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Eisuke FUJIMOTO, Takashi NOJIRI, Toyoshi KITA, Toshihito BABA, Masahir ...
1990 Volume 39 Issue 1 Pages
1-6
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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Hospitalized cases of surgical procedure for oral lesions in diabetic patients during 4 years (1984-1987) were investigated in this paper. Thirty-four subject cases were older than 40, and the ratio of male to female was 2 to 1. Twenty-one patients were referred from medical doctors, 9 patients from dentists, and 4 patients visited directly. The distribution of oral diseases in diabetic patients was as follows: 14 cases, inflammatory disorders, 11 cases tumors, 4 cases cysts, 3 cases injuries, and 2 cases others. Thirty-one patients sufferred from not only diabetes mellitus but also other systemic complications. At preoperative precautions 34 patients were controlled, with the advice of physician, for fasting blood glucose was less than 150 mg/dl and ketone bodies were negative. As to results, 28 patients got well, but in 6 patients some problems i. e. slow healing, infections, were observed. In conclusion, the factors related to healing process were discussed.
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Jouji NOMURA, Toshirou TAGAWA, Madoka INUI, Yoshio HIRANO, Nobuyuki TA ...
1990 Volume 39 Issue 1 Pages
7-15
Published: January 10, 1990
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We performed anti-cancer drug sensitivity testing in 2 human osteosarcoma cell lines from mandible (HOSM-1, HOSM-2). The drugs tested in this study were Methotrexate (MTX) and Cisplatinum (CDDP). In sensitivity testing, both growth inhibition and colony forming assays were used, and the following results were obtained.
1) It was found that CDDP was effective against HOSM-2, but not against HOSM-1.
2) MTX was effective against both HOSM-1 and HOSM-2, but HOSM-1 was more sensitive than HOSM-2.
3) The results of the growth inhibition assay were in good agreement with the results of the colony forming assay. However, the growth inhibition assay tended to be more sensitive than the colony forming assay.
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With special reference to the combination of polarities (N-pole, S-pole)
Haruhiko SAKAMOTO, Akihito ASAKURA
1990 Volume 39 Issue 1 Pages
16-20
Published: January 10, 1990
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The application of a permanent magnet of 1200 gauss (cylindrical 9 mm in diameter, 7 mm in height) onto the hamster's buccal pouch gave the following interesting results by the laser flowmeter of the peripheral circulatory kinetics according to a change in the combination of polarities (N-pole, S-pole):
1) Group (N-group) of hamsters, whose buccal pouch was subjected to the N-pole of the magnet for one minute and then for nine consecutive minutes.
The application of the N-pole caused an instantaneous increase in blood flow (one minute-value: 10.8±0.4ml/min/100g); this increment was constant, lasting up the ninth minute.
2) Group (NS-group) of hamsters, whose buccal pouch was subjected to the N-pole of the magnet for one minute and immediately thereafter to the S-pole for nine minutes.
The application of the S-pole after the N-pole caused only an increase in blood flow of 0.8±0.2ml/min/100g in one minute, but caused gradual increases up to the ninth minute. However, a significant difference from the N-group (p<0.001) was noted.
3) Group (S-group) of hamsters, whose buccal pouch was subjected to the S-pole for one minute and then for nine consecutive minutes.
The application of the S-pole caused an instantaneous increase in blood flow (one minutevalue: 10.6±0.8ml/min/100g): this increment was constant, lasting up to the ninth minute.
4) Group (SN-group) of hamsters, whose buccal pouch was subjected to the S-pole of the magnet for one minute and immediately thereafter to the N-pole for nine minutes. The application of the N-pole after the S-pole only an increase in blood flow of 0.9±0.2 ml/min/100g in one minute, but caused gradual increases up to the ninth minute. However, a significant diffecence from the S-group (p<0.001) was noted.
The above results revealed increases in blood flow of the buccal pouch for the N-group and the S-group, but not for the NS-group and the SN-group in combination of both poles, rather with significant differences from the N-group and the S-group.
This suggests that the application of a permanent magnet for the purpose of improving the blood flow leads to insuffecient improvement in the peripheral blood flow without due consideration of the combination of polarities.
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Masaru SASAKI, Ken ONODERA, Carlos HERNANDEZ, Kiyoshi OOYA, Seishi ECH ...
