Chronic kidney disease (CKD) is characterized by kidney dysfunction or proteinuria lasting more than 3 months, and the number of patients is increasing worldwide. In recent years, in addition to known causes of CKD such as chronic glomerulonephritis, diabetes, and hypertension, reports have noted the risk of developing CKD due to global environmental changes, which have not been mentioned in previous Japanese epidemiological studies. It is estimated that air pollution may be related to 6.4 million deaths annually worldwide. Typical air pollutants include particulate matter (PM), sulfur dioxide, nitrogen dioxide, carbon monoxide, and ozone. Cardiovascular disease and CKD are linked and share common mechanisms of onset and disease progression. Epidemiological studies have revealed that some cardiovascular diseases are caused by air pollution, such as PM2.5. However, studies on the relationship between air pollution and CKD have been scarce, and only in the 2020s did the evidence become more comprehensive in several countries. Nevertheless, there is still no evidence on this relationship from Japan. Analysis of ozone in particular, the only pollutant whose concentration continues to rise, warrants special attention, as the results of analyses in other countries indicate that it may be a risk factor for CKD.
View full abstract