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[in Japanese]
1985 Volume 14 Issue 3 Pages
1403
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Y. TERADA, T. MITSUI, T. FUJITA, H. IJIMA, H. MAETA, K. OKAMURA, A. SA ...
1985 Volume 14 Issue 3 Pages
1404-1406
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Under VVI pacing, effects on the cardiovascular system of rising from the supine to the sitting position were studied in three patients with pacemaker syndrome as compared in four control patients. In individuals with pacemaker syndrome, sudden sitting brought a fall in blood pressure and right atnal pressure, a decrease in atrial rate and %FS. In control group, pharmacological denervation disclosed the same hemodynamic changes as shown in pacemaker syndrome. A genesis of pacemaker syndrome was most likely due to autonomic insufficiency associated with diminished responses to baroreceptor stimulation.
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S. NAWA, Y. KIOKA, T. NAGAO, R. KOMODA, A. SHIMIZU, K. KINO, K. AOKAGE ...
1985 Volume 14 Issue 3 Pages
1407-1410
Published: June 15, 1985
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The rest pump function of the paced heart was reduced, and the decreased CI was kept by increasing EF. By changing the pacing rates, CI was linearly increased and myocardial function indices correlated significantly. For the exercise, the significant increases of cardiac pump function indices were observed, but the increased CI was not sufficient yet. Myocardial function indices showed-significant chronotropic changes. These were thought to be the physiological response to accelurate the cardiac contractility state.
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T. MASEKI, T. ISHIHARA, T. OHMIYA, Y. MIYATA, K. TAJIMA, T. ASAI, M. S ...
1985 Volume 14 Issue 3 Pages
1411-1414
Published: June 15, 1985
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The left ventricular function and the optimal A-V intervals of the physiologic VDD and DVI pacing were investigated by the multigated RI cardiac pool imaging. The optimal A-V intervals ranged from 100 to 200 msec, but varied from patient to patient. Compared with the VVI, the VDD and the DVI showed the improvement of end-diastolic volume (EDV), stroke volume (SV) and cardiac output (CO). The mean improvement of CO was about 19%. Especially at exercise, the physiologic VDD and DVI pacing provided large increase of CO compared with the VVI. The VVI pacing improved CO with compensatory increase of SV but it was a little. The VDD pacing obtained the significant improvement of CO with the increase of the pacing rate and SV. So superiority of the physiologic VDD and DVI pacing at rest and at exercise was shown. The multigated RI cardiac pool imaging is non-invasive and easy to repeat. It is useful to evaluate the LV function and to determine the optimal A-V intervals.
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M. KOKUBO, M. HOROSE, Y. KOJIMA, F. TAKEUCHI, K. AZUMA, T. MIYATA, K. ...
1985 Volume 14 Issue 3 Pages
1415-1418
Published: June 15, 1985
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The physiologic pacemaker has been implanted in 19 patients with atrioventricular block and two patients with S. S. S. Hemodynamic study has been carried out at rest. Cardiac index and stroke volume with atrial synchronous pacing is generally 20% higher than with ventricular pacing. CTR was reduced significantly. Pacemaker mediated tachycardia was recogniged in one patient. So that VDD mode was changed to VVI mode. P sensing failure was demonstrated in 6 patients. Pacing mode was changed to VOO and VVI mode in two patients. Brachial phlebographies was performed in 13 patients. Five patients showed complete occlusion and collateral formation. Four patients showed severe stenosis with collateralization.
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M. SASO, M. YOKOYAMA, J. KEI, H. KAIZUKA, Y. KASAGI, H. NAGARA, J. WAD ...
1985 Volume 14 Issue 3 Pages
1419-1422
Published: June 15, 1985
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We compared cardiac function and hemodynamics at VVI as well as DVI Pacing in patients after DDD Pacemaker implantation in 21 cases of Sick Sinus Syndrome and 9 cases of Complete Atrioventricular Block. 8 of 21 patients with Sick Sinus Syndrome showed retrograde conduction at VVI pacing. In the patients with retrograde conduction, at VVI pacing, the right atrial pressure was over 15mmHg, and cardiac output was too much decreased as venus return obstacle. In the right atrial mean pressure, VVI to DVI ratio was higher in the patients with Sick Sinus Syndrome without retrograde conduction than in the patients with complete atrioventricular block. This correlated with cardiac output, DVI to VVI ratio was higher in the patients with Sick Sinus Syndrome without retrograde conduction than in the patients with complete atrioventricular block. So we concluded that it is more necessary to do dual chamber pacing in the patients with Sick Sinus Syndrome than in the patients with complete atrioventricular block.
