I encountered lately a Down's syndrome child with cleft of the primary and secondary palates. The boy of five months after birth, whose father was 31 years old, and mother 32, a primipara, has experimenced no stillbirth or abortion previously. In whole course of the pregnancy she denied using medicines such as cortison, thalidomide and anti cancer agent. Also she made denied of being sent out radial rays, specific infectious diseases such as syphilis or rubella, poisoning and shock of mind. Parents hadn't the intermarriage and denied the heredo-diathetic disorders. The infant showed 3300 gram in birth-weight, weighter than the mean birth-weight in same age. Oral findings observed were the right complete cleft lip-jaw-palate in addition to open mouth, macroglossia, fissured tongue. Beside these, epicanthus, hypertelorism, flat occiput, oblique palpebral fissures, hyperextensibility, hyperflexibility, transverse palmar crease, small ear, low nasal crista, widely flat root of the nose, otitis media, separation of the rectus were recognized. Chromosomal analysis of peripheral lymphocytes was performed by the Method of Moorhead et al. A result was G21-trisomy of the high frequency in Down's syndromes, that is, 47, XY, 21+(Chicago Conference).
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