1990 Volume 39 Issue 1 Pages
21-25
Published: January 10, 1990
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A rare case of foreign body granuloma of the maxillary sinus in a 26 year old man is reported. The patient was treated 12 years ago, for maxillary sinusitis. Although he ran the normal course with no disavantageous effect, X-ray revealed opacity of the left maxillary sinus. Osteomatous lesion was suspected by scintigram. The mass filled of the maxillary sinus was enucleated and studied by light microscopy and X-ray analysis. Light microscopical examination of the lesion revealed foreign bodies surrounded by inflamed granulation tissue with associated multinucleated giant cells and reactive newly formed bone. X-ray analysis spectra of the foreign bodies showed a pronounced Iodine X-ray peak. These observations indicate that contrast medium penetrates into the bone and causes inflammatory response and reactive bone formation.
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Michitaka MURAKAMI, Toshikazu NAGATO, Hiroaki TANIOKA
1990 Volume 39 Issue 1 Pages
26-33
Published: January 10, 1990
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Morphological changes in myoepithelial cells (MECs) of rat sublingual salivary gland during development after parasympathetic denervation were examined by using the fluorescent probe for actin, nitrobenzoxadiazole (NBD)-phallacidin.
Surgigal parasympathetic denervation within 48 hours after birth totally inhibited the development of MECs. The effect of denervation was maximum at this operation date and diminished gradually thereafter. Denervation at 30 th postnatal day caused no detectable change. The same operation also was performed on adult rats and no morphological changes were observed in the MECs.
The findings suggested that the parasympathetic nerve has a significant neurotrophic effect on developing MECs.
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Toshikazu NAGATO, Michitaka MURAKAMI, Toshiaki UTSUMI, Hiroaki TANIOKA
1990 Volume 39 Issue 1 Pages
34-45
Published: January 10, 1990
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To elucidate the morphological changes of myoepithelial cells (MECs) in degenerating or dedifferentiating salivary glands, the excretory duct ligated rat sublingual glands were examined under transmission electron microscope and fluorescence microscope using nitrobenzoxadiazole (NBD)-phallacidin.
In the ultrathin sections, the MECs showed irregular profile and had thickened or wrinkled basal lamina on the basal surface 7 to 10 days after duct ligation. At 17 to 21 days after ligation, MECs showed disarrengement and decrease of the myofilaments in some terminal portions. Afterwards, morphological changes of the MECs progressed with term after duct ligations, and finally there were several terminal portions in which no MEC was distinguished from the other glandular epithelial cells at 40 days after ligation.
The fluorescence pattern emitted by MECs changed gradually in proportion to term after duct ligation. At 24 hours after ligation almost all MECs preserved stellate shape. At 10 days after ligation the basal surface of the terminal portions was covered broad and weak fluorescence. In some terminal portions, at 30 days after ligation, no fluorescence emitted by MECs was detected.
The present findings suggested as follows. It is supposed that morphological changes of MECs after duct ligation are caused by atrophy of the terminal portion due to acinar cell degeneration. In the most atrophic terminal portions, MECs degenerate or dedifferentiate, and then finally disappear. An adequate tension is required to maintain normal shape of MECs especially arrangement of myofilaments. It is also supposed that MECs are epithelial in origin.
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Narisato KANAMURA, Masato OKUDA, Nobuo UEMATSU, Kouji TSUKITANI, Nobut ...
1990 Volume 39 Issue 1 Pages
46-51
Published: January 10, 1990
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A case is reported of calcifying odontogenic cyst, which is caracterized by the appearance of ghost cells and calcification into the epithelial layer of the cyst wall. This lesion has been recognized as one of the odontogenic cysts. However, the histogenesis of the lesion is still controversial because some previously reported lesions were accompanied by odontogenic tumor.
In this case, a 60-year-old man suffered from swelling in labio-gingival junction of 21 and was referred to our clinic. The lesion was clinically diagnosed maxillary cyst by Xray and cystectomy was carried out under local anesthesia combined with intravanous sedation. Histopathologically the cyst wall consisted of stratified squamous epithelia and amelobl-ast-like epithelial layer with varying widths and calcification and ghost cells were present in the layer. No evidence of odontogenic tumor was seen. Therefore, the lesion was diagnosed odontogenic calcifying cyst. Electron probe X-ray microanalysis of this lesion revealed high peaks for calcium and phosphorus ions and a low peak for magunesium ions.
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Part I: sexal differences of masticatory structure
Masashi SUGISAKI, Kuniko SUZUKI, Akihiro IKAI, Haruyasu TANABE, Susumu ...
1990 Volume 39 Issue 1 Pages
52-63
Published: January 10, 1990
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908 Japanese dry skulls (3-84y) were investigated its masticatory parts about sex dimorphism. They were not cured their caries and defect of teeth.
