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Volume 67 (2014)
- Issue 6 Pages 283-
- Issue 5 Pages 237-
- Issue 4 Pages 171-
- Issue 3 Pages 119-
- Issue 2 Pages 65-
- Issue 1 Pages 3-
Predecessor
Volume 67, Issue 5
Displaying 1-3 of 3 articles from this issue
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Original Papers
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Naoki Akada, Masayuki Munekane, Takahiro Ida, Shinichiro Kamino, Shinj ...2014 Volume 67 Issue 5 Pages 237-244
Published: 2014
Released on J-STAGE: October 31, 2014
JOURNAL FREE ACCESSThe Fukushima nuclear accident released various radionuclides, including 137Cs, 131I and 90Sr, into the environment. At present, there is public concern about internal exposure to these radionuclides via contaminated foodstuffs, and therefore there is an urgent need for an effective and easily obtainable radioprotective agent. It has been reported that royal jelly (RJ) functions as an antioxidant for protection against DNA oxidation. We therefore postulated that administration of RJ would reduce internal exposure to radiation and/or promote the metabolic turnover of radionuclides. In this study, we evaluated whether or not RJ would act as a radioprotective agent. We analyzed the biodistribution of 137Cs, 131I and 85Sr in mice administered RJ orally for 1 week. Accumulation of these radionuclides was significantly decreased in the RJ-treated mice, and the radionuclides were mainly excreted into the urine. RJ decreased the accumulation of 131I in the thyroid gland particularly. In addition, we succeeded in visualizing the effect of RJ non-invasively by gamma-ray emission imaging (GREI) , which is a multiple nuclide imaging modality.View full abstractDownload PDF (4330K) -
Fumiko Sakata, Katsunori Sasaki, Takayuki Uchida, Kazuo Chiku, Yutaka ...2014 Volume 67 Issue 5 Pages 245-253
Published: 2014
Released on J-STAGE: October 31, 2014
JOURNAL FREE ACCESSAnemia is often observed in protein-energy malnutrition, and one of the major reasons for this is thought to be iron deficiency. It is now known that hepcidin-25 plays a critical role in iron metabolism. However, no reported studies have yet investigated the relationship between hepcidin-25 and nutritional conditions. From this viewpoint, we investigated the relationship between hepcidin-25-related iron metabolism and protein-energy malnutrition using rats fed a protein-free diet during their growth period. In addition, we investigated how the presence and absence of iron in a protein-free diet affects iron metabolism. Our findings suggested that anemia observed in protein-energy malnutrition during the growth period was attributable to functional iron deficiency, i.e. impairment of iron metabolism due to an increase of hepcidin-25 synthesis, and not to absolute iron deficiency. The iron supply would incur a risk of inducing an excess of iron, since the stored iron was increased in protein-energy malnutrition and no iron deficiency was observed even in the absence of an iron supply. Thus, it appears that the best way to overcome this disease condition is to rectify the nutritional deficiency.View full abstractDownload PDF (6654K) -
Yu Hatakeyama, Yasuna Kitano, Taro Honma, Shuang E, Kazushi Yamamoto, ...2014 Volume 67 Issue 5 Pages 255-270
Published: 2014
Released on J-STAGE: October 31, 2014
JOURNAL FREE ACCESSOur recent study showed that Japanese food typical of that consumed in 1975 had stronger caloric restriction (CR) -like effects than Japanese food typical of that consumed in 1960, 1990 and 2005. CR is useful for health maintenance, but maternal caloric restriction during gestation and lactation can have a negative impact on offspring. In this study using mice, we investigated the breast milk-mediated effects of Japanese food typical of that consumed during different periods in the past on offspring. Postnatal dams were given experimental diets including Japanese food typical of that consumed in 1960, 1975, 1990, or 2005, and the offspring were fed a high-fat diet after weaning at 3 weeks. The hepatic triacylglycerol level in the 1975 group was significantly higher in offspring and adults, whereas white adipose tissue weights in this group were lowest in all offspring. Lipid metabolism and lipolysis were also activated in white adipose tissue of offspring from dams fed the 1975 diet, whereas lipid metabolism was not activated in the liver. These results suggest that Japanese food typical of that consumed in 1975 promoted lipid accumulation in the liver and reduced the weight of white adipose tissue in infants via milk from the dam, this change persisting during and after growth.View full abstractDownload PDF (3872K)
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