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Volume 35, Issue 1
Displaying 1-13 of 13 articles from this issue
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Saburo USUTANI, Kazuyuki KIDA, Kunitaka NISHIYAMA, Shigeyuki NAKAJI, K ...1986 Volume 35 Issue 1 Pages 1-8
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSThe subjective symptoms, various blood components, radioallergosorbent test (RAST) and others were examined for the patients who developed nasal allergy each year during the time of artificial apple pollination (before artificial pollination, during the peak of pollination and one month after pollination) compared with those for a control group, and the following results were obtained.
1) The symptoms, the time of their appearance and the kind of symptoms were the same as those of the apple pollinosis.
2) The change in the pattern of the eosinophile count was the same as that of the subjective symptoms.
3) However, only 2 of the 11 patients had a RAST score of suspicious positive, and no difference was detected between these patients and the control group.
From these findings, the many cases of suspected apple pollen allergy were cosidered to have been sensitized by other pollen which have common antigenicity to apple pollen in addition to true apple pollinosis, or to be mistaken diagnosis of other pollen allerg.View full abstractDownload PDF (875K) -
Statistical investigation of patients who visited Department of Allergy, Saku Central Hospital from 1977 to 1983Toshihiko HORI, Hiroya OHYAMA, Yuzuru KAMBE1986 Volume 35 Issue 1 Pages 9-15
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSA statistical investigation was carried out into about 3, 000 patients who visited our department from 1977 to 1983. The results were as follows:
1. Allergic rhinitis and bronchial asthma were the most important allergic diseases in the rural area.
2. The number of patients with allergic rhinitis especially caused by pollen (so called “pollinosis”) was markedly increased in recent years.
3. Japanese cedar, orchard grass and mugwort were the most important causative agents of pollinosis in this area.
4. The number of patients of each pollinosis was largely changed by climate or other unknown factors in each year.
5. The number of patients of bronchial asthma caused by molds' spores gradually decreased.
6. An occupational pear and apple pollinosis caused by artificial pollination was considered to be the most inportant allergic disease due to farm work. Further investigations are required on this problem.View full abstractDownload PDF (744K) -
Nobuyuki HORIUCHI, Yukiho ANDO, Sukeo TSUGANE, Miyoji SHIMADA1986 Volume 35 Issue 1 Pages 16-26
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSAs part of our investigation into the allergic conditions that frequently plague farmers, we have conducted surveys on the prevalence of the skin disease which erupts probably as a result of allergic reaction. The findings are as follows:
1. Of the outpatients, 7.29% were suffering from contact dermatitis. Among the causarive agents closely related with agriculture were pesticides, chrysanthemums, lettuces, Primula obconica, melberries, rice plants, fertilizers, quicklime, celery, parsley etc. These were responsible for 17.2% of the cases of contact dermatitis.
2 Pesticide-induced dermatitis was found in 0.41% of the outpatients and 5.64% of the cntact dermatitis cases. Among the major offending pesticides were Des (DDVP), Difar (Zineb), Lannate (Mesomil), Maneb Dithane (Maneb) and Salithion.
3. The skin disease that seems to have occurred due to the exposure to sunlight accounted for 1.41% of the outpatients. Five of the dermatitis patients were victims of both sunlight and pesticides.
4. A patch test showed that Daconil, Difolatan and Altanon cause a strong, primary irritation, but their sensitizing effect is moderate when compared with Triazine and DDVP. The test also indicated that Topsin-M (Thiophanate), Salithion, Diazinon, Maneb Dithane and Dithane Stenless (Amobam) more or less render individuals sensitive.
5. A physical examination of farmers engaged in pesticide spraying revealed that 27.9% of the examinees have early signs of dermatitis on the back of their hands.
6. A follow-up survey of the patch test participants showed that most of them do not take proper measures against dermatitis caused by pesticides.View full abstractDownload PDF (1265K) -
Tetsuro FUJITA, Kazunori KATO, Yoshio TAKEDA, Yoshihisa TAKAISHI, Teru ...1986 Volume 35 Issue 1 Pages 27-33
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSSince 1976, allergic contact dermatitis caused by Chrysanthemum morifolium Ramalk (commercial name: Kinriki) occured on the grower in Tokushima Prefecture. Consequently, a systematic study aimed at the isolation of the allergen of the chrysanthemum was udertaken.
The allergens were contained in the fresh juice of the leaves of chrysanthemum and they were of two types: one was water-soluble and the other was fat-soluble, judging from the results of application test of the skin reaction for sensitized guinea pigs.
