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Volume 35, Issue 4
Displaying 1-18 of 18 articles from this issue
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Shunichi KAI, Miho SATO, Yutaka FUJITOMI, Shigeo YOKOYAMA1996 Volume 35 Issue 4 Pages 285-288
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAspiration cytology smears from 48 infiltrative ductal carcinomas of the breast, in which the diagnosis had been histologically confirmed, were stained immunocytochemically using a polyclonal antibody against the c-erbB-2 oncoprotein (ErbB-2). We analyzed the relations between the results of immunocytochemical staining for ErbB-2 and age, tumor size, histologic type and axillary lymph node metastasis, most of which are known to influence the prognosis of breast cancer, using a statistical examination (x2 or Mann-Whitney test). Expression of ErbB-2 was detected in 17 of the 48 cases (40%); 16 with axillary lymph node metastasis and 1 without metastasis. The ErbB-2 positivity rate was significantly higher in those with axillary lymph node metastasis than in those without metastasis (x2, P<0.01). The age, tumor size and histologic type had no bearing on the results of staining for ErbB-2 and axillary lymph node metastasis (Mann-Whitney or x2 test). The above results of immunocytochemical staining for ErbB-2 in aspiration cytology raise the possibility of being able to predict axillary lumph node metastasis of breast cancer preoperatively. We consider immunocytochemical staining for ErbB-2 in aspiration cytology to be clinically useful for assessing the prognosis of infiltrative ductal carcinoma of the breast.View full abstractDownload PDF (2407K) -
Junko MARUTA, Shiro NOGUCHI, Hiroto YAMASHITA1996 Volume 35 Issue 4 Pages 289-293
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSFine needle aspiration cytologies obtained from 7 cervical thymoma cases were studied. The sex ratio was 1: 6 (M: F) and the mean age was 55.3 years old. The cytology of these cervical thymomas was characterized by a pattern of two cells; epithelial cells and lymphocytes. The histological features were similar to those of mediastinal thymoma. The nuclear areas, major and minor axis lengths of the best fit ellipses, and the ration of 50 epithelial cells per specimen were measured using computer-assisted image analysis. On cytological examination of invasive tumors, a nuclear shaped ellipse of a small area with large CV was recognized. In encapsulated tumor a nuclear shape in proximity to a large area with small CV was seen. The ratios of major and minor axis lengths were the largest in the spindle cell type and the smallest in the mixed lymphoepithelial cell type, indicating an intimate relation between cytological features and histological type. Measurement of the nuclear area and axis lengths in addition to the cytological characterization may suggest the histological type and the presence of invasion.
Cervical thymoma occurred in 7 out of 498 (1.4%) patients with non-thyroidal cervical tumors, removed surgically, at Noguchi Thyroid Clinic and Hospital Foundation.
The presence of ectopic thymus along the developmental descent pathway, as well as cytological characteristics, should be considered when diagnosing cervical tumors cytologically.View full abstractDownload PDF (6878K) -
Toshiko JOBO, Kumi IWANAGA, Rinya SATOH, Kazuhiro TATEOKA, Hiroyuki KU ...1996 Volume 35 Issue 4 Pages 294-299
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn a group of 161 postmenopausal patients with ovarian tumors, aged 50 years or over, maturation indices (M.I.) in cervical cytological smears were investigated.
1. Eighty-five (52.8%) had benign tumors, 11 (6.8%) had borderline malignant tumors and 65 (40.4%) had malignant tumors.
2. Their ages ranged from 50 to 98 years, and 39 patients were in the 55-59 year age group and 38 in the 50-54 year age group. The malignancy rates were 50-55 % in the 55-69 year age group, but decreased in patients over 70 years of age.
3. Thirty-eight patients had been postmenopausal for 5 to 10 years and the rates of malignancy were higher in those who had been postmenopausal for 2 to 15 years.
