巻号一覧
25 巻 (2000)
- 6 号 p. 270-
- 5 号 p. 214-
- 4 号 p. 142-
- 3 号 p. 102-
- 2 号 p. 52-
- 1 号 p. 2-
25 巻, 2 号
選択された号の論文の7件中1～7を表示しています
- |<
- <
- 1
- >
- >|
-
酒井 秀紀2000 年 25 巻 2 号 p. 52-59
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーThis review summarizes about recent progress in the field of water channels (aquaporins) and volume-sensitive Cl-channels. Both channel proteins are deeply associated with the mechanism of water (liquid) permeation across the plasma membrane of cells. Aquaporins directly contribute to permeation of water molecules. So far, 10 kinds of mammalian aquaporins have been cloned and characterized. Each aquaporin has distinct characteristics in its biochemical, pharmacological and physiological aspects. Volume-sensitive K+ and Cl- channels are swelling-activated and involved in the cell volume regulation (regulatory volume decrease). Activation of the ion channels by hypotonic shock leads to the extrusion of water from cells. The swelling-activated Cl- channels in hepatocytes are inhibited by endogenous production of arachidonic acid. The cDNA coding volume-sensitive Cl- channels has not yet been found.抄録全体を表示PDF形式でダウンロード (1068K) -
市橋 等2000 年 25 巻 2 号 p. 60-66
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーThis report briefly describes overview of pharmaceutical formulation development of nifedipine once a day tablets. A technology applied to achieve once a day formulation was combination of coat-core structure of a tablet and hydrophilic matrix which release a drug substance slowly from a tablet in accordance with eroding process. Single erosion tablets were not successful because of loss of bioavailability of nifedipine. On the other hand a coat-core tablet which had a faster dissolving core part could achieve comparative bioavailability with a conventional tablet (nifedipine retard tablet Adalat L). Dissolution rate of coat layer and nifedipine ratio between coat and core were adjusted. Eight tablets were selected by mean of in vitro screening of dissolution testing and evaluated in dogs. The final tablet was selected by human pharmacokinetics study among four tablets. The selected tablet showed two peaks in plasma concentration profiles and achieved long lasting plasma concentration.抄録全体を表示PDF形式でダウンロード (812K) -
浅井 泰行2000 年 25 巻 2 号 p. 67-72
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーE5531, a synthetic disaccharide analog of the lipid A, was dispersed using a novel “pH-jump method”, which involves dispersing E5531 in an alkaline solution (0.003 N NaOH, pH 11.0) at 50°C and then mixing the solution with buffer to neutralize the pH 7.3. The size of the aggregates was approximately 20 nm and the structure was vesiclar. The membrane fluidity of the aggregates increased with increasing the dispersing time in 0.003 N NaOH solution. Using the samples with different membrane fluidity, the pharmacokinetics and ED50 were evaluated after intravenous administration into rats and mice. The data obtained confirmed that the membrane fluidity was correlated with the pharmacokinetics in rats and ED50 in mice.
The biological effects of E5531 were investigated. The pyrogenic activity of E5531 was weak and the profile of the increase in the rectal temperature of rabbits was different from that of the USP reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits.
In addition, in order to evaluate the effects of E5531 on the cell surface membrane, we used dipalmitoylphosphatidylcholine (DPPC) as a model membrane. E5531 decreased the phase transition temperature of DPPC and increased the fluidity at 37°C. These effects of E5531 on DPPC membrane were different from those of the lipid A from Escherichia coli and Salmonella minnesota.抄録全体を表示PDF形式でダウンロード (674K) -
Balagopal N. Nair, Tatsuya Okubo, Shin-ichi Nakao2000 年 25 巻 2 号 p. 73-85
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーMicroporous silica membranes are highly suitable for gas separation processes due to their high selectivity, and high stability at enhanced temperatures and in chemically aggressive environments compared to their polymeric counterparts. Sol-gel synthesis of silica sol and coating a substrate with that sol is the best-known way to produce microporous silica membranes. The structure of silica polymers/particles in the sol is the most important parameter deciding the final properties of the membrane. In this paper, some of the reported membrane processing methods and properties are compared to elucidate the structure of the membrane pores.抄録全体を表示PDF形式でダウンロード (1690K) -
寺本 正明, 松山 秀人, 大西 宣昭2000 年 25 巻 2 号 p. 86-92
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーExperiments on the removal of phenol by emulsion liquid membrane containing aqueous LiOH or NaOH solution in the inner aqueous phase were performed using a one-stage continuous stirred vessel and a two-stage countercurrent mixer-settler, and the effects of operation conditions such as phenol concentration, feed and emulsion flow rates and stirring speed on the pehnol removal were investigated.
When the liquid was withdrawn from the lower position of the stirred vessel, the hold-up (volume fraction of W/O emulsion) in the vessel increased, resulting in high phenol removal compared to the case when the liquid was withdrawn from the higher position of the vessel. The stage efficiency was more than 90% and at favorable conditions, the efficiency was as high as 99%, indicating very effective contact between external aqueous phenol solutions and W/O emulsion drops in the stirred vessel. The two-stage countercurrent mixer-settler was very effective for achieving high phenol removal. The W/O emulsion loaded with phenol could be demulsified by an electrocoalescer.抄録全体を表示PDF形式でダウンロード (896K) -
Sachio Miyairi2000 年 25 巻 2 号 p. 93-96
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーReduction of 2, 6-dichlorophenol indophenol (DPIP) with diphenylcarbazide (DPC) as a reductant was pH-dependently accelerated by surfactant micelles of anionic SDS, cationic CTAB, zwitterionic sulfobetaine-14 (SB-14) and nonionic lauryldimethylamine-N-oxide (LDAO). The acceleration effect was larger at acidic side than alkaline side with any surfactant, though its degree varied with the species of the surfactants. At pH 4.5, SDS accelerated the reaction by about 50 times which was the largest rate among those given by any surfactant at pH 4.5-8.1. Experimental results suggested that microenvironment as well as concentration of the reactants in micellar sphere might affect pH-dependent acceleration to an inherent extent of surfactant species.抄録全体を表示PDF形式でダウンロード (398K) -
礒部 真一, 長谷川 崇吉, 松本 吉正2000 年 25 巻 2 号 p. 97-99
発行日: 2000/03/01
公開日: 2011/03/04
ジャーナル フリーTypical modular-type filters have the housing and filter packed in one unit which must be replaced with an entirely new unit in order to exchange the filter. In pursuit of environmental preservation, we developed a new cartridge-type hollow fiber filter with a separate filter cartridge to be replaced by a new one, thus reducing cost and waste. This new full-size cartridge has a large diameter of six inches and an increased effective filtration area to efficiently handle large-volume capacity.抄録全体を表示PDF形式でダウンロード (674K)
- |<
- <
- 1
- >
- >|