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A Brief Review of 852 Patients Treated in Kurume University Hospital During the 10 years from 1971 to 1980
MINORU HIRANO
1982 年 29 巻 SUPPLEMENT 号 p.
S1-S7
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
During the 10 years from 1971 to 1980, 852 patients of histologically proven head and neck cancer were treated at our inpatient clinic. The most frequent pathology was carcinoma of the larynx, being followed by carcinomas of the maxillary sinus and the oral cavity. The 5-year survival rate was high for carcinomas of the thyroid gland (76.8%), larynx (69.4%), tongue (61.4%) and nasal cavity (60%). It was low for carcinomas of the epipharynx (17.8%) and hypopharynx and cervical esophagus (25.4%).
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Minoru Hirano
1982 年 29 巻 SUPPLEMENT 号 p.
Preface1
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
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Deport of 6 Cases
SHIGEJIRO KURITA, KAZUTO NAGATA, SHIGENOBU MIHASHI, TAKAO KASUYA, TOSH ...
1982 年 29 巻 SUPPLEMENT 号 p.
S9-S13
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Six cases of carcinoma of the external auditory canal, which were curatively treated in Kurume University Hospital, were reported. Five of these cases were squamous cell carcinoma and the other one was basal cell carcinoma. Three cases were female and the other 3, male. The age ranged 25 to 77 years. Curative treatment were done for 5 cases. Of these 5 cases, 3 cases were treated chiefly with surgical operation. Two of them are currently alive without tumor, while the other one died from gastric cancer 2 years and 9 months after the initial treatment, being free of the tumor present. Two cases were initially treated chieftly by radiotherapy. One of them is currently tumor-free and alive 1 year and 7 months after the treatment. In the other, recurrence of the primary lesion occurred 4 months later. Salvage operation was done and the recurrence was controlled. But the patient died from unknown etiology 2 years and 6 months after the initial treatment. The 6th patient was an inoperable case and palliative radiotherapy was done. The patient died from tumor 1 year and 1 month later.Three cases were female and the other 3, male. The age ranged 25 to 77 years. Curative treatment were done for 5 cases. Of these 5 cases, 3 cases were treated chiefly with surgical operation. Two of them are currently alive without tumor, while the other one died from gastric cancer 2 years and 9 months after the initial treatment, being free of the tumor present. Two cases were initially treated chieftly by radiotherapy. One of them is currently tumor-free and alive 1 year and 7 months after the treatment. In the other, recurrence of the primary lesion occurred 4 months later. Salvage operation was done and the recurrence was controlled. But the patient died from unknown etiology 2 years and 6 months after the initial treatment. The 6th patient was an inoperable case and palliative radiotherapy was done. The patient died from tumor 1 year and 1 month later.
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A Retrospective Investigation of 20 Patients
KAZUTO NAGATA, SHIGEJIRO KURITA, SHIGENOBU MIHASHI, MINORU HIRANO
1982 年 29 巻 SUPPLEMENT 号 p.
S15-S21
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 20 patients of carcinoma of the nasal cavity treated for the first time at Kurume University Hospital from 1971 to 1980 was completed. All patients underwent curative treatments. The results of this retrospective studies are summarised as follows. (1) Sex ratio between male and female was 1.2 to 1 (11/9). Age ranged from 36 to 73 years and the mean age was 56 years. (2) Histologically, 14 (70%) was squamous cell carcinoma, 2 (10%) lymphoepithelioma, 1 (5%) transitional cell carcinoma, 2 (10%) adenoid cystic carcinoma and 1 (5%) mucoepidermoid carcinoma. (3) The 3-year and 5-year actuarial survival rates were 74% and 60%. (4) There were 8 deaths, in which 6 were from tumor and 2 were from intercurrent disease.
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A Retrospective Investigation of 124 Patients
SHIGENOBU MIHASHI, KATSUHIKO MIHASHI, SHIGEJIRO KURITA, KAZUTO NAGATA, ...
1982 年 29 巻 SUPPLEMENT 号 p.