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O. KURODA, E. TATSUMI, S. MIYAGAWA, A. OKUDA, T. TAKAO, K. IHARA, T. Y ...
1985 Volume 14 Issue 3 Pages
1423-1426
Published: June 15, 1985
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Treadmill exercise test was performed in patients with complete A-V block having VDD, DDD pacemakers implanted. Maximum exercise tolerance was 7.4±1.6 Mets in VVI mode pacing (rate 70ppm), 9.4±2.1 Mets in VVI mode pacing (rate 120ppm), 11.5±2.4 Mete in VDD mode (rate 123.2±40.6ppm). The increase of maximum exercise tolerance in VDD mode pacing was attributed to physiological increase in heart rate and atrial function.
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M. MURASE, N. TANAKA, H. NOGAKI, E. TAKEUCHI, Y. SUENAGA, H. SAEGUSA, ...
1985 Volume 14 Issue 3 Pages
1427-1430
Published: June 15, 1985
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Sixty-five percent in SSS and fifteen percent in AVB had retrograde V-A conduction. The retrograde conduction time was 259±31 msec (mean±SD). The amplitude of retrogradely conducted P waves was revealed to be lower than that of antegrade P waves, 2.7±1.7mV vs 4.1±2.4mV in bipolar leads, and 3.0±1.6mV vs 3.4±1.5mV in unipolar leads respectively.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1431
Published: June 15, 1985
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H. MAKINO, Y. SAITOH, Y. MITAMURA, Y. SUZUKI, T. TACHIKI, T. MIKAMI
1985 Volume 14 Issue 3 Pages
1432-1435
Published: June 15, 1985
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A battery-type automatic defibrillator with a high-output pacing function was developed. The pacing function was activated after defibrillation to work as a high-output ventricular demand pacemaker. The residual energy in the output capacitor was used for pacing.
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F. ISOBE, T. FUJITA, T. OHE, K. SHIMOMURA
1985 Volume 14 Issue 3 Pages
1436-1439
Published: June 15, 1985
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The automatic implantable defibrillator (AID-B) is designed to monitor the cardiac activity continuously, to detect malignant ventricular tachyarrhythimas, and then to deliver the countershock to restore the normal rhythm. In Feb. 1984, the first implantation of this devise in Japan was performed at NCVC. Later, another one was implanted. The risk of the implantation of the devise are small and the side effects minimal. This new therapeutic devise maybe decrease the cardiac mortality.
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T. MIKI, M. YOKOYAMA, T. ITAOKA, M. SASOH, M. MURASUGI, J. WADA
1985 Volume 14 Issue 3 Pages
1440-1443
Published: June 15, 1985
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Experiences of new supraventricular anti-tachycardia pacemaker Eight patients with paroxysmal supraventricular tachycardia was treated with the implant of anti-tacky pacemaker (Symbios model 7008, Medtronic). Three out of eight patients had WPW syndrome. The new pacemaker has functions of DOD pacing as well as of anti-tacky pacing. For the treatment of anti-tachycardia, one of three modes (atrial burst, A-V dual demand and ventricular dual demand) can be programmed. In our two patients with WPW syndrome, A-V dual demand mode was employed, and atrial burst mode was chosen for the rest of six patients. Following the pacemaker implant, Hotter ECG monitoring was carried out. The model 7008 can detect the tachycardia attack by telemetry functions if patients suffered from attacks. Supraventricular tachycardias were terminated in four cases out of eight. In two cases of the rest subjective symptoms had improved. The telemetry functions of the pacemaker demonstrated the presence of tachycardia in the two. The other two cases did not develop the supraventricular tachycardia following implants. Authors conclude antitachy pacemakers are of benefit to those patients with paroxysmal supraventricular tachycardia.
