An 84-year-old man presented with a rapidly enlarging, elastic hard subcutaneous nodule at the root of the nose that had developed over four years since his initial visit. Dermoscopy performed at the initial consultation revealed blue/gray ovoid nests and arborizing vessels, raising the suspicion of cystic basal cell carcinoma based on these results and the clinical presentation. The nodule was excised, and full-thickness skin grafting was performed. Pathological examination revealed a giant cyst containing mucus, without evidence of necrosis in the surrounding tissue. Mucin deposition was suspected as the cause of cyst formation. This case exhibited the appearance of a subcutaneous nodule, rarely reported among cystic basal cell carcinomas, and was confirmed as a cyst by magnetic resonance imaging (MRI). Dermoscopy and biopsy are useful for diagnosis, and MRI is crucial for preoperative depth assessment.

A 12-year-old girl presented with swollen lips for one month. She was diagnosed with cheilitis granulomatosa by lip tissue biopsy. The swelling gradually improved with oral administration of tranilast and prednisolone. However, after prednisolone was tapered and discontinued, she suffered anal pain and a pus discharge from the anus. She was diagnosed with Crohn's disease after examinations at the Department of Pediatrics. After treatment for Crohn's disease, her lip swelling improved further. In reported cases of cheilitis granulomatosa associated with Crohn's disease in Japan, the onset age is often in the teens, and many patients subsequently develop Crohn's disease. Characteristically, histopathological findings of cheilitis granulomatosa may include lymphatic dilation within the lamina propria mucosa, perilymphatic granulomas, and histiocytic infiltration within the lymphatic vessels. It is necessary to consider whether Crohn's disease may complicate cheilitis granulomatosa.