巻号一覧
43 巻 (1996)
- 4 号 p. 249-
- 3 号 p. 185-
- 2 号 p. 115-
- 1 号 p. 1-
43 巻, 1 号
選択された号の論文の16件中1～16を表示しています
- |<
- <
- 1
- >
- >|
-
TAKEO OHSUGI, TORU DRANO, KENJI MASUNAGA, MASAHISA SHINGU1996 年 43 巻 1 号 p. 1-9
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーAn experimental rat model for vertical transmission of human T cell leukemia virus type I (HTLV-I) was used to examine whether the infection of offspring derived from HTLV-I carrier rats could be established during the suckling period. MT-2 (2 × 107) cells were injected into 5-week-old rats twice, at 2-week intervals. HTLV-I infected or non-infected female rats were mated with HTLV-I carrier male rats. The titer of serum antibodies against HTLV-I in the offspring derived from non-infected dams was less than 1:16 by the agglutination test during the suckling period. The serum antibodies of the offspring derived from the infected dams was less than 1:32 at 1 day after birth and increased steadily to 1:2048 at 14 days. However, the HTLV-I proviral sequences were not detected in any organs of the offspring during the suckling period as determined by the nested double polymerase chain reaction (PCR). These findings indicate that maternal antibodies against HTLV-I were not readily transmitted through the placenta and that the anti-HTLV-I antibodies in the offspring came from the milk of the dams. Furthermore, the HTLV-I infection in the offspring that was derived from the carrier dam may not be established during the suckling period but after weaning.抄録全体を表示PDF形式でダウンロード (5182K) -
TATSUYA ISHITAKE, TOSHIYUKI KIHARA, TSUNETAKA MATOBA1996 年 43 巻 1 号 p. 11-15
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーTo improve the conventional cold water immersion test for assessing peripheral circulatory function, the immersed area of the hand was changed in this study. Twenty-seven healthy medical students with a mean age of 24 years participated in the study. The cold water immersion tests were carried out using two methods (in 5°C water for 1 min), in which the immersed area was up to the metacarpophalangeal (MP) joints (hereafter, MP-method) which is a new method, or to the wrist (hereafter, W-method) which is a conventional method. The recovery of skin temperature, vibratory perception threshold and complaints of finger pain were determined during cold immersion tests with the two methods. The mean skin temperature for the MP-method after immersion recovered more quickly than that for the Wmethod. However, the time courses of recovering were parallel for the two methods. Significant differences were noted at 3 min, 5 min and 10 min after cessation of immersion. There was a significant positive correlation in the recovery rates at 5 min after immersion between the two methods (correlation coefficient = 0.65, p<0.01). The mean vibratory thresholds for the W-method were higher than those for the MP-method, and the difference was significant (p<0.01). All subjects preferred the MP-method to the W-method because there was less finger pain. These results indicate that the MP-method, immersion up to the MP joint of a hand, for assessing peripheral circulatory function is better than the W-method.抄録全体を表示PDF形式でダウンロード (2196K) -
KIMIO USHIJIMA, TAKASHI NISHIDA, NAOFUMI OHKURA, TORU SUGIYAMA, HARUO ...1996 年 43 巻 1 号 p. 17-24
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWe retrospectively reviewed 91 patients with epithelial ovarian cancer who underwent second-look operation (SLO). SLO identified a persistent tumor in 18 (19.8%) of 91 patients. Of these 18 patients, 13 (72.2%) showed disease progression after SLO. Patients with a positive SLO in which the identification of the persistent disease was only possible by washing cytological study showed better prognosis than patients with macroscopic lesions. Of the 73 patients with a negative SLO, 12 (16.4%) developed recurrence after cessation of treatment. These 12 patients were. from stage 1c to 3 with Grade 2 and 3 tumors. The SLO findings were more sensitive than the serum tumor marker in identifying persistent disease. Also we reviewed 55 patients having no SLO. Among 57 cases in stage 1 and 2 with Grade 1 tumor, there were no cases of recurrence, regardless of whether they had SLO or not. Our results suggest that SLO findings correlate well with the patient's prognosis. SLO may not be needed for patients in stage 1 and 2 with Grade 1 tumor. Patients with advanced stage disease with Grade 2 and 3 tumors have high-risk for recurrence after negative SLO. While SLO is still of benefit in management of ovarian cancer, refinements are needed to determine its indication and scheduling.抄録全体を表示PDF形式でダウンロード (1345K) -
KIMITAKA SAGAWA, SHIZUO HAGIWARA, KAZUKO KATAGIRI, MOTOKO SAKATA, HIRO ...1996 年 43 巻 1 号 p. 25-31