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H. AIDA, T. SHIMIZU, T. IRIYAMA, H. IWANAMI, K. SHIMAZU, S. SAKAMOTO, ...
1985 Volume 14 Issue 3 Pages
1444-1447
Published: June 15, 1985
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A study on a pacemaker which automatically regulates its rate with physical activity. A rate-responsive, activity-sensing pacemaker was implanted in two patients with complete heart block. Pacing rates of these two patients increased according to treadmill exercise. One patient remarkably improved exercise, tolerance but the other couldn't. This kind of pacemaker must be implanted in patients who improve the cardiac function and exercise tolerance by means of increasing heart rate.
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T. IGARI, S. HOSHINO, F. IWAYA, M. ANDO, T. ABE, K. TAKANO, K. HAGIWAR ...
1985 Volume 14 Issue 3 Pages
1448-1452
Published: June 15, 1985
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Atrial synchronous pacemakers are benefical to give a physiological heart rate increase with exercise. However, there are some patients who cannot receive these benefit because of sinus dysfunction. Recently we have a chance to use the devise of which an internal transducer senses the quantity of physical activity and its circuit translates it into pacing rate. The device was implanted in three patients with sinus node dysfunction (2) and advanced A-V block (1) who subsequently demonstrated a physiological response with exercise and improved exercise tolerance.
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T. TOYOSHIMA, T. TSUJI, T. TOGAWA, M. MIYAKE, K. TSUCHIYA, K. SUMA
1985 Volume 14 Issue 3 Pages
1453-1456
Published: June 15, 1985
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The new pacing system that generates optimal pacing rate according to patient's physical activity is developed. The system is divided into three parts, an external rate generator that estimates the activity from intensity of body acceleration and transmitts periodical pulses by radiofrequency in accordance with optimal rate, an implanted receiver and a conventional VDD or DDD pacemaker which accomplishes pacing triggered by the pulses.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1457
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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----Bioelectrophysical Responce during AAI and VVI pacing
K. KATSUMOT, T. NIIBORI, T. OKUNO, K. TAKEUCHI
1985 Volume 14 Issue 3 Pages
1458-1461
Published: June 15, 1985
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A two stage method was used for the study of electrode-myocardial interaction, to get clinical assessment of AVCE. A comparative study was made using other conventional Elsiloy electrodes. 48 patients were implanted with AVCE which had a electrode surface area of 12mm
2, 25 cases for VVI pacing and 23 cases for AAI pacing. Another 37 conventional Elsiloy and platinum electrodes with the surface area of 24 or 12mm
2 and 13 other various kinds of electrodes were used as a comparative study. Stimulation threshold, impedance between the electrodes, polarization voltages and endocardial R-wave or A-wave amplitude and also ST-segment changes were studied, during 7 days after lead implantation. AVCE had shown lower polarization voltages in both modes of VVI and AAI pacing, but nearly the same value of early change of stimulation threshold, as compared to either the conventional Elsiloy or platinum electrodes, was obtained clinically, using constant current stimulator of 1.8 msec pulse duration.
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S. TANAKA, M. KAJI, A. HARADA, Y. MATSUYAMA, F. SAITO, S. MATSUSHIMA, ...
1985 Volume 14 Issue 3 Pages
1462-1465
Published: June 15, 1985
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Four J-shaped 6991-U atrial polyurethane leads (Medtronic) were implanted in our clinic between 1980 and 1982. All of them have shown the pacing failure, sensing failure and early battery depletion due to insulation disruption between 2 and 45 postoperative menths. We strongly suggest to replace the lead as soon as pacing and sensing failure, sudden decrease of lead impedance (below 250 ohm) and pacing threshold are recognized.
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T. MIKI, M. YOKOYAMA, T. ITAOKA, S. TAHARA, M. MURASUGI, J. WADA
1985 Volume 14 Issue 3 Pages
1466-1469
Published: June 15, 1985
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Two patients with intravenous pacemaker electrodes presented dificulties of electrode removal. A 51 year old female with sick sinus syndrome had two fractured intravenous electrodes. Continuous traction of the lead was performed in vain for its removal. Under cardiopulmonary bypass, two leads were pulled out. One of these two leads could not be removed perfectly, because a part of lead tightly adhered to the subclaviari vein. The other case was a 67 year old male with complete A V block. The patient had infected two leads, showing intermittent fever. They were removed under bypass surgery.
