16 cases with febrile convulsion and 3 cases with acute recurrent cerevical lymphadenitis were studied as to the presence of allergic nasopharyngitis which is easily alleviated by treatment SCG nasal spray. All of cases had positive family history of allergy, showing charactaristic symptoms and signs of upper respiratory tract allergy.10 out of 14 cases showed hyperpyrexic episodes over 10 times per one year.5 out of 12 cases with febrile convulsion showed positive lg-E·ERAST. On the other hand,11 out of 13 cases subjected to cytological tests for basophilic cells or eosinophils in scraped specimens of nasal mucosa and adenoids showed positive results. Anti-allergic drugs with SCG nasal spray as the central figure were very effective to cure hyperpyrexia and thus of preventive effect on febrile convulsion and acute recurrent cerevical lymphadenitis.
Using specific radioimmunoassay we tried to determine whether any neuropeptides, VIP or SP, may exist in adenoidal and palatine tonsillar tissues in human. Adenoidal tissues of 8 cases (hypertrophic adenoids of patients aged 5 to 13 years,4 males and 4females) and palatine tonsillar tissues of 3 cases (hypertrophic tonsils of 3 cases aged 8 to 13 years,1male and 2 females)were obtained by operations. In the adenoids VIP values averaged 4492±1781pg/g w.w.t. and SP, in contrast,20±6pg/g w,w.t.. In the palatine tonsils VIP values averaged 3010±925pg/g w.w.t. and SP, in contrast,13±5pg/g w.w.t. Thus, the average of VIP level was 100-times higher than that of SP. Since VIP likely controls proliferation of lymphocyte subpopulation and SP causes so-called neurogenic inflammation, these findings suggest that neuropeptides, VIP and SP, are closely involved in the pathophysiology of inflammatory diseases in adenoids and palatine tonsils.