S23-S43
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 124 patients of carcinoma of the maxillary sinus treated at Kurume University Hospital from 1971 to 1980 was completed. Of these 124 patients, 111 patients had not been previously treated and underwent curative treatment, 8 patients underwent palliative treatment, and 5 patients were those who had been previously treated at other clinics. The results of this retrospective studies are summarized as follows: 1) In the 58 patients who were followed up for 5 years or more after the onset of initial curative treatment, the 3- and 5-year crude survival rates calculated by direct method were 58.6% and 51.7%, respectively. 2) In the 111 patients who underwent curative treatments, the 3- and 5-year cumulative survival rates calculated by the actuarial method were 61.8% and 52.3%, respectively. 3) Among various factors which can be determined before the treatment, T category and L. V. histological classification were considered to be useful in order to estimate the prognosis. 4) With respect to T categorization, the JJC proposal proved to be better than the A JC proposal. 5) The majority of causes of deaths was uncontrolled primary lesion. Involvement of the cervical lymph nodes were controlled in most cases and distant metastasis were not frequent. 6) As for the treatments, the best modalities appeared to be the following two combinations: (1) infusion, radiation and necrotomy followed by an eradicating surgery and (2) infusion, radiation and necrotomy associated with a mass reduction surgery. 7) Three year crude survival rate calculated by direct method was equally 80.0% in the above two combination therapies. Final conclusions on the comparison between these two Combination treatments await further followup studies of more patients.
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Report of 2 Cases
KAZUTO NAGATA, SHIGEJIRO KURITA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S45-S47
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Two cases of carcinoma of the frontal sinus, which were treated in Kurume University Hospital during the period of 10 years from 1971 to 1980, were reported. The incidence of primary carcinoma of the frontal sinus in all carcinomas of the paranasal sinuses was 1.5% (2/130) during this period at our department. In case 1, surgical removal of the tumor followed by radiation therapy in combination with local administration of Bleomycin was indicated. The patient did not continue to have treatments and died 11 months after the initiation of treatment. In case 2, surgical removal of the tumor followed by radiation in combination with intravenous administration of Bleomycin failed to control the primary lesion. Ophthalmectomy was added later, but the patient died with an intracranical invasion 1 year and 6 months after the onset of treatment.
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Report of 2 Cases
KAZUTO NAGATA, SHIGEJIRO KURITA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S49-S51
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Two cases of carcinoma of the ethmoid sinus was reported. One was a 72-year-old female and the other was a 25-year-old female. The first symptom was epistaxis and exophthalmus. No cervical lymphnode was palpable in both cases. They were treated with surgery and irradiation. The first case is recently alive 3 years and 6 months after the initial treatments with no evidence of recurrent tumor. The second case is recently alive 1 year and 1 month from the initial treatment without any evidence of the recurrent tumor.
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Report of a Case
KAZUTO NAGATA, SHIGEJIRO KURITA, SHIGENOBU MIHASHI, SHUN WATANABE
1982 年 29 巻 SUPPLEMENT 号 p.
S53-S55
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A case of carcinoma of the sphenoid sinus, which was treated in Kurume University Hospital for the period of 10 years from 1971 to 1980, was reported. The incidence of carcinoma of the sphenoid sinus in all carcinomas of the paranasal sinuses was 0.8% (1/130) in our department. The patient was a 70-year-old man. The tumor originated from the right sphenoid sinus and invaded the cranial base, presenting involvements of II-VI cranial nerves. Surgical removal of the mass followed by radiation therapy could not afford to prolong his life because of the extensive invasion.
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Report of a Case
TETSUJI YOSHIDA, KAZUTO NAGATA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S57-S59
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A case of squamous cell carcinoma presumably originating from the lacrimal sac of a 59-year-old female was reported. The first symptom was pain of the left orbit region and epiphora. Exophthalmus and swelling of the left orbit region followed. The patient was surgically treated with preand post-operative radiation. Additional surgeries, i. e. ophthalmectomy with partial maxillectomy and radical neck dissection were demanded for local and neck recurrences. The patient is currently alive 4 years after the final operation with no evidence of any recurrent tumor.
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A Retrospective Investigation of 113 Patients
HIROSHI OHKUBO, TATSUO MAEDA, MINORU HIRANO, SHIGEJIRO KURITA, SHIGENO ...
1982 年 29 巻 SUPPLEMENT 号 p.
