Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
8 巻, 4 号
選択された号の論文の7件中1~7を表示しています
  • 竹口 紀晃
    1983 年 8 巻 4 号 p. 194-203
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Movements of ions such as H+, Cl-, Na+, K+, Ca2+, and HCO3- in parietal cells are summarized. (Na+, K+) -ATPase (Na+/K+ antiport), an exchange diffusion system (Cl-/HCO3- antiport) and a NaCl symport system exist in the serosal (basolateral) membrane of the parietal cell, whereas (H+, K+) -ATPase (H+/K+ antiport) and K+-recycling system exist in the secretory (apical) membrane. The role and inter-connection of these ion transporting systems to produce gastric acid is elucidated from various levels of studies on gastric mucosa in vitro, gastric gland, parietal cell, gastric vesicles and artificial planar bilayer. Furthermore, hormonal regulation of acid secretion by histamine, acetylcholine, gastrin, and c-AMP in regard to ion transport is also summarized.
  • 品川 嘉也
    1983 年 8 巻 4 号 p. 204-211
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Theoretical basis for the overshoot uptake of n-glucose of the human erythrocytes and the intestinal brush border membrane vesicles is provided by means of the equation system of membrane transport. The overshoot uptake occurs when the solute concentration in membrane phase is higher than that in outside solution. It is shown that high concentration of solute in membrane phase drives the membrane oscillation being the type of limit cycle.
    1. Introduction.
    2. Two compartment cannot provide the overshoot uptake.
    3. Experiments on the overshoot uptake.
    4. Equation system of membrane transport.
    5. Limit cycle oscillation drived from the membrane transport equations.
    6. Conclusion.
    Mathematical appendix.
    The computer aided mathematical method to prove existence of the limit cycle is described in the mathematical appendix.
  • その設計思想
    宮木 義行, 藤本 輝雄
    1983 年 8 巻 4 号 p. 212-224
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    In order to prepare charge-mosaic membranes, many attempts have been made by many authors. In this article a historical survey is presented on the development of the methods for fablicating such membranes. A multiblock copolymer method is considered to be one of the most promising methods. Suitably designed ISIAI-type pentablock copolymers consisting of isoprene (I), styrene (S), and 4-vinylbenzyldimethylamine (A) with a three-layer-lamellar structure are stable to chemical treatments and successfully give a charge-mosaic membrane which shows a piezodialytic effect and a very high salt permeability. This membrane is useful for desalination of aqueous solutions containing organic substances of low molecular weights.
  • 又賀 昇
    1983 年 8 巻 4 号 p. 225-238
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Behaviors of heteroexcimers between pyrenes and N, N-dimethylanilines as well as dicyanobenzenes in aqueous micellar solutions, detergent vesicles and bilayer liposomes have been investigated by means of fluorescence measurements and laser photolysis. Strong quenching of pyrene fluorescence with those quenchers was observed while no heteroexcimer fluorescence was detected in detergent micellar and vesicle solutions. However, weak heteroexcimer fluorescence of pyrene-dimethylaniline systems was detected in single bilayer liposomes of phosphatidylcholines. The dependences of relative fluorescence yield and fluorescence decay curve upon the quencher concentration have been explained with equations derived on the basis of simple model. In accordance with the results of fluorescence measurements, the laser photolysis studies have demonstrated clearly the formation of ion radicals due to electron transfer in the case of micelles and detergent vesicles. Moreover, important roles of surface charges of these systems in the photoinduced charge separation processes have been confirmed. On the other hand, aggregation of dye ions due to the interaction with detergent micelles, premicelles, vesicles and high polymer electrolyte with opposite charges has been investigated by measuring the excimer formation and excitation transfer phenomena with ns and ps laser spectroscopic methods, results of which provide important informations upon the formation processes and structures of these organized systems.
  • Shozo Miyazaki, Shigemi Takeuchi, Mieko Sakamoto, Masahiko Takada
    1983 年 8 巻 4 号 p. 241-242
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Ethylene-vinyl alcohol (EVA1) copolymer was evaluated as a controlling membrane for the release of anticancer agents, 5-fluorouracil and ftorafur. The effect of comonomer ratio modifications on the drug permeation was studied. EVA1 copolymer membranes of ethylene contents of 32, 44, and 47 mol% were used. An increase in ethylene content of EVA1 copolymer decreased the drug permeability through the copolymer membranes.
  • Shintaro Furusaki, Tatsuji Kikuchi
    1983 年 8 巻 4 号 p. 243-248
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Continuous separation of proteins is studied by using electrophoresis. The apparatus is composed with electrophoresis cells which are separated by porous membranes. The value of pH is adjusted so as to be low near the anode and high near the cathode. Intermediate cells stand at intermediate values of pH. Some cells stand at pH's of the isoelectric points of desired proteins. By the driving forces originated by the electric potential field, proteins migrate toward the cells at their isoelectric points. This separation, continuous isoelectric focusing, is studied by measuring extent of migration of bovine serum albumin. Experimental results are discussed by use of a theory considering electrochemical mobility and flow pattern inside the cells.
  • Hezhe Zhang, Katsuhisa Sekine, Tetsuya Hanai, Naokazu Koizumi
    1983 年 8 巻 4 号 p. 249-254
    発行日: 1983/07/01
    公開日: 2011/03/04
    ジャーナル フリー
    Dielectric measurements were carried out on polystyrene films immersed in various kinds of electrolyte aqueous solutions. The observed dielectric relaxations were of the Debye type which was characteristic of the series combination of the polystyrene film and the ambient aqueous solution. Approximate formulas were derived of the dielectric theory of interfacial polarization for the bilamellar structure under the condition that the capacitance is much larger for the film than for the aqueous solution. Capacitance and conductance of the underwater film were evaluated from the dielectric observations by use of these approximate formulas. The film capacitance remained unchanged irrespective of the tonic species and the concentration of electrolyte solutions used, being inversely proportional to the thickness of the films. The relative permittivity of the polystyrene films was estimated to be 2.65. The ratio of the film conductivity to the solution conductivity for the same film was unaffected by the change in the concentration of electrolyte solutions, being in the order of 10-4. These features of the film capacitance and the conductivity ratio suggest that micropores in the film filled with the ambient electrolyte solutions are responsible for the electric conduction of the present underwater films.
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