巻号一覧
6 巻, 7 号
選択された号の論文の5件中1～5を表示しています
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特に細胞増殖調節と関連して山上 圭司, 小路 武彦, 寺山 宏1982 年 6 巻 7 号 p. 442-448
発行日: 1982年
公開日: 2010/10/21
ジャーナル フリーThe cancerous changes of plasma membrane activities were reviewed with special reference to the controlling mechanisms of cell proliferation. The article includes the following chapters in addition to introduction and conclusion. Chapter I. Cancerous changes of enzyme systems forming cyclic nucleotides; (a) adenylate cyclase and (b) guanylate cyclase. Chapter II. Cancerous change of cAMP-dependent protein kinase in plasma membranes. Chapter III. Role of plasma membranes in controlling the intracellular Ca2+ concentration, and cancerous changes of the controlling systems. Chapter IV. Cancerous changes of Ca2+calmodulin-dependent regulatory systems in plasma membranes; (a) calmodulin, (b) cAMP phosphodiesterase and (c) Ca2+, Mg2+-ATPase. Chapter V. Cancerous changes of other marker enzymes in plasma membranes; (a) 5'-nucleotidase, (b) alkaline phosphatase, and (c) ATPase.抄録全体を表示PDF形式でダウンロード (1152K) -
田中 裕, 井上 圭三1982 年 6 巻 7 号 p. 449-456
発行日: 1982年
公開日: 2010/10/21
ジャーナル フリーRecent progress in studies using liposome in reviewed
I Preparation of liposome
II Application of liposome as a drug carrier in vivo and in vitvo
1 Stability of liposome
2 Targeting
3 Release of drug at a localized region
4 Macrophage activation by MAF or MDP entrapped in liposome
5 Application to gene engineering抄録全体を表示PDF形式でダウンロード (1180K) -
核磁気共鳴法による研究京極 好正1982 年 6 巻 7 号 p. 457-471
発行日: 1982年
公開日: 2010/10/21
ジャーナル フリーThe phase transition temperature, fatty acids and phospholipids contents were measured for phospholipid vesicles prepared from a temperature sensitive mutant of unsaturated fatty acid auxotroph of E. coli K12. The transition temperature from the gel to liquid crystal states is closely related to the content of unsaturated fatty acids in phospholipids. This mutant grows at ordinal room temperature and also can grow at higher temperatures if some amounts of KCl, sucrose or glycerol are added to the culture medium. The role of these chemicals were investigated by measuring the stability for the osmotic pressure difference between the in-and outside of liposomes. KC1 and sucrose are found to act as osmotic stabilizers but glycerol seems to play a different role.
Nmr works on biomembranes using deuterium and phosphorus magnetic resonances were reviewed.抄録全体を表示PDF形式でダウンロード (4540K) -
山田 純男, 浜谷 健生1982 年 6 巻 7 号 p. 481-484
発行日: 1982年
公開日: 2010/10/21
ジャーナル フリーThe effect of radiation induced crosslinking on liquid permeation and selectivity was investigated by pervaporation of polyethylene, poly-4-vinylpyridine and polystyrene membranes. It was found that within the scope of certain radiation dose the radiation induced crosslinking which is relatively sparse has little effect on liquid permeation and separation regardless of the extent of swelling and flexibility of the polymer chain structure.抄録全体を表示PDF形式でダウンロード (585K) -
高木 昭夫, 石浦 章一1982 年 6 巻 7 号 p. 487-493
発行日: 1982年
公開日: 2010/10/21
ジャーナル フリーThe “membrane hypothesis” in the pathogenesis of Duchenne muscular dystrophy (DMD) implicates that primary abnormality resides in the membrane system of skeletal muscle and that the abnormality causes progressive breakdown of muscle cells. In DMD, CPK activity in serum is markedly elevated. Histolo gical studies showed that affected muscle contained many “opaque fibers”, or hypercontracted fibers. In these affected fibers, part of plasma membrane was disrupted and xtracellular space tracers invaded muscle cytoplasm. It is postulated that extracellular calcium also gets into sarcoplasm through disintegrated surface membrane and interferes various function of cells.
However, the elevation of serum CPK in DMD is explained by the efflux from necrotic muscle cells rather than by the leakage from live cells. Focal loss of plasma membrane might be a reflection of ongoing cell necrosis. Moreover, there is no information about the nature of genetic defect, which is speculated to reside in muscle membrane.
The validity of the membrane hypothesis is discussed and other theories on the pathogenesis are also enumerated.抄録全体を表示PDF形式でダウンロード (1293K)
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