The difference in the thermal change among various organs, such as cutis connective tissue, muscular membrane, muscles, liver, stomach and rectum arose by bathing with city water or many kinds of hot spring water which had been exposed to the air for 20min. Water temperature was 38.5C. Remarkable changes were seen in the organs of mesodermal origin. This result, I think, shows one of the effects of the hot spring water bathing. Serum concentrations of several fatty acids greatly increased but that of the rest decreased by taking bath. Some sorts of hot spring water were considered to promote the fatty acid metabolism. These facts seem to tell that the effects of hot spring water bathing on the connective tissue are some of the main causes of the bathing effect which is peculiar to the quality of hot spring water.
There is a difference between city water bathing and hot spring water bathing in changing lipid metabolism, steroid metabolism etc. in serum and connective tissue. Remarkable differences are seen due to the quality of hot spring water and also due to the duration of bathing. It is usually observed that fatty acid and steroid in serum increased and decreased contrary to those in connective tissue. From the changes of lipid metabolism I studied the special function of hot spring bathing.
Temporal change of skin temperature after a bathing with warm water is not always the same on all occasions. These differences are remarkably shown between bathing with warm city water and with hot spring water. Exercises have also considerable influence on time course of skin temperature. It was observed that the hot spring bathing decreased the difference of skin temperature between the left and right side, and the central and peripheral part of the body.
The effect of bathing with hot spring water did not originate from non-specific physical stimulation to the whole body, but each tissue, for examples, the bone marrow, subcutaneous connective tissue or liver, was influenced in a different manner. It was considered that there were close relation among these effects.
With the administration of radioactive, sulfate, and alkaline spring waters some desirable effects have been reported on the uric acid metabolism in gout. With simple thermal water, however, these have not yet been confirmed. In this report effects of Shimobe (simple thermal) water upon the purine metabolism were studied in human subjects by the determination of both orate and oxypurine in plasma and urine respectively. It was observed that oral administration of Shimobe thermal water for three days in succession increased the urinary excretions of urate and oxypurine and decreased their plasma levels.