4. Estrogenic activity as determined by M.I. was observed frequently in the group with ovarian tumors, in contrast to the control postmenopausal women without ovarian tumors. The strongest estrogenic activity was present in patients with malignant tumors.
5. Stronger estrogenic activities were noted in patients with mucinous cystadenocarcinoma, fibroma or granulosa cell tumor.
6. When the patients with ovarian tumors and control group were compared, a striking difference was found in patients who had been postmenopausal for more than 2 years. Those with ovarian tumors displayed strong estrogenic activity, while the control group appeared to have a significant drop in M.I.View full abstractDownload PDF (803K) -
Haruo TAKABAYASHI, Ryota FUJII, Soryu KUWABARA1996 Volume 35 Issue 4 Pages 300-302
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAmong 21 cases of endometrial carcinoma treated in our hospital from 1989 to 1994, we experienced 3 cases of false negative cytodiagnosis and 1 case of miscytodiagnosis. We have re-examined these cases to improve the accuracy of cytodiagnosis for endometrial carcinoma. The 3 false negative cases had well-differentiated adenocarcinomas and the 1 miscytodiagnosed case had a moderately-differentiatedadenocarcinoma. All three adenocarcinomas with false negative cytology were located around the uterine ostium of the fallopian tube. These findings suggest that it is necessary to obtain cell clusters from all areas, including those around the uterine ostium of the fallopian tube, to improve the accuracy of endometrial carcinoma cytodiagnosis.View full abstractDownload PDF (382K) -
Tadaaki IMAI, Hideki YOKONO, Tadashi MOTOORI, Takafumi IZUMI, Tatuo GE ...1996 Volume 35 Issue 4 Pages 303-308
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSNormal glandular cell clusters (n-GCC) and normal stromal cell sheets (n-SCS) were identified in endometrial cell samples, from normal females, obtained at Kitasato Medical Center Hospital, and their numbers and frequencies per slide were measured. The following results were obtained.
1) When analyzed according to age group among 354 cases, n-GCC was higher in occurrence in the groups composed of women in their 20 s, 30 s and 40 s than that of women in their 50 s or older (p<0.01). n-SCS also decreased in those in their 60 s, but was one decade later (p<0.01).
2) When analyzed according to menstrual cycle among 177 cases, cells in the proliferative phase showed greater preservation of n-GCC than those in the secretory phase (p<0.025).
3) Depending on the pre-or post-menopausal state of 270 cases, the mean number of n-GCC in post-menopausal woman was 1.7, but was 10.1 in pre-menopausal one (p<0.01).
It is worthwhile to identify n-GCC and n-SCS from the cellular group of normal endometrial cytology in order to make a differential diagnosis of endometrial neoplasias such as atypical hyperplasia and G 1 adenocarcinoma which are difficult to diagnose cytologically.View full abstractDownload PDF (10405K) -
Keiichi HOMMA, Keiichi NEMOTO, Yoshiaki WATANABE, Koei NISHIMURA, Koic ...1996 Volume 35 Issue 4 Pages 309-314
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case with a very small intravascular bronchioloalveolar tumor (IVBAT) is presented. A 61-year-old female was admitted to our hospital because of an abnormal pulmonary shadow. Chest X-ray showed an approximately 1 cm in diameter peripheral nodule, suspected to be a pulmonary adenocarcinoma, in the right S 2 segment. She underwent right upper lobectomy and mediastinal lymph node dissection. Histological examination of the tumor revealed IVBAT. Since the lobectomy, she has been in good health without recurrence.
In the needle aspirate, tumor cells showed several clusters in small masses or a sheet-like configuration. Tumor cells had oval nuclei and one or a few distinctive nucleoi. Chromatin was slightly dark and evenly distributed. Cytoplasm was pale green, cell borders unclear. Tumor cells had variable sized vacuoles. The outlines of large vacuoles were quite smooth, indicating vascular spaces.