S61-S78
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
During the 10 years from January 1, 1971 to December 31, 1980, 113 patients with histologically proven carcinoma of the lip and oral cavity were treated at the Department of Otolaryngology, Kurume University Hospital. Among the entire 113 cases, the site of the primary lesion was the lip in 3, the buccal mucosa in 7, the upper alveolus and gingiva in 6, the lower alveolus and gingiva in 6, the hard palate in 9, the tongue in 65, the floor of the mouth in 17 cases. The results of treatments were discussed chiefly for those patients who had not been previously treated and underwent curative treatment. They can be summarized as follows : (1) In 54 patients of carcinoma of the tongue who underwent curative treatments, the 3- and 5-year cumurative survival rates were 72.5% and 61.4%, respectively. Of the 19 patients who died, the cause of death was primary lesion in 3 (16%), neck metastasis in 6 (32%), distant metastasis in 1 (5%), complication in 2 cases (11%). (2) In 16 patients of carcinoma of the floor of the mouth who underwent curative treatments, both 3- and 5-year cumurative survival rates were 50% . The more advanced the disease was, the lower the survival rate. Of the 8 patients who died, the cause of death was primary lesion in 4, neck metastasis in 1, distant metastasis in 1, and surgical and other complications in 2. (3) In 21 patients of carcinoma of the other sites who underwent curative treatments, the 3- and 5-year cumurative survival rates were 60 % and 40% for the buccal mucosa, 66.7% and 66.7% for the upper alveolus and gingiva, 58.4% and 58.4% for the lower alveolus and gingiva, 25% and 25% for the hard palate, respectively.
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A Retrospective Investigation of 16 Patients
KOICHI MATSUO, MASAYUKI KAMIMURA, MINORU HIRANO, SHIGENOBU MIHASHI, KA ...
1982 年 29 巻 SUPPLEMENT 号 p.
S79-S85
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 16 patients of carcinoma of the epipharynx treated at Kurume University Hospital from 1971 to 1980 was completed. Thirteen patients underwent curative treatments and 3 were subjected to palliative treatments. The results of this retrospective study is summarized as follows: 1) In the 13 patients of curative treatments, both 3- and 5-year cumulative survival rates calculated by the actuarial method were 17.8%. 2) Of 9 deaths in the curative treatment group, the cause of death was primary lesion in 7, unknown in 1 and intercurrent disease in 1.
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A Retrospective Investigation of 43 Patients
KOICHI MATSUO, MASAYUKI KAMIMURA, MINORU HIRANO, SHIGENOBU MIHASHI, KA ...
1982 年 29 巻 SUPPLEMENT 号 p.
S87-S95
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 43 patients of carcinoma of the mesopharynx treated at Kurume University Hospital from 1971 to 1980 was completed. Thirty-one patients underwent curative treatment and 12 were subjected to palliative treatments. The results of this retrospective study are summarized as follows: (1) In the 31 patients of curative treatments, 3- and 5-year cumulative survival rates calculated by the actuarial method were 53.4% and 31.1%, respectively. (2) The more advanced the disease was, the lower the survival rate. (3) Of 18 deaths in the curative treatment group, the cause of death was primary lesion in 4, neck metastasis in 4, distant metastasis in 4, complication in 2 and intercurrent disease in 4. (4) Combined therapy of surgical and radiotherapeutic management was better treatment than radiation therapy only.
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A Retrospective Investigation of 67 Patients
MINORU HIRANO, SHIGEJIRO KURITA, KOHJI KURATOMI, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S97-S111
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 67 patients of carcinoma of the hypopharynx and cervical esophagus treated at Kurume University Hospital from 1971 to 1980 was completed. Fifty-four patients underwent curative treatments and 13 were subjected to palliative treatments. The results of this retrospective studies are summarized as follows: (1) In the 54 patients of curative treatments, 3- and 5-year cumulative survival rates calculated by the actuarial method were 39.0% and 25.4%, respectively. (2) The more advanced the disease was, the lower the survival rate. (3) Of 35 deaths in the curative treatment group, the cause of death was primary lesion in 4, neck metastasis in 8, distant metastasis in 8, surgery in 5, complication in 6, unknown in 1 and intercurrent disease in 4. (4) Pre-operative radiation did not result in improvement in the survival rate. (5) Application of Bleomycin did not reduce the development of distant metastasis. (6) With respect to reconstruction of the food channel, the technique which employed a secondary procedure with the use of hinge flap and DP flap yielded the best results.
