JOURNAL OF THE KYORIN MEDICAL SOCIETY

[title in Japanese]

Article type: Cover
2001 Volume 32 Issue 2 Pages Cover5-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.Cover5

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[title in Japanese]

Article type: Cover
2001 Volume 32 Issue 2 Pages Cover6-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.Cover6

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages App4-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.App4

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A Study on MR images of the Articular Cartilage in Medial-Type Osteoarthritis of the Knee

Hiroyuki MIYAZAKI, Yoshiaki ISHII, Mitsutoshi HAYASHI, Akihiro KOTANI

Article type: Article
2001 Volume 32 Issue 2 Pages 125-131
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.125_2

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Changes in the articular cartilage of 88 knees of 73 cases (age range 40〜78) diagnosed clinically and radiologically as OA (osteoarthritis) were studied by obtaining fat-suppressed MR images of the knee. On 27 knees out of the 88, moreover, macroscopic observation was performed to make a comparative study between the directly-observed findings and MR findings. Fat-suppressed MR images were obtained sagittally by 3D-FLASH (fast low angle shot) sequence. The examined regions consisted of the following 4 sites; the medial condyle of the femur, its lateral condyle, the medial condyle of the tibia, and its lateral condyle. The revealed conditions of the cartilage were morphologically classified into 4 Stages. The evidence of cartilage defect on MR images was most frequently found at the medial condyle of the femur, with the medial condyle of the tibia, the lateral condyle of the femur, and the lateral condyle of the tibia following in a less frequent order. Fat-suppressed MRI's sensitivity to cartilage defect against macroscopy was 94.5%, specificity 95.4%, and accuracy 95.2%. MR imaging using fat-suppression can reveal cartilaginous degeneration and defect so well that this technique provides an important indication for selecting a proper method of treatment.

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The influences of dopamine receptor antagonists on caffeine induced behavioral stimulant effect in rats.

Ryuji KATO, Chika MURAKAMI, Masae INOUE, Kunie KAMATA, Mikio NAKAMURA

Article type: Article
2001 Volume 32 Issue 2 Pages 133-139
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.133

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Previously we demonstrated that caffeine-induced behavioral stimulant effect is consequences of adenosine A_2 receptors blockade. Adenosine A_2 receptors are localized at striatum, nucleus accumbens and olfactory bulb. Furthermore it is well known that these regions were controlled by dopaminergic neuronal system. Present study examined the effects of dopamine receptor antagonists on caffeine-induced behavioral stimulant effect, using behavioral pharmacological methods. Locomotor activity was evaluated with the Open-Field apparatus. Intraperitoneal administration of caffeine (0, 3.3, 10, 30 mg/kg) dose-dependently increased locomotor activity in rats. Moreover, behavioral stimulant effect of caffeine (10 mg/kg) was dose-dependently attenuated by pretreatment of non-selective dopamine receptor antagonist (haloperidol ; 50, 100, 200 μg/kg i.p.), selective dopamine D_1 receptor antagonist (SCH-23390 ; 50, 100, 200 μg/kg i.p.), selective dopamine D_2 receptor antagonist (raclopride ; 0.5, 1.0 mg/kg i.p.), respectively. These results suggest that caffeine-induced behavioral-stimulaing effect may be related to the central dopaminergic neuronal system.

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Quantitative Analysis of Stress Proteins (Hsp70, Ubiquitin) for Diagnosis of Cause of Death in Forensic Autopsy Cases

Sakurako MATSUMURA

Article type: Article
2001 Volume 32 Issue 2 Pages 141-150
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.141

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This study is to estimate gene expression levels in stress protein such as Hsp70 and ubiquitin (Ub), for analyzing the causes of death, and to prove the findings being an effective measure to for a proper forensic diagnosis. Hsp70 level is significantly higher in heart, lung, spleen, and thymus of infant asphyxia than that observed in the infant endogenous group. The heart showed the highest level of the expression among other organs examines in the asphyxia group. The level of Ub did not show any significant difference among all organs between child asphyxia and child endogenous disease group. The result proved that Hsp70 measurement in the organs would provide a useful information to make forensic diagnosis in child asphyxia.

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A Case of Hepatopulmonary Syndrome with Compensated Alcoholic Cirrhosis

Yoshihisa SATO, Hideki TOKUUE, Toshiaki TANAKA, Saeko YAJIMA, Yasuharu ...

Article type: Article
2001 Volume 32 Issue 2 Pages 151-155
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.151

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A 62-year-old male was admitted in our hospital because of shortness of breath on exertion. He had been diagnosed as alcoholic cirrhosis by laparoscopic findings two years ago. His liver function was compensated state on admission. He showed severe hypoxia (PaO_236.1 mmHg) and severe disturbance of diffusing capacity of the lung. The chest film showed enlargement of the intrapulmonary vessels. The pulmonary perfusion scintigraphy showed severe uptake in the lungs, spleen, brain, kidneys and the other organs. According to these findings he was diagnosed as hepatopulmonary syndrome (HPS). He was treated by prostaglandin inhibitor and Chinese medicine for the porpose of decrease of nitric oxide. Its showed no effective, and he died of acute pneumonia. Patients with HPS generally have a poor prognosis, even if diagnosis is made at the early stage of the disease. Also HPS patients tend to complicate with decompensated liver cirrhosis. We believe it is important for discussing about this unusual and interesting case to know the pathophysiology of HPS.

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages 156-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.156_1

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages 156-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.156_2

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages 156-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.156_3

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages App5-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.App5

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages App6-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.App6

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages App7-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.App7

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[title in Japanese]

Article type: Appendix
2001 Volume 32 Issue 2 Pages App8-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.App8

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[title in Japanese]

Article type: Cover
2001 Volume 32 Issue 2 Pages Cover7-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.Cover7

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[title in Japanese]

Article type: Cover
2001 Volume 32 Issue 2 Pages Cover8-
Published: June 30, 2001
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.32.Cover8

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