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーTwo murine monoclonal antibodies (mAb) designated as NU-T1 and NU-T2 were generated to identify the novel antigens expressed on human T cells. NU-T1 reacted with peripheral blood T cells, but not with granulocytes or monocytes, whereas NU-T2 were not reactive with peripheral blood lymphocytes, granulocytes or monocytes. Both NU-T1 and NU-T2 reacted with thymocytes. The incidence of NU-T1 or NU-T2 reactivity with the leukemic cells from patients with various types of leukemia was as follows: 12/12 or 4/12 in acute lymphocytic leukemia (ALL) of T cell type, 6/6 or 0/7 in adult T cell leukemia, 0/6 or 0/19 in ALL of non-T non-B cell type, and 0/8 or 0/8 in acute myelocytic leukemia, respectively. The incidence of NU-T1 and NU-T2 reactivity with human leukemic T cell lines were 4/10 and 5/10, respectively. In contrast, neither NU-T1 nor NU-T2 reacted with B cell lines, non-T non-B cell lines, or myeloid cell lines tested. These results indicate that NU-T1 and NU-T2 recognize two distinct differentiation antigens expressed on the cells in the T cell lineage. These mAb would be useful reagents to study the function of human T cells and the immunophenotyping of human T cell malignancies.抄録全体を表示PDF形式でダウンロード (3692K) -
TORU SUGIYAMA, TAKASHI NISHIDA, SEISUKE KUMAGAI, KIMIO USHIJIMA, ATSUH ...1996 年 43 巻 1 号 p. 33-39
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーSelective delivery of a high level of cisplatin (CDDP) to the omentum, intraperitoneal disseminated tumors and lymph nodes was studied using a dosage form of CDDP-activated carbon. Although intraperitoneal CDDP-activated carbon delivered much higher levels of CDDP to the omentum, tumors and lymph nodes, a primary burst phenomenon of CDDP occurred just after administration. This indicates that activated carbon is an unsuitable particle to provide a slow steady release of CDDP.抄録全体を表示PDF形式でダウンロード (5771K) -
YUTAKA OGATA, KAZUO SHIROUZU, YOSHITO AKAGI, MAMORU HIRAKI, HIROHARU I ...1996 年 43 巻 1 号 p. 41-47
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWe have investigated the complications, toxicities, tumor response and survival rate with hepatic arterial (HA) chemotherapy for liver metastases from colorectal cancer. Forty-three patients with measurable liver metastases and 10 patients after the resection of liver metastases were treated with HA bolus mitomycin C (MMC) or continuous fluorouracil (5-FU) infusion between 1986 and 1994. The catheter-or reservoir-related complications such as catheter induced infection, subcutaneous reservour pocket infection, or catheter or hepatic artery occlusion occurred in 14 patients (26%) mainly in our early cases. Severe gastritis or a gastroduodenal ulcer developed in 12 patients (23%), in particular after treatment with continuous infusion of 5-FU and when the catheter was placed into the gastroduodenal artery during laparotomy. An ulcer often caused a serious complication such as a duodeno-biliary fistula, penetration into the hepatic artery or duodenal perforation. Also noted were upper gastrointestinal symptoms in 26 patients, hepatic toxicities in 3 patients, and bone marrow depression in 4 patients. Because of these complications and toxicities, HA therapy was discontinued in more than 60% of the cases. The overall tumor response rate was 17%. However, in the cases which were treated by 5-FU continuous infusion for longer than 3 months, the response rate was higher than 60%. There was no significant difference in survival rate between HA therapy and systemic palliative chemotherapy. These results suggest that it is important to prevent gastrointestinal toxicities in order to allow continuation of HA continuous 5-FU infusion therapy which could provide a higher response rate and a better survival for colorectal cancer patients with liver metastases.抄録全体を表示PDF形式でダウンロード (3483K) -
A Health Diary StudyRYOKO OSAKA, SOMSONG NANAKORN1996 年 43 巻 1 号 p. 49-54
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーA one-month health diary was used as a research instrument for measuring health care in the northeastern rural area of Thailand during the month of November, 1992. Three hundred forty-five respondents, which represents 22.2% of the total households in 12 villages from 2 districts in the Khon Kaen province of northeast Thailand, completed the health diaries. Self-medication was most practiced for health care (37.5% of ill persons) followed by health service utilization at local health center (19.4%), at community hospital (11.4%), at private clinic (11.4%), and by “wait and see” (9.0%). Analgesics were the most frequently used drugs for relief of fever, headache, common cold and abdominal pain. The use of a combination of drug (eg. a cocktail) was common as self-medication for relief of back and leg pain. Traditional or herbal drugs were a frequently chosen alternative for self-medication, both in adult and children. The authors suggest that the villagers should be educated concerning drug hazards in order to increase their background knowledge on drug use.抄録全体を表示PDF形式でダウンロード (735K) -
