The following analgesic effects have resulted from irradiating each finger joint (DIP, PIP, and MCP) of patients with rheumatoid arthritis for 20 seconds using the semiconductor laser, “uni-Laser” (10mw, 790nm) from ITO company. 1) Comparison of the post-exposure state with the pre-exposure state in the open test i) Of 13 cases of joint pain, 7 cases showed improvement and 6 cases showed no change with no case showing aggravation. ii) Duration of analgesic effect was less than 48 hours in 2 cases, less than 72 hours in 1 case, and more than 96 hours in 3 cases. 2) Comparison of the post-exposure state with the pre-exposure state in the single blind test on a total of 25 patients with rheumatoid arthritis. Twelve patients were exposed to the irradiation twice per week, 10 times a session (irradiated group) and 13 were exposed to the dummy of the above (control group). i) The irradiated group improved considerably in the number of painful joints, frequency of joint pain, and grasping power. The rate of improvement was superior to that of the control group (P<0.05). ii) No significant improvement in duration of morning stiffness was shown in either group.
Many researchers have pointed out that CO2 bathing directly effects expanding dermal vessels. To clarify the effect of CO2 bathing on red blood cell (RBC), the change of RBC viscosity after single bathing(for 10 minutes at 40°C) with artificial CO2 water made of sodium bicarbonate and citric acid dissolved in plain water was investigated. RBC viscosity was measured at both shear rates of 0.0439 (low) and 94.5 (high) sec-1 using a viscosimeter (Low Shear 30 made by Contraves). The subjects of this study consisted of three male patients and three female patients with a history of cerebro-vascular disease and ranging from 53 to 80 years old. The results are presented below. 1) On the twenty-first day of serial CO2 bathings, a significant decrease in RBC viscosity was found in these patients as compared with that in controls who were subjected to bathing with plain water. However, it was not found on the first day. RBC viscosity of the blood sample that has an elevated PCO2 due to the CO2 gas bubbled into it was measured in relation with the PCO2. RBC viscosity decreased gradually at both shear rates as the PCO2 was elevated and the MCV increased. 2) MCV increased significantly after single bathing on the twenty-first day of serial CO2 baths as compared to that of controls who were subjected to bathing with plain water. 3) ATP concentration in RBC decreased significantly after single bathing as compared to that before bathing. From these results, we can conclude that serial CO2 baths effectively decrease RBC viscosity due to the increase in MCV, which is attained by CO2 through “chloride shift.”
Many researchers have pointed out that CO2 bathing directly effects expanding dermal vessels. The authors have recently reported a decrease in red blood cell after CO2 bathing. To clarify other effects of CO2 bathing on RBC, the changes in the hemoglobinoxygen-dissociation curve (P50) were measured after single bathing (for 10 minutes at 40°C) with artificial CO2 water made of sodium bicarbonate and citric acid dissolved in plain water. P50 was measured with an oxygen-dissociation analyzer (HEMO-O-SCANTM made by American Instrument Company) and 2, 3-diphosphoglycerate (2, 3-DPG) in RBC, with enzymatic analysis. The subjects of this study consisted of six male patients and four female patients, ranging from 53 to 80 years old. The results are presented below. 1) Nine of ten patients showed an increase in P50 after 15 to 30 minutes of CO2 bathing. The remainder showed a transient increase in P50. 2) No significant increase in 2, 3-DPG concentration in RBC was found in the group subjected to CO2 bathing as compared to that of the controls who were subjected to plain water bathing. However, seven patients showed an increase in 2, 3-DPG after 15 to 30 minutes of CO2 bathing, and three patients showed a decrease in 2, 3-DPG. 3) Partial pressures of oxygen (PO2) and carbon dioxide (PCO2) in the venous blood were measured. Elevation of PO2, lowering of PCO2, and increase in pH were observed in almost all patients after a single CO2 bath. From these results, we can conclude that a single CO2 bath effectively decreases oxygen affinity of hemoglobin, presumably due to a rise in the blood temperature and partially due to an increase in 2, 3-DPG concentration in RBC.
This paper covers our recent study of the effect of acupuncture and moxibustion treatments on the exocrine function of the pancreas. The study consisted of pancereatic function diagnos-tant (PFD) tests on healthy adults. Stimulations with acupun-cture and moxibustion have been deeply concerned with “hi-no-zo, ” which is called the pancreas in current terminology, so they were applied to the meridian points in the dermatome referring to the pancreas. Measurements were made before giving a stimulus. after 6 consecutive stimuli were givem, after 12 consecutive stimuli were given, and 7 days atfer ceasing stimulation. No significant change in urinary output was obserued after the treatment. The p-aminobenzoic acid (PABA) excretion rate in urine showed conflicting results between acupuncture and moxibustion. Acupuneture increased the excretion rate while moxibustion suppressed it after single stimulus of each was applied. The excretion rate increased after either type of stimuli was applied repeatedly. Based on these results, we believe that the effect of stimuli to the meridian points which effect “hi-no-zo” in Oriental medicine on the exocrine function has been confirmed, although some fluctuations of vital reactions which depended on the number of stimuli were observed.
Experiments to determine the relationship between the exposure time following death from cold and the amount of residual NPN in blood and organs. Sixty rabbits weighing about 2500 grams were used in these experiments. Their whole bodies except the head and face were immersed in water at a temperature of 2 to 10°C and fastened by tight binding. Their rectal temperatures were measured five minutes apart using a thermocouple thermometer. The measured amount of residual NPN in tissues and blood with each experiment group by the Kjeldahl method after the death are as follows: 1) The amount of residual NPN in organs and blood differed depnding on aggressiveness and the length of time until death. 2) When the length of time until death was relatively short, the amount of NPN in organs decreased and that in blood increased. 3) When the length of time until death was relatively long, the amount of NPN inorgans increased extremely and that in blood also increased. 4) The amount of residual NPN in organs and blood starts to change at the initial stage of aggression.
The warming effect of natrium-hydrogen carbonate-sulfate springs was evaluated experimentally using rabbits with Na2SO4·NaHCO3 by means of medical mass spectrometry. No changes were seen on the subcutaneous tissue pO2 and pCO2. Regional subcutaneous tissue perfusion volume was calculated at 22.57±2.08ml/100g/min (SD=4.45, n=20, p<0.05) with Na2SO4·NaHCO3 bathings which was comparable to that of tap water bathing 20.85±3.56ml/100g/min, (SD=6.71, n=16, p<0.05). Our preliminary data of the following study indicate that the effect of warming with Na2SO4·NaHCO3 bathings is due possibly to some cellular changes in the connective tissue by mild stimulation of bathing, leading to amelioration of defense mechanism in the body; the study will be reported shortly.