歯科薬物療法
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
14 巻, 2 号
選択された号の論文の10件中1~10を表示しています
  • 小住 佳子, 大住 伴子, 宗 洋一郎, 東 泉, 黒木 賀代子
    1995 年14 巻2 号 p. 91-98
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    Sodium hypochlorite (NaOCl) is widely known to cause severe local irritation in a high concentration of 10 %, which is generally used for root canal cleaning in endodontic treatment. The cleaning effect has already been investigated in less than 10 % in order to find the minimal effective concentration. Little work, however, has been done to clarify its concentration-irritation relationship. In this study the solutions of serial dilutions in 2-n (n=0-8) of 10 % NaOCl and isotonic sodium chloride solution, a control, were injected intracutaneously into the skin of 3 rabbits, which were sacrificed 30 minutes, 3 days or 1 week after the injection. The sites of the injection and surrounding tissue were examined by the usual histopathological method. The changes in the structure caused by NaOCI were summarized as follows : Bleeding was found in all cases with concentration over 2.5 % throughout the observation period, and the most remarkable in the 30-minute case. Necrosis was caused in all cases over 5 % throughout the period, and in cases over 0.16 %, a degenerated tissue with hypochromatism, regarded as necrobiotic layer, appeared contiguous to the necrotic area in the 1-week case. Adjacent to the area of necrotic and necrobiotic, granulation tissue developed in cases over 0.63 %. Hyperaemia and inflammatory cell infiltration were observed in all cases over 0.04 % throughout the period and the latter was the most remarkable in the 3-day case. The findings related to inflammation were fewer as the concentration was lower, especially in cases less than 2.5%.
    From the above it was confirmed that the severe adverse reaction of the local tissue to the 10 % NaOCl was considerably reduced by decreasing its concentration.
  • ―ペリオクリンと歯石除去の併用効果について (その4ペリオクリン単独群, ペリオクリンと歯石除去の併用群および各種処置群との比較)
    上田 雅俊, 寺西 義浩, 中垣 直毅, 今井 久夫, 片桐 英一, 船岡 勝博, 福島 久典, 佐川 寛典
    1995 年14 巻2 号 p. 99-105
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    The clinical and microbial effects of Periocline® administration in periodontal pockets, in combination with scaling, were examined in patients using the following five groups. Five different sites, one in each quadrant, were randomly selected in each of 10 periodontal patients participating in this study. Each patient received the following treatment : scaling alone at one site (group A), Periocline® was administered four times at one-week intervals in combination with scaling at another site (group B), Periocline® was administrated four times at one-week intervals without scaling at the third site (group C), root planing alone at the fourth site (group D), and Periocline® was administrated four times at one-week intervals without scaling (group E) .
    The results obtained were as follows :
    1. Clinical findings, with exception of plaque index, showed improvement in groups B, C and D as compared with groups A and E throughout the observation periods.
    2. By phase contrast microscopy, both total bacterial count and spirochetal and motile rod incidence decreased in groups B, C and D as compared with groups A and E throughout the observation periods.
  • 宮坂 孝弘, 鈴木 宗一, 三須 徹, 山田 隆久, 佐藤 田鶴子, 藤田 裕紀, 野中 博子
    1995 年14 巻2 号 p. 106-109
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    Bleomycin (BLM) was locally administered by iontophoresis to treat a patient suffering from leukoplakia which developed on the back of the tongue. Except for erosion, no serious adverse effects were observed and the patient made favorable progress. The patient's clinical course is reported herein.
    Case : a 37-year-old male
    Present illness : Although the patient noticed leukoplakia on the back of the tongue in April 1992, he left it untreated because of the absence of disagreeable sensations including pain. The patient, however, recognized no improvement and was referred to this department for complete examination.
    Oral cavity findings : V-shaped leukoderma with relatively clear margins was observed nearly in the center of the back of the tongue. The leukoplakia was slightly protruded on the back of tongue and its roughness was palpable.
    Treatment and clinical course : With a diagnosis of leukoplakia, the patient received BLM local administration by iontophoresis from July 1992. A total of 9 sessions of iontophoresis was performed on 23 sites for 5 months. The clinical course was favorable and no recurrence was recognized. Therefore, BLM local administration by iontophoresis was proved to be effective therapy for leukoplakia.
  • 阪田 久美子, 沢田 東子, 斉藤 里香, 影向 範昭, 土田 八重子, 森塚 光子, 若松 佳子, 星野 文子, 水野 隆, 山本 加代子 ...
    1995 年14 巻2 号 p. 110-118
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    A comparison of studies between drug information services (DIS) in the hospitals of the private dental colleges and those of other hospitals was carried out by using questionnaires taken in 1984 and 1991. In the first study (in 1984), main DIS (documentation, response to request, support for pharmacy and therapeutic committee) in dental hospitals was the same as in other hospitals, but total activity was less. In the second study (in 1991), the activity of education for students and the collection of reports of adverse drug reaction were better performed in dental hospitals than other hospitals. Other specific points of DIS in dental hospitals were emphasized for the collection of information about drug interactions and the response to the request for drug therapy.
    Further, the general activity of DIS in dental hospital pharmacies was less than in other hospitals. The training of staff and the development of a technique for DIS were inadequate in each hospital. By the self-assessment of DIS on the basis of 5 points taken in the questionnaires in each hospital, the means were 2.2 in dental hospitals and 2.9 in other hospitals.
    The pharmacists in dental hospitals have to improve DIS for development of pharmaceutical care in dental hospitals.
