Journal of The Japanese Stomatological Society
Online ISSN : 2185-0461
Print ISSN : 0029-0297
ISSN-L : 0029-0297
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Volume 70, Issue 4
Displaying 1-5 of 5 articles from this issue
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  • A case of nivolumab-associated mucous membrane pemphigoid involved oral mucosa
    Itsuki HAYASHI, Makoto TOIDA, Hiroki MAKITA
    2021 Volume 70 Issue 4 Pages 290-296
    Published: 2021
    Released on J-STAGE: December 25, 2021
    DOIhttps://doi.org/10.11277/stomatology.70.290
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    We report a case of nivolumab-associated mucous membrane pemphigoid in the oral mucosa. A 72-year-old male patient receiving immunotherapy by nivolumab for lung carcinoma visited our department with a chief complaint of intraoral pain. Erosive change was observed at the left buccal mucosa without any extraoral erosive changes. Considering autoimmune blistering diseases, tissue biopsy and immunoserological tests were performed. Histopathological examination showed subepithelial cleaves, and direct immunofluorescent examination revealed linear deposits of IgG and C3 along the epithelial basement membrane. The immunoserological assay showed an increase in anti-BP180 antibody titer. Based on the above, the diagnosis of mucous membrane pemphigoid was made. Nivolumab was not withdrawn, and the oral mucosal lesion healed in 6 months with oral corticosteroid, and the patient remains in good condition.
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  • An autopsy case of malignant melanoma of the hard palate with multi-organ metastasis after frequent recurrences for 17 years
    Takanori KOBAYASHI, Akihiko IIDA, Kaya NARIMATSU, Atsushi UENOYAMA, Ei ...
    2021 Volume 70 Issue 4 Pages 297-303
    Published: 2021
    Released on J-STAGE: December 25, 2021
    DOIhttps://doi.org/10.11277/stomatology.70.297
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    Malignant melanoma is a high-grade malignant neoplasm of melanocytes or nevus cells. We report an autopsy case of malignant melanoma of the hard palate with multi-organ metastasis after frequent recurrences for 17 years. The patient was a 55-year-old female. She was referred to our department for treatment of malignant melanoma of the hard palate, which had been diagnosed by a biopsy in the department of dermatology. Although we resected the lesion, in situ oral mucosal melanoma recurred frequently after primary surgery. Eventually, she died of multi-organ metastasis. A post-autopsy review of specimens excised by each surgery suggested that remnants of the intraepithelial lesion might have been responsible for recurrences and progression. Therefore, it is important to provide as wide a safety margin as possible in surgical therapy, and to establish individualized multimodal therapy including chemotherapy, immunotherapy, and heavy ion radiotherapy.
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  • An adult submandibular cystic lymphangioma successfully treated with local injection of OK-432: a case report
    Jun ISHIKAWA, Yumiko UCHIYAMA, Reita YASUE, Kazuya NAMBU, Keisuke SUGI ...
    2021 Volume 70 Issue 4 Pages 304-308
    Published: 2021
    Released on J-STAGE: December 25, 2021
    DOIhttps://doi.org/10.11277/stomatology.70.304
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    In about 90％ of cases, lymphangioma develops within 2 years of age; it rarely occurs in adults. Conventionally, the cases in adults have often been resected surgically. However, postsurgical functional and/or esthetic complications are major hurdles. Here, we report a case of cystic lymphangioma in the submandibular space, which developed in a 31-year-old woman. She presented with an elastic soft, painless mass in the left submandibular region. Imaging findings revealed a multilocular cystic lesion. 15 ml of serous yellow fluid including lymphocytes was aspirated. Consequently, cystic lymphangioma in the left submandibular region was diagnosed. Local injection of OK-432 was performed. The lesion was significantly reduced, and no recurrence was observed at 18 months after initial treatment.
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  • Usefulness of bone metabolism marker in predicting the risk of ARONJ development
    Kazuo RYOKE, Naomi TANIGUCHI, Yuh YOSHIDA, Takashi NARAI, Nobuyuki FUJ ...
    2021 Volume 70 Issue 4 Pages 309-316
    Published: 2021
    Released on J-STAGE: December 25, 2021
    DOIhttps://doi.org/10.11277/stomatology.70.309
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    The aim of this study was to determine, in a clinical setting, the usefulness of bone metabolism markers of the typeⅠ collagen cross-linked N-telopeptide （NTX） test and the bone specific alkaline phosphatase （BAP） test in the development and management of anti-resorptive agents-related osteonecrosis of the jaw （ARONJ） in patients taking bisphosphonate （BP） and/or receptor activator of NF-κB ligand （RANKL） antibody. A total of 101 patients （osteoporosis: 64 cases, malignant tumor: 37 cases） underwent serum NTX and BAP measurements. The significant correlation between ARONJ and those bone metabolism markers was analyzed by logistic regression. As a result, the development of ARONJ was not correlated with any level of NTX, but was correlated with the lower level of BAP. BAP was suggested to be a significant factor affecting the development of ARONJ. The morbidity risk of ARONJ was high at less than 12.35μg/l of BAP, moderate between 12.35μg/l and 15.25μg/l, and low at more than 15.25μg/l. In cases of oral surgery such as tooth extraction and alveolar bone operation for patients taking BP and/or RANKL antibody, it is suggested that the value of BAP might be a very significant indicator of ARONJ development.
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