Antitumor effect by docetaxel (DOC) combined with hyperthermia for oral cancer and resistant tumor against cisplatinum (CDDP) were analyzed by mean of proliferation assay method using cell lines of human tongue squamous cell carcinoma (SAS) in vitro. Result of this experimental study, number of cells of SAS was remarkably decreased according to the concentration of dosage of DOC and different circumstances at the temperatures of 37, 40 and 43°C. This may consist of hypersensitivity of DOC. Moreover, tumor cells might be showed suppressive effects at the different concentration of DOC from 0.1 to 10μg/mL under the circumstance of 37°C and 40°C showed antitumor effects under different temperatures of 43°C for the resistant cells against CDDP. Based on these results, it is considered to be DOC act the hyperthermic sensitivity and effective against resistance of CDDP in hyperthermic chemotherapy using DOC in clinic.

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We examined the effect of a moisturizing mouth spray which contains lactoferrin, β-glucan, and hyaluronic acid as active ingredients, on 13 outpatients with xerostomia sensation and two inpatients with serious xerostomia.
The spray was used for these outpatients for 2 weeks, and the subjective symptoms regarding oral conditions before and after usage were evaluated by a questionnaire, consisting of 14 questions, using the five-point categorical Likert scale. According to the comparison between before and after the spray usage in each of the 14 questions by the Wilcoxon-signed rank test, oral dryness was significantly improved and mucous membrane pain was significantly reduced.
For the two patients with serious xerostomia, the moisture content of oral mucosa was measured by a moisture checker. The values of the moisture checker after spraying were 4.6- and 12.6-fold higher at 5 min than those before spraying, and were at least maintained (7.1-fold and 13.0-fold, respectively) at 10 min. After three weeks of using the spray, the values were 18.6- and 20.4-fold greater than the initial levels.
These results suggest that the spray containing lactoferrin, β-glucan, and hyaluronic acid effectively improved xerostomia both subjectively and objectively.

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Only a few analgesics are applicable to odontogenic pain under the existing Japanese health insurance system, although there are many kinds of analgesics available for medical diseases. Therefore, additional analgesics have been requested to be prescribed against odontogenic pain to the patient, especially with systemic diseases. On the other hand, it is necessary to establish an appropriate quantitative method to evaluate the effect of analgesics against odontogenic pain. Visual analogue scale (VAS) has recently come into general to evaluate the effect of analgesics against pain. The aim of this study was to establish a quantitative criterion for evaluating the effect of analgesics on odontogenic pain.
One hundred and sixteen patients with odontogenic pain were prescribed 60mg loxoprofen sodium hydrate, 500mg mefenamic acid or 400mg acetaminophen. They recorded the strength of odontogenic pain by VAS before medication and at 15 and 30 minutes, 1, 2, 3 and 5 hours after medication, and also graded strength, promptness and durability of analgesic effect at four ranks.
The decreased/increased rate of VAS value (VAS⊿%) significantly decreased after taking analgesics. There were no significant differences in VAS⊿% change among the three analgesics. It was found that VAS⊿% was correlated with patient's satisfaction with analgesic effects, including strength, promptness and durability of the prescribed drugs.
The results of this study suggested that the pain evaluation method by VAS used in this study may be useful to evaluate the effectiveness of analgesics against odontogenic pain.

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