MOTOKO SAKATA1996 年 43 巻 1 号 p. 55-61
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーMAGE gene family encodes tumor-specific antigens recognized on HLA-A1 by cytotoxic T lymphocytes. We have investigated the mRNA expression of MAGE gene family in lung cancers using MAGE gene specific primers, reverse transcription-polymerase chain reaction (RT-PCR) an restriction enzyme analysis. MAGE-1, -3, -4, -41 or -6 gene was respectively expressed in 6, 5, 6, 7, and 4 of 53 lung cancer tissues (8 to 13%) or in 0, 6, 6, 7 or 8 of 14 lung cancer cell lines (0 to 53%). These results suggest that a substantial proportion of lung cancers express MAGE genes.抄録全体を表示PDF形式でダウンロード (5020K) -
A Thin-Section CT Scoring SystemYOSHIKO SUEYASU1996 年 43 巻 1 号 p. 63-71
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーThe usefulness of thin-section computed tomography (CT) in the identification of the specific and clinically relevant pathologic changes in airway disease has been well documented. However, this approach has not been used for objective evaluation in patients with diffuse panbronchiolitis. Therefore attempts were made to use it in patients with diffuse panbron-chiolitis. The study group included 12 men and 10 women, 17 to 69 years of age (mean, 47 years) with diffuse panbronchiolitis. All patients were evalu-ated by thin-section CT and pulmonary function testing. The CT score was calculated by a modified score criteria. The correlations between the CT score and the pulmonary function parameters were assessed by Pearson's linar regression analysis. Bronchiolar inflammation and airway-ectasia were present in all 22 patients. Periairway thickening was present in 17 patients. Pus plugging was present in 18 patients. Two patients had bullae formation, and 6 had air-trapping. Pulmonary collapse or consolidation was evident in 6 patients. The CT score demonstrated a significant negative correlation with FEV1% (r=-3.267, p=.0230), %VC (r=-4.658, p=.0018), and arterial blood oxygen concentration (r=-1.009, p=.0381). The thin-section CT findings in patients with diffuse panbronchiolitis closely resembled those in patients with cystic fibrosis, previously described. Furthermore, a CT scoring system is useful for objective evaluation of lung disease severity in patients with diffuse panbronchiolitis.抄録全体を表示PDF形式でダウンロード (7320K) -
HARUO MURAOKA, TOSHIAKI SANEFUJI, RYUJI KEIDA, RIKO TSUJI, HIROHIKO AB ...1996 年 43 巻 1 号 p. 73-77
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWe experienced a case of chronic hepatitis type C accompanied with hallucination and delusion induced by interferon (IFN) therapy positive. The case was a 47-year-old male, whose laboratory data showed positive for anti-Hepatitis C Virus (HCV) and elevated transamninase level. He was treated with 6 MU/day of natural-type IFN-α (HLBI). Sleeplessness and delusions of persecution developed about 2 months after the start of IFN therapy. The interview of the psychiatrist disclosed that the patient had a history of addiction to drugs, and these psychiatric symptoms were diagnosed as being of “the flashback phenomenon.” These side effects were improved after the administration of psychotropics and it was suggested that we had to take care of the development of flashback phenomenon during the treatment of IFN in cases of chronic hepatitis with a history of addiction to drugs.抄録全体を表示PDF形式でダウンロード (2063K) -
HISAFUMI KINOSHITA, HIROYASU IMAYAMA, HIRONOBU SOU, JUNJI SHIBATA, NOB ...1996 年 43 巻 1 号 p. 79-85
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーA 51-year-old man had repeated admissions and discharges from the hospital for alcohol dependence and alcoholic hepatitis. Thereafter, with a diagnosis of chronic pancreatitis, he was examined on an outpatient basis. He presented with right hypochondriac pain as the chief complaint, and was admitted to the hospital because of a suspected acute exacerbation of chronic pancreatitis. Pyrexia and jaundice were present from about the 5th hospital day, and he was admitted to Kurume University Hospital with a diagnosis of obstructive icterus. Percutaneous transhepatic biliary tract drainage (PTBD) was immediately performed. A roentgenogram revealed moderate dilatation of the extrahepatic bile ducts and stricture of the intrapancreatic common bile duct. No calculi were observed in the gallbladder or bile ducts by ultrasonography of the abdominal region. The main pancreatic duct was dilated to 10mm, and a strong echo, probably a calculus, was observed in the main pancreatic duct. Pancreatoduodenectomy was performed with a diagnosis of stricture of the common bile duct due to chronic pancreatitis with a pancreatic stone. Examination of the excised specimens revealed a rigid pancreatic head; and when the common bile duct was incised, no stricture was observed. A milk-white calculus about 10mm in diameter was observed in the common channel of the lower portion of the common bile duct. The orifice of the pancreatic duct was also observed at the same site. The common channel was about 20mm long, and malfusion of the pancreatobiliary ducts was observed. The obstructive icterus was due to an impaction of the pancreatic stone at the confluence of the pancre-atobiliary ducts. The calculus was composed of calcium carbonate, and the histopathological findings in the pancreas showed chronic pancreatitis.抄録全体を表示PDF形式でダウンロード (6236K) -
