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Volume 37, Issue 4
Displaying 1-13 of 13 articles from this issue
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Naomi YAMATO, Sachiko NAGUMO, Takeshi HORAI, Tsutomu KASUGAI, Hiroki K ...1998 Volume 37 Issue 4 Pages 383-388
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To determine if c-erbB-2 oncoprotein (ErbB-2) can be demonstrated immunocytochemically using cytologic specimens of breast carcinoma. To assess the association between overexpression of ErbB-2 and histologic comedo type as a poor prognostic factor of local recurrence after breast conserving-surgery.
Study design: Cytologic smears of 67 patients with breast carcinoma were stained with anti-ErbB-2 monoclonal antibody. Cytologic characteristics of tumor cells were compared between the ErbB-2-positive and negative group.
Results: Seventeen of the 67 tumors (25%) reacted positively for the presence of ErbB-2. Intraductal lesions of the comedo type were observed in 10 of the 17 ErbB-2 positive tumors (59%). Among 50 ErbB-2 negative tumors, 47 tumors (94%) did not have the comedo lesion. Thus, expression of ErbB-2 seems to be associated with histologic comedo type. Tumor cells in the ErbB-2-positive cases were characterized cytomorphologically by abundant cytoplasm, large nuclei, and visible nucleoli. Anisokaryosis was remarkable in these cases. On the other hand, tumor cells without ErbB-2 were less atypical, having small nuclei and obscure nucleoli.
Conclusion: ErbB-2 staining on the cytologic smear of breast carcinoma is helpful for the prediction the presence of comedo type.View full abstractDownload PDF (5181K) -
Satoshi OKAMOTO, Ryo KONNO, Tadao TAKANO, Satoshige WAGATSUMA, Satoru ...1998 Volume 37 Issue 4 Pages 389-393
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We investigated the application of immunohistochemistry for differential diagnosis of ovarian cancer cells and mesothelial cells in ascites.
Study Design: A total of 40 malignant ovarian tumors 11serous cystadenocarcinomas, 9 mucinous cystadenocarcinomas, 5 endometrioid adenocarcinomas, 9 clear cell adenocarcinomas, 3 dysgerminomas, 1 yolk sac tumor, and 2 MMTs were strdied. The surgical specimens were examined by immunohistochemistry with Ber-EP 4, HBME-1, CA 125, and EMA monoclonal antibodies, to determine an antibody that may discriminate between ovarian cancer cells and mesothelial cells.
Result: More than 80% of ovarian cancers were positive for Ber-EP 4. Ber-EP 4 widely stained mucinous cystadenocarcinoma and EMA widely stained serous cystadenocarcinoma. Immunocytochemistry of mesothelifal cells with Ber-EP 4 was negative. Therefore immunocytochemistry with Ber-EP 4 was useful to discriminate between ovarian cancer cells and mesothelial cells.
Conclusion: The results suggest that immunohistochemistry with Ber-EP 4 may provide a method of differential diagnosis in ascites cytology.View full abstractDownload PDF (5893K) -
Report of two casesAkihiko KAWAHARA, Toshiro YOKOYAMA, Tomoko YOSHIDA, Setsuo SUGISHIMA, ...1998 Volume 37 Issue 4 Pages 394-399
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Warthin tumor arises mainly in the parotid gland of the old male, but intensive metaplastic changes are rare. We describe two casas associated with intensive squamous or mucous metaplasia.
Cases: The patients were a 73-year-old male (case 1) and a female of age (case 2). In case 1, imprint cytology specimen revealed a large number of aggregating or isolated metaplastic squamous cells in a necrotic background with lymphocytes and neutrophils. Oncocytic cells with eosinophilic cytoplasm were also found. Imprint cytology of case 2, revealed a large number of aggregating or isolated metaplastic mucous cells representing fine and granular chromatin in a mucoid background including lymphocytes.
Histologically, both cases showed elongated or dilated ductal structures, in which oncocytic cells were replaced by metaplastic squamous or mucous cells, including degenerative or mucoid materials. Marked stromal fibrosis was seen in many areas of the first case, whereas there was little evidence of inflammation in case 2.