The fresh juice of the chrysanthemums was fractionated with ammonioum sulfate saturation method and the active precipitates were chromatographed on Sephacryl S-300 and DEAE-cellulose column, successively. The most active fractions contained sugar and protein, suggesting that the water-soluble principles are high molecular glyco-protein. The other hand fat-soluble fraction was obtained from ethyl acetate extract of the supernatant of 65% ammonium sulfate saturation. The extract was chromatographed on silica gel column and on the thin layer to yield 5, 7-dihydroxychromone (I) and sesquiterpens (II-VI). Unfortunately, at that time the sensitization of ginea pigs was unsuccessfuly. Therefore their compounds could not be tested for the allergenic reaction.
When the precipitates of ammonium sulfate were extrcted with ethyl acetate, the allergenic activeity of the precipitates decreased. However, re-addition of the ethyl acetate extracts to the extracted precipitates recovered the activity. Cross reaction between the juice of leaves and sesquiterpene lactone, alantolactone, failed on skin reaction of sensitized ginea pigs.View full abstractDownload PDF (815K) -
Akiyoshi BANDO, Tsuyoshi IMURA, Hajime MATSUURA, Nobuko KISHIMOTO, Har ...1986 Volume 35 Issue 1 Pages 34-38
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSWe have reported that many chrysanthemum- and lettuce-growers have dermatitis caused by juice of the leaves of these plants and that this dermatitis is caused by an allergic mechanism. In arecent questionnaire on the cause of this dermatitis, half the farmers answerd that it was due to agricultural chemicals. Therefore, we tested the farmers by skin patch tests with several widely used chemicals. In the tests, daconil gave the strongest reaction, results being positive in 60% of the farmers. Daconil was very irritative and phototoxic, the percentage of positive reactions in the patch test with 800 times diluted daconil solution of the concentration commonly used being about 30% after 48 hours and about 60% at 48 hours after peeling off the patch.
The parcentage of positive reactions in the skin patch test with several fractions of chrysanthemums on chrysanthemum-growers were significantly higher than non-farm-workers. Similary, tests with allergen extracted from lettuce showed a significantly higher percentage incidence in lettuce -growers than in other subjects. The patch test with 4000 times diluted daconil solution showed ahigher incidence in farmers than in other subjects. Therefore, 4000 times diluted daconil solution seems to cause allergic contact dermatitis in farmers, and as farmers reported, dermatitis seems to be caused by allergy to farm products, and the irritability, phototoxicity and allergenicity of TPN (Daconil).View full abstractDownload PDF (657K) -
Tsuyoshi Imyra, Akiyoshi Bando, Takashi Murata, Hiroshi Kubo, Yoshio T ...1986 Volume 35 Issue 1 Pages 39-44
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSA 52-years-old female farmer has suffered from bronchial asthma during the last 10 years during the lettuce growing season (NOV.-May). Laboratory test findings showed that her sumptoms were due to type I allergy. Namely, she showed eosinophilia, an increased level of Ig E and an immediate positive reaction to intracutaneous lettuce allergen. But, she gave negative reactions in RAST and immediate skin reaction test to 23 common allergens. By provocation tests she showed positive reactions to both the environment (FEV1.0-26.8%) and allergen inhalation (FEV1.0-30.0%), and had amoderate attack 15 minutes after inhalation of undiluted lettuce juice. The allergen was extracted from fresh lettuce juice by Coca's method. The protein concentration of the allergen was 8.74 mg/ml and its concentration in crude juice was 0.874 mg/ml.
Inhalation of lettuce juice during the harvest time was concluded to be the cause of this allergy.
A survey of farmers cultivating lettuce by a questionnaire and by mass physical examination revealed dermatitis as the most frequent complaint, with a similar incidence (7.1%) of respiratory symptoms including rhlnitis. However, further detailed questioning showed that the cause of most respiratory symptoms was not allergic, and the intracutaneous reaction of the farmers to the allergen was similar to that of control subjects who were not farm workers. The positive rate of the skin patch test was significantly higher in farmers growing lettuce than in control who were not farm workers.
