[in Japanese]

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At first part, historical development of psychotherapy for schizophrenia is reviewed. After Freud's pessimism about it, there are many successors who want to apply psychotherapy for schizophenia. Comparing with early 1930, recently the number of the papers about psychotherapy for schizophrenia had a tendency to decrease, but it is understood as one of the important approach for schizophrenia. In the second part, mainlv the basic theory and practice of phychotherapy are discussed. As in the other therapy for schizophrenia, there are basic method and practice for them, and except the ideas it is very difficult to succeed in treating and understanding schigophrenics.

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A 36 year old man. March, 1968 : He was admitted to a hospital on suspicion of hypoplastic anemia or aleukemic leukemia. Then he suffered from serum hepatitis following blood transfusion. November, 1968 : The patient, admitted to the Internal Department of Gunma University Hospital, received blood transfusion and insulin therapy under the diagnoses of aplastic anemia and diabetes mellitus. But his diabetes could not be successfully controlled with insulin. September, 1969 : The hemogram showed the appearance of immature leukocytes, and the simultaneous studies of iliac bone marrow revealed gradual increase in promylocytes. January, 1970 : He finally died, presenting the symptom like bronchopneumonia. Autopsy findings Hemosiderin pigmentation : In the liver and pancreas most remarkable hemosiderin pigmentations were observed along with advanced fibrosis. The exocrine glands, endocrine glands, and myocardium also showed marked pigmentation. The spleen, lymph nodes, and bone marrow had considerable pigmentation as well. As to the skin, the epidermis showed increased in melanin pigment and the sweat glands exhibited pigmentation of hemosiderin. Leukemic cell infiltration : Marked infiltrations were found in the spleen, lymph nodes, bone marrow, liver, adrenal glands, kidneys, and heart. Fungus infection : Mucormycosis was recognized in the lungs, menignges, heart, ribs, stomach, and kidneys. Aspergillosis was found in the right lung together with mucormycosis, and candidiasis was recognized on the bases of lingual and gastric ulcers. As mentioned above, this case showed the histologic picture almost indistingulishable from idiopathic hemochromatosis except for slight hepatic fibrosis and finally he died of infarction resulting from pulmonary mucormycosis.

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Atropine has been used as an antispasmodic agent for a great many years. But, owing to its inconvenient side effects, such as mouth dryness and mydriasis, the use of atropine was sometimes questionable. In this test, we used atropine-N-n-octyl bromide (Ad 122), one of synthetic antispasmodic agents, as an analgesic in a broad sense, for the treatment of gynecological disorders. The obtained effective results were as follows : Efficiency for all cases : 70.1% Efficiency for abdominal and lower abdominal pains : 81.0% Efficiency for lumbago : 53.3% Objective and subjective side effects were not recognized in any cases. This drug seems to have considerable analgetic effect on abdominal and lower abdominal pains, when it is used in parallel with the aetiological treatments.

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It is well known that antibiotics treatment causes the disturbance in intestinal microflora followed by some disorders, such as diarrhoea, gastrointestinal disorders, superinfections, increased susceptivility to salmonellae etc. On the other hand, it has been reported that the above described side reactions of antibiotics could be inhibited by the combining administration of an antibiotic resistant enterococcus-Str. fecalis B1O-4R-, with antibiotics. In the present studies clinical effect of Enteronon-R was investigated for gynecological patients who were treated with ABPC-an synthetic penicillin. As the control a part of patients was treated with ABPC without Enteronon R. Furthermore, enterococcal flora and fate of B 10-4R in feces of the patients were also investigated. As the result, effect of Enteronon R could not be confirmed clinically in this studies, because any side reactions of ABPC were not observed in both experimental group and control group. However, it was demonstrated that the enterococcal flora was greatly decreased after ABPC treatment and the decreased flora was normalized by a combined administration of Enteronon R. In addition, from the state of colonies and drug-resistance, the authors learned that antibiotic resistant enterococcus possibly settled to increase in intestinal tract. Side effects supposed to be caused by Enteronon R could not be recognized.

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