Conclusion: Metaplastic changes in Warthin tumor should be better recognized for distinction from especially malignant neoplasms of salivary gland origin, such as squamous cell carcinoma or mucoepidermoid carcinoma, by routine cytological examination.View full abstractDownload PDF (11398K) -
Masashi KAWAMOTO, Haruhiko SHIMAZAWA, Miyuki MATSUBARA, Yasuhiko WATAR ...1998 Volume 37 Issue 4 Pages 400-404
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: The presence of intracytoplasmic lumina (ICL) is a useful marker for the diagnosis of adenocarcinoma of the breast. However, ICL may also be observed in cases of mastopathy and fibroadenoma (FA).
Case: A 32-year-old Japanese female had a solitary mass in her right upper breast during her pregnancy. Three months after weaning, aspiration cytology showed 2 distinct cell clusters. One was compatible with FA, but the other consisted of fewer cells showing nuclear atypism and numerous ICL. The ratios of ICL were 0.3% in the former cluster and 4.4% in the latter. An excised specimen revealed a typical FA with surrounding mammary glands some of which showed lactation. Epithelial cells from both areas had ICL.
Conclusion: Atypical cell clusters seemed to be derived from non-tumorous ductal cells. Cellular atypia and the increase in ICL may be modified by a hormonal effect early after weaning.View full abstractDownload PDF (6090K) -
Yuka KANZAKI, Kazuo INAMOTO, Yoichi KIMURA, Yuki SUGISHITA, Maki NUNOM ...1998 Volume 37 Issue 4 Pages 405-408
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Infarction of benign breast lesions is relatively uncommon. We report a case of infarction of the breast during pregnancy and lactation.
Case: A 28-year-old woman, gravida 2, para 1, noticed a mass in the BD area of the right breast, and was admitted to the Department of Surgery, Kyoto Min-iren Chuo Hospital at which time she was 29 weeks pregnant. There were many epithelial cells and necrotic debris in the background in the postpartal aspiration smear. It was difficult to differentiate breast infarction from breast cancer.
Conclusion: When necrotic debris is seen in the background without malignant cells in an aspiration smear, breast infarction must be considered as one diagnotic possibility.View full abstractDownload PDF (8085K) -
Hideaki KIYOTA, Shouji YAMADA, Midori TAKAHASHI, Motoshige KUDO1998 Volume 37 Issue 4 Pages 409-412
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Infiltrating lobular carcinoma of both breasts in a 35-year-old woman, who was breast feeding her 6-month-old baby is described.
Case: The patient complained of progressively increasing swelling and pain of the bilateral breasts. An aspiration cytologic study on admission indicated lactating adenoma. A week later a cytologic study was repeated, based on suspicion of an inflammatory carcinoma. Simultaneous needle biopsy and systemic examinations revealed bilateral infiltrating lobular carcinoma of the breasts with widespread hepatic metastasis. The initial and repeat cytologic findings were essentially the same and very similar to those of an ordinary lactating adenoma, showing small varyious shaped clusters of tumor cells with focal mild piles and loose cohesion. The cells had abundant foamy cytoplasms and eccentric small round nuclei with enlarged nucleoli and fine chromatin. Furthermore, frequent mild nuclear size variation and perinucleolar halo were seen. The isolated scattered tumor cells had varying amounts of cytoplasm, and none were naked. A few cell clusters of ductal origin were found, but there was no atypia. Histologic findings were consistent with infiltrating tumors composed of sheets and cords of polygonal clear foamy cells and edematous fibrous stroma.
Conclusion: This is an unusual case and, to our knowledge, the first cytologic report of infiltrating lobular carcinoma-arising in the lactating breast in the literature.View full abstractDownload PDF (6666K) -
Yuka IDEI, Satoe KAMADA, Yukari HIRATE, Kaori MINAMI, Sohei KITAZAWA, ...1998 Volume 37 Issue 4 Pages 413-417
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Myoepithelioma of the salivary gland is a rare tumor. It has been allocated a category in more recent classifications, such as the 1991 WHO revision.