Allergic disease caused by lettuce might be generated as allergic dermatitis of type IV. Type I allergy caused by lettuce is rare, but here we reported one case of this rare type.View full abstractDownload PDF (694K) -
Tsuyoshi IMURA, Akiyoshi BANDO, Yasuo WADA, Yasushi FUKUSHIMA, Ryozo H ...1986 Volume 35 Issue 1 Pages 45-54
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSThree patients with hypersensitivity pneumonitis caused by inhalation of spores of Cortinus shiitake (Lentinus edodes) cultivated in vinyl houses were observed. These three patients developed the disease after harvesting shiitake for several hours in closed frame houses with a heater in the autum and winter. The frames were full of spores of shiitake and the patients suffered from a discordant feeling, systemic weakness, a feeling of cold, fever (over 38 C), a feeling of airway occlusion, a slight cough and sputum. These symptoms disappeared during rest the next day.
Case 1 was examined by the inhalation provocation test with a suspension of shiitake spores and spore-allergen. This test caused several clinical symptoms (fever, airway occlusion and various symptomatic feelings), leucocytosis, decrease of PaO2 a positive reaction of CRP and X-ray findings (appearance of interstitial pneumonitis shadows).
The 3 patients were considered to be suffering from allergic hypersensitivity pneumonitis due to inhalation of spores of Cortinus shiitake, because of their work, the development of symptoms after work in specific occupational conditions, a positive reaction to precipitating antibody against spore-allergen of shiitake, negative reactions to precipitation antibodies to 11 molds-allergens, various abnormal values in immunological tests and a positive reaction in a provocation test in one case.
In a survey of 45 shiitake-grower, it was found that 6 (13.3%) suffered from respiratory disease. No difference was found in the incidence of intracutaneous reactions to spore-allergen or allergen of dried shiitake in non-farm workers. Among 31 growers of shiitake a precipitation antibody to spore-allergen was observed only in these three patients. These results indicate that an allergic disposition is very important for development of hypersensitivity pneumonitis.View full abstractDownload PDF (4164K) -
Atsushi UEDA, Koji AOYAMA, Yasuyuki FUJITA, Tadako UEDA, Fumi MANDA, T ...1986 Volume 35 Issue 1 Pages 55-66
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSAn epidemiological survey on allergic conditions of 58 male (aged 38.6±11.8yrs) and 47 female (aged 42.2 ± 9.6yrs) farmers engaged in growing chrysanthemums.
Among the subjects, 47% of males and 62% of females had complaints of at least one of inquired allergic symptoms associated with the work. The immediate type of allergic reaction on nasal and/ or upper respiratory system raised in the process of sorting flowers in the working room and delayed ype of contact dermatitis in pinching the lateral bud of chrysanthemums or spraying agricultural chemicals in the field were the main complaints of those farmers.
Incidence of positive reaction for patch testing to six kinds of chrysanthemums was 5% for males and 17% for females and that of eight kinds at agricultural chemicals was 34% and 45% for each sex. And relatively high incidence was also observed in those subjects from other immunological tests such as determination of serum immunoglobulin, prick testing and calculation of eosinophil in blood and rhinorrhoea.
There were 39 (67%) males and 36 (77%) females who had at least one of the abnormal finding of those test items above mentioned. However, not the particular kind of Chrysanthemum cultivated in that area was found to be strong causative allergen for the observed allergic conditions.
From these results, it is indicated that relatively high incidence of allergic disorders may be found in the chrysanthemum growers due to inhalation and/or contact of some kinds of allergens introduced from the process of growing to forwarding, such allergen as Chrysanthemum itself, agricultural chemicals and other elements.View full abstractDownload PDF (1376K) -
Kosei YONEMITSU, Masataka NAGANO, Minako SUMI, Junichiroh OHTA, Hisae ...1986 Volume 35 Issue 1 Pages 67-71
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSIn order to investigate an effective therapy on paraquat poisoning, acute toxicity studies were performed using mice as experimental animals.
According to the mechanisms of paraquat toxicity, which is caused by superoxide radical and singlet oxygen geneation with subsequent initiation of membrane damaging process of ipid peroxidation ascorbic acid and superoxide dismutase (SOD) were injected intravenously to paraquat-poi-soned mice. The therapeutic effects of the two reagents against the paraquat toxicties were monitored using both mortality rates and boby weight changes of the mice for 10 days expeimental period.
No significant differences of the mortality rates were observed between the ascorbic acid injected group and the control group. On the contrary, the mortality rate of the paraquat poisoned mice treated with SOD was higher than that of the control group, suggesting the toxicities of H2O2 produced by SOD and Superoxide. This finding is to be taken consideration as a warning against a single use of SOD as a therapy for paraquat poisonig cases.View full abstractDownload PDF (564K) -
Suguru TORII, Tetsuo SUYAMA, Jun-ichi KUNOGI, Hitoshi SHIMOJO, Hiromu ...1986 Volume 35 Issue 1 Pages 72-75
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSInvestigation was made into knee joint problems among tea pickers through a questionnaire. Following this, physical examinations were given and radiography was taken.