Results
Male condylar breadth and M. masseter origin length were wider than these of female in over 20 years old groups, and were caused by their functional discrimination. Edentulous group reduced their breadth and length, especially in condylar breadth. Old edentulous group indicated morphological non-sexual dimorphism. Male number of loss of teeth were same as female. Attrition showed functional discrimination between male and female, but we could not clearly that of causes. Bite relation of anterior teeth were pointed out their sex differences, and results of attrition were under consideration, we thought that the teeth application or use differed between male and female. It was caused by functional decline and effect of sex hormones that old female edentulous showed reduction of condylar breadth and M. masseter origin length.
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Yoshinori JINBU, Yoko AKASAKA, Nobuhisa KUBOTA, Yoshihisa WATANABE
1990 Volume 39 Issue 1 Pages
64-71
Published: January 10, 1990
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Dimethylbenzanthracene (DMBA) is a well known carcinogenetic reagent which causes epithelial and non-epithelial malignant tumors in oral mucosa. We investigated the effect of DMBA on that of microfilaments, keratin-intermediate-filaments, microtubules and desmosomes in cultured gingival keratinocytes in order to clarify the changes in the distribution of cytoskeleton and desmosomes in the process of carcinogenesis.
Normal human gingival keratinocytes were cultured by explant and DMBA was added to medium (final concentration was 4 μg/ml) after 3 weeks from initial culture. Keratinocytes were gradually transformed from a characteristic “pavement form” to an irregular fibroblastic form for 1 week. These shape changes became more remakable for 2 weeks. Under these conditions, remarkable changes of the distribution of cytoskeleton and desmosomes were observed by immunofluorecence microscope using monoclonal antibodies to a-actin, keratin and desmoplakin I, II.
The staining pattern became anomalous from a homogeneous and we observed strong stainings in the peripheral region of cytoplasm when antiactin monoclonal antibody was used. We also observed the changes in keratin-intermediate-filaments, i.e. redistribution to anomalous, disappearance or indistinction, and these structural changes became more remarkable in proportion to the shape changes of the cells. Similar structural changes were observed in microtubules. Staining of desmoplakin I, II corresponded with cell membranes in control cells. However, such stainings were not seen after addition of DMBA.
These results suggest that DMBA induced structural changes in all three cytoskeleton and desmosomes, and then shape changes of cells. These changes may be important for the process of carcinogenesis in epithelial cells.
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Yasuyuki YOKOYAMA
1990 Volume 39 Issue 1 Pages
72-89
Published: January 10, 1990
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Rabbits received an oral administration of 3.5 g/kg calcium lactate, and also an intra-abdominal injection of 1, 25-dihydroxyvitaminD
3 1μg/kg. Both were administered once a day for 3-4 days continuously. These doses of calcium lactate and 1, 25-dihydroxyvitaminD
3 clearly increased serum calcium. The continuous changes in total calcium and serum ionic calcium were checked. I also examined how they influenced the function of the parathyroid cells, thyroid parafollicular cells and the dentine calcification figure. After that I compared the control. The results are as follows.
(1) After the administration, serum total calcium and serum ionic calcium promptly and clearly increased. Also there were consecutive repeated increases in serum calcium. As mentioned, the rabbit received an injection once a day. The tendency was much more remarkable in the calcium lactate group than in the 1, 25-dihydroxyvitaminD3 group.
(2) In the parathyroid cells, cell organelles decreased in number while secretory granules increased. 1, 25-dihydroxyvitamin D
3 had a much more remarkable effect on the secretory granules than calcium lactate. The cell organelles increased in the thyroid parafollicular cells, while the secretory granules decreased. This was just the opposite of the results obtained with the parathyroid cells. This time calcium lactates had a more marked effect than 1, 25-dihydroxyvitamin D
3.
(3) When the calcification figure for dentine became high, an area of calcification was produced.
(4) From these results I learned that when an over dose of calcium lactate and 1, 25-dihydroxyvitaminD
3 was given to the rabbit, there was an increase in serum total calcium and serum ionic calcium. Also the control of the secretory granules of the parathyroid cells, and the function of the cells decreased, but the function of the thyroid parafollicular cells increased. I concluded that the increase in serum calcium quicken the calcium absorption of dentine.
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Hideaki SAKASHITA, Masaru MIYATA, Morimoto HAYASHI, Hiroshi KURUMAYA
1990 Volume 39 Issue 1 Pages
90-98
Published: January 10, 1990
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Malignant neoplasms, which originated from organs other than those of the head and neck, metastatic to the oral and maxillofacial region are rare.
Three cases of metastatic carcinoma of the oral and maxillofacial regions were reported.
Case 1 was a 66-year-old woman with adenocarcinoma of the common bile duct which metastasized to the maxillary gingiva. Case 2 was a 61-year-old man with squamous cell carcinoma of the esophagus which metastasized to the bilateral submandibular lymph nodes. Case 3 was a 74-year-old man with adenocarcinoma of the lung which metastasized to the tongue. Death usually comes in only a few months after the discovery of the metastatic lesions.