Case: We report a case of myoepithelioma arising in a minor salivary gland of the tongue. A 60-year-old man presented to an outside hospital in July 1996 for further examination of tumor of the tongue. Magnetic resonance imaging (MRI) showed that the tumor was of low intensity in the T 1-weighted image, and of high intensity in the T 2-weighted image. Fine-needle aspiration of the tumor was performed and the Papanicolaou-stained smear revealed that the tumor cells were uniform, and were either scattered or in a cluster. The nuclei of the tumor cells were oval, eccentric and some of them were large. Macroscopically, the tumor was 3.7×2.5×3.0cm in size and surrounded by a fibrous capsule. The cut surface of the tumor was grayish and solid. Histologically, the tumor was composed of plasmacytoid cells with round eccentric nuclei surrounded by an abundant eosinophilic cytoplasm. Immunohistochemistry with antibodies to S-100, keratin and vimentin showed strongly positive staining, and there was weak staining for α-smooth muscle actin. Ultrastructural examination revealed many intermediate filaments in the cytoplasm of the tumor cells. A diagnosis of myoepithelioma was established from these pathological findings.
Conclusion: The appearance of plasmacytoid cell in aspiration cytology from salivary gland tumors seem to be a useful finding for the diagnosis of myoepithelioma.View full abstractDownload PDF (9687K) -
Tetsuya OKAZAKI, Katsunari KINA, Naoko OKUYAMA, Reiko KAZAMA, Junichi ...1998 Volume 37 Issue 4 Pages 418-422
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Lymphoepithelial cyst of pancreatic origin is an extremely rare tumor, and no detailed description of cytological diagnosis of this lesion is available. We encountered a case of lymphoepithelial cyst originating in the tail of the pancreas. We report the case focusing on cytological findings, and compare our results of other reported cases.
Case: A 66-year-old man was scheduled for resection of a large intestinal polyp. Preoperative examination revealed increased serum tumor marker (CEA, CA 19-9 and SPan-1) levels and a more detailed examination was conducted. Abdominal ultrasonography showed a cystic lesion measuring 4 cm in diameter with irregular internal signals in the tail of the pancreas. Computed tomography revealed a multilocular cystic lesion with a relatively distinct boundary and intraluminal septa. Cystadenoma or adenocarcinoma was suspected and combined resection of tail of pancreas and spleen was performed. Intraoperative cytological examination of the cyst fluid showed a small number of lymphocytes and histiocytes or squamous cells against a background of keratinized materials.
Cholesterol crystals were observed in Giemsa staining. In the imprint smears, in addition to the cyst fluid findings, squamous cells, metaplastic cells and columnar cells that showed keratinization and an affinity to orange G, and some cells that probably originated from sebaceous glands were also observed.
Conclusion: This case presented with an extremely rare lesion. Since cytologic diagnosis is easy, intraoperative examinations of the aspirated cystfluid or imprint smears are useful as a rapid diagnostic test.View full abstractDownload PDF (6979K) -
Yoshiyuki TADAOKA, Mitsuyoshi HIROKAWA, Etsuko NAKAMURA, Keiko FUKUOKA ...1998 Volume 37 Issue 4 Pages 423-426
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report the cytology of a gastrointestinal stromal tumor of the jejunum in a 22-year-old female patient with von Recklinghausen's disease. Scraped cytology was performed from a mass of the jejunum, measuring 2.0×1.5×.3 cm. The smear revealed individually scattered, naked tumor cells. The nuclei were spindle-shaped, and showed snapped indentation. The cytoplasms were faintly stained and their cell borders were indistinct. The cytologic findings were similar to those of schwannoma and leiomyoma. Immunohistochemically, the tumor cells were positive for vimentin and CD 34, and were negative for S-100 protein. Histological diagnosis was gastrointestinal stromal tumor, of uncertain malignant potential. Spindle-shaped nuclei with snapped indentation have not been decribed in schwannoma or leiomyoma, but it remains unclear whether these features suggest a diagnosis of gastrointestinal stromal tumor.View full abstractDownload PDF (5873K) -
Takaki SAKURAI, Mitsuyoshi HIROKAWA, Michio SHIMIZU, Kiyomi TERAYAMA, ...1998 Volume 37 Issue 4 Pages 427-430
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of sarcomatoid renal cell carcinoma with chromophobe component. To our knowledge, there have been no cytological reports of such a coexistence n the English literature. The patient was a 57-year-old Japanese woman with a renal mass measuring 12×8×8 cm. Ilistologically, the tumor was composed Predominantly of sarcomatoid renal cell carcinoma and also chromophobe renal cell carcinoma. The patient died of multiple metastaess two months after a nephrectomy. It is interesting that aggressive sarcomatoid renal cell carcinoma and chromophobe renal cell carcinoma predicting a favorable prognosis coexisted in our case.View full abstractDownload PDF (5937K) -
Mitsuko KANDA, Hideo TATEISHI, Muneyasu SATO, Hironobu ADACHI, Hisao I ...1998 Volume 37 Issue 4 Pages 431-434
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Vaginal adenocarcinoma is a rare malignant tumor. We report herein a case of primary vaginal adenocarcinoma which developed after total abdominal hysterectomy with unilateral salpingo-oophrectomy.
