JOURNAL OF THE KYORIN MEDICAL SOCIETY
Online ISSN : 1349-886X
Print ISSN : 0368-5829
ISSN-L : 0368-5829
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Volume 25, Issue 3
Displaying 1-18 of 18 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1994 Volume 25 Issue 3 Pages Cover9-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.Cover9
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1994 Volume 25 Issue 3 Pages Cover10-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.Cover10
    JOURNAL FREE ACCESS
    Download PDF (248K)
  • Evaluation of Imaging Capability of Microcatheters for Hepatic Artery Using Various Kinds of Contrast Material : In vitro and In vivo Study
    Sintarou DOUNO
    Article type: Article
    1994 Volume 25 Issue 3 Pages 413-422
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.413
    JOURNAL FREE ACCESS
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    In order to establish the optimal injection technique for abdominal digital subtraction angiography (DSA), flow rate measurment was performed under various combination of the currently available iodinated contrast materials and different types of coaxial microcatheters. In vitro study was done utilizing a plastic model of abdominal aorta with the tip of catheter positioned at the presumed proper hepatic artery. Twenty ml of contrast material was injected by a pressure injector with a rate of 3 ml/sec at 300 or 600 psi and actual flow volume was measured. In vivo study was performed also by placing the catheter tip at the proper hepatic artery using the same injection factors. Evaluation of imaging capability was made by calculating iodine delivery rate (IDR) in in vitro study and by visual scoring in in vivo study. The results suggest that the best quality DSA images with injection to the proper hepatic artery using coaxial microcatheter can be obtained by the nonionic monomeric contrast materials of medium concentration.
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  • Rectal Mucosal Blood floow in Ulcerative Colitis
    Hisashi ITO, Shoji MARUYAMA, Ken-ichi FUKUSHIMA, Ichiro ORIMA, Akikuni ...
    Article type: Article
    1994 Volume 25 Issue 3 Pages 423-426
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.423
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    Ulcerative colitis is a chronic inflammatory disease of colonic mucosa and its pathogenesis remains unknown. Mucosal blood flow was measured by an electrolytic flow meter under colonoscopy with a sensor in the rectal mucosal layer of ulcerative colitis patients and healthy control subjects. We evaluated the effect of ulinastatin (UST) on blood flow in patients with ulcerative colitis. In the active stage of ulcerative colitis, the rectal mucosal blood flow was decreased compared with that of the healthy control subjects but it improved after venous injection of UST and predonisolone. These data indicate that microcirculatory disturbances may be involved in ulcerative colitis.
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  • The Role of TNFα and Efficacy of Protease Inhibitor in Inflammatory Bowel Disease Morbidity
    Katsuaki UNO
    Article type: Article
    1994 Volume 25 Issue 3 Pages 427-437
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.427
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    Recently, it has been reported that cytokines are related to the morbid state of inflammatory bowel disease, and one of them, TNFα rises to a high level in the active stage. Our institution first discovered that protease inhibitors have inhibitory effects against TNFα products. We examined 83 cases of this disease to elucidate future application. Camostat mesilate, a protease inhibitor with inhibitory effects against TNFα products was added to a floating culture of monocyte from the patient, and it effectiveness was ascertained. After that, a clinical study on camostat mesilate showed significant improvement in 92.3% out of 13 cases of Crohn's disease and 81.2% out of 16 cases of ulcerative colitis. Treatment employing protease inhibitors has not yet been reported. Also, there is a good possibility that camostat mesilate will allow a reduction in steroid hormone treatment, and thus decrease the unfavorable side effect of the latter. It appears remarkably effective to cure inflammatory bowel disease.
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  • Radiotherapy Combined with Intracavitary Irradiation for Uterine Cervical Cancer : Study of Survival Rate, Patterns of Recurrence and Complication
    Junko KUSUDA, Yoshiyuki MIZUTANI, Ayako YOSHINO, Makoto TAKAYAMA, Yosh ...
    Article type: Article
    1994 Volume 25 Issue 3 Pages 439-447
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.439
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    Survival rates and patterns of recurrence in 137 patients with uterine cervical cancer were determined. These patients were treated by radiotherapy with high-dose rate intracavitary irradiation using remote afterloading system (RALS) at Kyorin university Hospital from Oct. 1987 to Dec. 1992. Age range was from 29 to 87 years. According to clinical staging of UICC, stage I, II, III, and IV were observed in 29, 62, 33, and 13 cases respectively. Cumulative 5-year survival rate of all cases was 72 %. Cumulative 5-year survival rates were 100 % for stage I, 81 % for stage II, 38 % for stage III, and 27 % for stage IV. Cumulative 5-year survival rates of the postoperative radiotherapy and radical radiotherapy groups were 75 % and 90 % respectively. There was significant difference of survival rates between the postoperative radiotherapy group and the radical radiotherapy group. As patterns of recurrence, extrapelvic metastasis was more frequent than local recurrence. In stages II and III, recurrent patterns were extrapelvic metastasis in most cases. Of 18 cases with extrapelvic metastasis, there were 10 cases of paraaortic lymphnode metastasis. With increase in the control rate of parraortic lymphnode metastasis, survival rate of patients with uterine cervical cancer increased. Four of 5 cases with local recurrence controled by intracavitary irradiation is effective for local recurrence control. Rectal and bladder complications following radiotherapy were observed in 25 cases. However, all cases with complication after radiotherapy were treated conservatively, excluded 1 case (vasicorectal fistula).