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S. ISHIMARU, T. SHIMIZU, A. HAKOSHIMA, M. KITAMURA, M. YAMADA, S. KOIK ...
1985 Volume 14 Issue 3 Pages
1470-1472
Published: June 15, 1985
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A case of successful removal of infected endocardial pacemaker electrode with fined tip by continuous traction was reported. The experimenmtal investigation revealed that electrode catheter can be damaged by traction over 1kg in weight, and electrode fins can easely be torn off by traction in weigh of 300g. It is suggested that adhesion between the electrode and the endocardium should be deviced to be mainly promoted by electrode fins, in order to remove the electrode catheter without hazardous complications
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N. SHIRAKAWA, H. AIDA, T. SHIMIZU, T. IRIYAMA, H. IWANAMI, K. SHIMAZU, ...
1985 Volume 14 Issue 3 Pages
1473-1476
Published: June 15, 1985
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Two hundred and fortynine insertions of transvenous endocardial electrode lead have been performed at the Depertment of Thoracic and Cardiovascular Surgery, Hospital of Kanazawa Medical University, to August 1984.
We extracted the lead, which was complete distruption and migrated the right ventricle, by means of the grasp forceps for polypectomy without open heart surgery. As this procedure is safty and easy to extract the fructured lead in the intracardiac cavity, it is advisable to use this forceps.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1477
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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H. TSURUTA, K. OGAWA, S. YAMAMOTO, M. NAKAO, T. ASADA, T. HIKAMI, K. K ...
1985 Volume 14 Issue 3 Pages
1478-1480
Published: June 15, 1985
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Seventy pacemaker implantations were performed since Aug. 1981 to Oct. 1984 in Himeji Brain and Heart Center. Of these 70, arrhythmias and malfunction, such as, myopotential interference, reentrant loop tachycardia, pseudo-pseudo fusion, and malfunction of demand pacemaker, were seen in 4. Myopotential interference is unipolar sensing abnormality caused by myopotential. Reentrant loop tachycardia was seen in DDD pacemaker. It may appear when ventricular paced beats are conducted retrogradely to the atria as the ensuing P wave triggers the pacemaker to stimulate the ventricle. Pseudo-pseudo fusion is delivery of an atrial spike within the QRS complex in DVI pacemaker. Then ventricular spike is seen in T wave. Malfunction is serious problem, every malfunction must be reported to get better pacemaker.
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M. KAJI, A. HARADA, M. YOSHIMORI, F. SAITO, S. MATSUSHIMA, M. IKESHITA ...
1985 Volume 14 Issue 3 Pages
1481-1484
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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With ever increasing number of pacemaker implantations, it has become necessary to rationalize and simplify treatments of such patients. This is a report on the data processing of patients by the application of NEC Model PC-9801 Computer.
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H. AIDA, T. SHIMIZU, T. IRIYAMA, H. IWANAMI, K. SHIMAZU, S. SAKAMOTO, ...
1985 Volume 14 Issue 3 Pages
1485-1488
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Intracardiac potentials were measured and followed up by telemetric pacemaker systems after pacemaker implantation. Intracardiac amplitudes of P and R waves were maintained postaperatively. Intracardiac myopotentials were also measured and tachycardia due to oversensing of myopotentials was studied on the intracardiac electrocardiogram. The influence of electromagnetic interference was also examined by means of transcutaneous electrical nerve stimulator. Measurements of postoperative intracardiac amplitudes are of clinical use.
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Y. MATSUNAGA, K. KIYOHARA, T. MAGARA, T. MISAKI, T. IWA
1985 Volume 14 Issue 3 Pages
1489-1492
Published: June 15, 1985
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The daily changes in pacing threshold were measured on 30 patients with implanted pacemakers, using “Vario function” and Holter ECG. 15 patients showed the changes; in 8 patients the threshold increased in the night. In 2 patients who were implanted for 1 to 3 weeks, the threshold gradually increased until 7 or 8 postoperative days and then decreased. Especially for such patients, We need to measure the daily changes in pacing threshold.
