Histochemical studies of Human Papillomavirus (HPV) were carried out in 16 cases of cervical condyloma of the uterus using the Vira-type HPV tissue hybridization kit (Torei-Fuji Bionics). 1) Nine of the 16 cases immunohistochemically demonstrated 6/11 type HPV-DNA. 2) Five of the 9 cases showed a positive reaction to antigen-antibody immunohistochemical staining. 3) The epithelial distribution of positive HPV-DNA hybridization was as follows: upper 1/3 layers in 3 cases (33.3 %), upper 2/3 layers in 4 cases (44.5 %), and all layers in 2 cases (22.2 %). 4) There were more findings of koilocytosis, dyskeratosis and parakeratosis in positive HPV-DNA cases than in negative cases.

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Serum sialic acid and C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) in 40 patients with juvenile rheumatoid arthritis (JRA) and 9 patients with childhood systemic lupus erythematosus (SLE) were studied. There was a significantly higher level of serum sialic acid in active JRA patients (108.9±26.1 mg/dl) than in control subjects (67.9±10.2 mg/dl) and inactive JRA patients (76.8±11.4 mg/dl). There was significant correlation between serum sialic acid and ESR. The results demonstrated that serum sialic acid can be useful as an indicator of disease activity in JRA. Furthermore, serum sialic acid was a more valuable factor than ESR in cases with a polyarticular onset and seronegative JRA. Serum sialic acid level and ESR usually were normal (66.4±18.9 mg/dl) in childhood SLE even though the disease was active and/or there was infection. We suggest that, in cases of childhood SLE, CRP can be an important indicator in distinguishing between relapse and infection when a patient has a high fever.

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Distribution of arterial supply in human skeletal muscles has been examined in a series of our laboratory studies. This paper reports on the distribution of arterial supply observed by injecting acrylic pigment into the arteries of the extensor hallucis longus muscles of 10 bodies with 20 sides in the cases of Japanese adults. The muscle is mainly supplied by a branch from the A. tibialis anterior (Ta) after running through the membrana interossa cruris (mic). In many cases, a portion of the muscle (around its origin) is supplied by a branch of the A. peronea (Pe) after running through the mic. Among these arterial branches of the muscle are the R. extensor hallucis longus (Rehl) which supplies this muscle alone, and branches which are common with other muscles (om). 1) Classifications of arteries and frequency of their distribution Type I-a: A. recurrens tibialis anterior (Rta), which branches from Ta just after entering mic, is distributed in the upper-upper part of the muscle, and Ta (om), TA (Rehl) and Pe are distributed in the upper-lower, middle and lower parts, respectively, of the muscle…(5 %). Type I-b: Same as Type I-a but lacking Rta…(80 %). Type II-a: Same as Type I-a but lacking Pe…(5%). Type II-b: Same as Type I-b but lacking Pe…(10%). In the case of the types-a, in which Rta is distributed, the upper-upper part of the muscle is well organized. In regard to branches of the Ta, the ramus perforans (pb) is present in half of all cases, proceeding on to supply the M. extensor digitorum longus after running through the Ta. The Type I-a arterial supply exists on both the right and left sides of the body (male). 2) Nutrient artery areas of distribution Type I-a: Ta (Rta), 7.9 %; Ta (om), 60 %; Ta (Rehl), 36.1 %, and Pe, 4.2 %. Type I-b: Ta (om), 58.6 %; Ta (Rehl), 36.1 %; Ta (other branches), 0.6 %, and Pe, 4.8 %. Type II-a: Ta (Rta), 9.0 %; Ta (om), 48.4 %, and Ta (Rehl) 42.6 %. Type II-b: Ta (om), 65.6 %, and Ta (Rehl), 34.4 Ta is present in 96.0 % of all cases, while Ta (om) is present in an average of 58.9 % (pb is present in 27.1 % of these). Ta (Rehl), which is present in all cases, accounts for a 35.8 % area of distribution. 3) The total numbers of nutrient arterial branches counted ranged from 11 to 22, with 14 (20 %) and 16 (20 %) registering the highest frequencies.

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Case 1 was a 28-year-old female who complained of unsymmetrical breasts. Mammography, ultrasonography and MRI revealed a 7.2×6.8 cm adenolipoma in the right breast, and resection was performed. Case 2 was a 43-year-old female who complained of a small tumor in the lower/outer quadrant D area of her right breast. The first examination confirmed a tumor in the right breast D area. Another larger tumor measuring 5.2×4.6 cm was detected by palpation in the upper/outer quadrant CE area in the same breast. The D area tumor was diagnosed as a cyst by ultrasonography, and the CE area tumor was suspected of being an adenolipoma. Only the adenolipoma was resected. Generally, subjective symptoms are very scarce in cases of adenolipoma, but mammography and MRI examinations are effective in diagnosis of this disease Adenolipoma of the breast is a rare benign tumor, and only 13 cases including our one have been reported in Japan.

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A 16-year-old female was admitted with complaints of headache and fever. At admission, she demonstrated a stiff neck, Homer's sign, papilledema, mild paraparesis, bilateral Babinski's sign, and neurogenic bladder. Her blood sedimentation rate was 69 mm/h. A tuberculin skin test was moderately positive. Cerebro-spinal fluid analysis revealed a cell count of 156/μl (92 % lymphocytes), protein 560 mg/dl, and glucose 23 mg/dl. Chest X-ray revealed mild pleural effusion on the right side. Although tubercle bacilli were not detected, a diagnosis of tuberculous meningitis was made on the basis of the aforementioned findings. Anti-tuberculosis drugs and prednisolne were administered. On the 30 th day after onset, and 7 th day of therapy, superficial sensory loss and root pain at Th3-Th9 developed. Superficial sensory loss then extended to Th9-Thll on the right side. Spinal arachnoiditis was confirmed by myelogram and MRI. MRI was especially useful for visualizing the location and degree of the lesion. Since 1956, this and 11 other cases of tuberculous spinal arachnoiditis caused by the spread of infection from intracranial meningitis have been reported in Japan. Anti-tuberculosis drugs and corticosteroids should be administered as soon as possible to prevent the development of arachnoiditis. It also is important to commence radiological examination in the early stages.

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