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Eisaku UETA, Yukihiro TATEMOTO, Jyusui HIROTA, Tokio OSAKI
1990 Volume 39 Issue 1 Pages
99-106
Published: January 10, 1990
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We reported here a largely enlarged schwannoma deeply situated in the upper cervix.
A 27-year-old man visited with complaining of an asymptomatic solid mass in the upper neck left side. A hen-egg size, somewhat movable mass was palpated in the deep layer under the sternocleidmastoid muscle and clear pulsation could be detected on the overlaying skin. By CT scanning test, echogram and angiography, the mass appeared mostly solid, and the mass made the lateral pharyngeal wall protrude and it laterally pushed up the cervical blood vessels. The lesion was considered a benign tumor to be removed. By cutting down the sternocleidmastoid and digastric muscle, and also the internal jugular vein and external carotid artery, the deeply situated tumor of 6.0×4.5×4.0 cm was extirpated. Microscopic observation revealed that the tumor was nearly solid, while bloody content cystic cavities existed in some places, and the tumor consisted of cells having not-clearly palisaded spindle shape nuclei and curling, or longitudinally arranged cytoplasmic fibers which sometimes run in the same direction. The cells were positive for S-100 protein in the immunostaining, and the tumor was diagnosed as a schwannoma, Antoni's B type. After the surgery, palpebral movements of the diseased side were disturbed for some months, and the appearance of Horner's syndrome seemed the result of denervation caused by the tumor removal. From the above, we considered the tumor might have originated from the cervical sympathetic nerve.
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Hitoshi OHARA, Yasunori SUMI, Minoru UEDA, Hideki MIZUTANI, Toshio KAN ...
1990 Volume 39 Issue 1 Pages
107-114
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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When diagnosing diseases in the oral and maxillofacial region, radiographic diagnosis plays an important part. However, the problem encountered is the difficulty to image three dimensional constructions from conventional X-rays.
Recent improvements in medical imaging process based on advanced computer technology have facilitated not only more precise diagnosis of diseases but also improved treatment for diseases in the oral and maxillofacial region.
The purpose of this report is to evaluate the various aspects and functions of three dimensional display by means of computerized tomography in oral and maxillofacial regions.
We have clinically applied this method to fifteen patients. The diagnosis using three dimensional display is superior that of X-ray display due to the following points:
1. The entire display can be directly observed in its three dimensions.
2. Dislocation and defect of the bone can be detected clearly.
3. The display can be further observed by changing to optional directions, as well as cross sections.
4. The data can be collected by observers with less variation of interpretations between them.
5. Not only can distance be measured but volume and space can also be computed.
On the other hand, there are the following problems for further consideration of the the three dimensional display.
1. When exposure times increase, exposure dose also increases.
2. It takes more time to take three dimensional displays, therefore it is difficult to keep the body stationary.
3. The artifact will occur when metals are presented in part of exposure fields.
4. When the threshold does not set properly, the display can not be shown precisely.
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Hidehiko YOSHIDA, Fujio ATSUTA, Michitoki KINEHARA, Kikuo TAKAHASHI, Y ...
1990 Volume 39 Issue 1 Pages
115-125
Published: January 10, 1990
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Thirty-five patients with head and neck tumors were evaluated by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting magnet system (Picker International VISTA-MR).
Over 80% cases were clearly demonstrated on their images with T1 and/or T2 weighted images. All detected tumors with T2 weighted images exhibited high-slightlyhigh signal intensity compared with the muscle. However, with T1 weighted spin echo images, almost all tumors showed iso intensity to the muscle, and some could not be distinguished from surrounding tissues.
With MR imaging, generally, maxillary lesions were most clearly detected and were best in image quality. Conversely, with tumors of the tongue and floor of the mouth, their images were not suitably obtained. Regarding malignancy of tumors, MRI did not provide any specific patterns and could not identify each lesion between benign and malignant tumors.
Metallic artifacts due to Pd dental crowns were generally seen as areas of local signal void in 3-5 cm diameter. Moreover, ferromagnetic dental appliances, such as orthodontic bands and Co-Cr-Ni crowns, produced extensive facial distortions.
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Norihiko OKADA, Shigetoshi SHIODA
1990 Volume 39 Issue 1 Pages
126-133
Published: January 10, 1990
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Recently, S-100 protein positive dendritic cells (S-100 (+) cells) in the lymph nodes were shown to be Langerhans cells or interdigitating cells, and these cells in the lymph nodes, as well as in the epidermis and oral mucosa, have been thought to play a role as antigen presenting cells. But the existence and distribution of these cells in various lymph node lesions have never been morphologically investigated in detail.
