Various mucosal diseases such as oral potentially malignant disorders (OPMD) and squamous cell carcinoma (SCC) may develop in the oral cavity and are difficult to differentiate. Optical instruments are not invasive and can be repeatedly used. Since 2010, we have used optical instruments effectively to improve diagnosis and treatment. In this study, we conducted subjective and objective evaluations using an optical instrument for distinguishing between leukoplakia and SCC.
Thirty patients diagnosed with tongue SCC and leukoplakia at the Department of Oral and Maxillofacial Surgery, Tokyo Dental College in Chiba, between 2013 and 2015 were selected and evaluated using the optical instrument IllumiScan
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In the subjective evaluation by the optical instrument, Fluorescence Visualization Loss (FVL) was confirmed in all SCC cases. In the objective evaluation, SCC was lower than leukoplakia in luminance (SCC 37.9 vs leukoplakia 49.9cd/m2). In coefficient of variation of luminance, SCC was higher than leukoplakia in luminance (SCC 0.23 vs leukoplakia 0.15). The control was not significant (area of control: SCC 843 vs leukoplakia 832, luminance of control: SCC 50.3 vs leukoplakia 48.5). Regarding luminance ratio, SCC was lower than leukoplakia in luminance (SCC 62.9 vs leukoplakia 104.1%). In the objective evaluation, statistical differences were found in luminance, coefficient of variation of luminance and luminance ratio.
It was suggested that subjective and objective evaluations using optical instruments may be useful for differentiating leukoplakia and SCC.
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