The aforementioned findings correspond essentially to the cytological characteristics described in several reports on IVBAT and epithelioid hemangioendothelioma. In the cytology of IVBAT, cytoplasmic morphology is more reliable than nuclear findings. In particular, the most important features of IVBAT are (1) pale and vacuolated cytoplasm, and (2) vacuoles with smooth outlines, suggesting vascular spaces.View full abstractDownload PDF (7250K) -
Toshiaki KUNIMURA, Nobuo MIYASAKA, Nobuyuki OOIKE, Akiko ARAKAWA, Keik ...1996 Volume 35 Issue 4 Pages 315-320
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAn autopsy case of mucin producing cancer of the pancreas is reported. An 84-year old man was admitted our hospital, complaining of upper abdominal pain. Clinically, serum CA 19-9 and CEA were elevated, and diffuse dilatation of the main pancreatic duct was revealed by abdominal CT, US and ERCP. He died of respiratory failure and an autopsy was performed Postmortem, the main pancreatic duct and its first branch were markedly enlarged, and yellowish mucinous pancreatic juice filled the duct. Cytological examination of the pancreatic juice revealed adenocarcinoma cells and borderline malignant cells as well as goblet type metaplastic cells with massive mucin production.
Histological examination of the pancreas revealed intraiuctal papillary adenocarcinoma, adenoma and hyperplasia of the first branch of the main pancreatic duct. These histological findings are considered to reflect the cytological findings.
Hyperplasia-adenoma-carcinoma sequence is one of the characteristics of mucin producing cancer of the pancreas. Thus, attention must to be paid to the characteristics observed on cytological examination of pancreatic juice.View full abstractDownload PDF (15540K) -
Takenobu NAKAGAWA, Motohiro TAKEYA, Hidehiro TOKUNAGA, Husayo KAWAMURA ...1996 Volume 35 Issue 4 Pages 321-326
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAn autopsy case of malignant adrenal pheochromocytoma with distant metastasis nine years after adrenalectomy is reported. A 43-year-old female with “Sipple's syndrome” had undergone bilateral adrenalectomy under a diagnosis of pheochromocytoma at the age of 34, and a thyroidectomy for medullary carcinoma at the age of 39. At autopsy, metastatic sites included the lungs, liver, lumbar vertebra and sacrum.
Cytological features from the metastatic tumors were as follows:(1) The smear background showed tumor diathesis.(2) Most tumor cells were small and had high nuclear-cytoplasmic ratios.(3) Tumor cells showed many mitotic figures.
Immunohistochemically, most tumor cells in the primary tumor, as well as the metastatic tumor, were positive for neuron specific enolase (NSE), chromogranin A, and S-100 protein. Adrenocorticotropic hormone (ACTH) positive cells were present in the pulmonary metastatic tumors.
As no detailed reports on the cytological features of malignant pheochromocytoma have been presented, to our knowledge, the data obtained from the present case are potentially useful for making the differential diagnosis between benign and malignant pheochromocytoma.View full abstractDownload PDF (10632K) -
Hiroko KOTANI, Yuuko KOORITANI, Katsutoshi MIHARA, Masami NISHIDA, Hir ...1996 Volume 35 Issue 4 Pages 327-331
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAn extremely rare case of pleural cavity involvement of Bence Jones kappa type multiple myeloma in a 55-year-old woman was diagnosed from the first positive cytologic specimen of pleural fluid.
