Previously, we have reported that
Candida strains were morefrequently detected in the oral cavity of hemodialysis patients, particularly long-term patients, than in that of the patients with chronic glomerulonephritis ans conservative chronic renal failure. In the present study, we conducted a screening test for the prevalence of serum
Candida antigen in hemodialysis patients and determined
Candida species in the oropharyngeal portion of those with serum
Candida antigen. Serum
Candida antigen was found in 18.75% of the hemodialysis paients in our renal unit. Furthermore,
Candida strains were detected in the oropharyngeal portion in 75.0%of those with serum
Candida antigen. The percentage was higher than that of hemodialysis patients without serum
Candida antigen (50.0%).
Candida species determined in the oropharyngeal portion of the hemodialysis patients with serum
Candida antigen were
C. albicans (66.7%),
C. glabrata (55.6%),
C. krusei (11.1%), and
C. parapsilosis (11.1%). There were no significant differences in age, hemodialysis periods, and the serum values of the nutrional markers (serum total protein, albumin, transferrin, and total cholesterol) between the hemodialysis patients with serum
Candida antigen and those without. Generally, it is well known that hemodialysis patients are theso-called immunocompromised host. Therefore, it is necessary to examine serum
Candida antigen and to determine
Candida species in the oropharyngeal portion, wherewas first possible portion of mycotic infection, beforehand so as to predict the occurrence of invasive
Candidiasis
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