The activities for protecting health of inhabitants in the southern part of Ehime Prefecture (people call this part of the prefecture “Nan'yo”) has been developed by the Center of Rural Medicine, since it was established in November, 1965 as an auxiliary organization of the Ehime Prefectural Kitauwa Hospital.
Nan'yo covers an area of 1, 790.3 km² and has 348, 065 population (1970).It consists of two cities, nineteen towns and two villages, and has five Health Centers.
The phenomenon called “over-sparseness of population”, which is one of the manifestations of the contradiction inevitable to the capitalism in Japan is also observed more and more conspicuously in Nan'yo.
In this situation the Center of Rural Medicine pursues the activities of health protection based on the need of inhabitants as a part of the communal program for establishing health protection system, which is pushed forward in cooperation with the Health Centers, the Medical Association of Ehime Prefecture, Tottori University and the agricultural cooperative association.
The main features of the activities for protecting health of inhabitants are as follows.
1) To gain a closer cooperation of the administration of the prefecture
2) To establish a communal system of health protection in cooperation with various medical organizations
3) To establish hospitals based on the need of inhabitants
4) To urge the more substantial medical policy of the communities
5) To contribute to the deepening of understanding in social medicine of medical and paramedical students

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What has attracted the attention of the author in his studies of insecticide poisoning in the last 20 years is whether or not insecticides cculd possibly be detected from serum in the cases of poisoning with organophosphorous insecticides. This time, the author has been able to detect organophosphorus, used in insecticides, from the serum of 15 such cases with a gaschromatograph. He has come to realize the feasibility of detecting it, regardless whatever the quantity is, from patients affected to a considerably serious degree. No organophosphorus could be detected from the control group, suggesting that it penentrated the bodies in spraying work, but no by means of food. There are many aspects that have yet to be studied from many points of view, but the author considers the findings of this study to be of much significance to the studies of insecticides in the future.

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A study was performed on sickpersons using Alkylphosphates as agricultural chemicals to cultivate apples in the rural sections of Aomori prefecture.
The results obtained can be summarized as follows.
1) In order to diagnose the intoxication of Alkylphosphates, it is very important to measure the serum ChE of farmers having relation with agricultural chemicals.
2) Serum ChE of humans is a unspecial ferment, but it is very useful practicaly to determine serum ChE-rate clinic, aly, instead of special ChE (cell ChE).
3) According to my experiment, the alteration of serum ChE-rate is very faint underΔPh 0.60 of serum ChE-rate, so it is very necessary to determine the pathological limit-line of serum ChE onΔph 0.60 during the investigation of the intoxication of Alkylphosphates.
4) A special finding of serum ChE was found on the observation of serum ChE-rate during the intoxication of Smithion.
5) We have to be careful of mixing of agricultural chemicals also, to avoid the intoxication of Alkylphosphates, in addition to the danger of scattering of them.
6) On account of making confirm the mean of the serum ChE-rate more, it is very necessary to investigate following the ChE-rate continually a long time.
7) After the changing of the Alkylphosphates, having a strong poison, the decrease of sickpersons, suffering of the intoxication of it, is found clearly now.
8) So we have to perform the group-investigation of serum ChE of farmers using agricultural chemicals very soon, because of using a lot of Alkylphosphates since about 20 years, in the rural sections of Aomori prefecture.

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A study was performed on the liver functions of persons using alkylphosphates as agricultural chemicals to cultivate apples in the rural sections of Aomori Prefecture.The results obtained can be summarized as follows.
1) GOT-test was one sharp reaction of many liverfunction tests, being carried out after using alkylphosphates. But, a extremly high value of GOT was not found and its value returned to the normal level gradually after ending these works.
2) From the investigation of GOT-value and various conditions during using alkylphosphates, the relationship of GOT and the length of time or period for using them was not found clearly in this study.
3) ChE is a ferment against alkylphosphates and one special reaction of liverfunction test also, but the results of ChE-test was not refered in this paper. When we think of ChE-test as a liverfunction, ChE-value of some persons having the low value of ChE do not return to the normal level as shown in (I) report.
4) From the long term observation on GOT-test, a high value was seen clearly about one month after using of alkylphosphates, specially scattering of them.
5) The abnormal values of TTT, ZTT and CCLF of liverfunctions were not found in acut intoxications of alkylphosphates.
6) From the urine urobilinogen-test. the positive cases were present to some degree, but the relationship of the urine urobilinogen-test and GOT was not seen in all cases.
7) From the finding of the liverfunction-tests after the long term observation, it is quite possible that the liverfunctionslesion will advance after the repeating using of alkylphosphates, scattering or mixing of them every year. Because, the farmers, living in Aomori prefecture, used them to culivate apples since about fifteen years.
8) So I think of, may be in future. being found some persons having the liverfunctions-lesion with the another findings or symptomes. These persons may be diagnosed as the so called chronic intoxication caused by alkylphcsphates after some yedrs.
9) As he shown in next paper. a being of the chronic intoxication caused by alkylphosphates is doutful now, but some persons having the liverfunctions-lesion and the another findings are found in the rural sections of Aomori Prefecture.

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