-
Article type: Cover
1996 Volume 27 Issue 1 Pages
Cover1-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
Article type: Cover
1996 Volume 27 Issue 1 Pages
Cover2-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
1-2
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
Kohzo NARA
Article type: Article
1996 Volume 27 Issue 1 Pages
3-16
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
Extracellular levels of serotonin (5-HT) and dopamine (DA) in the rat hippocampus were measured by using in vivo brain microdialysis in order to study the effects of acute and chronic administration of fluvoxamine, selective serotonin reuptake inhibitor (SSRI). Extracellular levels of 5-HT were significantly elevated 40 min after single i. p. injection of fluvoxamine but rapidly recovered to baseline levels. Peak level of 5-HT was twice times higher compared to baseline and saline control. There were no significant differences between baseline levels in 5-HT and DA in fluvoxamine treated group and those in saline control following chronic administration of fluvoxamine for 14 days using osmotic minipump. Additional i.p. injection of fluvoxamine after chronic pretreatment with fluvoxamine showed significant and dose-dependent increase in 5-HT compared to saline pretreated animals. This increase in 5-HT was more continuous compared to the changes in 5-HT in single administration of fluvoxamine. These results suggest that chronic administration of fluvoxamine and other SSRIs show prolonged elevation in extracellular levels of 5-HT and down regulation of 5-HTiA autoreceptor may be involved in these net increase in serotonergic neurotransmission.
View full abstract
-
Yuji ASOH
Article type: Article
1996 Volume 27 Issue 1 Pages
17-25
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
To clarify the changes in brain elasticity and intracranial physiology related to aging, the author reports cardiac-gated cine MR studies on pulsatile brain motions in 28 adults, 40 to 84 years old (mean, 61.3 years), including asymptomatic lacunar stroke. There was a -10〜-25% change in the lateral ventricular sizeduring a cardiac cycle. The size of the lateral ventricle decreased during cardiac systole, in paticular at 20〜50 % of the R-R interval with two/three reversed peaks similar to the reversed "ICP pulse waveform". In the elderly, above 70 years, the size of the lateral ventricle fluctuated smaller during a cardiac cycle. There was a -10〜-18% change in the lateral ventricular size during a cardiac cycle. The ventricular size variations were complex, but these results indicate the changes in intracranial compliance related to brain atrophy resulting from aging.
View full abstract
-
Katsuhiko YOSHIMOTO
Article type: Article
1996 Volume 27 Issue 1 Pages
27-39
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
The effects of the antidiabetic drug biguanide (Metformin, Buformin) and vasoactive peptide bradykinin on glucose transport were investigated in isolated rat adipocytes. 10^<-4>M Metformin and Buformin had no significant effect on basal 2-deoxy-D-glucose transport. In contrast, 10^<->4M Metformin and Buformin increased insulin-stimulated glucose transport in rat adipocytes, which is associated with a potentiation of insulin-induced translocation of GLUT4 from an intracellular pool to the plasma membranes. On the other hand, high concentration of Buformin (10^<-3>M) decreased both insulin-stimulated and -nonstimulated glucose transport, as a result of its inhibition of GLUT4 translocation. Bradykinin increased glucose transport under both insulin-stimulated and -nonstimulated conditions in rat adipocytes. Although bradykinin had no effect on the translocation of GLUT4 from an intracellular pool to the plasma membranes, bradykinin increased GLUT4 protein biosynthesis, suggesting that increased GLUT4 protein plays a part of role in activating the glucose transport.
