巻号一覧
35 巻 (2010)
- 6 号 p. 261-
- 5 号 p. 210-
- 4 号 p. 160-
- 3 号 p. 100-
- 2 号 p. 42-
- 1 号 p. 2-
35 巻, 5 号
選択された号の論文の8件中1～8を表示しています
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巻頭言
特集：境界領域シンポジウム「材料と細胞および生体成分との相互作用」
総説
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竹本 直紘, 寺村 裕治, 岩田 裕治2010 年 35 巻 5 号 p. 210-216
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスSurface modification of living cells with natural or synthetic polymers is a useful tool in biomedical engineering. Various functional groups and bioactive substances can be introduced to the cell surface through covalent conjugation, hydrophobic interaction, or electrostatic interaction. In this review, we provide an overview of methods and polymers employed in cell surface modification, and also discuss their applications to transplantation of islets of Langerhans for treatment of type 1 diabetes.抄録全体を表示PDF形式でダウンロード (895K) -
石原 一彦, 井上 祐貴, 松野 亮介2010 年 35 巻 5 号 p. 217-223
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスPreparation and characterization of the cell membrane-inspired polymer materials, which contain 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, are reviewed. The MPC polymer can provide the biointerface to suppress completely the interactions with proteins and cells. Also, on the surface, the biomolecules are immobilized without significant reduction of the their biological activity. Polymer nanoparticles covered with the biointerface and contained quantum dot (QD) s is prepared as the novel bioimaging devices. The kinetic behavior in cytoplasm of the polymer nanopartcles is discussed. Although this nanoparticles can avoid the nonselective cellular uptake from mammalian cells, when bioactive molecules are immobilized, the nanoparticles can provide the various information about the specific interaction between biomolecules and cells. From these findings, it is concluded that the nanoparticles are candidates for the role of stable and highly sensitive fluorescent bioimaging probes in the fields of nanomedicine. Controlling interactions with cells is receiving considerable importance in biomedical fields, including nanobioengineering and cell and tissue engineering. The biointerface described here are a promising design for revealing a universal platform that integrates polymer chemistry; material science; and engineering, biochemistry, cell biology, and nanofabrication.抄録全体を表示PDF形式でダウンロード (847K) -
～リポソームを1単位とする材料創成を目指して～馬越 大2010 年 35 巻 5 号 p. 224-229
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスLiposome, a closed phospholipid bilayer membrane, can induce the “molecular recognition” function under “stress” condition through its stress-response dynamics, resulting in the induction of new values on its surface. The utilization of their functions could enable us to design and develop a new-conceptual membrane system which can mimic the potential and real functions of biomembrane.抄録全体を表示PDF形式でダウンロード (1371K)
特集：日本膜学会膜学研究奨励賞（2010）受賞総説
総説
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吉井 範行2010 年 35 巻 5 号 p. 230-235
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスA novel analytical methodology was developed by using NMR experiments and a large scale molecular dynamics calculation to obtain detailed information on thermodynamic stability, mobility, and kinetics of binding/dissociation of drugs in lipid membranes and micelles. First, the drug binding and mobility in lipid bilayer membrane were quantified in situ by using the multinuclear solution NMR combined with the pulsed-field-gradient (PFG) technique. One-dimensional and PFG 19F and 1H NMR signals of an anticancer drug, 5-fluorouracil (5FU) were analyzed in the presence of large unilamellar vesicles (LUVs) of egg phosphatidylcholine (EPC) as model cell membranes. The simultaneous observation of the membrane-bound and free 5FU signals enables to quantify in what amount of 5FU is bound to the membrane and how fast 5FU is moving within the membrane. The kinetics of membrane binding and dissociation was also quantified by PFG NMR. The 19F NMR signal of 5FU was analyzed by the solution of Bloch equation with exchange terms. The rate constants of 5FU binding and dissociation were determined and compared with the translational diffusion. Finally, the stability of a water molecule in the core of the micelle was investigated quantitatively from calculating the free energy of transfer from the bulk to micelle core, by using the thermodynamic integration method based on a molecular dynamics calculation.抄録全体を表示PDF形式でダウンロード (814K)
原著
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野村 幹弘, 門間 慶太, 木村 紗有佳, 松山 絵美, 三宅 遼, 内海 惠介2010 年 35 巻 5 号 p. 236-241
