An in-depth clinical experience investigation was performed post marketing surveillance based on the actual situation of the use of alminoprofen, after whose approval on the manufacture of the drug for clinical evaluation of its effects on postexodontic swelling and pain. In particular, the effectiveness and safety of the drug, which were prospective research factors, were investigated in a pediatric patient group, and then compared with those of an adult patient control group. The time at which the drug exerted its analgesic effect after administration was also studied in detail.
This analysis included 111 patients (47 pediatric patients and 64 adult patients), all of whom except for 17 cases receiving consecutive medication. According to the patients impressions of the drug's effectiveness, it was effective or better in 100% of pediatric patients and was effective or better in 95.2% of the adult patients. The drug was very effective in 42.2% of the pediatric patients and 14.5% of the adult patients, indicating a significantly higher efficacy rate in the pediatric patient group.
The degree of final global implement was moderate or better in 78.7% of the pediatric patients and slight or better in 95.7%. It was moderate or better in 64.1% of the adult patients and slight or better in 92.8% of the adult patients, showing no significant difference in the degree of final global improvement between the pediatric and the adult groups.
The frequency of the analgesic effect was analyzed according to the time of occurrence of the analgesic effect. The frequency of analgesic effect exerted within 15 minutes after administration was relatively high, 44.4% (55.3% for pediatric patients and 36.1% for adule patients) .
Adverse drug reactions were observed in 2 (1.6%) of the 128 patients ; each experienced mild nausea and fever (0.8%) . There were no serious adverse drug reactions.
The drug was useful or better in 78.7% and slightly useful or better in 95.7% of the pediatric patients, which it was useful or better in 62.5% and slightly useful or better in 90.6% of the adult patients, showing no significant difference between the two groups.
The results suggest that alminoprofen is very useful for treatment of postexodontic pain in pediatric as well as adult patients.

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Serum concentrations of Methotrexate (MTX) were evalated in oral cancer patients treated with combination therapy of MTX·5-FU. The dose of MTX (1-2.5mg/kg) was determined according to the functional condition of the kidney. Blood samples were taken immediately after the administration of MTX and at 6, 24, and 48 hours after the administration. MTX in serum was then measured by Fluorescence Polorization Immunoassay.
The results obtained were as follows :
1.Serum concentration of MTX reached teh effective concentration for therapy (1×10^-5M) immediately after the administration.
2. At 24 hours after the administration, serum concentration of MTX dropped below the concentration (1×10^-5M) that was reported to cause critical side effects.
3. The administration of calcium leucovorin was effective in preventing side effects such as stomatitis.
4. This combination therapy could also be applicable to the patients with slight kidney dysfunction.
These results suggest that monitoring the change of MTX concentration in serum is useful for making a treatment plan of MTX·5-FU therapy and for preventing critical side effects.

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In the present study, collagen pellets containing minocycline (M-P) and lysozyme chloride (L-P) were examined for the slow release of drugs and their effects on inflammatory symptoms. Testing of slow release was conducted using the UV measurement method (in vitvo) and HPLC (in vivo) for M-P and bioassay for L-P. Clinical examination (GI, BOP, and SI) as well as determination of lysozyme chloride concentration and the amount of gingival crevicular fluid (GCF) were performed in 12 patients with adult periodontotitis before, and 1, 3 and 7 days after administration of L-P or oral Leftose^®. Seventeen patients with adult periodontitis receives M-P alone or in combination with L-P. The minocycline concentration and amount of GCF were determined together with the clinical examination in these patients before, and 3 and 7 days after administration. The results showed that L-P provides lower drug release rates than M-P. The lysozyme chloride concentration in periodontal pockets increased on days 1 and 3 of administration in the L-P group, and on days 3 and 7 in the oral Leftose^® group. Both the concentration and percent residue of minocycline in periodontal pockets were higher in the combined M-P and L-P group than in the group that received M-P alone. Clinical symptoms of inflammation improved more in the L-P group than in the oral Leftose^® group, and in the combined M-P and L-P group than in the group that received M-P alone. GCF also decreased significantly in these groups over time. These results indicate that inflammatory symptoms are improved soon after local L-P administration and that the retention of minocycline in periodontal pockets is elevated after M-P administration

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We applied Beriplast^® P in various oral surgical procedures for 30 patients and studied its usefulness. Beriplast^® P was especially useful for post-extraction hemostasis in patients with hemorrhagic tendency and for protecting the wound surface of the palate. Beriplast^® P was also found to have no negative effects such as infection and delayed healing.

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This has been a report of headache as side effects after administration of antimicrobial agent. We encountered two cases. Case 1 was diagnosed as having chronic mandibular osteomyelitis. Cefteram pivoxil (CFTM-PI) was administrated to this patient in three 200 mg doses daily, one dose after each meal. The patient complained of a headache 2 to 3 hours after receiving the initial dose of 200mg.
Case 2 was diagnosed as possibly having postoperative infection. Roxithromycin (RU28965) was given in two 150 mg doses daily after breakfast and dinner for 4 days. This patient complained of a headache after the initial dose of 150mg, and it lasted for 4 days.
In these two cases, appearance of the headache occurred at about the time of maximum serum level.
We report these cases, because there have been few reports of headache as a side effect of these antibiotics.

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Clarithromycin (CAM) has been recognized superior to the commonly used Macrolide derivatives erythromycin (EM) in the susceptibility of causative organisms in odontogenic infections. This time, we have tested MICs against Oral Streptococci 79 strains. MIC90 was 0.20jtg/ml in CAM, so far 0.39pg/ml in EM against Oral Streptococci.
Oral dose of 200mg CAM was administered before exodontia in 133 patients. CAM valued ≥0.2μg/ml in 32 out of 45 cases between 120 and 180 minutes.

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