In this study, we examined 30 cases of tongue carcinoma with metastases in the lymph nodes immunohistochemically, and showed the existence and distribution of S-100 (+) cells in the metastatic cancer tissues within the cervical nodes. We could recognize numerous S-100 (+) cells in the active metastatic cancer tissues in the lymph nodes, however, the number of these cells in the degenerated or necrotic cancer nests, or around these areas markedly decreased.
These immunohistochemical findings suggested that there had been close relationships between these S-100 (+) cells and the lymphocytes even in the metastatic cancer tissues in the lymph nodes. We discussed the functional role of these S-100 (+) cells in metastatic cancer tissues in the lymph nodes with a review of past literature.
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Jea Ryong KANG, Masao ITO, Hideharu SUZUKI, Kiyonobu SASASHIMA, Toshio ...
1990 Volume 39 Issue 1 Pages
134-139
Published: January 10, 1990
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We carried out dental treatment in a 42 year-old woman with Eisenmenger's syndrome. We were able to manage her safely and follow her progress. In patients with this condition, dental treatment can give rise to cyanosis, cerebral abscess, cardiac failure, pneumonia and bacterial endocarditis. To prevent these severe complications we had to manage this patients carefully before, during and after her dental treatment. Before treatment, we confirmed that her general condition was good and we gave her Bacampicillin. During treatment we monitored her blood pressure and pulse and used N20 anesthesia. After treatment, she was given oxygen and antibiotic was continued until the next day. During dental treatment her general condition was stable and there were no accidents. However, when chair time exceeded 30 minutes, she had dizziness and difficulty in standing after treatment. She recovered from these complications after oxygen inhalation and rest.
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Inhibition of wound contraction and collagen gel contraction with a topical smooth muscle antagonist
Shinichi SASAKI, Minoru UEDA, Koji EBATA, Toshio KANEDA, Shinsuke SAGA ...
1990 Volume 39 Issue 1 Pages
140-150
Published: January 10, 1990
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We studied the effects of smooth muscle antagonist, papaverine, on the contraction of the open wound in rat dorsal skin. When papaverine was dressed on the wound in the back of rats twice a day, the contraction of the wounds was inhibited by 28%, when compared with the control wounds. In order to analyze in vitro papaverine effect on the wounds contraction, human oral fibroblasts were cultured three dimensionally in hydrated collagen gels containing papaverine. Treatment with papaverine inhibited the contraction of collagen gels in a dose-dependent manner. W e also examined the change of the shape of papaverine-treated fibroblasts in the collagen gels. Whereas non-treated fibroblasts showed a lot of filopodia with fine branches in the tips, fewer and shorter filopodia with less branching were observed in papaverine-treated cells. The organization of actin filaments in the fibroblasts cultured three-dimensionally in the collagen gels was examined by staining with fluorescent dye conjugated phalloidin. In control cultures, well-organized stress fibers were formed in the projection of the cells. On the other hand, disruption of stress fibers in the projections and aggregation of actin filaments were observed in papaverine-treated fibroblasts.
These results indicate that papaverine inhibits wound contraction via its effects on the organization of actin filaments in fibroblasts.
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Hiroyuki ABE, Hiroaki KATAUMI, Tsuneko OGINO, Hideki OGIUCHI
1990 Volume 39 Issue 1 Pages
151-157
Published: January 10, 1990
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The nasolabial cyst is one of the infrequently observed lesions of the face.
A case of nasolabial cyst in the right nasal ala is reported. A 44-year-old woman complained of swelling without tenderness of the right nasal ala. Roentgen examination showed no abnormal condition. Diagnosis was nasolabial cyst. The lesion was completely excised under local anesthesia. The cyst was the size of the tip of a thumb on the bone surface below the right pyriform aperture. The cyst wall was soft and partially connective with the mucous membrance of the floor of the nose. Histopathological examination revealed stratified ciliated epithelium with many goblet cells.
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Masayuki KANEKO, Kazuko KANEKO
1990 Volume 39 Issue 1 Pages
158-168
Published: January 10, 1990
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Soft X-ray radiography, microradiography and scanning electron microscopy (SEM) were used in the experimental study on mandibular bone fractures in rats. Fifty male rats of about 200 g were offered to this investigation, and bone factures were produced in the right mandibulac. Examinations with three modalities were carried out imediately, 3 days, 7 days, 14 days, 21 days, 28 days, 35 days, 42 days and 49 days after fracturing.
The soft X-ray radiograms showed no changes until the 3 rd day. The radiolucency of fractured regions was gradually decreased from the 7 th day until the 42 nd day. Those obtained on the 49 th day showed the same images as those obtained from the control rats.