View full abstract
-
Kiyotake IWAMORI
Article type: Article
1996 Volume 27 Issue 1 Pages
41-50
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
The value of myocardial contrast echocardiography (MCE) for predicting left ventricular wall motion after percutaneous transluminal coronary angioplasty (PTCA) was investigated. The subjects were 21 patients undergoing PTCA of the left anterior descending coronary artery (LAD) at 1-3 months after acute anteroseptal myocardial infarction. MCE was performed immediately after PTCA, and the ratio of the peak intensity (Pl) of myocardial staining for each of the 3 segments supplied by the LAD to that for the posterior wall (Pl ratio) was calculated using computer image analysis. Results were compared with the conventional contrast score determined visually. A significant correlation was observed between the Pl ratio and the wall motion score at 3 months after PTCA (r=-0.67, p<0.01). The Pl ratio was 0.90±0.21 for normokinetic segments, 0.73±0.13 for hypokinetic segments, 0.75±0.16 for severely hypokinetic segments, and 0.47±0.19 for akinetic segments. Thus, the Pl ratio decreased along with the progressive impairment of wall motion. In addition, post-PTCA wall motion inproved as the Pl ratio increased. When the Pl ratio was ≥0.6, improvement of wall motion at 3 months after PTCA could be predicted with a sensitivity of 100.0% and a specificity of 75.0%, even for akinetic segments. These values were higher than those for visual evaluation. The results suggested that quantitation of myocardial staining using the Pl ratio determined by MCE may be useful for predicting long-term left ventricular wall motion recovery after PTCA.
View full abstract
-
Akira SASAKI
Article type: Article
1996 Volume 27 Issue 1 Pages
51-61
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
Dual single photon emission computed tomography (SPECT) was performed in 30 patients with Duchenne's muscular dystrophy (DMD) using ^<201>thallium (Tl) for myocardial perfusion ^<123>I-β-methyl-p-iodophenylpentanoic acid (BMIPP) for myocardial fatty acid metabolism scintigraphy. The left ventricle was divided into 9 regions, and accumulation of the radiotracers was assessed visually for each region to calculate defect score for each tracer. There was some degree of decrease in the myocardial accumulation of both tracers in all DMD patients. Reduced accumulation was most common at the apex (BMIPP, 70 %; Tl, 63 %), followed by the posterior wall, lateral wall, and anterior wall. It was less common on the apical side of the ventricular septum for both tracers (BMIPP, 3 %; Tl, 17 %). Accumulation of Tl was lower than BMIPP in 18/30 patients (60 %) and higher in 9 (30 %), while both tracers showed equal accumulation in 3 (10 %). BMIPP showed higher accumulation than Tl in all regions but the septum. A significant negative correlation was found between the defect scores for both tracers and the left ventricular ejection fraction (LVEF) (r=-0.629 for Tl; r=-0.567 for BMIPP). The strongest negative correlation was that between the sum of the Tl and BMIPP defect scores and the LVEF (r=-0.681). Dual SPECT myocardial scintigraphy with Tl and BMIPP provided an accurate evaluation of the progression of cardiac lesions in DMD by detecting abnormalities of the myocardial metabolism of each substance thereby enabling the assessment of left ventricular function.
View full abstract
-
Minako MORITA
Article type: Article
1996 Volume 27 Issue 1 Pages
63-75
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
It has been known that intracerebroventricular (i. c. v.) administration of 6-hydroxydopamine (6-OHDA) induces severe symptoms such as akinesia, adipsia, and aphagia in adult rats. However, in immature rats to which 6-OHDA was administered at the neonatal period (2 and 4 days old), hyperactivity in locomotion, rearing, and grooming was observed, and the brain dopamine turnover ratio was also increased. The present study was made to investigate the mechanisms for abnormal behaviors and brain mono-amine turnover ratios in neonatally 6-OHDA-treated immature rats. The administration of 6R-5, 6, 7, 8-tetrahydro-L-biopterin (6R-BH4, i. c. v.), an agent for raising dopamine and serotonin turnover on the 24th day, suppressed the abnormal behaviors to the intact level and increased brain serotonin turnover ratio, with dopamine turnover ratio unaffected. The administration of naloxone (NX, s. c.), an opioid peptide receptor antagonist on the 24th day, resulted in quit same effects. These data suggest that activated abnormal behaviors were caused by the increase in dopamine turnover ratio due to the compesatory mechanism for 6-OHDA-induced dopamine neuron injury, and that 6R-BH4 and naoxone-induced increase in serotonin turnover ratio had a suppressive effect on abnormal hyperactivity.