Of the male respondents, 18.9% said that they have pains in the knee (s). The corresponding figure for the women was a high as 38.5%. The number of men and women who complained of knee pain increased with age. However, it was not clear whether the incidence of knee pain has any bearing on the number of years they had worked or working hours per day. Rather, it seems to depend on the configuration of the plantation.
Knee pain occurs more frequently in persons working on sloping and hilly lands than those working on flat land. The difference in Q-angle is wider in the hilly area than in the flat land.
X-ray examination of the knee joint of the persons who complained of sensations revealed degenerative changes in the form of the synovial cavity. Changes in the form of the patella were more evident in the persons working on the sloping land than on the flat land.
On the slope, tea pickers have to bend their knees, requring femoral quadriceps and crural triceps to maintain contraction for cours. Thus the level of stress on the kneecaps becomes high.
To prevent knee joint injuries, improvement of footings, mechanization of collecting work, decreases in the frequency of decending and ascending the slop, and having a rest at proper intervals are necessary.
Furthermore, it is necessary to strengthen femoral quadriceps by excercise and control weight.View full abstractDownload PDF (3278K) -
Masanori KANEKO, Tetsuo SUYAMA, Jun'ichi KUNOKI1986 Volume 35 Issue 1 Pages 76-79
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSOver the past three years, we have treated 10 patients suffering from delayed ulnar nerve paralysis. Of the patients, five were tea pickers. One tea picker had both elbows affected. With one exception, the cases were diagnosed as degenerative arthropathy. All the patients were of advanced age.
When they first visited our hospital, their chief complaint was numbness in the hand, which was subsequntly confirmed clinically. They did not complain about muscular atrophy of the hand and clawhand deformity.
Surgical operation was performed on the patients, excepting one case. After operation, theyfared well. Subjective symptoms were improved. However, clinical evaluation did not always agree with the degree of satisfaction on the part of the patients.View full abstractDownload PDF (3723K) -
Tomoo SHIRAKURA, Tomio OCHI, Eiichi TERASHIMA1986 Volume 35 Issue 1 Pages 80-90
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSDuring Nov. 1978 and Jul. 1985, we had operated 27 cases of malignant tumors of biliary tracts, namely 16 cases of gallbladder cancers, 9 bile duct cancers, one gallbladder sarcoma and one metastatic tumor of gallbladder from gastric cancer.
The average age of the patients is 70 years old and the ratio of man and woman is 1 to 2.2 in gallbladder cancers and 5 to 4 in bile duct cancers.
Regarding to the diagnostic approach to these diseases, excretery or indirect cholangiographies (OC, DIC) were not useful, but ultrasonic scanning (US) was so effective that we were able to diagnose 2 cases of early gallbladder cancers and get important views in all others.
In 5 cases which we could diagnose as gallbladder cancer preoperatively, only one was resectable to be healthy now. 5 cases diagnosed samely while the operation were all unresectable for the tumors had extremely advanced. In the rest 6 cases diagnosed postoperatively, 5 were now healthy during 19 and 84 months after operation.
All of the bile duct cancer patients were recognized jaundice clinically. 8 patients were diagnosed as cancer by method of direct cholangiography (PTC, ERCP) and seven were resected resulting that five are now surviving for 7 and 67 months after operation. 3 of them presented infiltration to gallbladder and or pancreas, but are alive over three years.
According to these facts and in order to find early or resectable cancers of biliary tract, we began mass screening using US for the inhabitants and have found, for only two years, 1 case of liver metastatic tumor from gastric cancer, 19 cases of asymptomatic gall stones and 4 cases of polypoid lesions of the gallbladder.
Now a 53 year old man who was found an early cancer of the gallbladder ultrasonographically, was examined for electron microscopic observation. Summarily, almost of the cancer cells are resembling each others without goblet and Paneth cells, and surrounded with basement membrane.
Intracellulary, there are abundant organelles and secretery granules. Golgi apparatuses are extremely developed and GERLs are also seen frequently.View full abstractDownload PDF (22794K) -
[in Japanese]1986 Volume 35 Issue 1 Pages 91-95
Published: May 30, 1986
Released on J-STAGE: August 11, 2011
JOURNAL FREE ACCESSDownload PDF (852K)
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