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A Retrospective Investigation of 252 Patients
HIROSHI KAWASAKI, KATSUHIKO MIHASHI, MINORU HIRANO, SHUN WATANABE, KAT ...
1982 年 29 巻 SUPPLEMENT 号 p.
S113-S128
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 252 patients of carcinoma of the larynx treated for the first time at Kurume University Hospital from 1971 to 1980 was completed. Two hundred and forty-four patients underwent curative treatments while 8 were palliatively treated or referred to other hospitals. The results of this retrospective studies are summarized as follows: (1) In 244 patients of curative treatments, 5-year cummulative survival rate calculated by the actuarial method was 69.4%. (2) There were 88 supraglottic, 150 glottic and 6 subglottic carcinomas. Five-year cumulative survival rate for each of these groups was 54.8%, 77.9% and 50.0%, respectively. (3) The more advanced the disease was, the lower the survival rate. (4) Of 67 deaths in the curative treatment group, the cause of death was primary lesion in 3, neck metastasis in 12, distant metastasis in 14, unknown in 2 and intercurrent disease in 36. (5) There was an appreciable improvement in the results of treatment in the era between 1971 and 1980 compared to the era between 1960 and 1970 in our department.
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A Retrospective Review of 18 Patients
SHUICHI ESAKI
1982 年 29 巻 SUPPLEMENT 号 p.
S129-S135
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Malignant tumor of the major salivary glands is not very common and its histological condition is varied. During the 10 years following 1971, 18 cases of malignant salivary gland tumors were seen in our department. Surgery as the first step of management was the routine approach used in our hospital for all patients presenting with tumor of the major salivary glands. Five-year cumulative survival rate calculated by the actuarial method was 56% for the primary cases which underwent curative treatment.
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A Retrospective Investigation of 75 Patients
SHINYA ARAKI, YOSHIO HIRADE, MASAMI ASO, SHIGENOPU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S137-S149
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review was completed of 69 patients treated at Kurume University Hospital from 1971 to 1980 for carcinoma of the thyroid gland. Sixty-one cases underwent curative treatments and 8 were subjected to palliative treatments. The results of this retrospective study are summarized as follows: (1) In the patients of curative treatments, 5-year and 10-year cumulative survival rates calculated by the actuarial method were 76.8% and 63.0%, respectively. (2) The factors which presented significant influences on the prognosis were age, histological type an surgical treatment. (3) All of the undifferentiated carcinoma cases died from primary lesion. (4) The patients over 65 years old tended to present lower survival rates than did the younger patients. (5) In both of the 2 cases of isthmus carcinoma which was treated by a localized removal, a local recurrence developed.
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Report of 4 Cases
KAZUTO NAGATA, SHIGEJIRO KURITA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S151-S154
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Four cases of cervical lymphnode metastasis of squamous cell carcinoma of unknown origin were reported. Three of these 4 patients were treated with radical neck dissection, and one patient was treated with removal of the tumor. Three patients died within 1 year from the initial treatment and 1 patient died from a neck recurrence 3 years and 5 months after the initial treatment.
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Report of a Case
SHIGEJIRO KURITA, KAZUTO NAGATA, SHIGENOBU MIHASHI, RURIKO TERASAWA
1982 年 29 巻 SUPPLEMENT 号 p.
S155-S159
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A case of malignant melanoma arising from the nasal cavity of a 65-year-old male was reported. The first symptom was nasal obstruction and epistaxis. Polyp-like tumors were observed in the left nasal cavity. X-ray films revealed an involvement of the maxillary and ethmoid sinuses. An extensive surgical procedure including ophthalmectomy was refused by the patient, and therefore, partial maxillectomy and cryosurgery were done as the initial treatment. But recurrences of the primary lesion occurred. Total maxillectomy, ophthalmectomy, radical neck dissection and immunotherapy were done for the recurrent tumors. An invasion into the frontal cranial base was observed during the final operation. Purulent meningitis occurred after the surgery. The patient died 1 year and 10 months after the initial treatment.