  • 吉沼 直人, 音琴 淳一, 辻 康雄, 小林 雅実, 藤川 謙次, 伊藤 公一, 村井 正大
    1995 年14 巻2 号 p. 119-124
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    The purpose of this study was to evaluate the effect of 0.4% stannous fluoride (SnF2) gel on clinical parameters (plaque control record, plaque index, gingival index and bleeding on probing) and the number of Streptococcus mutans in saliva. Ten subjects were instructed to brush their teeth using 0.4% SnF2 gel twice a day for two weeks. After the examination of each clinical parameter, each subject was instructed to stop using the SnF2 gel for the subsequent another two weeks. The clinical findings were then reexamined and analyzed, in comparison with those at the first 2-week examination, The results indicated that use of the 0.4% SnF2 gel significantly improved clinical parameters and reduced the number of S. mutans in saliva. Therefore, 0.4% SnF2 gel seems to be a useful agent for chemical plaque control.
  • 浅木 信安, 鴨井 久博, 我妻 瑞穂, 宇野 文重, 奈良 あかね, 廣木 千恵, 長内 麻子, 鴨井 久一
    1995 年14 巻2 号 p. 125-131
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    The usefulness of Electrolized Oxidizing Water as a chemical plaque control agent was investigated. The subjects were 30 female volunteers ranging from 15 to 25 years of age, in whom the Plaque Index and Gingival Index were controlled to zero level before initiation of the study. The subjects were divided into three groups, ordered to rinse their mouth with Electrolized Oxidizing Water, distilled water or 0.05% CPC during the study interval, and not allowed to use a toothbrush or other cleaning devices during this period. The following clinical parameters were measured 0, 3, 7 and 10 days after initiation of the study ; 1) Plaque Index, 2) Gingival Index, 3) Gingival crevicular fluid level, 4) Bacterial flora, and 5) Halitosis. As a result, suppression of plaque increase, prevention of gingivitis and prevention of halitosis were noted after mouth rinsing with Electrolized Oxidizing Water and 0.05% CPC. These findings indicate that Electrolized Oxidizing Water ingredients are useful as a chemical plaque control agent.
  • 出山 義昭, 松本 章, 吉村 善隆, 鈴木 邦明
    1995 年14 巻2 号 p. 132-137
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    骨芽細胞様細胞株MC3T3-E1を通常のαMEM培地 (1.87mM Ca2+, 対照群) ならびに低カルシウム培地 (0.34mM Ca2+, 低カルシウム群) で通法によりsubconfluenceまで培養し, 無血清培地と交換した後, 24時間さらに培養した.それらの細胞に, カルシウムイオノホアであるA23187, Ca2+, あるいはA23187+Ca2+を添加し, それぞれ30分後に細胞は回収して全RNAを抽出してc-fos mRNAの発現をNorthern blot法を用いて分析を行った.その結果, A23187単独添加の場合, c-fos mRNAは対照群の方が低カルシウム群と比べより強く発現したが, Ca2+, あるいはA23187+Ca2+添加のいずれの場合においても, 対照群と比較して低カルシウム群において, c-fos mRNAの発現の発現がより増大していることが示された.また, 対照群においてはA23187単独添加の場合と比較して, A23187+Ca2+添加の場合, c-fos mRNA発現の低下が認められた.これらの事実から低カルシウム環境下に置かれるとMC3T3-E1細胞はCa2+流入に対する感受性が亢進し, A23187添加によるc-fos mRNAの発現が増大していることが示され, 低カルシウム環境という異常な環境に抗して, 正常機能を維持しようとする何らかの機構が作動していることが示唆された.また, 細胞外カルシウム濃度が増大すると, A23187添加によるCa2+流入に伴う細胞内情報伝達に抑制が生じていることが示唆された.
  • 水川 展吉, 西嶋 寛, 三好 憲裕, 森 貴幸, 西嶋 克巳
    1995 年14 巻2 号 p. 138-140
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    Chronic hyperplastic oral candidiasis is a disease which features the development of white lesions resembling leukoplakia. Although there have been a number of reports on this disease from foreign countries, it has rarely been reported in Japan.
    This disease is basically treated with antifungal agents. However, it often requires longterm therapy, and epithelial dysplasia may remain in some cases, even after the fungus has been eliminated. Moreover, since malignant transformation has been reported, surgical excision should be performed when the disease has run an excessively long course.
    The experience with a patient, who was histopathologically diagnosed as having chronic hyperplastic oral candidiasis is reported. A summary of this case is presented along with a reviw of the literature.
    A 67-year-old man visited our clinic with the chief complaint of bilateral buccal mucosal pain while eating. After making a clinical diagnosis of lichen planus, biopsy was performed, resulting in a histopathological diagnosis of chronic hyperplastic oral candidiasis. With antifungal therapy, the lesions disappeared within three months after diagnosis at our clinic. The patient has not relapsed up to the present (January 31, 1995) .
  • 河野 誠之, 佐々木 次郎, 山崎 純子
    1995 年14 巻2 号 p. 141-144
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
    Oral dose of 200mg sparfloxacin (SPFX) was administered before exodontia to 94 patients. The drug concentration of sparfloxacin in the effusion from the exodontia wound was measured from 615 to 1097 minutes after preoral administration. In 31 cases, the drug concentration in the gingival crevicular fluid was measured.
    SPFX has been recognized that 80% of MIC against Oral Streptococci was 0.39μg/ml. SPFX valued ≥0.39μg/ml in 73 cases out of 94 cases (77.7%) in the effusion from exodontia wound and valued ≥0.59μg/ml in all cases in the gingival crevicular fluid.
  • 1995 年14 巻2 号 p. 145-147
    発行日: 1995/08/01
    公開日: 2010/06/08
    ジャーナル フリー
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