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスSilica-organic hybrid membranes were successfully prepared on γ-alumina substrates by using a counter diffusion CVD method. Propyltrimethoxysilane (PrTMOS) was employed as a silica source, and O3 was used as a reactant. Deposition temperatures of the CVD were very important parameters for the membrane properties. C3H6/C3H8 peremeance ratio was 12.1 at 320 °C through a membrane prepared at 320 °C. C3H6/C3H8 peremeance ratios were proportional to N2/SF6 permeance ratios showing that the C3H6/C3H8 selectivity are due to a molecular sieving mechanism. The decomposition mechanism of propyl groups on silica surface was discussed by using powders prepared by hydrolysis of PrTMOS. Propyl groups were partially decomposed under 320 °C of an O3 atmosphere. This indicates that the obtained membrane was a silica-organic hybrid membrane.抄録全体を表示PDF形式でダウンロード (733K) -
門馬 友紀, 梅野 太輔, 斎藤 恭一, 須郷 高信2010 年 35 巻 5 号 p. 242-247
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスGallium (Ga) ions as an affinity ligand were immobilized to the polymer chain grafted onto a porous hollow-fiber membrane to specifically capture phospho-compounds. An epoxy-group-containing vinyl monomer, glycidyl methacrylate, was graft-polymerized to an electron-beam-irradiated porous hollow-fiber membrane. The partial conversion of the epoxy group into an iminodiacetate group was effective in increasing the molar conversion in the subsequent introduction of a nitrilotriacetate group capable of forming a complex with Ga ions. The amount of Ga ions immobilized was 0.55 mmol per gram of the membrane. The overall rate of adsorption of phosphotyrosine to the Ga-ion-immobilized porous hollow-fiber membrane increased with an increase in the rate of permeation of phosphotyrosine solution through the pores because of the negligible diffusional mass-transfer resistance of phosphotyrosine to the affinity ligand.抄録全体を表示PDF形式でダウンロード (758K) -
Fitriani, Masashi Sekiguchi, Takao Kokugan2010 年 35 巻 5 号 p. 248-256
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスA reverse osmosis experiment was performed to separate and concentrate lactate from cassava fermentation broth. Pure lactic acid and ammonium lactate solutions were also used as model solutions. The influence of operating conditions, including feed velocity, transmembrane pressure and feed concentration, on the filtration properties (permeate flux, rejection and osmotic pressure) were studied. The concentration factor of lactic acid during batch operation of reverse osmosis was also evaluated. In the laminar flow regime, permeate flux increased with increasing of feed velocity due to concentration polarization of the solute on the membrane surface. However, the permeate flux was not affected by feed velocity in the turbulent regime. Permeate flux and rejection increased with transmembrane pressure and decreased with feed concentration due to higher osmotic pressure. At a transmembrane pressure of 5.5 MPa and an initial feed velocity of 0.7 m/s, lactic acid in the model solutions could be concentrated from three to six times; however, the concentration factor in fermentation broth only reached two. The degree of concentration increase of lactic acid was affected by the presence of medium and residual sugar in the fermentation broth, as both may contribute to the increase of osmotic pressure and also polarize the concentration effect that occurs on the membrane surface.抄録全体を表示PDF形式でダウンロード (785K)
製品 & 技術
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竹本 信一郎2010 年 35 巻 5 号 p. 257-259
発行日: 2010年
公開日: 2015/06/17
ジャーナル オープンアクセスWhile the test standard exists for conventional types of contact lenses to determine their Oxygen Permeabilities (DK Values) by Electrode Method (FATT Method) in accordance with ISO 9913-1, there has been no such standard established for optional coloured types.
In the meantime, with an increase in recent medical accident cases reported as owing to wide and extensive use of these coloured types, or their abuse, such as Angiogenesis (generation of new blood vessels) on the cornea by insufficient supply of oxygen, Ministry of Health, Labour and Welfare, Government of Japan legislated lately on April 28, 2009 that the colored types in question shall be tested for DK Values by FATT Method in accordance with ISO 18369- 4. This TRS Model K-316, introduced to meet needs under the circumstances above, is designed to allow the easy and time-saving determination of oxygen permeabilities pertinent to polymers materials and products ranging widely from films, sheets to membranes of medical applications , especially, soft contact lenses in commercially available product shape.
Presented here are features of TRS Model K-316, its Measurement Method and Principle, and Measurement Examples (by both TRS Models K-316 and K-315-N GAS PERMEABILITY TESTER per Differential Pressure Method).抄録全体を表示PDF形式でダウンロード (706K)
編集後記
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