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S. HORIKOSHI, S. MIYAZAWA, T. HORIGUCHI, Y. MOCHIZUKI, T. ARAI, M. YUJ ...
1985 Volume 14 Issue 3 Pages
1493-1496
Published: June 15, 1985
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The effect of nuclear magnetic resonance (NMR) imaging on eight representative cardiac pacemakers was studied. The results indicate that the threshold for initiating the asynchronous mode of a pacemaker is 11 gauss, although the pacemaker is not damaged by NMR imaging. When the demand type pacemaker is programmed to magnet response “OFF” under the gradient magnetic field and radiofrequency, pacing pulse of the unit is suppressed or is turned to fixed rate mode by sensing circuit discrimination. Therefor it should be better for us to refrain from giving NMR imaging to a patient with a pacemaker.
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M. YOSHIMORI, M. IKESHITA, S. TANAKA, N. YAMATE, T. SHOJI, K. OSUGI
1985 Volume 14 Issue 3 Pages
1497-1499
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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We often use an electromagnetic flow meter to measure cardiac output during electrical stimulation of the heart. When we give electrical stimuli in close to the measuring probe without-using this system, the flow baseline is unstable and the flow values are not reliable. In this case, we attach a gate circuit to the flow meter. This gate is closed only 5 cosec by the gete control pulse synchronized with pacing pulse. By using this system stable flow values are alwase available.
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Tetsuo KIDO, Yasumasa MONDEN, Kazuya NAKAHARA, Kiyoshi OHNO, Hajime MA ...
1985 Volume 14 Issue 3 Pages
1500-1504
Published: June 15, 1985
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An experimental study on diaphragm fatigue following diaphragm pacing Using mongrel dogs diaphragm pacing was performed to see a cause of pacing failure. Stimulation frequencies were set at 37/min (n=5), 25/min (n=5), and 12/min (n=4). Myoaction potential (Edi) decreased significantly (p<0.001) at the 60% of transdiaphragmatic pressure (Pdi), (from 319±141μV at baseline to 194±120μV at fatigue). Aminophylline infusion after muscle fatigue caused in remarkable increase in Pdi without no remarkable change in Edi. We conclude that the diaphragm muscle fatigue by itself was a cause of pacing failure.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1505
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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T. IGARI, S. HOSHINO, F. IWAYA, M. ANDO, T. ABE, K. TAKANO, M. TANJI, ...
1985 Volume 14 Issue 3 Pages
1506-1511
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Polypropylene hollow-fiber hemoconcentrator (MERA, 1.0m
2) was used for ultrafiltration during thirty cardiopulmonary bypass (CPB) without donor blood. Also, it was used for concentrating and reusing the diluted blood after CPB. Hemodilution rate was kept statiscally same value at the end of CPB. Sieving coefficient of albumin and free-Hb was 0.4 to 0.5 and it was beneficial for reusing the concentrated diluted blood. Extravascular lung water showed lower value compared with CPB without ultrafiltration.
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T. SASAKI, M. NAKANO, K. SUZUKI, A. MIZUNO, H. FURUKAWA, T. ARAI, H. K ...
1985 Volume 14 Issue 3 Pages
1512-1515
Published: June 15, 1985
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Postbypass hemoconcentration was achieved with plasmaseparator, Plasmaflo AP-08H® (10cases) [GroupI] and with new device, ASA-1200 (10cases)[GroupII]. Changes of blood components before and after hemoconcentration were analized. Ht significantly increased in both Groups, and RBC, Hb, WBC, Plat too. Free Hb was slightly concentrated in both Gourps, but not significantly. Serum protein was not concentrated in GourpI, but significantlyconcentrated in GroupII. The new blood-concentrator is therefore, recognized to bs an effective device for the hemoconcentration after cardiopulmonary bypass.
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I. NAKADA, Y. TOKUNAGA, S. ISHIHARA, S. SUZUKI, H. AKAMA, K. SOEJIMA, ...