View full abstract
-
Nobuhiro NISHIMURA
Article type: Article
1996 Volume 27 Issue 1 Pages
77-88
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
It has been known that serotonin (5-HT)-induced specific behavior, 5-HT syndrome (locomotion activity, rearing, for epaw padding, headweaving), mediated via central 5-HT receptors, 8-Hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT) has inhibitory action to 5-HT turnover at presynaptic 5-HT_<1A> receptors, however, it induces 5-HT syndrome as 5-HT administration. The detail mechanisms of eliciting the behaviors are not fully understood at present. In this study, the effect of intracerebroventricular (i. c. v.) administration of 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT) on 8-OH-DPAT-induced behaviors were examined. Only the enhancement of forepaw padding was significantly antagonized but others were not. This result suggest that forepaw padding is related to presynaptic 5-HT_<1A> receptors in 5-HT neuron and other behaviors are mediated pospsynaptic 5-HT_<1A> receptors. On the other hand, in order to examine the interaction between opioid peptide neuron and 5-HT neuron, we observed the influence of opioid peptide receptor antagonist, naloxone on 5-HT syndrome induced by 8-OH-DPAT. Pretreatment with naloxone inhibited dose dependently the increase in 8-OH-DPAT-induced forepaw padding, however, not other contents. From the result of this study, it is indicated that the opioid peptidergic system may be very closely related to serotonergic system on 8-OH-DPAT-induced forepaw padding in rats.
View full abstract
-
Masami TSUNODA, Aya NAKASE, Hiroshi IRIE, Hidemi KOIKE, Yoshikazu YOSH ...
Article type: Article
1996 Volume 27 Issue 1 Pages
89-92
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
We reported MRI findings in a 24-year-old woman with Wilson's disease, whose neurological symptoms appeared about 9 months ago. In this early stage of damage of the central nervous system, T2-weighted MR images showed localized high intensity in the lateral portion of the thalamus corresponding to the VL nucleus. This early change in the VL nucleus may have possibly occurred, because this nucleus receives afferent fibers from the basal ganglia and cerebellum which are comparatively vulnerable in this disease. In T2-weighted MR images of the brainstem, there was high intensity in the superior cerebellar peduncle, which may be correlated with the kinetic tremor of this patient, and in broad areas including the tegmentum and the basis of the pons without neurological symptoms. Further examination of cases will be needed, before these characteristic MRI changes, especially those in the VL nucleus can be established as common findings in early stages of this progressive disease.
View full abstract
-
Seiyu HIGA, Yasuhide IWAO, Ruriko OZAWA, Saeko HOUKI, Mie SATO, Miki K ...
Article type: Article
1996 Volume 27 Issue 1 Pages
93-96
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
A 38-year-old female suffered from a deterioration of adult-type atopic dermatitis. She had been diagnosed as atopic dermatitis and allergy since her childhood and treated in another clinic. We performed bilateral stellate ganglion block over 100 times for her. After the treatment, disappearance of itching and edema relieved her from the persistent sleeplessness, and laboratory findings showed an improvement of eosinophilia (30 % to 4 %), however there was still abnormality in IgE-RAST against house dust. We concluded that stellate ganglion block is a choice of the treatment for an atopic dermatitis in adult.
View full abstract
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
97-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
98-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
98-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
98-99
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
99-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
99-100
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
100-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
100-101
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
101-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
101-102
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
102-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
102-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
103-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
103-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
103-104
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
104-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
104-105
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
105-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
105-106
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
106-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
106-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
106-107
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
107-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
107-108
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
108-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
1996 Volume 27 Issue 1 Pages
108-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
109-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
109-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
109-110
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
110-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
110-111
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
111-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
111-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
112-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
112-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
113-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
113-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 27 Issue 1 Pages
114-
Published: March 31, 1996
Released on J-STAGE: February 13, 2017
JOURNAL
FREE ACCESS