The microradiograms also did not demonstrate noteworthy changes until the 3 rd day after fracturing. Some early changes and new callus formation in the periosteal regions were observed from the 7 th day, and the calification of callus was gradually increased until the 42 nd day. Those images obtained on the 49 th day showed the same findings as those obtained from the control rats.
The SEM images showed a slight bone absorption in the cortex regions from the 3 rd day after fracturing. The most remarkable absorption was observed on the 14 th day, and the regeneration of those regions was increased from the 21 st day until the 42nd day. Those images obtained on the 49 th day showed the same findings as those obtained from the control rats.
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Report of two cases and review of the literature
Yusuke TAKEUCHI, Kimiyoshi TAKEHARA, Yasushi HAYASHI, Yasuyuki GOTO, M ...
1990 Volume 39 Issue 1 Pages
169-174
Published: January 10, 1990
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We reported here on two cases of radiation-induced cancer developed in the oral and maxillofacial region. Two cases were as follows:
Case I: In 1951, 23-year old man was irradiated externally for treatment of actinomycosis in the right mandible. In 1978, 27 years later, the man was admitted to our hospital for squamous cell carcinoma in the right buccal mucosa.
Case II: In 1974, 64-year old man was treated by external radiation therapy following chemotherapy for tongue cancer of the right side. In 1988, 14 years later, the squamous cell carcinoma in the labial mucosa of the left side developed.
In both cases, the cancers developed in the previous irradiated area. As in the primary malignant case there were some difficulties in distinguishing radiation-induced cancer from late recurrence, was used diagnostic criteria of radiation-induced cancer by Satoh's and Sakai's.
The detailed relationship between irradiation dose and carcinogenesis was unknown. It is important that the evaluation of irradiation effect and the risk of carcinogenesis be established.
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Iwai TOHNAI, Hideki MIZUTANI, Minoru UEDA, Yusuke TAKEUCHI, Yasuyuki G ...
1990 Volume 39 Issue 1 Pages
175-183
Published: January 10, 1990
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In the present study we investigated the clinical and histopathological effects of PP therapy by combined use of Cisplatin (CDDP) and Peplomycin (PEP) for 22 cases of the carcinoma of the tongue. The results were as follows ;
1. The clinical response rate was 81.8 %(including 2 CR, 16PR, 3MR and one NC).
2. The histopathological response rate was 50.0 %(including 2 Gradeo II, 9 Grade II a, 4 Grade II b, 6 Grade III and one Grade IV).
3. The clinical effects did not always agree with the histopathological effects. There were discrepancies between clinical and histopathological effects, especially in PR determined by clinical findings.
4. From the view points of the WHO Grade, the histopathological effects by Obosi Shimosato classification results that there was effectiveness among 11 cases of 18 of Grade I (64.7 %), and none of Grade II and III.
5. From the view points of the mode of invasion, the histopathological effects results that there was effectiveness among 7 cases of 8 of 1, 2 type (87.5 %), 3 cases of 8 of 3 type (37.5 %), one case of 4 of 4C type (25.0 %) and none of 4D type.
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Akiyo NAKAHATA, Tomio AZUMA, Hiroyo DEGUCHI, Yoshio HAYASHI, Tetsuo YA ...
1990 Volume 39 Issue 1 Pages
184-191
Published: January 10, 1990
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A case of adenomatoid odontogenic tumor which occurred in maxilla of a 22- year-old Japanese female is reported. The patient first noticed buccal swelling in upper left molar region and was treated with extraction of the second molar. The roentgenogram revealed a well-circumscribed and oval radiolucency between the left premolar and the tuberosity in maxilla, associated with an impacted third molar. It contained many dense radiopaque foci, suggesting tumor or tumor-like lesion. Roots of the teeth adjacent to the lesion were absorbed. After an incisal biopsy, radical resection of the left maxilla was performed. Macroscopically, the tumor was encapsulated by fibrous connective tissue. On cut sections, the solid tumor mass showed yellowish-white in color with irregular-sized cystic spaces in the peripheral region. A number of calcified foci were observed within the tumor. Microscopically, the tumor mainly consisted of polygonal or spindle-shaped epithelial cells arranged with convoluted, duct-like structures containing a single layer of columnar or cuboidal cells. Nuclei of these cells were usually located apart from luminal portion. No distinct substances were observed in most lumina, whereas degenerated stromal tissues or blood vessels were occasionally contained. The eosinophilic substances with calcified foci were mostly seen at peripheral portion in the solid tumor clumps, and also within the tumor clumps in part. These substances could not be referred to as enamel, dentin or cementum, but some of them were similar to osteoid. Histochemical examination revealed that eosinophilic material within the tumor clumps showed positive reaction with Congo red and PAS stains, but negative in the peripheral portion. No reccurence has occurred to date three and a half years after the operation.