1985 Volume 14 Issue 3 Pages
1516-1519
Published: June 15, 1985
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A single pass ultrafiltration (SPUF) with Hemo-Concentrator® (HC) was employed in 6 patients. It was expected that the blood components salvaged at the outlet of the HC would be sufficient to allow direct transfusion. At the end of bypass, the blood in the oxygenerator (1433±314ml) was pumped directly into the patient (9.5±1.8min) through the HC. Suction (-300--400mmHg) applied to the device extracted plasma water (700±163ml). SPUF concentrated diluted blood as follows; Ht from 24.2±2.6% to 42.0±4.2% and TP from 3.5±0.2g/dl to 8.1±2.6g/dl. Control group were transfused the diluted pump blood. Compared the SPUF group with the control group, there were no significant differences in the amount of postoperative bleeding and laboratory data. SPUF with the HC is an efficient, rapid and safe method for obtaining whole blood for blood conservation and volume control.
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K. SOEJIMA, H. KOYANAGI, R. NAKANO, S. SUZUKI, Y. SAKAI
1985 Volume 14 Issue 3 Pages
1520-1522
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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New hemofilter (HF) has been manufactured for concentration of priming blood in cardiopulmonary bypass (CPB). Priming of this HF which is hollow fiber type, is 75ml.. Materials of fibers are polymethyl metacrylate. UFR is 22ml./hour/torr (Bovine blood, 25°C, Ht25%, TP3.0g/dl). Quality test was performed with remaining human blood after CPB (n=5). When the blood was concentrated until mean value of 68.8±19.0%, absolute sieving coefficients (SCOE) in free Hb was 10.9±3.0% and in TP was 2.9±0.9% (p<0.01). This HF has high UFR and filtration performance of free Hb.
But SCOE of fee Hb is not yet satisfactory, we will improve the SCOE of free Hb.
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S. TAKAMOTO, S. KYO, K. HASEGAWA, Y. YOKOTE, R. OMOTO, K. KENMOKU, T. ...
1985 Volume 14 Issue 3 Pages
1523-1526
Published: June 15, 1985
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We developed an intraoperative autotransfusion system with regional heparinization, “Hemosaver”. The system was consisted of two roller pumps, a reservoir, a bubble detector, a Swank filter, a heater and infusion pumps for heparin and protamine. Autotransfusion volume is displayed. ACT in the body is kept aroud 200 sec. Hemosaver was used in 10 patiens. Easy handling, usefulness and safety of Hemosaver were proved clinically.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1527
Published: June 15, 1985
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R. HATTORI, M. FUKUYAMA, T. SAKAI, I. YADA, M. KUSGAWA
1985 Volume 14 Issue 3 Pages
1528-1531
Published: June 15, 1985
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We observed complement activation comparatively in non-haemic (8 patients) and haemic (7 patients) cardiopulmonary bypass. In cases of haemic priming, plasma levels of C
3 and C
4 were significantly decreased along with cardiopulmonary bypass, whereas in non-haemic cases C
3 levels were decreased but C
4 were not. We also found that by incubation of heparinized blood with silicone and polyesther membranes C
3 levels were decreased but C
4 were not. It is concluded that alternative pathway activation of complement is mainly occured in cardiopulmonary bypass without homologous blood and both alternative and classical pathway are involved with homologous blood.
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Y. SUZUKI, H. NIHEI, N. MIMYRA, Y. SUZUKI, M. UEDA, K. FUSE, T. KANNO, ...
1985 Volume 14 Issue 3 Pages
1532-1535
Published: June 15, 1985
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Post-pump syndrome occurs sometimes after cardiopulmonary bypass. It is thought that C3a and C5a play a causative role in the induction of the syndrome. The following conclusions about cardiopulmonary bypass using O
2 bubble oxygenator and membrane oxygenator were obtained. (1) Maximum decrease of WBC count occuredrto 61.7% at 30 min. followed by rebound. (2) Platelet count, C3, C4 and CH50 did not change. (3) C3a levels incresed to about 15 folds of pre-bypass level. No difference of C3a levels was observed between venous line and arterial line. (4) C5a levels raised either at venous line and arterial line.