Case: The patient, a 58-year-old female, was admitted to Matsue City Hospital because of atypical genital bleeding. The patient had undergone a hysterectomy and right oohporectomy for uterine leiomyoma, 14 years ago. The tumor, 2.5×2.9 cm in size, was localized on the vaginal stump with metastasis in the left iliac lymph nodes.
Cytological examination revealed aggregated or individual tumor cells with a necrotic background. These tumor cells had large, clear cytoplasms which stained with right green on Papanicolaou stain. The eccentric nuclei had irregular margins with prominent, round nucleoli. Microscopical examinations indicated endometrioid adenocarcinoma, coexisting with Gartner's cyst which consisted of a single layer of columnar epithelia, with almost no areas of clear cell adenocarcinoma. The tumor cells infiltrated near to the cyst but were not connected with this cyst. This vaginal adenocarcinoma was considered to originate from Gartner's duct cyst.
Conclusion: This vaginal adenocarcinoma developed after hysterectomy with benign disease. A sufficent longterm follow-up including cytological examinations is necessary for patients who have undergone hysterectomy.View full abstractDownload PDF (5921K) -
Yoko FUJITA, Kazuo INAMOTO, Yuka KANZAKI, Yoichi KIMURA, Yasushi WAKAT ...1998 Volume 37 Issue 4 Pages 435-439
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Struma ovarii is an uncommon tumor accounting for 1-3% of ovarian teratomas and it rarely shows malignant changes, making it difficult to establish diagnostic criteria for malignancy.
Cases: Three cases of struma ovarii are described, occuring in women between 37 and 47 years of age. The tumors, all unilateral, ranged from 6.5 to 7.0 cm in the greatest diameter. They all were multicystic and partially solid in one case. Imprint cytology showed thyroid follicular cells with many macrophages in the background. In one case with packed follicles, histological examination revealed struma ovarii with the features of thyroid follicular adenoma. In another case with papillary clusters showing nuclear atypia but lacking the “ground glass” or grooved nuclei, histological examination revealed struma ovarii with marked papillary formation but lacking the cytologic features required for a diagnosis of malignancy.
Conclusion: Imprint cytology of struma ovarii is similar to that of the thyroid gland proper and in the case of proliferative struma ovarii, careful cytological and histological examination should be undertaken.View full abstractDownload PDF (6162K) -
Masanori FUNAHASHI, Chiyuki KANEKO, Kazuo KATOO, Nanao NOMURA, Masanor ...1998 Volume 37 Issue 4 Pages 440-441
Published: July 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a rare case of a 78-year-old woman with anaplastic carcinoma of the thyroid diagnosed by fine needle aspiration cytology. Cytological tumor features included many dispersed fusiform cells, a high N/C ratio, and oval nuclei with few nucleoli. Many tumor cells had hemosiderin granules in the cytoplasm. Granules were also observed in the resected thyroid tissue with Prussian blue stain. In cytologic examination of the thyroid anaplastic carcinoma, it is important to differentiate between tumor cells containing hemosiderin granules and cells of benign cystic change lesions.View full abstractDownload PDF (3460K)
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