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Kumiko OI, Toshio FUJIKI, Kazuhito IDA, Hidenori NINOMIYA, Akiko OGAWA ...
1990 Volume 39 Issue 1 Pages
192-197
Published: January 10, 1990
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The outpatients at the Second Department of Maxillofacial and Oral Surgery Nagasaki University Dental School Hospital during the four years from April, 1984 to March, 1988 were analyzed statistically.
The total number of the patients was 3608. 38 % of them were eighteen to thirty nine years of age and the number of the patients over sixty years old have tended to increase.
38.3 % of all patients were refered to our Department by dental practitioners.
77.3 % of the patients over sixty years old showed to have general disease, 42 % of them had cardiovascular disease.
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Tamotsu YOSHIKAWA, Hirofumi MURASE, Maki TANAKA, Tsuyoshi TANAKA, Tomo ...
1990 Volume 39 Issue 1 Pages
198-206
Published: January 10, 1990
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Gingival hyperplasia is a well-known side effect of the drug pheytoin. Recently, case reports which other medications induced-gingival hyperplasia such as Cyclosporin -A (CsA), an immunosuppressive agent, and Nifedipine, a calcium-channel blocker, in the treatment of angina pectoris, hypertension. W e encountered two cases of Nifedipine-induced gingival hyperplasia. One patient was given Nifedipine 30 mg/day, Diltiazem 90 mg/day for about 3 years and subsuauently gingival hyperplasia was observed. The other patient was given Nifedipine 30 mg/day for 6 months, after gigival hyperplasia was observed. Two cases upon oral examination showed marked gingival hyperplasia of nodular type on the maxillary anterio teeth. We performed gingivectomy with CO
2 laser after oral hygiene measures on one. The other patient was treated oral hygiene method
This resulted in unevenful recovery, and no sign of reccurence was seen
The Nifedipine-induced gingival hyperplasia is rare and the mechanisms of action of Nife-dipine are not clarified at present. But it is expected that the number of cases of Nifedipi-ne-induced gingival hyperplasia may increase in Japan
Thus we should consider the mode of chemotherapy and attempt to improve periodontal gingival treatment.
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Atsushi MORI, Toshirou TAGAWA, Jouji NOMURA, Madoka INUI, Hiroshi NAKA ...
1990 Volume 39 Issue 1 Pages
207-213
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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A survey of 1, 617 histopathological diagnoses in our department was conducted for the 12 years from April 1976 to March 1988. The percentage of all cases was 5.7 % of the total number of outpatients in our department.
The following results were obtained: Inflammatory disease was diagnosed in 549 cases (34.0 %), cysts in 454 cases (28.1 %), tumors in 270 cases (16.7 %), tumor like lesions in 247 cases (15.3 %), and other lesions in 97 cases (6.0 %). The ratio of benign to malignant tumor was 1: 1. The rate of malignancy was 8.4 % of all cases and squamous cell carcinoma comprised 77.9 % of malignant tumors. A total of 79.9 % of the cysts were jaw cysts and the most frequent diagnosis was radicular cyst (44.3 % of all cysts).
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2 Clinico-pathological study of the squamous cell carcinoma
Toshirou TAGAWA, Jun MATSUMOTO, Yoshio HIRANO, Taku MURATA, Kazuhisa B ...
1990 Volume 39 Issue 1 Pages
214-221
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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A mode of invasion and grade of malignancy was analyzed on the initial biopsy specimen of 87 patients with squamous cell carcinoma treated at the Department of Dental and Oral Surgery of Mie University Hospital from 1976 to 1987
The mode of invasion and malignancy points (grade) were investigated by means of Yamamoto and Kohama's method ; Type 3 (48.3%) and grade 2 (51.7%) showed the highest incidence. Type 1 (4.6%) and grade 4 (3.4%) indicated the lowest rate. The grade points of upper gingiva were higher than that of lower gingiva. There was correlation between histological malignancy including both criteria mentioned above and clinical evaluation of regional lymphonode metastasis. The mortality rate in patients with severe invasion (type 4) was higher comparison with low malignant group.
This study suggests a positive relationship between histological malignancy examined on the initial biopsy specimen and clinical course of case with squamous cell carcinoma of oral cavity.
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Masahito INADA, Mitsuhisa OKITSU, Jun SHIMADA, Yoshiro YAMAMOTO, Takes ...
1990 Volume 39 Issue 1 Pages
222-227
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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Cementifying fibroma is a relatively rare benign tumor. The incidence of this disease is estimated to amount to apProximately 2% of total odontogenic tumors.