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Y. MIYAMOTO, H. HIROSE, H. MATSUDA, S. NAJANO, Y. SASAKO, K. NISHIGAKI ...
1985 Volume 14 Issue 3 Pages
1536-1539
Published: June 15, 1985
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Complement activation during cardiopulmonary bypass was evaluated utilizing model circuit and classical pathway was found to be more activated compared to alternative pathway. In addition, it was indicated that this activation was strongly inhibited by FUT-175, new synthetic complement inhibitor.
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T. IGARI, S. HOSHINO, F. IWAYA, T. ABE, M. ANDO, K. TAKANO, M. TANJI, ...
1985 Volume 14 Issue 3 Pages
1540-1547
Published: June 15, 1985
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Thromboxane A
2 and OKY-046 during cardiopulmonary bypass, Seven patients who underwent valvular operations in which cardiopulmonary bypass without donor blood was used had rapid elevations of plasma thromboxane B
2 which did not return to normal during bypass. In eight patients receiving with OKY-046, inhibitor of thromboxane synthesis, 10ug/kg/min from induction of anesthesia till the end of bypass, OKY-046 eliminated the rise in TXB
2, but did not affected the changes in platelet count, leucocyte count, screen filtration pressure, scanning electron microscopy of blood filter, and postoperative hemodynamics including extravascular lung water.
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-Comparison between CPB using pros tacyc i l i n analogue alone and heparin alone
T. TAKAHAMA, K. SUDO, Y. KOTSUKA, K. WAKE, M. KAWAUCHI, Y. YOKOI, A. M ...
1985 Volume 14 Issue 3 Pages
1548-1551
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Prostacyclin analogue enabled CPB protecting platelet by reversible inhibitory effect on platelet aggregation, but caused some promotion of blood coagulation and fibrinolysis. Heparin proved to inhibit blood coagulation system completely, but caused much damage on platelets.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1552
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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T. ITO, T. SASAKI, T. KAZUI, S. KOMATSU, H. HARADA, T. OHNO, M. EBUOKA
1985 Volume 14 Issue 3 Pages
1553-1556
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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Recently it has been reported that cerebral circulatory arrest (CCA) is a very useful method for resection of aortic arch aneurysm. Using somatosensory evoked potentials (SSEP), which is a modality for detection of functional integrity of central nervous system, our experimental study was designed to clarify as to how long CCA would be safe for under deep hypothermia. Adult dogs were divided into two groups. Group I(N=12) was cooled to rectal temperature(RT) 20°C with cardiopulmonary bypass(CPB). And Group II(N=11) was also cooled to 15°C. In Group I, in cooling phase, SSEP-amplitude lowered gradually., and disappeared completely at 22°C. Following CCA, in rewarming phase, SSEPappeared again. Recovery of SSEP-amplitude, when CCA time was 30 min., was significantly(P<0.01) higher than that for more than 45 min at the end of CPB. While, in Group II, significant (P<0.05) recovery was shown unless CCA time exceeds 60 min. One patient underwent arch replacement using CCA (RT 16.5°C).Cerebral ischemic time was thirty-nine minutes. She was extubated on the first postoperative day and free from neurological damage. It was concluded that (1) ;CCA at RT 20°C and 15°C would be safe for at least 30 min and 60 min, respectively. (2) ;aortic arch reconstruction using CCA was a simplified technique in practice.
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H. SAIGUSA, T. NIIMI, K. YOSHIDA, K. OGAWA, Y. SUENAGA, E. TAKEUCHI, E ...
1985 Volume 14 Issue 3 Pages
1557-1560
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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One of the most clitical coanplication by using deep hypothermia is cereblovasular microembolism caused by the difference of solubility of oxygen and carbonediooxide. This study is examined on the microbubbles created by the different type oxygenator-by mean of ultrasonic echograply; two kinds of membrane oxygenator (Mesasilox, Capiox) and few kings of bubble oxygenator (Siley 070, BO55, Harvey H-1500, Harvey H-1500 (New-type) MI crobubbles were not visualized during the rewarming froan 20°to, 36°C in the cases of membrane oxygenator, but they were visualized in the cases of bubble oxygenator.