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  • Identification and Characterization of Ca^<2+>-transport ATPase from Bovine Aortic Smooth Muscle Microsomes
    Makoto USHIMARU
    Article type: Article
    1994 Volume 25 Issue 3 Pages 449-460
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.449
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    Crude microsomal fraction was prepared from bovine aortic smooth muscle. The aortic microsome (AM) retained a membrane bound Ca^<2+>-pump activity that was two orders of magnitude lower than that of skeletal muscle sarcoplasmic reticulum (SR). When AM mambrane proteins, solubilized with polyoxyethyleneglycol-9-laurylether (C_<12>E_9), were separated by a column chromatography in the presence of the detergent, the protein with apparent molecular mass of about 100 kDa was eluted together with other membrane proteins. Adenosine 5'-triphosphate (ATP)-dependent Ca^<2+>-transport activity was restored when proteoliposomes were reconstituted from this fraction with soybean asolectin. Rabbit antiserum raised against the 100 kDa protein crossreacted with the Ca^<2+>-transport ATPase of rabbit skeletal muscle SR. Furthermore, antibody against Ca^<2+>-transport ATPase purified from scallop adductor muscle SR recognized the 100 kDa protein of AM as well as Ca^<2+>-ATPase of rabbit skeletal SR. The 100 kDa protein was phosphorylated with ATP to form an acylphosphate in the same manner as the Ca^<2+>-transport ATPase of skeletal SR. When AM membrane was solubilized in C_<12>E_9 and passed through a calmodulin linked affinity column, the 100 kDa protein was not retained by the column, and almost all this protein was recovered from the passed through fraction. These results suggest that 100 kDa protein of AM membrane has the same characteristics as the Ca^<2+>-transport ATPase of SR in the skeletal muscle.
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  • Antioxidant Action of Furan Fatty Acids : Reactions with Reactive Oxygen Species
    Youji OKADA
    Article type: Article
    1994 Volume 25 Issue 3 Pages 461-476
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.461
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    As a continuation of the work on the biological roles of naturally occurring furan fatty acids (Furan acids), I studied on their antioxidant activity, especially the ability to scavenge biologically important oxidants, peroxy] radical (ROO・), hydrogen peroxide (H_2O_2), hydroxyl radical (・OH), superoxide (O_2^-) and hypochlorous acid ion (-OCl). Scavenging of t-butylperoxyl radical ((CH_3)_3COO・) was confirmed by electron spin resonance (ESR) spectrometry, using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trap. The antioxidant action of furan acids during oxidation of linoleic acid in aqueous dispersion previously reported can thus be explained as primarily due to the ability to scavenge the linoleic acid peroxyl radical (LOO・). These acids effectively react with ・OH, an extremely strong oxidant, with a second-order rate constant of 1.71×10^<10>M^^<-1>s^<-1>, as determined by ESR spectrometry. The ability of Furan acids to scavenge ・OH was compared with that of known ・OH scavengers such as dimethylsulfoxide, mannitol, histidine and ethanol. They are also a strong inhibitor of linoleic acid oxidation initiated by ・OH. They are scavengers of -OCl, being able to protect α_1-antiproteinase from inactivation by -OCl. In contrast, reactions of Furan acids with H_2O_2 and O_^- could not be detected by the methods in this study. Overall, these results show Furan acids to possibly be useful as antioxidants in biological systems.
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  • [title in Japanese]
    Article type: Bibliography
    1994 Volume 25 Issue 3 Pages 477-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.477
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages 479-480
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.479
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages 481-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.481_1
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages 481-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.481_2
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages 481-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.481_3
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages App8-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.App8
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages App9-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.App9
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1994 Volume 25 Issue 3 Pages App10-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.App10
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1994 Volume 25 Issue 3 Pages Cover11-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.Cover11
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  • [title in Japanese]
    Article type: Cover
    1994 Volume 25 Issue 3 Pages Cover12-
    Published: September 30, 1994
    Released on J-STAGE: February 13, 2017
    DOIhttps://doi.org/10.11434/kyorinmed.25.Cover12
    JOURNAL FREE ACCESS
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