A Case ReportTADAMITSU KAMEYAMA, YUMIKO NAGAO, JINGO KUSUKAWA, SHINICHIRO TERASAKI, ...1996 年 43 巻 1 号 p. 87-89
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーRecurrent herpetic infection on the mobile mucosa such as the oral floor, has not been reported previously. A case of recurrent herpetic infection of the oral floor in a 52-year-old man is presented. This case illustrates the fact that recurrent herpetic lesions can occur anywhere in the intra-oral mucosa.抄録全体を表示PDF形式でダウンロード (1653K) -
A Case ReportJUNJI OHTA, MASAFUMI MARUIWA, MASANORI NOUTOMI, HIROYUKI FUNATSU, YOSH ...1996 年 43 巻 1 号 p. 91-95
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWe presented a case of a 71-year-old woman who presented irregular mucosal folds with tiny depressions and multiple erosions with ulceration in the stomach, on endoscopy and roentgenography. Histological findings from biopsy specimens showed dense and mildly atypical lymphoidlike cells invading the submucosa. Immunohistochemical examinations revealed monoclonal reactivity of Heavy-chain. She was then diagnosed to have low grade malignant lymphoma in the stomach and underwent total gastrectomy. The resected cancer demonstrated the pathological features including small lymphocytic plasmacytoid cells and lymphoepithelial lesions characteristic of a mucosa-associated lymphoid tissue (MALT) lymphoma. The lymphoma cells expressed B cell markers with a phenotype of IgG and λ type. It is difficult to make a firm diagnosis of a MALT lymphoma from only small biopsy specimens. Accordingly it is necessary to complete the observed clinical process, endoscopic and roentgenographic findings with immunohistochemical characteristics to determine diagnosis. The MALT lymphoma should be treated as a low-grade malignancy and diagnosis sufficiently early can lead to a favorable prognosis.抄録全体を表示PDF形式でダウンロード (4405K) -
A Case ReportYUMIKO NAGAO, MICHIO SATA, KUNITAKA FUKUIZUMI, HIROSHI HARADA, YUMIKO ...1996 年 43 巻 1 号 p. 97-100
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーPreviously, we reported the high prevalence of hepatitis C virus (HCV) infection in patients with oral cancer or oral lichen planus in Kyushu, Japan. We now report a 61-year-old man with chronic hepatitis C and no oral lesions who developed oral cancer 6 months after interferon therapy (interferon α [HLBI], 6 million units (MU) daily for 2 weeks and then 3 times a week for 14 weeks). This case emphasizes the need for periodic oral cavity examinations of hepatitis C patients and contributed to the investigation of oral cancer and HCV.抄録全体を表示PDF形式でダウンロード (1702K) -
NAOTAKA MURAKAMI, TAKAHO TANAKA, YASUHIRO OHMORI, YUICHIRO SHIROUZU, S ...1996 年 43 巻 1 号 p. 101-106
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWe experienced a case of rectal schwannoma which was diagnosed before surgery. In this paper we have described this rare case and have discussed a number of similar cases reported in the literature.抄録全体を表示PDF形式でダウンロード (3537K) -
Assessment in One Case Treated with a Benzodiazepine Anxiolytic DrugHIROO KUWAHARA, MASATOMO SUETSUGI, YASUSHI MIZUKI, MASATOSHI TANAKA1996 年 43 巻 1 号 p. 107-113
発行日: 1996/04/01
公開日: 2009/08/11
ジャーナル フリーWave-form analysis and detection of sleep spindles should be automatically performed to achieve objective and highly precise determination of the pattern of appearance of sleep spindles. The conditions fo constructing the automatic analysis and detection are as follows: 1) it is recommended that EEGs be sampled at 500 Hz or higher intervals; 2) the digital filter with the threshold that is most appropriate for removal of artifacts should be used; 3) various conditions for the analysis and detection of wave-forms are widely used; and 4) a procedure for inspecting and reading record paper should also be included in the set-up. Taking these points into consideration, the authors developed an automatic analysis system for sleep spindles, which employs a computer. The system was applied to a case preliminarily treated with a benzodiazepine anxiolytic drug, ethyl loflazepate (CM6912). The assessment using this system revealed that the CM6912 administration induced an increase in sleep spindles, delayed frequency, and caused amplitude increases and a prolonged duration. frequency, and caused amplitude increases and a prolonged duration.抄録全体を表示PDF形式でダウンロード (4445K)
- |<
- <
- 1
- >
- >|