More than 95% of the cells in pleural fluid were atypical plasma cells. In Wright-Giemsa stained smears, large atypical plasma cells had abundant basophilic cytoplasm. Their nuclei were round to oval in shape. In some instances, nuclear notches or clefts were observed. The chromatin was finely reticular and nucleoli were prominent. In addition, small atypical cells had strongly basophilic cytoplasm and their chromatin was coarse. Immunocytochemically, atypical plasma cells were positively stained for kappa light chain immunoglobulin and epithelial membrane antigen. Most of the atypical plasma cells were negative for leukocyte common antigen staining but some of the atypical plasma cells did show weakly to moderately positive staining.View full abstractDownload PDF (6919K) -
Takehisa MATSUI, Toshitaka UEHARA, Yusaku SANO, Michihiro SAKAMOTO, Ts ...1996 Volume 35 Issue 4 Pages 332-337
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of malignant Müllerian mixed tumor (MMMT) in a 56-year-old female, who complained of irregular genital bleeding, is reported. The MMMT in this case was composed of well differentiated adenocarcinoma, an endometrial type component of the carcinoma, and a malignant rhabdoid tumor (MRT) as an element of the sarcoma. The imprint smears revealed many clusters of tumor cells, an observation compatible with adenocarcinoma, and a scattered distribution of tumor cells thought to represent MRT cells. MRT cells showed intracytoplasmic inclusions, that were confirmed electromicroscopically to be a condensate of intermediate fibers. MRT cells also revealed green colored granules in the cytoplasm, possibly mitochondria electronscopically. Reports of MMMT with MRT are very rare in the international literature. To our knowledge, this case report of MMMT with MRT is the first in Japan.View full abstractDownload PDF (11817K) -
Toshimi TAKAHASHI, Takeo NISHINO, Kazuhito FUJISAKI, Koichi KUBOTA, To ...1996 Volume 35 Issue 4 Pages 338-343
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA 51-year-old female, gravida one and para one, noticed lower abdominal pain. Ultrasonographic examination revealed an ovarian tumor and serological tests disclosed high levels of CA 125 (300 u/ml) and CA 19-9 (104 u/ml) suggesting malignancy. A high level of ACTH was also detected, suggesting Cushing syndrome. Six months after a curative resection, she developed recurrence at the abdominal wall. She died three months later despite radiation and chemotherapy.
The ovarian tumor was located on the left side and was cystic, measuring 16 cm in diameter. The solid area was yellowish in color at the cut surface and stamp cytology specimens were taken from this portion. The tumor cells were discrete and/or in clumps. The nucleoli were round and the chromatin was increased in amount with scant indistinct cytoplasms. Some multinucleation, cannibalism, tubuli and rosettes were also seen.
Histologically, an undifferentiated carcinoma pattern predominated with focal tubular, trabecular and insular features. Grimerius staining was clearly positive but focal, as was immunostaining for chromogranin A, ACTH and serotonin. Ultrastructural study showed oval to round granules in cytoplasms, measuring 200-300 nm in diameter, compatible with neurosecretory granules. To our knowledge, this is only the second case report of malignant ovarian carcinoid with ectopic ACTH-syndrome reported in the international literature to date.View full abstractDownload PDF (15370K) -
Masaya NAKAMURA, Giichi SUNAGA, Yoshihisa KASHIWASE, Tetsushi SUITO, M ...1996 Volume 35 Issue 4 Pages 344-345
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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Masatomo KIMURA, Kouhei TANAKA, Kiyomi NONAKA, Tomoko FURUTA, Shigeo H ...1996 Volume 35 Issue 4 Pages 346-347
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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Toshiharu MAEDA, Keizo FURUYA, Tomoko TAKEDA, Eriko OHIZUMI, Masahiro ...1996 Volume 35 Issue 4 Pages 348-349
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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Masatomo KIMURA, Kiyomi NONAKA, Michiyo KARASUNO, Kazunori NISHI, Shig ...1996 Volume 35 Issue 4 Pages 350-351
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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Shinji KAGAMI, Masatoshi WATANABE, Taizo SHIRAISHI, Ryuichi YATANI1996 Volume 35 Issue 4 Pages 352-353
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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Akemi OHNO, Mika KITAYAMA, Tsuneko IKEDA1996 Volume 35 Issue 4 Pages 354-355
Published: July 22, 1996
Released on J-STAGE: November 08, 2011
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1996 Volume 35 Issue 4 Pages e1
Published: 1996
Released on J-STAGE: November 08, 2011
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