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Report of a Case
SHIGEJIRO KURITA, KAZUTO NAGATA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S161-S163
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Malignant melanoma of the oral cavity is a relatively rare condition. A 57-year-old female case of malignant melanoma arising from the oral cavity was treated in Kurume University Hospital. The initial symptom was a tumor formation of the neck. The primary tumor was located on the right upper gingiva. The patient was successfully treated with partial maxillectomy and radical neck dissection and is currently alive 2 years and 10 months after the initial treatment with no evidence of recurrent tumor.
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Report ot 7 cases
SHIGEJIRO KURITA, KAZUTO NAGATA, SHIGENOBU MIHASHI, KATSUHIKO MIHASHI, ...
1982 年 29 巻 SUPPLEMENT 号 p.
S165-S173
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Seven cases of sarcoma of the maxilla or the maxillary sinus, which were treated at the Kurume University Hospital, were reported. Histologically, 2 cases were osteosarcoma, 1 leiomyosarcoma, 1 rhabdomyosarcoma, 1 fibrosarcoma, 1 mesenchymal chondrosarcoma, and 1 chondrosarcoma. Their age ranged from 12 to 67 years with a mean age of 36 years. Curative treatments were performed in 5 cases. Of these 5 cases, 1 case of osteosarcoma died within a year and 1 case of chondrosarcoma died 2 years and a month after initial treatment. The other 3 cases, which were a leiomyosarcoma, a fibrosarcoma and a mesenchymal chondrosarcoma, are alive . Two cases, which were osteosarcoma and rhabdomyosarcoma, were inoperable. Palliative treatments were done for them, but they died within a year.
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Report of 3 Cases
SHIGEJIRO KURITA, KAZUTO NAGATA, SHIGENOBU MIHASHI
1982 年 29 巻 SUPPLEMENT 号 p.
S175-S178
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
Two cases of malignant schwannoma and a case of ganglioneuroblastoma of the neck treated in Kurume University Hospital from 1971 to 1980 were reported. Of the 2 cases of malignant schwannoma, one was a 30-year-old male who died 7 years and 6 months after the initial treatment with primary lesion and pulmonary metastasis. Another was a 49-year-old female who experienced repeated local recurrence. One year and 6 months after her hospital discharge, the patient is recently alive with the primary tumor remaining. The case of ganglioneuroblastoma was a 3-year-old girl who was treated with irradiation and chemotherapy. Four years and 6 months after the initial treatment the patient is alive without any evidence of recurrent tumor.
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A Retrospective Study of 75 Patients
TADASHI MOTOORI, KATSUHIKO MIHASHI, FUMIO SUEYOSHI, SHIGENODU MIHASHI, ...
1982 年 29 巻 SUPPLEMENT 号 p.
S179-S194
発行日: 1982/09/01
公開日: 2009/08/11
ジャーナル
フリー
A retrospective review of 75 patients of malignant lymphoma treated at the Department of Otolaryngology, Kurume University Hospital, during the 10 years from 1971 to 1980 was carried out. In this study, the determinate cases consist of previously untreated 61 patients with histological diagnosis of malignant lymphomas. The results were seen as follows; (1) A patient of Hodgkin's disease, mixed cellularity (MC) in CS III, nodal lesion, was a 26-year-old male. He is currently alive 45 months after the initial treatment with no evidence of relapsing lesion. (2) In 60 patients with non-Hodgkin's lymphomas, 1-, 2-, and 5-year cumulative survival rates calculated by the actuarial method were 65.5 %, 54.8 %, and 44.8 %, respectively. (3) In patients with non-Hodgkin's lymphomas in early stages or of the Waldeyer's ring, prognosis was better. (4) Patients in advanced stages presented lower survival rate. (5) Diffuse lymphoma, pleomorphic type showed the worst survival rate. (6) Among 31 deaths, 21 (68 %) were death from tumor dissemination, 5 (16%) from complication, 2 (6 %) from unknown cause, 3(10%) from intercurrent disease. (7) Pulmonary complications, particularly, pneumonitis was the most serious complication in non-Hodgkin's lymphomas. (8) Relapse rate was 44% in early stages. Relapse occurred most frequently within 1 year, but there were some late relapses. (9) Two patients with non-Hodgkin's lymphomas of the Waldeyer's ring had a gastrointestinal involvement at relapse. (10) Lastly, we propose diagnostic and therapeutic protocols for the patients with malignant lymphomas.
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