. As an result, the scheme and the prototype of the knowledge framework for the basic balneology was built. The logically extended anatomically hierarchical index could offer the seamless and logical continuity from genome to human/environment. The EBM based quality assessment enhanced the reliability of knowledge, and the knowledge representation based on the logical conceptual unit approach offered the unification of the different grain size knowledge.
We surveyed 1, 312 pregnant women who were puerperal in-patients of this clinic by retrospective investigation for the effect of hot-spring bathing on the birth weights of babies they delivered. The women were classified into eight groups. Group 1 consisted of 14 pregnant women who took hot-spring baths every day and delivered male babies. Group 2 consisted of 115 pregnant women who took plain-water baths with additives every day and delivered male babies. Group 3 consisted of 139 pregnant women who took plain-water baths without additives every day and delivered male babies. Group 4 consisted of 16 pregnant women who took showers every day and delivered male babies. Group 5 consisted of 17 pregnant women who took hot-spring baths every day and delivered female babies. Group 6 consisted of 133 pregnant women who took plain-water baths with additives every day and delivered female babies. Group 7 consisted of 136 pregnant women who took plain-water baths without additives every day and delivered female babies. Group 8 consisted of 17 pregnant women who took showers every day and delivered female babies. The weights of male babies were 3069.8±357.1g in group 1, 3139.3±396.0g in group 2, 3147.8±382.8g in group 3, and 3037.4±363.7g in group 4. The weights of female babies were 2966.2±337.9g g in group 5, 3050.7±390.6g in group 6, 3087.2±353.1g in group 7, and 3047.9±295.6g in group 8. The weights of male babies were proportional to the duration of bathing. The weights of female babies were also proportional to the duration of bathing. The weights of the placentas of male babies were not proportional to the duration of bathing. The weights of the placentas of female babies were proportional to the duration of bathing. The ratio of the weights of male babies to the weights of the placentas was proportional to the duration of bathing. The ratio of the weights of female babies to the weights of the placentas was not proportional to the duration of bathing. The conclusion: The above results demonstrate that pregnant women may take hot-springs baths without any adverse effect on the baby.
This study was conducted on 82 nonsmoking healthy young volunteers divided into two groups. The GB37 group consisted of 39 people who were subjected to stimulation of the Guangming (GB37), and the control group consisted of 43 people who were not so stimulated. Blood-flow velocity and pulsatility index (PI) in the central retinal artery (CRA) of the right eye were measured using Color Doppler imaging. Blood pressure and heart rate were also measured at the same time. The type of stimulus was acupuncture applied on the right GB37 with the needle retained for 15min. Seven measurements were made at intervals of 7.5min during a 45-minute period while the subject was in the sitting position. The GB37 group was first measured just before stimulation and observed for 30 min after the needle was removed. There were significant differences in blood-flow velocity and PI between the two groups. In the GB37 group, blood-flow velocity in the CRA increased remarkably and PI decreased remarkably. These values scarcely changed in the control group. There were no significant differences in blood pressure or heart rate between the two groups. These results suggest that acupuncture stimulus on GB37 changes the circulation of CRA by a mechanism other than blood pressure, resulting in an increase in retinal blood-flow volume.
Traditional Japanese massage, Anma therapy has a long history and popularity in Japan. It is known to maintain well-being, promote health, treat illness and prevent disease empirically, however, it is difficult to find published studies. It is necessary to explore the mechanisms of traditional Japanese massage, Anma therapy scientifically, thus, this preliminary study was examined. In this study, three clients assigned to the Anma therapy group participated in five Anma therapy sessions (two per week for two and a half consecutive weeks) of 40 minutes duration. Three healthy volunteer students assigned to a non-intervention group participated in one session involving rest on a bed. Immediate changes between pre- and post-therapy, and longer-term changes between first and last session were observed. In the results, for the Anma therapy group immediate changes were lower subjective symptom and state anxiety scores, with general longer-term effects. Another immediate change in the Anma therapy group was an increase in secretory immunoglobulin A in saliva, but salivary cortisol concentrations did not change. These results suggest that Anma therapy may be physically and psychologically effective in ameliorating subjective symptoms and anxiety, and enhancing immune function, though sample sizes used were too small to analyze statistically. In addition, the result from salivary cortisol concentration implies that effect of Anma therapy is different from that of Western style massage.