Recently we encountered a 46-year-old woman who developed this disease in the lower jaw from the second premolar to the first molar. The lesion was surgically excised under local anesthesia.
Histopathological examination of the excised specimen revealed that the tumor tissue cont. ained cementum-like calcareous substance in the fibrous tissue which was compcsed of fine collagen fibers and immature stellate fibroblasts.
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Part I, Successive contrast of T/C and tumor weight
Ryuzo KATO, Etsuhide YAMAMOTO, Kiyomasa NAKAGAWA, Shinichi NOZAKI, Shi ...
1990 Volume 39 Issue 1 Pages
228-238
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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Antitumor activity of
Propionibacterium acnes strain KT-28, an isolate from oral cavity, was examined by using mice inoculated with Sarcoma 180, Ehrlich carcinoma. or Meth A cells. Formalin-killed cells harvested from 48 hr culture in Tamai-Fukuda medium showed stronger antitumor activity compared with those from other cultures. In order to purify the antitumor substance, the ultrasonic sediment was digested with trypsin and pronase (protease-treated ultrasonic sediment). This preparation showed strong antitumor activity to all tumor cells tested ; tumor weight ratios were 20.7-26.2 % and values of T/C ranged from 127.6 % to more than 146.2 %. Furthermore, lipid was removed from the protease-treated ultrasonic sediment by treatment with a mixture of methanol and chroloform (lipid-free ultrasonic sediment). The antitumor activity of lipid-free ultrasonic sediment preparation was nearly the same as that of protase-treated ultrasonic sediment preparation; tumor weight ratios were 20.7-29.7 % and values of T/C were 124.7-140.2 %. The antitumor activity may be peptidoglycan of cell wall.
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Yutaka OKADA, Soichiro ASANAMI, Fumihiro OHSAKA, Shinobu IKEUCHI, Kimi ...
1990 Volume 39 Issue 1 Pages
239-245
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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We performed immunochemotherapy mainly by long-term consecutive administration of OK-432, a non-specific immunopotentiator, as adjuvant therapy in cases of oral cancer. We used the Su-PS skin test, an extremely simple method for routine clinical practice, as an immunological parameter. Changes in the Su-PS skin test value and peripheral lymphocytes were investigated in 22 cases administered OK-432 for at least 2 years. The Su-PS skin test values before OK-432 administration were compared in cases with good and with poor prognosis. The Su-PS skin test values, PHA reaction values and NK activity were also compared in cases administered and not administered OK-432. The following results were obtained.
1) Su-PS values increased significantly during frequent OK-432 administration (5 KE, once a week) when compared with before administration, but there was no increase during intermittent administration (5 KE, once every 2 weeks to one month). There were no significant differences in changes in peripheral lymphocytes.
2) Su-PS values before OK-432 administration were clearly lower in cases with poor prognosis than in those with good prognosis.
3) In a comparison between the OK-432 frequent administration group and non-administration group, Su-PS and PHA values increased significantly, and NK activity tended to in crease in the former group.
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Masatoshi OHNISHI, Kayoko OHTSUKI, Eizi NAKAYAMA
1990 Volume 39 Issue 1 Pages
246-255
Published: January 10, 1990
Released on J-STAGE: September 07, 2011
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In order to approach a small lesion within the temporomandibular joint, the conventional therapeutic treatment is open surgery which has the possible disadvantage of surgical invasion including skin damage and exfoliation. Since 1985 we have applied a method of arthroscopic laser surgery to lesions within the temporomandibular joint because the method has the least surgical invasion. The outline of arthroscopic surgery by Nd-YAG laser is described in this report.
We investigated cases of recurrent dislocation, anterior disc displacement and fibrous adhesion of the temporomandibular joint where conservative therapy was ineffective and double contrasted CT scanning and arthrotomography showed the suspicion of organic changes within the temporomandibular joint cavity.
We examined the upper joint cavity by temporomandibular joint arthroscopy. In cases where results indicated the necessity of surgical operation, we practiced arthroscopic surgery after visualizing the lesion by arthroscopy. The new technique using the double-channel cannula by the needle scope which we recently invented visualized the lesion and we infused NdYAG laser fiber into the cavity for treatment of the area around the intra-articular wall
The separation, removal and vaporization of the adhesive area and cicatrix tissue were effective treatment against fibro-adhesion and fibrous ankylosis. We formed fresh injury by cauterization of the retrodiscal synovial membrane against hypermobility, recurrent dislocation and disc displacement, where we also practiced arthroscopic suturing when necessary. Observation after the operation revealed that we had obtained successful results, thus arthroscopic laser surgery was proven to be beneficial
We reported on arthroscopic laser surgery for temporomandibular joint disorders and the outline of the clinical results of these cases after operations.
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