巻号一覧
44 巻 (2019)
- 6 号 p. 276-
- 5 号 p. 210-
- 4 号 p. 142-
- 3 号 p. 92-
- 2 号 p. 40-
- 1 号 p. 2-
44 巻, 2 号
選択された号の論文の7件中1～7を表示しています
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特集：脂質膜研究の新潮流：基礎物性と応用展開
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松木 均, 後藤 優樹, 玉井 伸岳2019 年 44 巻 2 号 p. 40-49
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスPhosphatidylethanolamines (PEs) are a major kind of phospholipids found in biological membranes. They exist universally in the membranes from prokaryotes to eukaryotes and play an important roll in several membrane–related cellular processes. In this review, the thermotropic and barotropic phase transitions of bilayer membranes of various PEs with different molecular structure (chain length, chain unsaturation, chain linkage or head-group size) are systematically described by using the temperature–pressure phase diagrams and thermodynamic quantities of the phase transitions. Especially, the characteristic features of the PE bilayer membranes are explained by comparing the results with those of the corresponding phosphatidylcholine (PC) bilayer membranes.抄録全体を表示PDF形式でダウンロード (953K) -
高橋 浩, 高木 俊之, 園山 正史2019 年 44 巻 2 号 p. 50-56
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスSince the carbon–fluorine bond is one of the strongest bonds, fluorocarbons are chemically and thermally very stable. Owing to the unique properties of the fluorinated segments, fluorinated amphiphilic molecules have attracted much attention in biotechnology and biomedical research fields. In the 1990s, some partially fluorinated phospholipids were synthesized and their properties were investigated by the groups of Santaella and Vierling with the intention to apply the stable liposome made from partially fluorinated phospholipids to drug delivery. While recently we have been working on synthesizing and characterizing a series of partially fluorinated phosphatidylcholines (PF–PCs) that have even numbers of carbon atoms in their partially fluorinated acyl chains as similar to naturally occurring PCs with the intention to use PF–PCs as new tools for membrane protein researches. In this review article, we focus on 1,2–di(11,11,12,12,13,13,14,14,14–nonafluorotetradecanoyl)–sn–glycero–3–phosphocholine (F4–DMPC) within the series of PF–PCs that we synthesized, and describe the synthetic method, characterization of F4–DMPC bilayers and the behavior of bacteriorhodopsin, a membrane protein reconstituted in F4–DMPC bilayer liposomes. Finally, we briefly discuss the prospects of PF–PC as tools for membrane protein researches.抄録全体を表示PDF形式でダウンロード (854K) -
瀧上 隆智2019 年 44 巻 2 号 p. 57-62
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスSoft interfaces including liquid/liquid interfaces are regarded as a model for biological membrane. One of the fascinating subjects is heterogeneity of interfacial films such as “raft” in biological membranes. In this paper, the structure and property of adsorbed films of fluorocarbon alcohols at oil/water interfaces were examined by interfacial tensiometry, Brewster angle microscopy, and X–ray refrectometry to understand the relation between condensed domain formation and line tension. It was found that the contact energy at domain boundary of pN (10–12 N) order affects appreciably the domain morphology. The liquid ordered (Lo)/liquid disordered (Ld) coexisting in lipid vesicle was also studied by quantifying the line tension on the basis of Fourier analysis of domain boundary. A low line tension (0.2~0.8 pN) in this system would be originated from a deviation of molecular orientation from spontaneous curvature at domain boundary.抄録全体を表示PDF形式でダウンロード (879K) -
豊田 太郎, 杉山 博紀2019 年 44 巻 2 号 p. 63-68
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスIn 2001, Szostak, Bartel, and Luisi proposed a concept of “protocell” that is composed of lipid bilayer membrane and capable to evolve and continue metabolism. Eighteen years have passed since then, with the development of various technologies, the protocell has come just before the realization. The protocell is a chemical model that elaborately imitates the dynamics of living cells in a constitutive approach. In order to understand these studies, especially for graduate students and researchers from other fields, we classify chemical models of cell–sized closed lipid bilayer membrane (giant vesicle) in eight directions and discuss them here: preparation of giant vesicles, encapsulation of DNA/RNA, introduction of membrane proteins, install of cell division mechanics, self–reproduction, functionalization for motility, signal communication, and recurrent cycle of mutation and selection.抄録全体を表示PDF形式でダウンロード (1136K) -
馬越 大, 菅 恵嗣2019 年 44 巻 2 号 p. 69-75
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスThe emergent functions of liposome (vesicle) membranes were introduced, focusing on the chirality, together with the characterization of various kinds of properties of membranes. The obtained data would enable us to utilize the liposome membrane as a platform the chiral recognition and conversion of molecules.抄録全体を表示PDF形式でダウンロード (1587K) -
酒井 秀樹2019 年 44 巻 2 号 p. 76-84
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスVesicles with bimolecular membranous structure have been used as a drug carrier in drug delivery systems, a biomembrane model, and so on. Recently, vesicles have also attracted attentions with a view to application for cosmetics and foods industries since they can not only entrap water–soluble substances in their core, but also solubilize oily substances in the bilayer membrane. In this review article, photochemical control of vesicle formation using photoswitchable surfactants (azobenzene–modified surfactant, cinnamic acid–modified surfactant) and photochemical release control of encapsulated aqueous model drug are described. In addition, preparation of silica hollow nanoparticles using vesicles formed by cationic surfactant mixture as a structure directing agent is also introduced.抄録全体を表示PDF形式でダウンロード (1121K)
製品& 技術
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竹下 俊光2019 年 44 巻 2 号 p. 85-88
発行日: 2019年
公開日: 2019/04/03
ジャーナル オープンアクセスA membrane filtration has been used for various applications such as drinking water treatment, pure water recycle, and waste water treatment. Although the membrane filtration can separate impurities from water precisely, it cannot handle with many impurities more than that assumed. It is necessary for expansion of membrane filtration to improve the operation flux and anti–fouling. We have been developing “Direct coagulation membrane filtration method” that is the combination technology of the coagulation and our membrane module having a high resistance for suspended solids. We had tested “Direct coagulation membrane filtration method” in the lab–scale and the pilot–scale. In the labscale test, we could observe an effect of the coagulation for anti–fouling and detachability of suspended solids. In the pilot-scale test, we could demonstrate that our membrane module can be operated stably with coagulation.抄録全体を表示PDF形式でダウンロード (814K)
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