Flomoxef Sodium (FMOX), a new oxacephem antibiotic, was preoperatively administrated by i.v. drip infusion at a dose of 2 g for half hours in patients with cyst formation in the jaw. Then the consentration of FMOX in serum, jaw bone, cyst wall or cyst like structure in the jaws, and its content, all collected during operation, were examined. Moreover, the pharmacokinetic analysis using compartment model was performed, and following result were obtained :
1. Peak levels of FMOX in serum, bone, cyst wall and its content were 122.30, 16.72 41.08, 8.48μg/ml, respectively, and the time of peak level were 0.5, 0.62, 0.61, 1.89 hours, respectively.
2. The half life of FMOX (β-phase) were 1.35, 1.35, 1.35, 2.08 hours, respectively.
3. The AUC values of FMOX were, 149.0, 27.4, 66.0, 52.9μg.h/ml, respectively.

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Acute and subacute toxicities of gargle (TG-89), containing azulene sodium sulfonate and benzethonium chloride, were investigated to obtain the following results : The LD₅₀ value in the acute toxicity study was approximately 1500 folds of the estimated clinical dose. In the acute toxicity study, disorders such as congestion observed by histopathological examination in the liver, kidney and spleen were found over 1000 folds of the estimated clinical dose. In the subacute toxicitiy study, no significant abnormality in general behavior, body weight, naked eye observation in gingiva was found. Histopathological examination also indicated no specific disorder except for the high doses. A trend of hypertrophy in the liver was indicated at a high dose of the gargle in acute and subacute toxicity tests. Thus, the gargle, containing azulene sodium sulfonate and benzethonium chloride, may be applied safely as an external preparation in the oral cavity.

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The Effect of gargle (TG-89) containing azulene sodium sulfonate and benzethonium chloride, on experimental gingivitis and surgical wound in rats was investigated. Experimental gingivitis was prepared by irritating the labial gingival tissue in mandibular associated with incisors of Wistar rat with a bundle of 30 needles. Surgical wound was made by incising holizontal-vertical lattice by a scalpel in the same region as above. Three formulations (high, medium, low) of the TG-89 were applied on the lesion once a day. Pysiological sailne solution was used as a negative control. Rats with no treatment were considered as an intact control. The lesion was examined by naked eye and then extracted and subjected to a histopathological examination. The results are as follows : (1) By naked eye observation, TG-89 led to decreased bleeding and earlier desquamation of necrotic lesion. (2) By the histopathological examination, it was found that TG-89 led to decrease inflammation and quickened repair. Thus, TG-89 might depress the inflammation of experimental gingivitis and surgical wound and it might also hasten the repair process of the lesion.

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In order to obtain a longer effective time with same dose of antibacterial agents, by contriving efforts on method of intravenous injection, the blood level of antibacterial agent was compared.
Three method of intravenous injection practically used in clinical study were adopted in the present study. Cephaloridine was three methods of intravenous injection, individually in NZW rabbits. The blood levels of cephaloridine were measured and compared. The blood levels were further subjected to pharmacokinetics and moment analysis to find the superiority or inferiority. The rerults showed that drip infusion (continuous intravenous injection), simultaneously with rapid intravenous injection (group-1) was excellent, drip infusion (continuous intravenous injection) only (group-3) is a little inferior and the two-time rapid intravenous injection (group-2) the worst.

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