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K. KITAURA, Y. WADA, M. KADOWAKI, Y. SASAKI, K. OGA, T. OKA
1985 Volume 14 Issue 3 Pages
1561-1564
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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To investigate regional oerebral blood flow (CBF) of oerebral aortex following circulatory arrest with reperfusian, 15 mandrel dogs were subjected to cardiopulmonary bypass(CPB) using a pulsatile pump. Flow rate of perfusion was prescribed to 100 ml/kg/mm during the experiment. CBF was surveyed by means of hydrogen clearance method. CBF at normothermic perfusion using a pulsatile pump was not decreased compared with CBF before CPB, and reduced to about 38% of CHF before circulatory arrest (esophageal temperature 20°C). CBF following circulatory arrest with reperfusion (36°C) has improved to that of normothermic perfusion before circulatory arrest. CBF immediately after reperfusion was markedly increased cranpered with CBF before circulatory arrest (about 300%), in spite of same esophageal temperature, flow rate of perfusion, and arterial pressure. This fact suggests that CBF immediately after reperfusicn increases because of progressive vasodilatation during circulatory arrest, but more precise studies of metabolism, histology or cerbral circulation are required.
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M. OHTANI, H. HIROSE, S. MATSUDA, S. NAKANO, T. SAKAKIBARA, M. KANEKO, ...
1985 Volume 14 Issue 3 Pages
1565-1568
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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The effect of prostaglandin E
1 on the activation of platelet during cardiopulmonary bypass: Platelet activation during the first 60 min of cardiopulmonary bypass(CPB) was studied in 13 cases by measuring platelet count (P-C), platelet factor 4(PF4), β -thromboglobulin(βTG) and thromboxane B
2. In group I (control), P-C were reduced to 72% of the initial values of CPB, and PF4, STG were increased to 210%, 209%, respectively. In group II and III, receiving 50 and 100ng/kg/min of prostaglandin E
1 during CPB, P-C remained in the initial values. The increase of PF4 was less than in group I. Thromboxane B
2 showed no changes in each groups. Prostaglandin E
1 proved to prevent the reduction of P-C and release of PF4 during CPB.
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-A cctnparative study between continuous and intermittent drainage-
H. KAIZUKA, T. HINO, T. IRIE, Y. KASAGI, T. ITAOKA, H. NAGARA, M. YOKO ...
1985 Volume 14 Issue 3 Pages
1569-1572
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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We examinedthe intermittent pump drainage and the venous pulsatile flow through the development of the automatically controled extracorporeal circulation system. In this report, we examined the intraluminal pressure of the venous circuit in both continuous and intermittent pump drainage.
And also examined the efficacy of the compliance chamber in the venous circuit for the pressure fluctuation.
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H. MATSUKURA, K. SAKAI, T. TANABE, T. MURAMATSU
1985 Volume 14 Issue 3 Pages
1573-1576
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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The enzymes, cathechoramine and metabolic changes were studied by three dimensional graph in one hundred twenty six patients with extracorporeal circulation with core cooling . The following results were obtained 1) The lactic acid metabolism and carbohydrate metabolism were correlated to perfusion period rather than low body temparature by core cooling. 2) The influence on changes of enzymes with extracorporeal circulation was indicated by CPK rather than LDH or GOT. 3) The low perfusion pressure at immediate periods on extracorporeal circulation was correlated to bloody kinin level rather than serum adrenal in levels.
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[in Japanese]
1985 Volume 14 Issue 3 Pages
1577
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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T. YAMAGUCHI, S. TAMIYA, T. MATSUZAKI, H. NAKAKURA, T. ITO, H. YOKOYAM ...
1985 Volume 14 Issue 3 Pages
1578-1582
Published: June 15, 1985
Released on J-STAGE: October 07, 2011
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The clinical study was performed to compare the pulsatile (which obtained with Gambro pump and PBP device) with the nonpulsatile flows during the cardiopulmonary bypass. The effects of puisalite flow on the total peripheral resistance index and plasma renin activity were significantly more benefical than the nonpulsatile flow.
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